Compounds > 4-oxo-2-nonenal
Page last updated: 2024-09-05

4-oxo-2-nonenal and alpha-synuclein

4-oxo-2-nonenal has been researched along with alpha-synuclein in 8 studies

Compound Research Comparison

Studies
(4-oxo-2-nonenal)		Trials
(4-oxo-2-nonenal)		Recent Studies (post-2010)
(4-oxo-2-nonenal)		Studies
(alpha-synuclein)		Trials
(alpha-synuclein)		Recent Studies (post-2010) (alpha-synuclein)
9404710,821298,011

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's5 (62.50)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Bergström, J; Ingelsson, M; Karlsson, M; Lannfelt, L; Näsström, T; Nikolajeff, F; Wahlberg, T1
Barbu, M; Bergström, J; Ekberg, M; Fagerqvist, T; Ingelsson, M; Karlsson, M; Kasrayan, A; Lannfelt, L; Näsström, T; Nikolajeff, F1
Bergström, J; Fagerqvist, T; Ihse, E; Ingelsson, M; Kahle, PJ; Karlsson, M; Kasaryan, A; Lannfelt, L; Lindström, V; Näsström, T; Nikolajeff, F; Outeiro, TF; Sahlin, C; Schell, H; Tucker, SM1
Bergström, J; Cai, Y; Ingelsson, M; Karlsson, M; Kasrayan, A; Lannfelt, L; Lendel, C; Nikolajeff, F; Österlund, L1
Almandoz-Gil, L; Bergström, J; Ihse, E; Ingelsson, M; Karlsson, M; Khoonsari, PE; Kultima, K; Lendel, C; Musunuri, S; Sigvardson, J; Welander, H1
Almandoz-Gil, L; Bergström, J; Ingelsson, M1
Andersen, C; Christiansen, G; Grønnemose, AL; Jørgensen, TJD; Mulder, FAA; Nielsen, J; Nowak, JS; Otzen, DE; Pedersen, JN1
Andersen, CB; Arnspang, EC; Clausen, MP; Lausdahl, AK; Mulder, FAA; Nielsen, J; Otzen, DE1

Other Studies

8 other study(ies) available for 4-oxo-2-nonenal and alpha-synuclein

ArticleYear
The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers.
    Biochemical and biophysical research communications, 2009, Jan-23, Volume: 378, Issue:4

    Topics: Aldehydes; alpha-Synuclein; Amyloid; Chromatography, High Pressure Liquid; Humans; Lipid Peroxidation; Microscopy, Atomic Force; Molecular Weight; Parkinsonian Disorders; Protein Conformation; Sodium Dodecyl Sulfate

2009
The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties.
    Free radical biology & medicine, 2011, Feb-01, Volume: 50, Issue:3

    Topics: Aldehydes; alpha-Synuclein; Cell Survival; Humans; Inclusion Bodies; Lipid Peroxidation; Protein Multimerization; Protein Stability; Protein Structure, Secondary; Tumor Cells, Cultured

2011
Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo.
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2013, Volume: 20, Issue:4

    Topics: Aldehydes; alpha-Synuclein; Animals; Brain; Cell Line, Tumor; Humans; Mice; Mice, Transgenic; Microscopy, Atomic Force; Parkinson Disease

2013
Changes in secondary structure of α-synuclein during oligomerization induced by reactive aldehydes.
    Biochemical and biophysical research communications, 2015, Aug-14, Volume: 464, Issue:1

    Topics: Aldehydes; alpha-Synuclein; Chromatography, Gel; Circular Dichroism; Humans; Kinetics; Molecular Weight; Oxidation-Reduction; Protein Multimerization; Protein Structure, Secondary; Recombinant Proteins

2015
Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways.
    Free radical biology & medicine, 2017, Volume: 110

    Topics: Aldehydes; alpha-Synuclein; Amino Acid Sequence; Endopeptidase K; Humans; Hydrogen-Ion Concentration; Lipid Peroxidation; Oxidative Stress; Peptide Fragments; Protein Multimerization; Proteolysis; Solutions

2017
Generation and Characterization of Stable α-Synuclein Oligomers.
    Methods in molecular biology (Clifton, N.J.), 2018, Volume: 1779

    Topics: Aldehydes; alpha-Synuclein; Electrophoresis, Polyacrylamide Gel; Humans; Microscopy, Atomic Force; Parkinson Disease; Protein Multimerization; Protein Stability

2018
Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications.
    Biochemistry, 2021, 11-30, Volume: 60, Issue:47

    Topics: Aldehydes; alpha-Synuclein; Cell Line, Tumor; Humans; Lipid Peroxidation; Nuclear Magnetic Resonance, Biomolecular; Parkinson Disease; Protein Aggregates; Recombinant Proteins; Scattering, Small Angle; X-Ray Diffraction

2021
4-Oxo-2-nonenal-Induced α-Synuclein Oligomers Interact with Membranes in the Cell, Leading to Mitochondrial Fragmentation.
    Biochemistry, 2023, 08-15, Volume: 62, Issue:16

    Topics: Aldehydes; alpha-Synuclein; Humans; Lipid Peroxidation; Parkinson Disease

2023