4-nitroimidazole has been researched along with metronidazole in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (12.82) | 18.7374 |
| 1990's | 7 (17.95) | 18.2507 |
| 2000's | 4 (10.26) | 29.6817 |
| 2010's | 12 (30.77) | 24.3611 |
| 2020's | 11 (28.21) | 2.80 |
| Authors | Studies |
|---|---|
| Barbaro, AM; Biagi, GL; Borea, PA; Cantelli-Forti, G; Guerra, MC; Hrelia, P | 2 |
| Klobusicky, M; Valent, M | 1 |
| Haggoud, A; Reysset, G; Sebald, M | 1 |
| Church, DL; Laishley, EJ; Rabin, HR | 1 |
| Alvarez, MV; Izquierdo, MC; Lopez Zumel, MC; Santos, L | 1 |
| Guissani, A; Henry, Y; Hickel, B | 1 |
| Adomat, H; Farrell, NP; Skov, KA | 1 |
| Edwards, DI; Tocher, JH | 1 |
| Bellotti, MG; Dubini, F; Riviera, L; Scaltrito, MM | 1 |
| Baggio, A; Bossa, MR; Casolari, C; Castelli, M; Cermelli, C; Malagoli, M; Paolucci, F; Roffia, S; Rossi, T; Ruberto, AI | 1 |
| Chalkley, LJ; Lubbe, MM; Stanley, K | 1 |
| Fernández-Verdugo, A; Pérez, F; Pérez, S; Vázquez, F | 1 |
| Kapp, U; Kozielski-Stuhrmann, S; Leiros, HK; Leonard, GA; McSweeney, SM; Terradot, L | 1 |
| Gremaud, E; Guy, PA; Huré, I; Mottier, P | 1 |
| Andersen, YS; Arzu, LV; Brown, SE; Davids, BJ; Eckmann, L; Fokin, VV; Gillin, FD; Hruz, P; Kalisiak, J; Kangas, K; Miyamoto, Y; Sharpless, KB; Smith, DK; Tripp, JC; Upcroft, JA; Upcroft, P; Valdez, CA | 1 |
| Burgess, AG; Crozet, MD; Dunn, LA; Eckmann, L; Gillin, FD; Krauer, KG; Upcroft, JA; Upcroft, P; Vanelle, P | 1 |
| Cerecetto, H; Fernández, S; Giglio, J; Rey, A | 1 |
| Alipour, E; Emami, S; Foroumadi, A; Moshafi, MH; Nakhjiri, M; Negahbani, AS; Omrani, M; Shafiee, A; Siavoshi, F; Sorkhi, M; Vosooghi, M; Yahya-Meymandi, A | 1 |
| Kovachev, S; Kovacheva-Aleksandrova, M; Vatcheva-Dobrevsky, R | 1 |
| Cerecetto, H; Fernández, S; Giglio, J; Rey, AM | 1 |
| Kovachev, S; Vatcheva-Dobrevski, R | 1 |
| Guo, B; Li, BZ; Li, P; Mao, C; Threapleton, DE; Wang, JY; Xu, JM; Ye, DQ; Ye, QL; Yuan, JQ; Zhang, C | 1 |
| Gupta, G; Gupta, S; Kumar, J; Kushwaha, B; Lal, J; Maikhuri, JP; Mandalapu, D; Sankhwar, SN; Sharma, VL; Shukla, M; Siddiqi, MI; Singh, N; Tanpula, DK | 1 |
| Rejczak, T; Tuzimski, T | 1 |
| Alauzet, C; Aujoulat, F; Lozniewski, A; Marchandin, H | 1 |
| Alauzet, C; Lozniewski, A; Marchandin, H | 1 |
| Abdala, ME; Carranza, PG; Di Lullo, D; Luna, BE; Luque, ME; Rivero, FD; Rivero, MB | 1 |
| Kissinger, P; Muzny, CA; Van Gerwen, OT | 1 |
| Brito, K; Cañete, R; Herrera, E; Kofoed, PE; Noda, AL; Rodríguez, M; Ursing, J | 1 |
| Hanevik, K; Mørch, K | 1 |
| Bourla, LN; Camino, AF; Legendre, D; Muzny, CA; Van Gerwen, OT | 1 |
| Alva-Murillo, N; Avila, EE; Ramírez-Ledesma, MG; Rodríguez, MC | 1 |
| Boyce, G; Edwards, J; Edwards, RJ; Parboo, M | 1 |
| McNeil, CJ; Muzny, CA; Williamson, JC | 1 |
| Augostini, P; Bradley, ELP; Raphael, BH; Secor, WE | 1 |
| Akbar, N; Hussain, K; Khalid, M; Khan, NA; Shah, MR; Siddiqui, R | 1 |
| Andreini, C; Conti, L; Fagorzi, C; Giacomazzo, GE; Giorgi, C; Guerri, A; Mengoni, A; Pagliai, M; Perito, B; Valtancoli, B | 1 |
| Boyd, P; Dallal Bashi, YH; Karl Malcolm, R; McCoy, CF; Zhao, X | 1 |
5 review(s) available for 4-nitroimidazole and metronidazole
| Article | Year |
|---|---|
[Trichomonas infection in the female and the current status].
