Page last updated: 2024-09-04

4-methylumbelliferylguanidinobenzoate and hymecromone

4-methylumbelliferylguanidinobenzoate has been researched along with hymecromone in 36 studies

Compound Research Comparison

Studies
(4-methylumbelliferylguanidinobenzoate)
Trials
(4-methylumbelliferylguanidinobenzoate)
Recent Studies (post-2010)
(4-methylumbelliferylguanidinobenzoate)
Studies
(hymecromone)
Trials
(hymecromone)
Recent Studies (post-2010) (hymecromone)
37001,24118323

Protein Interaction Comparison

ProteinTaxonomy4-methylumbelliferylguanidinobenzoate (IC50)hymecromone (IC50)
Testosterone 17-beta-dehydrogenase 3Homo sapiens (human)1

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199027 (75.00)18.7374
1990's7 (19.44)18.2507
2000's2 (5.56)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nadler, HL; Rao, GJ; Walsh-Platt, M1
Nadler, HL; Platt, MW; Rao, GJ1
Smith, KL; Steven, FS; Tisdale, MJ1
Curry, PT; Kitchin, RM; Waller, DP; Zaneveld, LJ; Ziemer, T1
Falase, EA; Storey, BT; Teuscher, C1
Griffin, MM; Steven, FS1
Binder, BR; Geiger, M1
Castellino, FJ; Urano, S; Urano, T1
Benau, DA; Storey, BT2
Ikeda, K; Ohta, N; Yotsuyanagi, T1
Jeyendran, RS; Kaminski, JM; Kennedy, W; Reid, DS; Smith, D; Zaneveld, LJ1
Castellino, FJ; Hill, KA1
Punnett, HH; Qureshi, AR1
Nadler, HL; Walsh, MM3
Brandt, NJ; Schwartz, M1
Mesirow, KH; Nadler, HL; Rembelski, P1
Branchini, BR; Bruns, WT; Rosenstein, BJ; Salituro, GM1
Brock, DJ; Hayward, C1
Branchini, BR; Rosenstein, BJ; Salituro, GM1
Schwartz, M1
Riordan, JR; Seger, E; Tümmler, B1
Beyler, SA; Zaneveld, LJ2
Green, JR; Lentze, MJ; Rossi, E; Schubiger, G; Sidiropoulos, D1
Griffin, MM; Itzhaki, S; Short, AK; Steven, FS1
Nadler, HL; Rao, GJ; Walsh, MM1
Puigserver, A; Wicker, C1
Gerbie, AB; Meserow, K; Nadler, HL; Rembelski, P1
Johnson, AE; Morrissey, JH; Neuenschwander, PF; Payne, MA1
Anees, M; Benbow, EW1
Anees, M1
Elrod, KC; Schechter, NM; Selwood, T1
Gombos, L; Gráf, L; Málnási-Csizmadia, A; Medveczky, P; Simon, Z; Szilágyi, L; Tóth, J1

Other Studies

36 other study(ies) available for 4-methylumbelliferylguanidinobenzoate and hymecromone

ArticleYear
Protease deficiency in plasma of patients with cystic fibrosis. Reduced reaction of 4-methylumbelliferylguanidinobenzoate with plasma of patients with cystic fibrosis.
    Enzyme, 1979, Volume: 24, Issue:4

    Topics: Benzamidines; Child; Cystic Fibrosis; Guanidines; Humans; Hymecromone; Peptide Hydrolases; Trypsin Inhibitors; Umbelliferones

1979
Reaction of 4-methylumbelliferylguanidinobenzoate with proteases in plasma of patients with cystic fibrosis.
    Enzyme, 1978, Volume: 23, Issue:5

    Topics: Adolescent; Arginine; Binding Sites; Child; Child, Preschool; Cystic Fibrosis; Guanidines; Humans; Hymecromone; In Vitro Techniques; Isoelectric Focusing; Molecular Weight; Peptide Hydrolases; Umbelliferones

1978
Observations on the inhibition of serum and cell surface enzymes by eicosapentaenoic acid.
    Journal of enzyme inhibition, 1992, Volume: 6, Issue:4

