4-oxo-2-nonenal has been researched along with 4-hydroxy-2-nonenal in 43 studies
| Studies (4-oxo-2-nonenal) | Trials (4-oxo-2-nonenal) | Recent Studies (post-2010) (4-oxo-2-nonenal) | Studies (4-hydroxy-2-nonenal) | Trials (4-hydroxy-2-nonenal) | Recent Studies (post-2010) (4-hydroxy-2-nonenal) |
|---|---|---|---|---|---|
| 94 | 0 | 47 | 3,034 | 26 | 1,103 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (34.88) | 29.6817 |
| 2010's | 27 (62.79) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Baraldi, PG; Geppetti, P; Materazzi, S; Preti, D | 1 |
| Blair, IA; Lee, SH; Oe, T | 1 |
| Doorn, JA; Petersen, DR | 2 |
| Liu, Z; Minkler, PE; Sayre, LM | 1 |
| Arora, JA; Blair, IA; Lee, SH; Oe, T | 1 |
| Carbone, DL; Doorn, JA; Ickes, BR; Kiebler, Z; Petersen, DR | 1 |
| Lee, HG; Lin, D; Liu, Q; Perry, G; Sayre, LM; Smith, MA | 1 |
| Doorn, JA; Hurley, TD; Petersen, DR | 1 |
| Kovacic, P | 1 |
| Lin, D; Sayre, LM; Tang, X; Yuan, Q; Zhu, X | 1 |
| Blair, IA; Kurangi, RF; Tilve, SG | 1 |
| Sayre, LM; Zhu, X | 1 |
| Doorn, JA; Petersen, DR; Stewart, BJ | 1 |
| Kuiper, HC; Miranda, CL; Sowell, JD; Stevens, JF | 1 |
| Carbone, DL; Doorn, JA; Kirichenko, OV; Petersen, DR; Reigan, P; Roede, JR | 1 |
| Joss, J; Jubert, C; Kuiper, HC; Langsdorf, BL; Mata, JE; Miranda, CL; Stevens, JF | 1 |
| Fujimoto, Y; Kitamura, T; Negoro, M; Sakuma, S | 1 |
| Goto, T; Lee, SH; Oe, T; Takahashi, R | 1 |
| Azenkeng, A; Hoffmann, MR; Picklo, MJ | 1 |
| Barbu, M; Bergström, J; Ekberg, M; Fagerqvist, T; Ingelsson, M; Karlsson, M; Kasrayan, A; Lannfelt, L; Näsström, T; Nikolajeff, F | 1 |
| Botella, JA; Kisiela, M; Martin, HJ; Maser, E; Schneuwly, S; Ziemba, M | 1 |
| Marnett, LJ; McGrath, CE; Porter, NA; Tallman, KA | 1 |
| Gu, X; Salomon, RG | 1 |
| Li, Q; Puchowicz, MA; Tomcik, K; Zhang, GF; Zhang, S | 1 |
| El-Kabbani, O; Endo, S; Hara, A; Hojo, A; Matsunaga, T; Yamane, Y | 1 |
| Alcón, E; Hidalgo, FJ; Zamora, R | 1 |
| Lee, SH | 1 |
| Beavers, WN; Codreanu, SG; Liebler, DC; Marnett, LJ; Porter, NA; Tallman, KA; Ullery, JC; Zhang, B; Zhu, J | 1 |
| Aldini, G; Altomare, A; Bertoletti, L; Carini, M; Colombo, R; Colzani, M; De Lorenzi, E; Marchese, L; Regazzoni, L; Vistoli, G | 1 |
| Prokai, L; Prokai-Tatrai, K; Szarka, S | 1 |
| Backos, DS; Fritz, KS; Galligan, JJ; Jiang, H; MacLean, KN; Petersen, DR; Reigan, PR; Shearn, CT; Smathers, RL | 1 |
| Hintzpeter, J; Martin, HJ; Maser, E | 1 |
| Bhatnagar, A; Kapoor, A; Singh, M | 1 |
| Bergström, J; Cai, Y; Ingelsson, M; Karlsson, M; Kasrayan, A; Lannfelt, L; Lendel, C; Nikolajeff, F; Österlund, L | 1 |
| Annibal, A; Burchardt, N; Fedorova, M; Ferreri, C; Gille, L; Jovanovic, O; Pashkovskaya, AA; Pohl, EE; Sansone, A; Vazdar, M | 1 |
| Krewenka, C; Moldzio, R; Pohl, EE; Vazdar, K; Zimmermann, L | 1 |
| Margetić, D; Vazdar, K; Vazdar, M; Vojta, D | 1 |
| Almandoz-Gil, L; Bergström, J; Ihse, E; Ingelsson, M; Karlsson, M; Khoonsari, PE; Kultima, K; Lendel, C; Musunuri, S; Sigvardson, J; Welander, H | 1 |
