4-nitrososulfamethoxazole has been researched along with sulfamethoxazole in 10 studies
*Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208) [MeSH]
*Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208) [MeSH]
| Studies (4-nitrososulfamethoxazole) | Trials (4-nitrososulfamethoxazole) | Recent Studies (post-2010) (4-nitrososulfamethoxazole) | Studies (sulfamethoxazole) | Trials (sulfamethoxazole) | Recent Studies (post-2010) (sulfamethoxazole) |
|---|---|---|---|---|---|
| 11 | 1 | 5 | 5,813 | 680 | 1,216 |
| Protein | Taxonomy | 4-nitrososulfamethoxazole (IC50) | sulfamethoxazole (IC50) |
|---|---|---|---|
| Dihydropteroate synthase | Escherichia coli K-12 | 4.7 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 4.7 | |
| Dihydrofolate reductase | Pneumocystis carinii | 0.1 | |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | 4 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ay, M; Çelik, A; Güngör, T; Yetiş, G | 1 |
| Naisbitt, DJ; Park, BK; Pirmohamed, M; Stalford, AC; Vilar, FJ; Wilkins, EG | 1 |
| Britschgi, M; Burkhart, C; Depta, JP; Naisbitt, DJ; Park, KB; Pichler, WJ; von Greyerz, S | 1 |
| Lavergne, SN; Maki, JE; Trepanier, LA; Volkman, EM; Yoder, AR | 1 |
| Bajad, SU; Graziano, FM; Guzinski, MV; Kurian, JR; Lavergne, SN; Maki, JE; Trepanier, LA; Yoder, AR | 1 |
| Ashby, CA; Clarke, SE; Farrell, J; Naisbitt, DJ; Park, BK; Pirmohamed, M; Rieder, MJ; Sanderson, JP; Tucker, MJ | 1 |
| Faulkner, L; Gibson, A; Naisbitt, DJ; Ogese, M; Park, BK; Peckham, D; Saide, K; Sullivan, A; Wang, E; Whitaker, P | 1 |
| Alfirevic, A; Baker, DM; Faulkner, L; Naisbitt, DJ; Ogese, MO; Park, BK; Peckham, D; Pirmohamed, M; Saide, K; Sette, A; Whitaker, P | 1 |
| Alfirevic, A; Faulkner, L; Gibson, A; Kevin Park, B; Naisbitt, DJ; Pirmohamed, M; Sullivan, A; Tailor, A; Usui, T | 1 |
| Al-Attar, Z; Alfirevic, A; Esser, PR; Faulkner, L; Gibson, A; Lichtenfels, M; Martin, SF; Naisbitt, DJ; Ogese, M; Park, BK; Pirmohamed, M | 1 |
1 trial(s) available for 4-nitrososulfamethoxazole and sulfamethoxazole
| Article | Year |
|---|---|
Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso.
Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Cell Separation; Cyclic N-Oxides; Drug Hypersensitivity; Female; Glutathione; HIV Infections; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Oxidation-Reduction; Spin Labels; Sulfamethoxazole | 2006 |
9 other study(ies) available for 4-nitrososulfamethoxazole and sulfamethoxazole
| Article | Year |
|---|---|
Modification of existing antibiotics in the form of precursor prodrugs that can be subsequently activated by nitroreductases of the target pathogen.
Topics: Anti-Bacterial Agents; Disk Diffusion Antimicrobial Tests; Drug Resistance, Bacterial; Kinetics; Nitroreductases; Prodrugs; Spectrophotometry, Ultraviolet; Staphylococcus; Sulfamethoxazole | 2016 |
Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.
Topics: Adult; Chromatography, High Pressure Liquid; Cysteine; Disease Progression; Drug Hypersensitivity; HIV Infections; HIV-1; Humans; Middle Aged; Oxidation-Reduction; Sulfamethoxazole; Sulfhydryl Compounds | 2000 |
Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells.
Topics: Adult; Anti-Infective Agents; CD4-Positive T-Lymphocytes; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Down-Regulation; Drug Hypersensitivity; Drug Interactions; Female; Glutathione; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Receptors, Antigen, T-Cell; Sulfamethoxazole | 2001 |
Evaluation of the clinical, immunologic, and biochemical effects of nitroso sulfamethoxazole administration to dogs: a pilot study.
Topics: Animals; Anti-Infective Agents; Antibody Formation; Ascorbic Acid; Biotransformation; Cysteine; Dogs; Drug Hypersensitivity; Female; Glutathione; In Vitro Techniques; Pilot Projects; Random Allocation; Spleen; Sulfamethoxazole | 2005 |
Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling.
Topics: Animals; Anti-Infective Agents; Aryl Hydrocarbon Hydroxylases; CD40 Antigens; CD40 Ligand; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Dendritic Cells; Drug Hypersensitivity; Granulocyte Colony-Stimulating Factor; HIV Infections; Humans; Interleukin-3; Mice; Mice, Inbred BALB C; Recombinant Fusion Proteins; Recombinant Proteins; Sulfamethoxazole; Up-Regulation | 2007 |
Negative regulation by PD-L1 during drug-specific priming of IL-22-secreting T cells and the influence of PD-1 on effector T cell function.
Topics: Adult; Anti-Bacterial Agents; B7-H1 Antigen; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Fas Ligand Protein; Female; Flow Cytometry; Floxacillin; Humans; Interferon-gamma; Interleukin-13; Interleukin-2; Interleukin-22; Interleukin-5; Interleukins; Lymphocyte Activation; Programmed Cell Death 1 Receptor; Protein Binding; Sulfamethoxazole; Young Adult | 2014 |
HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis.
Topics: Alleles; CD4-Positive T-Lymphocytes; Cell Proliferation; Cystic Fibrosis; Drug Hypersensitivity; Female; HLA-DQ beta-Chains; Humans; Lymphocyte Activation; Male; Sulfamethoxazole | 2015 |
Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity.
Topics: Adult; Biological Specimen Banks; Cell Proliferation; Cells, Cultured; Coculture Techniques; Cytokines; Drug Hypersensitivity; Female; Gene Frequency; Histocompatibility Testing; HLA Antigens; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Risk Assessment; Sulfamethoxazole; T-Lymphocytes; Toxicity Tests; Young Adult | 2016 |
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors.
Topics: CD4-Positive T-Lymphocytes; CTLA-4 Antigen; Drug Hypersensitivity; Haptens; Hepatitis A Virus Cellular Receptor 2; Humans; Immunologic Memory; Lymphocyte Activation; Programmed Cell Death 1 Receptor; Receptors, Antigen, T-Cell, alpha-beta; Sulfamethoxazole; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory | 2017 |