Topics: Female; Humans; Metronidazole; Nitroimidazoles; Trichomonas Vaginitis | 1992 |
Comparative effectiveness and tolerance of treatments for Helicobacter pylori: systematic review and network meta-analysis.
Topics: Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Drug Therapy, Combination; Helicobacter Infections; Helicobacter pylori; Humans; Levofloxacin; Metronidazole; Nitroimidazoles; Probiotics; Proton Pump Inhibitors | 2015 |
Metronidazole resistance and nim genes in anaerobes: A review.
Topics: Anti-Infective Agents; Bacteria, Anaerobic; Drug Resistance, Bacterial; Genetic Variation; Metronidazole; Nitroimidazoles; Oxidation-Reduction; Oxidoreductases | 2019 |
Updates in trichomonas treatment including persistent infection and 5-nitroimidazole hypersensitivity.
Topics: Antiprotozoal Agents; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Humans; Male; Metronidazole; Nitroimidazoles; Recurrence; Sexually Transmitted Diseases; Trichomonas Infections; Trichomonas vaginalis | 2020 |
Giardiasis treatment: an update with a focus on refractory disease.
Topics: Adult; Albendazole; Antiprotozoal Agents; Benzimidazoles; Child; Diarrhea; Drug Resistance; Drug Therapy, Combination; Female; Giardia; Giardiasis; Humans; Male; Mebendazole; Metronidazole; Nitroimidazoles; Quinacrine | 2020 |
1 trial(s) available for 4-nitroimidazole and metronidazole
| Article | Year |
|---|---|
[Efficacy of combined 5-nitroimidazole and probiotic therapy of bacterial vaginosis: randomized open trial].
Topics: Adolescent; Adult; Anti-Infective Agents; Female; Humans; Lacticaseibacillus rhamnosus; Lactobacillus acidophilus; Metronidazole; Middle Aged; Nitroimidazoles; Probiotics; Tinidazole; Vagina; Vaginosis, Bacterial; Young Adult | 2013 |
33 other study(ies) available for 4-nitroimidazole and metronidazole
| Article | Year |
|---|---|
The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles.
Topics: Animals; Bile; Infusions, Intravenous; Kinetics; Male; Nitroimidazoles; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1987 |
Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Kidney; Nitroimidazoles; Rats; Rats, Inbred Strains; Solubility; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thiazoles; Time Factors | 1986 |
Cloning of a Bacteroides fragilis chromosomal determinant coding for 5-nitroimidazole resistance.
Topics: Bacteroides fragilis; Blotting, Southern; Cloning, Molecular; Conjugation, Genetic; Drug Resistance, Microbial; Metronidazole; Nitroimidazoles; Ornidazole; Plasmids; Tinidazole; Transformation, Bacterial | 1992 |
Reduction of 2-, 4- and 5-nitroimidazole drugs by hydrogenase 1 in Clostridium pasteurianum.
Topics: Clostridium; Ferredoxins; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hydrogenase; Kinetics; Metronidazole; Misonidazole; Nitroimidazoles; Oxidation-Reduction | 1990 |
Radiosensitization by quaternary salts of 5-nitroimidazole derivatives.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Mesocricetus; Metronidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1989 |
Radicals of nitroimidazole derivatives: pH dependence of rates of formation and decay related to acid-base equilibria.
Topics: Acid-Base Equilibrium; Anti-Bacterial Agents; Antineoplastic Agents; Hydrogen-Ion Concentration; Metronidazole; Nitroimidazoles; Pulse Radiolysis; Radiation-Sensitizing Agents | 1987 |
Platinum complexes with one radiosensitizing ligand [PtCl2(NH3) (sensitizer)]: radiosensitization and toxicity studies in vitro.
Topics: Animals; Cisplatin; Cricetinae; In Vitro Techniques; Metronidazole; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Thiazoles | 1987 |
Evidence for the direct interaction of reduced metronidazole derivatives with DNA bases.
Topics: Adenine; Cyclohexanols; Cytosine; Dimethylformamide; Electrochemistry; Hydrogen-Ion Concentration; Metronidazole; Nitroimidazoles; Oxidation-Reduction; Thymine | 1994 |
Susceptibility of Helicobacter pylori and pharmacokinetic properties in mice of new 5-nitroimidazole derivatives devoid of mutagenic activity in the Ames test.