    Topics: Animals; Cachexia; Carboxylic Ester Hydrolases; Eicosapentaenoic Acid; Endopeptidases; Hymecromone; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Rhodamines; Tissue Plasminogen Activator; Weight Loss

1992
The lack of mutagenicity of aryl 4-guanidinobenzoates in the transplacental micronucleus assay in mice.
    Reproductive toxicology (Elmsford, N.Y.), 1990, Volume: 4, Issue:2

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Erythrocytes; Female; Fetus; Guanidines; Hematopoietic System; Hymecromone; Mice; Micronucleus Tests; Mitosis; Mutagens; Placenta; Pregnancy; Staining and Labeling

1990
Purification and preliminary characterization of guinea pig testicular proteinase inhibitors.
    Molecular reproduction and development, 1991, Volume: 29, Issue:1

    Topics: Animals; Chromatography, Ion Exchange; Chymotrypsin; Coumarins; Electrophoresis, Polyacrylamide Gel; Guinea Pigs; Hymecromone; Kinetics; Male; Protease Inhibitors; Spectrophotometry, Ultraviolet; Sperm Maturation; Substrate Specificity; Testis; Trypsin; Trypsin Inhibitors

1991
Similarities between single-chain tissue plasminogen activator and the cell-surface proteinase, guanidinobenzoatase.
    Biochemical Society transactions, 1990, Volume: 18, Issue:4

    Topics: Benzoylarginine-2-Naphthylamide; Carboxylic Ester Hydrolases; Cell Membrane; Endopeptidases; Fluorescent Dyes; Hymecromone; Rhodamines; Substrate Specificity; Tissue Plasminogen Activator

1990
Tissue-type plasminogen activator and urokinase: differences in the reaction pattern with the active-site titrant 4-methylumbelliferyl-p-guanidinobenzoate hydrochloride.
    Biochimica et biophysica acta, 1987, Mar-18, Volume: 912, Issue:1

    Topics: Binding Sites; Humans; Hymecromone; Isoflurophate; Kinetics; Spectrometry, Fluorescence; Tissue Plasminogen Activator; Umbelliferones; Urokinase-Type Plasminogen Activator

1987
Reaction of tissue-type plasminogen activator with 4-methylumbelliferyl-p-guanidinobenzoate hydrochloride.
    Biochemical and biophysical research communications, 1988, Jan-15, Volume: 150, Issue:1

    Topics: Acylation; Binding Sites; Hymecromone; Isoflurophate; Kinetics; Recombinant Proteins; Tissue Plasminogen Activator; Umbelliferones

1988
Relationship between two types of mouse sperm surface sites that mediate binding of sperm to the zona pellucida.
    Biology of reproduction, 1988, Volume: 39, Issue:2

    Topics: Animals; Binding Sites; Female; Fluorometry; Galactosyltransferases; Hydrolysis; Hymecromone; Male; Mice; Mice, Inbred Strains; Ovum; Solubility; Sperm-Ovum Interactions; Spermatozoa; Trypsin Inhibitors; Zona Pellucida

1988
Degradation of 4'-methylumbelliferyl 4-guanidinobenzoate catalyzed by human serum albumin.
    Chemical & pharmaceutical bulletin, 1988, Volume: 36, Issue:6

    Topics: Humans; Hydrolysis; Hymecromone; Kinetics; Protein Binding; Serum Albumin; Umbelliferones

1988
Effect of aryl 4-guanidinobenzoates on the acrosin activity of human spermatozoa.
    Biology of reproduction, 1987, Volume: 36, Issue:5

    Topics: Acrosin; Benzoates; Contraceptive Agents, Female; Endopeptidases; Gelatin; Guanidines; Humans; Hymecromone; In Vitro Techniques; Male; Protease Inhibitors; Spectrophotometry; Spermatozoa

1987
Characterization of the mouse sperm plasma membrane zona-binding site sensitive to trypsin inhibitors.
    Biology of reproduction, 1987, Volume: 36, Issue:2

    Topics: Animals; Binding Sites; Cell Membrane; Female; Hydrolysis; Hymecromone; Male; Mice; Sperm-Ovum Interactions; Spermatozoa; Trypsin; Trypsin Inhibitors; Zona Pellucida