| Almandoz-Gil, L; Bergström, J; Ingelsson, M | 1 |
| Arnett, D; Geldenhuys, WJ; Konkle, M; Menze, MA; Quillin, A | 1 |
| Fujioka, S; Lee, SH; Oe, T; Takahashi, R | 1 |
| Andersen, C; Christiansen, G; Grønnemose, AL; Jørgensen, TJD; Mulder, FAA; Nielsen, J; Nowak, JS; Otzen, DE; Pedersen, JN | 1 |
3 review(s) available for 4-oxo-2-nonenal and 4-hydroxy-2-nonenal
| Article | Year |
|---|---|
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Asthma; Humans; Ion Channel Gating; Neurons; Pain; Peripheral Nervous System Diseases; Pulmonary Disease, Chronic Obstructive; Transient Receptor Potential Channels | 2010 |
Protein adducts generated from products of lipid oxidation: focus on HNE and one.
Topics: Aldehydes; Animals; Humans; Lipid Peroxidation; Oxidation-Reduction; Oxidative Stress; Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2006 |
[Oxidative stress-mediated chemical modifications to biomacromolecules: mechanism and implication of modifications to human skin keratins and angiotensin II].
Topics: Aldehydes; Angiotensin II; Animals; Aspartic Acid; Cardiovascular Diseases; DNA; DNA Damage; Glutamyl Aminopeptidase; Humans; Keratins; Lipid Peroxides; Mass Spectrometry; Methionine; Oxidative Stress; Reactive Oxygen Species; Receptor, Angiotensin, Type 2; Skin | 2013 |
40 other study(ies) available for 4-oxo-2-nonenal and 4-hydroxy-2-nonenal
| Article | Year |
|---|---|
Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins.
Topics: Aldehydes; Antioxidants; Ascorbic Acid; Buffers; Copper; Cyclooxygenase 1; Cyclooxygenase 2; DNA Adducts; DNA Damage; Epoxy Compounds; Ferrous Compounds; Humans; Isoenzymes; Linoleic Acids; Lipid Peroxides; Membrane Proteins; Metals; Mutagens; Oxidants; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases | 2001 |
Covalent modification of amino acid nucleophiles by the lipid peroxidation products 4-hydroxy-2-nonenal and 4-oxo-2-nonenal.
Topics: Aldehydes; Amino Acids; Arginine; Cysteine; Histidine; Kinetics; Lipid Peroxidation; Lysine; Protein Processing, Post-Translational; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity | 2002 |
Covalent adduction of nucleophilic amino acids by 4-hydroxynonenal and 4-oxononenal.
Topics: Aldehydes; Amino Acids; Kinetics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2003 |
Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal.
Topics: Aldehydes; Amino Acid Sequence; Apoproteins; Chymotrypsin; Cross-Linking Reagents; Mass Spectrometry; Molecular Sequence Data; Myoglobin; Peptide Fragments; Proteins; Pyrroles; Trypsin | 2003 |
4-Hydroperoxy-2-nonenal-induced formation of 1,N2-etheno-2'-deoxyguanosine adducts.
Topics: Aldehydes; Deoxyguanosine; DNA Adducts; Epoxy Compounds | 2005 |
Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease.
Topics: Aldehydes; Animals; Disease Models, Animal; HSP90 Heat-Shock Proteins; Lipid Peroxidation; Liver Diseases, Alcoholic; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2005 |
4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal.