Topics: Animals; Anti-Bacterial Agents; Benzyl Alcohols; Female; Helicobacter pylori; Metronidazole; Mice; Microbial Sensitivity Tests; Mutagenicity Tests; Nitroimidazoles; Rats; Rats, Sprague-Dawley | 1993 |
In-vitro studies of two 5-nitroimidazole derivatives.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Candida; Clostridium; Electrochemistry; Escherichia coli; Metronidazole; Microbial Sensitivity Tests; Nitroimidazoles; Oxidation-Reduction; Sulfones | 1997 |
Prevalence of nim genes in anaerobic/facultative anaerobic bacteria isolated in South Africa.
Topics: Actinomyces; Actinomycetales; Anti-Bacterial Agents; Bacterial Infections; Bacteroidaceae; Bacteroides; Clostridium; DNA, Bacterial; Drug Resistance, Microbial; Humans; Metronidazole; Nitroimidazoles; Prevotella; Propionibacterium; Sequence Analysis, DNA; South Africa | 1999 |
Prevalence of 5-nitroimidazole-resistant trichomonas vaginalis in Oviedo, Spain.
Topics: Animals; Antitrichomonal Agents; Drug Resistance, Microbial; Humans; Metronidazole; Microbial Sensitivity Tests; Nitroimidazoles; Ornidazole; Prevalence; Spain; Tinidazole; Trichomonas vaginalis | 2001 |
Structural basis of 5-nitroimidazole antibiotic resistance: the crystal structure of NimA from Deinococcus radiodurans.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Binding Sites; Chromatography, Gel; Crystallography, X-Ray; Deinococcus; Dimerization; Drug Resistance, Bacterial; Electrons; Electrophoresis, Polyacrylamide Gel; Fourier Analysis; Histidine; Metronidazole; Models, Chemical; Models, Molecular; Nitroimidazoles; Nitroreductases | 2004 |
Analysis of four 5-nitroimidazoles and their corresponding hydroxylated metabolites in egg, processed egg, and chicken meat by isotope dilution liquid chromatography tandem mass spectrometry.
Topics: Animals; Chickens; Chromatography, Liquid; Dimetridazole; Food Handling; Hydroxylation; Ipronidazole; Meat; Metronidazole; Nitroimidazoles; Ovum; Ronidazole; Spectrometry, Mass, Electrospray Ionization; Veterinary Drugs | 2006 |
Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia.
Topics: Animals; Antiprotozoal Agents; Drug Discovery; Drug Resistance; Electrochemical Techniques; Giardia lamblia; Giardiasis; Metronidazole; Nitroimidazoles; Oxidation-Reduction | 2009 |
A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro.
Topics: Antiprotozoal Agents; Drug Resistance; Free Radicals; Giardia lamblia; Metronidazole; Nitroimidazoles; Protozoan Proteins; Pyruvate Synthase | 2010 |
Synthesis and biological characterisation of novel dithiocarbamate containing 5-nitroimidazole (99m)Tc-complexes as potential agents for targeting hypoxia.
Topics: Animals; Carbamates; Cell Hypoxia; Metronidazole; Mice; Neoplasms; Nitroimidazoles; Organotechnetium Compounds; Radionuclide Imaging; Radiopharmaceuticals | 2011 |
5-Nitroimidazole-based 1,3,4-thiadiazoles: heterocyclic analogs of metronidazole as anti-Helicobacter pylori agents.
Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Helicobacter pylori; Metronidazole; Microbial Sensitivity Tests; Nitroimidazoles; Structure-Activity Relationship; Thiadiazoles | 2011 |
[Short - term combined 5-nitroimidazole treatment in vaginal dysbacteriosis with dominant anaerobic species].
Topics: Administration, Intravaginal; Adolescent; Adult; Anti-Infective Agents; Bacteria, Anaerobic; Drug Therapy, Combination; Female; Gardnerella vaginalis; Humans; Metronidazole; Middle Aged; Nitroimidazoles; Tinidazole; Vagina; Vaginosis, Bacterial; Young Adult | 2011 |
Influence of ligand denticity on the properties of novel ⁹⁹mTc(I)-carbonyl complexes. Application to the development of radiopharmaceuticals for imaging hypoxic tissue.
Topics: Animals; Cell Line, Tumor; Click Chemistry; Contrast Media; Coordination Complexes; Diagnostic Imaging; Humans; Ketones; Ligands; Metronidazole; Mice; Mice, Inbred C57BL; Neoplasms; Nitroimidazoles; Protein Binding; Proteins; Radionuclide Imaging; Radiopharmaceuticals; Rhenium; Technetium; Tissue Distribution | 2012 |
2-Methyl-4/5-nitroimidazole derivatives potentiated against sexually transmitted Trichomonas: Design, synthesis, biology and 3D-QSAR study.