1987
The effect of monovalent cations on the pre-steady state reaction kinetics of bovine activated plasma protein C and des-1-41-light chain activated plasma protein C.
    The Journal of biological chemistry, 1987, Jan-05, Volume: 262, Issue:1

    Topics: Animals; Binding Sites; Cations, Monovalent; Cattle; Cesium; Enzyme Activation; Hymecromone; Kinetics; Peptide Fragments; Protein C; Sodium

1987
Carrier detection in cystic fibrosis.
    The Journal of pediatrics, 1985, Volume: 106, Issue:6

    Topics: Adult; Blood Proteins; Calgranulin A; Cystic Fibrosis; Heterozygote; Homozygote; Humans; Hymecromone; Lectins; Middle Aged

1985
Prenatal detection of cystic fibrosis on amniotic fluid.
    Lancet (London, England), 1980, Jul-12, Volume: 2, Issue:8185

    Topics: Amniotic Fluid; Cystic Fibrosis; Electrophoresis, Polyacrylamide Gel; Female; Humans; Hymecromone; Pregnancy; Pregnancy Trimester, Second; Umbelliferones

1980
False-negative results with methylumbelliferylguanidinobenzoate reactive proteases in cystic fibrosis pregnancies.
    Lancet (London, England), 1981, Nov-28, Volume: 2, Issue:8257

    Topics: Amniocentesis; Amniotic Fluid; Clinical Enzyme Tests; Cystic Fibrosis; False Negative Reactions; Female; Humans; Hymecromone; Peptide Hydrolases; Pregnancy; Pregnancy Complications; Prenatal Diagnosis; Umbelliferones

1981
Prenatal detection of cystic fibrosis.
    Lancet (London, England), 1981, Nov-28, Volume: 2, Issue:8257

    Topics: Amniocentesis; Amniotic Fluid; Clinical Enzyme Tests; Cystic Fibrosis; False Positive Reactions; Female; Humans; Hymecromone; Peptide Hydrolases; Pregnancy

1981
4-methylumbelliferylguanidinobenzoate reactive plasma "protease" in cystic fibrosis is albumin.
    Lancet (London, England), 1982, Mar-13, Volume: 1, Issue:8272

    Topics: Clinical Enzyme Tests; Cystic Fibrosis; Heterozygote; Humans; Hymecromone; Peptide Hydrolases; Serum Albumin; Umbelliferones

1982
Prenatal diagnosis of cystic fibrosis by methylumbelliferylguanidinobenzoate protease titration in amniotic fluid.
    Prenatal diagnosis, 1983, Volume: 3, Issue:1

    Topics: Amniotic Fluid; Cystic Fibrosis; Female; Gestational Age; Humans; Hymecromone; Peptide Hydrolases; Pregnancy; Prenatal Diagnosis; Umbelliferones

1983
Identification of the major 4-methylumbelliferyl p-guanidinobenzoate-hydrolyzing plasma protein in cystic fibrosis: implication for intrauterine and heterozygote detection.
    Pediatric research, 1983, Volume: 17, Issue:11

    Topics: Adolescent; Adult; Amniotic Fluid; Child; Child, Preschool; Chromatography, Gel; Cystic Fibrosis; Genetic Carrier Screening; Humans; Hydrolysis; Hymecromone; Middle Aged; Prenatal Diagnosis; Serum Albumin; Umbelliferones

1983
A serine protease activity of human serum albumin towards 4-methylumbelliferyl-guanidinobenzoate (MUGB) and diisopropyl fluorophosphate (DEP): implications for the use of MUGB reactivity in amniotic fluid in prenatal diagnosis of cystic fibrosis.
    Clinica chimica acta; international journal of clinical chemistry, 1982, Sep-15, Volume: 124, Issue:2

    Topics: Amniotic Fluid; Cystic Fibrosis; Endopeptidases; Female; Humans; Hymecromone; Isoflurophate; Pregnancy; Prenatal Diagnosis; Serine Endopeptidases; Serum Albumin; Substrate Specificity

1982
Systematic study of the hydrolysis of 4-methylumbelliferylguanidinobenzoate in plasma from patients with cystic fibrosis and controls.
    Clinica chimica acta; international journal of clinical chemistry, 1982, Oct-27, Volume: 125, Issue:2

