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4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19904 (17.39)18.7374
1990's4 (17.39)18.2507
2000's5 (21.74)29.6817
2010's9 (39.13)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Abell, CW; Brossi, A; Gessner, W; Shen, R1
Good, AC; Peterson, SJ; Richards, WG1
Castagnoli, N; Mabic, S1
Sullivan, JP; Tipton, KF1
Hansen, S; Jones, K; Perry, TL; Wall, RA1
Cavalla, D; Hadjiconstantinou, M; Laird, HE; Neff, NH1
Abell, CW; Brossi, A; Gessner, W; Shen, RS1
Iwasaki, K; Naritomi, Y; Niwa, T; Noda, K; Shiraga, T1
Hattori, K; Ishida, J; Iwashita, A; Matsuoka, N; Mihara, K; Yamamoto, H1
Cano, J; Hernández-Romero, MC; Machado, A; Santiago, M1
Dodd, CA; Klein, BG1
Ansah, TA; Bubser, M; Deutch, AY; Ferguson, MC; Montine, TJ; Nayyar, T; Neely, MD; Shawn Goodwin, J1
Fujita, K; Katafuchi, T; Kido, MA; Nakabeppu, Y; Noda, M; Ohno, M; Sakumi, K; Seike, T; Takaki, A; Tanaka, Y; Yamada, H; Yamaguchi, H; Yamakawa, Y; Yutsudo, N1
Cho, KH; Cho, SH; Hong, J; Ju, MS; Kim, DH; Kim, HG; Kim, SY; Lee, EH; Oh, MS; Park, W1
Cho, KH; Doo, AR; Eun-Kyung, K; Hong, J; Jung, JH; Jung, WS; Kim, SN; Lee, H; Moon, SK; Park, HJ; Park, JY1
Choi, JG; Huh, Y; Kim, HG; Kim, MC; Kim, SY; Oh, MS; Yang, WM1
Charlton, C; King, JM; Mackey, V; Muthian, G; Smith, M1
Bai, J; Jia, JJ; Kwon, Y; Wang, SD; Zeng, XS1
Inoue, T; Murayama, N; Sasaki, E; Shimizu, M; Uehara, S; Uno, Y; Yamazaki, H1
Bai, Q; Gao, J; Jia, Y; Jiang, R; Lai, F; Liu, X; Tang, Y; Xiao, H; Xie, W1
Goshima, Y; Hasegawa, M; Hensley, K; Masukawa, D; Nagai, J; Ohshima, T; Togashi, K; Tonouchi, A1
Agúndez, L; Antunes, AS; Bardelli, M; Bezard, E; Björklund, A; Björklund, T; Dovero, S; Henckaerts, E; Li, Q; Linden, RM; Pioli, EY; Rosenblad, C1
Cui, X; He, Z; Hu, L; Hua, L; Li, M; Liu, J; Yan, J1

Other Studies

23 other study(ies) available for 4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

ArticleYear
Synthesis and dihydropteridine reductase inhibitory effects of potential metabolites of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dihydropteridine Reductase; Humans; Hydroxylation; NADH, NADPH Oxidoreductases; Pyridines; Structure-Activity Relationship

1985
QSAR's from similarity matrices. Technique validation and application in the comparison of different similarity evaluation methods.
    Journal of medicinal chemistry, 1993, Oct-01, Volume: 36, Issue:20

    Topics: Carbolines; Chemical Phenomena; Chemistry, Physical; Electrochemistry; Imidazoles; Indoles; Molecular Structure; Pyridines; Structure-Activity Relationship

1993
Assessment of structural requirements for the monoamine oxidase-B-catalyzed oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridine derivatives related to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
    Journal of medicinal chemistry, 1996, Sep-13, Volume: 39, Issue:19

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding Sites; Cattle; Dopamine Agents; Kinetics; Liver; Molecular Structure; Monoamine Oxidase; Oxidation-Reduction; Structure-Activity Relationship; Substrate Specificity

1996
Interactions of the neurotoxin MPTP and its demethylated derivative (PTP) with monoamine oxidase-B.
    Neurochemical research, 1992, Volume: 17, Issue:8

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cattle; Dihydropyridines; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction

1992
4-phenylpyridine and three other analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lack dopaminergic nigrostriatal neurotoxicity in mice and marmosets.
    Neuroscience letters, 1987, Mar-20, Volume: 75, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Callitrichinae; Carbolines; Corpus Striatum; Dopamine; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Parkinson Disease; Pyridines; Substantia Nigra; Tetrahydroisoquinolines

1987
Intracerebroventricular administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its metabolite 1-methyl-4-phenylpyridinium ion (MPP+) decrease dopamine and increase acetylcholine in the mouse neostriatum.
    Neuropharmacology, 1985, Volume: 24, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcholine; Animals; Caudate Nucleus; Choline; Dopamine; Injections, Intraventricular; Male; Mice; Putamen; Pyridines

1985
Inhibition of dihydropteridine reductase by novel 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs.
    Science (New York, N.Y.), 1984, Apr-27, Volume: 224, Issue:4647

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dihydropteridine Reductase; Humans; Hydroxylation; Liver; NAD; NADH, NADPH Oxidoreductases; Pyridines; Rats; Structure-Activity Relationship; Synaptosomes

1984
Isolation and characterization of an alicyclic amine N-sulfotransferase from female rat liver.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:8

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acid Sequence; Animals; Chromatography, DEAE-Cellulose; Cytosol; Electrophoresis, Polyacrylamide Gel; Female; Immunoblotting; Immunochemistry; In Vitro Techniques; Liver; Male; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sulfotransferases

1994
4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Oct-01, Volume: 15, Issue:19

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Antipyrine; Benzamides; Humans; Inhibitory Concentration 50; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Structure-Activity Relationship