Topics: Aldehydes; Butylamines; Cell Line; Cell Survival; Cysteine; Cysteine Proteinase Inhibitors; Histidine; Humans; Immunohistochemistry; Indicators and Reagents; Kinetics; Lysine; Neurons; Neurotoxicity Syndromes; Oxidative Stress; Proteins; Schiff Bases; Spectrophotometry, Ultraviolet | 2005 |
Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Alkylation; Binding Sites; Enzyme Inhibitors; Fatty Acids, Unsaturated; Glutathione; Humans; Kinetics; Mitochondria; NAD; Oxidation-Reduction; Peptide Fragments; Peptide Mapping; Recombinant Proteins; Trypsin | 2006 |
Novel electrochemical approach to enhanced toxicity of 4-oxo-2-nonenal vs. 4-hydroxy-2-nonenal (role of imine): oxidative stress and therapeutic modalities.
Topics: Acrolein; Aldehydes; Biochemistry; Electrochemistry; Electron Transport; Imines; Models, Biological; Models, Chemical; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species | 2006 |
Convenient and efficient syntheses of 4-hydroxy-2(E)-nonenal and 4-oxo-2(E)-nonenal.
Topics: Aldehydes; Hydrolysis; Molecular Structure; Oxidation-Reduction | 2006 |
Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal.
Topics: Aldehydes; Kinetics; Linoleic Acid; Mass Spectrometry; Models, Molecular; Molecular Conformation; Proteins; Schiff Bases | 2007 |
Residue-specific adduction of tubulin by 4-hydroxynonenal and 4-oxononenal causes cross-linking and inhibits polymerization.
Topics: Aldehydes; Animals; Brain; Cattle; Cross-Linking Reagents; Cysteine; Electrophoresis, Gel, Two-Dimensional; Lysine; Mass Spectrometry; Oxidative Stress; Polymers; Tubulin | 2007 |
Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress.
Topics: Acetylcysteine; Aldehydes; Animals; Biomarkers; Carbon Tetrachloride; Chromatography, Liquid; Lactones; Linoleic Acid; Lipid Peroxidation; Mass Spectrometry; Models, Chemical; Oxidative Stress; Rats; Rats, Inbred F344 | 2008 |
In vitro and in silico characterization of peroxiredoxin 6 modified by 4-hydroxynonenal and 4-oxononenal.
Topics: Aldehydes; Animal Feed; Animals; Antioxidants; Computational Biology; Cross-Linking Reagents; Ethanol; Liver; Male; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Peroxiredoxin VI; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
Quantitation of mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in a smoking cessation study.
Topics: Acetylcysteine; Adolescent; Adult; Aged; Aldehydes; Female; Humans; Male; Middle Aged; Oxidative Stress; Reference Values; Smoking Cessation; Young Adult | 2010 |
Xanthine oxidase-derived reactive oxygen species mediate 4-oxo-2-nonenal-induced hepatocyte cell death.
Topics: Aldehydes; Animals; Apoptosis; Dose-Response Relationship, Drug; Hepatocytes; In Vitro Techniques; Rats; Reactive Oxygen Species; Xanthine Oxidase | 2010 |
Mass spectrometric characterization of modifications to angiotensin II by lipid peroxidation products, 4-oxo-2(E)-nonenal and 4-hydroxy-2(E)-nonenal.
Topics: Aldehydes; Amino Acid Sequence; Angiotensin II; Borohydrides; Chromatography, High Pressure Liquid; Lipid Peroxidation; Oligopeptides; Oxidation-Reduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors | 2010 |
Trans-4-oxo-2-nonenal potently alters mitochondrial function.
Topics: Aldehyde Dehydrogenase; Aldehydes; Animals; Brain; Cell Respiration; Glutathione; Lipid Peroxidation; Mitochondria; Mitochondrial Swelling; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 2011 |
The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties.
Topics: Aldehydes; alpha-Synuclein; Cell Survival; Humans; Inclusion Bodies; Lipid Peroxidation; Protein Multimerization; Protein Stability; Protein Structure, Secondary; Tumor Cells, Cultured | 2011 |
The Drosophila carbonyl reductase sniffer is an efficient 4-oxonon-2-enal (4ONE) reductase.
