Page last updated: 2024-09-03

4-n-butylanilino datp and aphidicolin

4-n-butylanilino datp has been researched along with aphidicolin in 4 studies

*Aphidicolin: An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells. [MeSH]

*Aphidicolin: An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells. [MeSH]

Compound Research Comparison

Studies
(4-n-butylanilino datp)
Trials
(4-n-butylanilino datp)
Recent Studies (post-2010)
(4-n-butylanilino datp)
Studies
(aphidicolin)
Trials
(aphidicolin)
Recent Studies (post-2010) (aphidicolin)
9001,6473136

Protein Interaction Comparison

ProteinTaxonomy4-n-butylanilino datp (IC50)aphidicolin (IC50)
DNA polymerase catalytic subunitHuman alphaherpesvirus 1 strain KOS0.438
DNA polymerase catalytic subunitHuman alphaherpesvirus 1 strain 170.5
DNA polymerase catalytic subunitHuman herpesvirus 5 strain AD1690.4435
DNA polymerase catalytic subunitHuman herpesvirus 3 strain Dumas1.6
DNA polymerase alpha catalytic subunitHomo sapiens (human)2.98
DNA polymerase catalytic subunitHuman herpesvirus 6 (strain Uganda-1102)0.4

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19904 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Popanda, O; Thielmann, HW1
Blanco, L; Salas, M1
Bambara, RA; Bodner, JB; Crute, JJ; Harwell, LW; Lord, EM; Marraccino, RL; Sabatino, RD; Wahl, AF1
Lee, MY; Toomey, NL; Wright, GE1

Other Studies

4 other study(ies) available for 4-n-butylanilino datp and aphidicolin

ArticleYear
DNA polymerase alpha from normal rat liver is different than DNA polymerases alpha from Morris hepatoma strains.
    European journal of biochemistry, 1989, Jul-15, Volume: 183, Issue:1

    Topics: Adenosine Triphosphate; Animals; Aphidicolin; Binding Sites; Cell Differentiation; Cells, Cultured; Centrifugation, Density Gradient; Chromatography, Gel; Deoxyguanine Nucleotides; Diterpenes; DNA Polymerase II; DNA Replication; DNA, Single-Stranded; Kinetics; Liver; Liver Neoplasms, Experimental; Rats; Rats, Inbred Strains; Templates, Genetic; Tumor Cells, Cultured

1989
Effect of aphidicolin and nucleotide analogs on the phage phi 29 DNA polymerase.
    Virology, 1986, Volume: 153, Issue:2

    Topics: Adenosine Triphosphate; Aphidicolin; Bacteriophages; Deoxyguanine Nucleotides; Diterpenes; DNA Replication; Exodeoxyribonuclease V; Exodeoxyribonucleases; Nucleic Acid Synthesis Inhibitors; Nucleotides; Virus Replication

1986
Properties of two forms of DNA polymerase delta from calf thymus.
    Biochemistry, 1986, Dec-02, Volume: 25, Issue:24

    Topics: Adenosine Triphosphate; Animals; Aphidicolin; Cattle; Deoxyguanine Nucleotides; Diterpenes; DNA Polymerase III; DNA-Directed DNA Polymerase; Isoenzymes; Kinetics; Nucleic Acid Synthesis Inhibitors; Thymus Gland

1986
Differential inhibition of human placental DNA polymerases delta and alpha by BuPdGTP and BuAdATP.
    Nucleic acids research, 1985, Dec-09, Volume: 13, Issue:23

    Topics: Adenosine Triphosphate; Aphidicolin; Bacillus subtilis; Deoxyguanine Nucleotides; Diterpenes; DNA; DNA Polymerase II; DNA Polymerase III; Dose-Response Relationship, Drug; Female; Humans; Nucleic Acid Synthesis Inhibitors; Placenta; Pregnancy; Templates, Genetic

1985