Topics: Animals; Chemistry Techniques, Synthetic; Drug Design; Drug Resistance; HeLa Cells; Humans; Male; Metronidazole; Models, Molecular; Molecular Conformation; Nitroimidazoles; Quantitative Structure-Activity Relationship; Rats; Safety; Sexually Transmitted Diseases; Trichomonas vaginalis | 2016 |
A QuEChERS-Based Sample Preparation Method for the Analysis of 5-Nitroimidazoles in Bovine Milk by HPLC-DAD.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Dimetridazole; Food Analysis; Food Contamination; Liquid-Liquid Extraction; Metronidazole; Milk; Nitroimidazoles; Reproducibility of Results; Ronidazole; Sensitivity and Specificity; Specimen Handling | 2017 |
A sequence database analysis of 5-nitroimidazole reductase and related proteins to expand knowledge on enzymes responsible for metronidazole inactivation.
Topics: Anti-Infective Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Computational Biology; Drug Resistance, Bacterial; Genetic Variation; Metronidazole; Nitroimidazoles; Oxidoreductases | 2019 |
Flow cytometry evaluation of in vitro susceptibility of bovine isolates of Tritrichomonas foetus to metronidazole.
Topics: Animals; Cattle; Flow Cytometry; Inhibitory Concentration 50; Metronidazole; Nitroimidazoles; Parasitic Sensitivity Tests; Tritrichomonas foetus | 2019 |
5-Nitroimidazole refractory giardiasis is common in Matanzas, Cuba and effectively treated by secnidazole plus high-dose mebendazole or quinacrine: a prospective observational cohort study.
Topics: Adult; Aged; Antiprotozoal Agents; Cuba; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Feces; Female; Giardia lamblia; Giardiasis; Humans; Male; Mebendazole; Metronidazole; Middle Aged; Nitroimidazoles; Prospective Studies; Quinacrine; Treatment Outcome; Young Adult | 2020 |
Management of Trichomoniasis in the Setting of 5-Nitroimidazole Hypersensitivity.
Topics: Female; Humans; Metronidazole; Nitroimidazoles; Trichomonas Infections; Trichomonas vaginalis; Trichomonas Vaginitis | 2021 |
The antimicrobial peptides LL-37, KR-20, FK-13 and KR-12 inhibit the growth of a sensitive and a metronidazole-resistant strain of Trichomonas vaginalis.
Topics: Antimicrobial Peptides; Antiprotozoal Agents; Drug Resistance; Humans; Metronidazole; Trichomonas Infections; Trichomonas vaginalis | 2022 |
Trichomoniasis refractory to 5-nitroimidazole therapy in Trinidad.
Topics: Female; Humans; Metronidazole; Trichomonas Infections; Trichomonas Vaginitis; Trinidad and Tobago | 2023 |
Successful Treatment of Persistent 5-Nitroimidazole-Resistant Trichomoniasis With an Extended Course of Oral Secnidazole Plus Intravaginal Boric Acid.
Topics: Female; Humans; Metronidazole; Tinidazole; Trichomonas Infections; Trichomonas Vaginitis | 2023 |
In Vitro Testing of Trichomonas vaginalis Drug Susceptibility: Evaluation of Minimal Lethal Concentrations for Metronidazole and Tinidazole That Correspond With Treatment Failure.
Topics: Drug Resistance; Female; Humans; In Vitro Techniques; Metronidazole; Pharmaceutical Preparations; Tinidazole; Treatment Failure; Trichomonas Infections; Trichomonas vaginalis; Trichomonas Vaginitis | 2023 |
Azole and 5-nitroimidazole based nanoformulations are potential antiamoebic drug candidates against brain-eating amoebae.
Topics: Amebicides; Amoeba; Antiprotozoal Agents; Azoles; Brain; Fluconazole; Humans; Itraconazole; Metronidazole; Naegleria fowleri | 2023 |
Ruthenium(II) Polypyridyl Complexes and Metronidazole Derivatives: A Powerful Combination in the Design of Photoresponsive Antibacterial Agents Effective under Hypoxic Conditions.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Coordination Complexes; Ligands; Metronidazole; Ruthenium | 2023 |
Physicochemical considerations in the formulation development of silicone elastomer vaginal rings releasing 5-nitroimidazole drugs for the treatment of bacterial vaginosis.
Topics: Administration, Intravaginal; Anti-Bacterial Agents; Contraceptive Devices, Female; Delayed-Action Preparations; Female; Humans; Metronidazole; Ornidazole; Silicone Elastomers; Tinidazole; Vaginosis, Bacterial | 2023 |