Topics: Alcohol Oxidoreductases; Aldehydes; Animals; Cloning, Molecular; Drosophila melanogaster; Drosophila Proteins; Lipid Metabolism; Neurodegenerative Diseases; Oxidation-Reduction; Oxidative Stress; Recombinant Proteins | 2011 |
Structure-activity analysis of diffusible lipid electrophiles associated with phospholipid peroxidation: 4-hydroxynonenal and 4-oxononenal analogues.
Topics: Aldehydes; Cell Line, Tumor; Chromatography, High Pressure Liquid; Diffusion; Humans; Hydrolysis; Interferon-gamma; Interleukin-1beta; Interleukin-6; Lipid Peroxidation; Lipopolysaccharides; Oxidation-Reduction; Phagocytosis; Phosphatidylcholines; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2011 |
Fragmentation of a linoleate-derived γ-hydroperoxy-α,β-unsaturated epoxide to γ-hydroxy- and γ-oxo-alkenals involves a unique pseudo-symmetrical diepoxycarbinyl radical.
Topics: Aldehydes; Epoxy Compounds; Free Radicals; Hydrolysis; Iron; Linoleic Acids; Lipid Peroxidation; Oxidation-Reduction; Tandem Mass Spectrometry | 2012 |
Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver.
Topics: Aldehydes; Alkenes; Animals; Biomarkers; Diet, High-Fat; Diet, Ketogenic; Dietary Fats, Unsaturated; Glutathione; Lipid Peroxidation; Liver; Male; Mass Spectrometry; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar | 2012 |
Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers.
Topics: 20-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Aldehydes; Aldo-Keto Reductase Family 1 Member C3; Cell Line, Tumor; Cisplatin; Colonic Neoplasms; Drug Resistance, Neoplasm; HeLa Cells; HT29 Cells; Humans; Hydroxyprostaglandin Dehydrogenases; MCF-7 Cells; Oxidative Stress; Proteasome Endopeptidase Complex | 2013 |
Strecker-type degradation of phenylalanine initiated by 4-oxo-2-alkenals in comparison to that initiated by 2,4-alkadienals, 4,5-epoxy-2-alkenals, or 4-hydroxy-2-nonenal.
Topics: Acetaldehyde; Aldehydes; Lipid Peroxidation; Maillard Reaction; Oxidation-Reduction; Phenylalanine | 2013 |
Alkylation damage by lipid electrophiles targets functional protein systems.
Topics: Aldehydes; Alkylation; Cell Line; Electrons; Glutathione; Humans; Lipids; Protein Interaction Maps; Proteins; Proteome | 2014 |
Advanced glycation end products of beta2-microglobulin in uremic patients as determined by high resolution mass spectrometry.
Topics: Acrolein; Aldehydes; Arginine; beta 2-Microglobulin; Glucose; Glycation End Products, Advanced; Glyoxal; Humans; Mass Spectrometry; Pyruvaldehyde; Uremia | 2014 |
Application of screening experimental designs to assess chromatographic isotope effect upon isotope-coded derivatization for quantitative liquid chromatography-mass spectrometry.
Topics: Acrolein; Aldehydes; Animals; Carbon Isotopes; Chromatography, Liquid; Deuterium; Female; Isotope Labeling; Malondialdehyde; Mice, Inbred Strains; Nitrogen Isotopes; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Temperature | 2014 |
Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.
Topics: Adenosine Triphosphatases; Aldehydes; Amino Acid Sequence; Animals; Computer Simulation; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Humans; Inflammation; Liver Diseases, Alcoholic; Male; Mice; Mice, Inbred C57BL; Models, Molecular; Oxidative Stress; Protein Binding; Protein Folding; Protein Structure, Tertiary; Unfolded Protein Response | 2014 |
Reduction of lipid peroxidation products and advanced glycation end-product precursors by cyanobacterial aldo-keto reductase AKR3G1—a founding member of the AKR3G subfamily.
