Compounds > 4-oxo-2-nonenal
Page last updated: 2024-09-05

4-oxo-2-nonenal and lysine

4-oxo-2-nonenal has been researched along with lysine in 10 studies

Compound Research Comparison

Studies
(4-oxo-2-nonenal)		Trials
(4-oxo-2-nonenal)		Recent Studies (post-2010)
(4-oxo-2-nonenal)		Studies
(lysine)		Trials
(lysine)		Recent Studies (post-2010) (lysine)
9404737,44962211,213

Protein Interaction Comparison

ProteinTaxonomy4-oxo-2-nonenal (IC50)lysine (IC50)
Cationic amino acid transporter 3Homo sapiens (human)158

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (60.00)29.6817
2010's4 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Doorn, JA; Petersen, DR1
Liu, J; Sayre, LM; Xu, G; Yuan, Q; Zhang, WH1
Arora, JS; Blair, IA; Lee, SH; Oe, T1
Lee, HG; Lin, D; Liu, Q; Perry, G; Sayre, LM; Smith, MA1
Sayre, LM; Zhu, X1
Doorn, JA; Petersen, DR; Stewart, BJ1
Beavers, WN; Galligan, JJ; Hill, S; Marnett, LJ; Rose, KL; Tallman, KA; Tansey, WP1
Amarnath, K; Amarnath, V1
Cui, Y; Hao, Q; Li, X; Li, XD; Lin, J1
Fu, L; Liebler, DC; Liu, K; Porter, NA; Sun, R; Tallman, KA; Tian, C; Yang, J; Yang, Y1

Other Studies

10 other study(ies) available for 4-oxo-2-nonenal and lysine

ArticleYear
Covalent modification of amino acid nucleophiles by the lipid peroxidation products 4-hydroxy-2-nonenal and 4-oxo-2-nonenal.
    Chemical research in toxicology, 2002, Volume: 15, Issue:11

    Topics: Aldehydes; Amino Acids; Arginine; Cysteine; Histidine; Kinetics; Lipid Peroxidation; Lysine; Protein Processing, Post-Translational; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity

2002
Model studies on protein side chain modification by 4-oxo-2-nonenal.
    Chemical research in toxicology, 2003, Volume: 16, Issue:4

    Topics: Acetylcysteine; Aldehydes; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Histidine; Imidazoles; Linoleic Acid; Lysine; Magnetic Resonance Spectroscopy; Oxygen; Proteins; Pyrroles; Ribonucleases; Stereoisomerism; Structure-Activity Relationship

2003
A novel lipid hydroperoxide-derived cyclic covalent modification to histone H4.
    The Journal of biological chemistry, 2003, Oct-24, Volume: 278, Issue:43

    Topics: Aldehydes; Amino Acid Sequence; Animals; Carbon Isotopes; Cattle; Cyclization; Deuterium; Histidine; Histones; Lipid Peroxides; Lysine; Peptides, Cyclic; Spectrometry, Mass, Electrospray Ionization

2003
4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal.
    Chemical research in toxicology, 2005, Volume: 18, Issue:8

    Topics: Aldehydes; Butylamines; Cell Line; Cell Survival; Cysteine; Cysteine Proteinase Inhibitors; Histidine; Humans; Immunohistochemistry; Indicators and Reagents; Kinetics; Lysine; Neurons; Neurotoxicity Syndromes; Oxidative Stress; Proteins; Schiff Bases; Spectrophotometry, Ultraviolet

2005
Long-lived 4-oxo-2-enal-derived apparent lysine michael adducts are actually the isomeric 4-ketoamides.
    Chemical research in toxicology, 2007, Volume: 20, Issue:2

    Topics: Aldehydes; Amides; Animals; Borohydrides; Cattle; Lactoglobulins; Linoleic Acid; Lysine; Molecular Structure; Stereoisomerism; Time Factors

2007
Residue-specific adduction of tubulin by 4-hydroxynonenal and 4-oxononenal causes cross-linking and inhibits polymerization.
    Chemical research in toxicology, 2007, Volume: 20, Issue:8

    Topics: Aldehydes; Animals; Brain; Cattle; Cross-Linking Reagents; Cysteine; Electrophoresis, Gel, Two-Dimensional; Lysine; Mass Spectrometry; Oxidative Stress; Polymers; Tubulin

2007
Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics.
    Journal of the American Chemical Society, 2014, Aug-27, Volume: 136, Issue:34

    Topics: Acylation; Aldehydes; Binding Sites; Cell Line, Tumor; DNA Adducts; Epigenesis, Genetic; Histones; Humans; Lysine; Models, Molecular; Nucleosomes; Oxidative Stress; Protein Processing, Post-Translational

2014
Scavenging 4-Oxo-2-nonenal.
    Chemical research in toxicology, 2015, Oct-19, Volume: 28, Issue:10

    Topics: Aldehydes; Free Radical Scavengers; Lipid Peroxidation; Lysine; Proteins; Pyridoxamine; Pyrroles

2015
Histone Ketoamide Adduction by 4-Oxo-2-nonenal Is a Reversible Posttranslational Modification Regulated by Sirt2.
    ACS chemical biology, 2017, 01-20, Volume: 12, Issue:1

    Topics: Aldehydes; Animals; HeLa Cells; Histone Code; Histones; Humans; Lysine; Mice; Models, Molecular; Protein Processing, Post-Translational; RAW 264.7 Cells; Sirtuin 2

2017
Chemoproteomics Reveals Chemical Diversity and Dynamics of 4-Oxo-2-nonenal Modifications in Cells.
    Molecular & cellular proteomics : MCP, 2017, Volume: 16, Issue:10

    Topics: Aldehydes; Amides; Cell Line; Cysteine; Histone Code; Humans; Lipid Peroxidation; Lysine; Oxidation-Reduction; Proteome; Proteomics; Pyrroles; Schiff Bases

2017