2005
Zocor Forte (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not.
    European journal of pharmacology, 2009, May-01, Volume: 609, Issue:1-3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Lipopolysaccharides; Male; Microdialysis; Nerve Endings; Neuroprotective Agents; Parkinson Disease; Perfusion; Rats; Rats, Wistar; Simvastatin

2009
Pyrethroid and organophosphate insecticide exposure in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease: an immunohistochemical analysis of tyrosine hydroxylase and glial fibrillary acidic protein in dorsolateral striatu
    Toxicology and industrial health, 2009, Volume: 25, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Chlorpyrifos; Disease Models, Animal; Drug Combinations; Drug Interactions; Glial Fibrillary Acidic Protein; Insecticides; Mice; Mice, Inbred C57BL; Neostriatum; Neuropil; Parkinsonian Disorders; Permethrin; Tyrosine 3-Monooxygenase

2009
Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation.
    The European journal of neuroscience, 2009, Volume: 30, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Aged, 80 and over; Animals; Cell Count; Cerebral Cortex; Denervation; Dopamine; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Norepinephrine; Parkinsonian Disorders; Serotonin

2009
Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
    PloS one, 2009, Sep-30, Volume: 4, Issue:9

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopamine; Hydrogen; Lipid Peroxidation; Mice; Neurodegenerative Diseases; Neurons; Oxidative Stress; Oxygen; Parkinson Disease; Risk; Water; Water Supply

2009
Protective effects of Chunghyuldan against ROS-mediated neuronal cell death in models of Parkinson's disease.
    Basic & clinical pharmacology & toxicology, 2010, Volume: 107, Issue:6

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Antioxidants; Caspase 3; Cell Death; Cells, Cultured; Disease Models, Animal; Dopamine; Drugs, Chinese Herbal; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Neuroprotective Agents; Neurotoxins; Oxidopamine; Parkinson Disease; PC12 Cells; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Substantia Nigra

2010
Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+/MPTP-induced cytotoxicity in vitro and in vivo.
    Journal of ethnopharmacology, 2010, Sep-15, Volume: 131, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Caspase 3; Cell Line, Tumor; Chromones; Cytotoxins; Disease Models, Animal; Dopamine; Drugs, Chinese Herbal; Enzyme Inhibitors; Humans; Magnoliopsida; Male; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Neuroblastoma; Neurons; Neuroprotective Agents; Parkinson Disease; Phosphorylation; Phytotherapy; Proto-Oncogene Proteins c-akt

2010
Polygalae radix inhibits toxin-induced neuronal death in the Parkinson's disease models.
    Journal of ethnopharmacology, 2011, Mar-24, Volume: 134, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Brain; Caspase 3; Cell Death; Disease Models, Animal; Dopamine; Male; Medicine, Korean Traditional; Mice; Mice, Inbred C57BL; Neurons; Nitric Oxide; Oxidopamine; Parkinson Disease; PC12 Cells; Phytotherapy; Plant Extracts; Plant Roots; Polygala; Rats; Reactive Oxygen Species

2011
L-Dihydroxyphenylalanine modulates the steady-state expression of mouse striatal tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine and its metabolites in an MPTP mouse model of Parkinson's disease.
    Life sciences, 2011, Oct-24, Volume: 89, Issue:17-18

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Aromatic-L-Amino-Acid Decarboxylases; Corpus Striatum; Dopamine; Female; Gene Expression Regulation; Levodopa; Mice; Mice, Inbred C57BL; Parkinson Disease; Parkinson Disease, Secondary; Tyrosine 3-Monooxygenase

2011
The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease.
    Free radical biology & medicine, 2014, Volume: 67

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Caspase 12; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Gene Expression Regulation; Heat-Shock Proteins; MAP Kinase Kinase 4; Mice; Mice, Transgenic; MPTP Poisoning; PC12 Cells; Protein Serine-Threonine Kinases; Rats; Signal Transduction; Thioredoxins; TNF Receptor-Associated Factor 2; Transcription Factor CHOP

2014
Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).
    Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:5

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Callithrix; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dinitrocresols; Female; Hydroxylation; Inactivation, Metabolic; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Oxygenases

2015
Intestinal Pathology and Gut Microbiota Alterations in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Mouse Model of Parkinson's Disease.
    Neurochemical research, 2018, Volume: 43, Issue:10

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Disease Models, Animal; Enteric Nervous System; Gastrointestinal Diseases; Gastrointestinal Microbiome; Inflammation; Male; Mice, Inbred C57BL; Parkinson Disease

2018
Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's model mice.
    Genes to cells : devoted to molecular & cellular mechanisms, 2019, Volume: 24, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopaminergic Neurons; Intercellular Signaling Peptides and Proteins; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Motor Activity; Neostriatum; Nerve Degeneration; Nerve Tissue Proteins; Parkinson Disease; Phosphorylation; Substantia Nigra; Suppression, Genetic

2019
Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease.
    Brain : a journal of neurology, 2019, Aug-01, Volume: 142, Issue:8

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Dependovirus; Drug Evaluation, Preclinical; Female; Genes, Reporter; Genes, Synthetic; Genetic Vectors; GTP Cyclohydrolase; Humans; Levodopa; Macaca mulatta; Male; Motor Activity; Parkinsonian Disorders; Pars Compacta; Proof of Concept Study; Putamen; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tyrosine 3-Monooxygenase

2019
MiR-302b-5p enhances the neuroprotective effect of IGF-1 in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease by regulating inducible nitric-oxide synthase.
    Cell biochemistry and function, 2020, Volume: 38, Issue:8

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Line, Tumor; Humans; Insulin-Like Growth Factor I; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neuroprotective Agents; Nitric Oxide Synthase Type II; Parkinson Disease, Secondary

2020