Topics: Aldehyde Reductase; Aldehydes; Aldo-Keto Reductases; Amino Acid Sequence; Bacterial Proteins; Catalytic Domain; Glycation End Products, Advanced; Humans; Kinetics; Ligands; Lipid Peroxidation; Models, Molecular; Molecular Sequence Data; Protein Conformation; Recombinant Proteins; Sequence Homology, Amino Acid; Synechocystis | 2015 |
Oxidative and reductive metabolism of lipid-peroxidation derived carbonyls.
Topics: Acrolein; Alcohol Oxidoreductases; Aldehyde Dehydrogenase; Aldehyde Reductase; Aldehydes; Aldo-Keto Reductases; Glutathione; Lipid Peroxidation; Lipids; Malondialdehyde; Oxidation-Reduction; Oxidative Stress; Oxidoreductases; Protein Carbonylation; Reactive Oxygen Species | 2015 |
Changes in secondary structure of α-synuclein during oligomerization induced by reactive aldehydes.
Topics: Aldehydes; alpha-Synuclein; Chromatography, Gel; Circular Dichroism; Humans; Kinetics; Molecular Weight; Oxidation-Reduction; Protein Multimerization; Protein Structure, Secondary; Recombinant Proteins | 2015 |
The molecular mechanism behind reactive aldehyde action on transmembrane translocations of proton and potassium ions.
Topics: Aldehydes; Fatty Acids; Humans; Ion Channels; Lipid Bilayers; Mitochondrial Proteins; Molecular Dynamics Simulation; Potassium; Protein Conformation; Protons; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Uncoupling Protein 1 | 2015 |
Nutrient deprivation in neuroblastoma cells alters 4-hydroxynonenal-induced stress response.
Topics: Aldehydes; Animals; Cell Line, Tumor; Cell Shape; Cell Survival; Energy Metabolism; Glucose; Glutamine; Lipid Peroxidation; Membrane Potential, Mitochondrial; Mice; Mitochondria; Neuroblastoma; Oxidation-Reduction; Oxidative Stress; Time Factors | 2017 |
Reaction Mechanism of Covalent Modification of Phosphatidylethanolamine Lipids by Reactive Aldehydes 4-Hydroxy-2-nonenal and 4-Oxo-2-nonenal.
Topics: Aldehydes; Mass Spectrometry; Phosphatidylethanolamines; Proton Magnetic Resonance Spectroscopy; Spectroscopy, Fourier Transform Infrared | 2017 |
Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways.
Topics: Aldehydes; alpha-Synuclein; Amino Acid Sequence; Endopeptidase K; Humans; Hydrogen-Ion Concentration; Lipid Peroxidation; Oxidative Stress; Peptide Fragments; Protein Multimerization; Proteolysis; Solutions | 2017 |
Generation and Characterization of Stable α-Synuclein Oligomers.
Topics: Aldehydes; alpha-Synuclein; Electrophoresis, Polyacrylamide Gel; Humans; Microscopy, Atomic Force; Parkinson Disease; Protein Multimerization; Protein Stability | 2018 |
4-Hydroxynonenal and 4-Oxononenal Differentially Bind to the Redox Sensor MitoNEET.
Topics: Aldehydes; Binding Sites; Humans; Mitochondrial Proteins; Models, Molecular; Molecular Structure; Oxidation-Reduction | 2019 |
Angiotensin II-Induced Oxidative Stress in Human Endothelial Cells: Modification of Cellular Molecules through Lipid Peroxidation.
Topics: Aldehydes; Angiotensin II; Ascorbic Acid; Carbon Isotopes; Cell Line; Copper Sulfate; Endothelial Cells; Humans; Isotope Labeling; Linoleic Acid; Lipid Peroxidation; Oxidative Stress; Receptor, Angiotensin, Type 1 | 2019 |
Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications.
Topics: Aldehydes; alpha-Synuclein; Cell Line, Tumor; Humans; Lipid Peroxidation; Nuclear Magnetic Resonance, Biomolecular; Parkinson Disease; Protein Aggregates; Recombinant Proteins; Scattering, Small Angle; X-Ray Diffraction | 2021 |