    Topics: Adolescent; Adult; Child; Child, Preschool; Cystic Fibrosis; Drug Stability; Enzyme Activation; Female; Histidine; Humans; Hydrolysis; Hymecromone; Kinetics; Male; Methods; Peptide Hydrolases; Umbelliferones

1982
Antifertility activity of systemically administered proteinase (acrosin) inhibitors.
    Contraception, 1982, Volume: 26, Issue:2

    Topics: Acrosin; Amidines; Animals; Benzamidines; Benzoates; Contraceptive Agents, Female; Drug Implants; Female; Hymecromone; Mice; Protease Inhibitors; Umbelliferones

1982
Prenatal diagnosis of cystic fibrosis: false negative result with the 4-methylumbelliferyl-p-guanidinobenzoate assay for proteases in amniotic fluid.
    European journal of pediatrics, 1982, Volume: 139, Issue:1

    Topics: Amniotic Fluid; Cystic Fibrosis; False Negative Reactions; Female; Humans; Hymecromone; Isoelectric Focusing; Molecular Weight; Peptide Hydrolases; Pregnancy; Prenatal Diagnosis; Reference Values

1982
Inhibition of in-vitro fertilization of mouse gametes by proteinase inhibitors.
    Journal of reproduction and fertility, 1982, Volume: 66, Issue:2

    Topics: Acrosin; Animals; Benzamidines; Benzoates; Dose-Response Relationship, Drug; Fertilization in Vitro; Hymecromone; Kinetics; Mice; Protease Inhibitors; Trypsin Inhibitors

1982
beta-Naphthylamidase activity of the cell surface of Ehrlich ascites cells. Reversible control of enzyme activity by metal ions and thiols.
    British journal of cancer, 1981, Volume: 44, Issue:5

    Topics: Aminopeptidases; Animals; Auranofin; Aurothioglucose; Carcinoma, Ehrlich Tumor; Cathepsin H; Cathepsins; Cell Membrane; Cells, Cultured; Cysteine Endopeptidases; Dithiothreitol; Dose-Response Relationship, Drug; Edetic Acid; Gold; Gold Sodium Thiomalate; Hymecromone; Mice; Zinc

1981
Reaction of 4-methylumbelliferylguanidinobenzoate with proteases in human amniotic fluid.
    Pediatric research, 1980, Volume: 14, Issue:4 Pt 1

    Topics: Amniotic Fluid; Arginine; Chloroform; Cystic Fibrosis; Ellagic Acid; Female; Guanidines; Humans; Hydrolysis; Hymecromone; Peptide Hydrolases; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Prenatal Diagnosis; Umbelliferones

1980
Methylumbelliferylguanidinobenzoate-reactive proteases in human amniotic fluid: Promising marker for the intrauterine detection of cystic fibrosis.
    American journal of obstetrics and gynecology, 1980, Aug-15, Volume: 137, Issue:8

    Topics: Amniocentesis; Amniotic Fluid; Cystic Fibrosis; Female; Humans; Hymecromone; Peptide Hydrolases; Pregnancy; Umbelliferones

1980
Intrauterine detection of cystic fibrosis.
    Pediatrics, 1980, Volume: 66, Issue:5

    Topics: Amniotic Fluid; Chromatography, Gel; Cystic Fibrosis; Female; Humans; Hymecromone; Isoelectric Focusing; Peptide Hydrolases; Pregnancy; Prenatal Diagnosis; Umbelliferones

1980
Further studies on subunit III of bovine procarboxypeptidase A. Structure and reactivity of the weakly functional active site.
    FEBS letters, 1981, Jun-01, Volume: 128, Issue:1

    Topics: Amino Acid Sequence; Animals; Benzoates; Binding Sites; Carboxypeptidases; Carboxypeptidases A; Cattle; Chymotrypsin; Chymotrypsinogen; Guanidines; Hymecromone; Protein Conformation; Trypsin; Trypsinogen

1981
Prenatal detection of cystic fibrosis.
    American journal of obstetrics and gynecology, 1981, Dec-15, Volume: 141, Issue:8

    Topics: Amniotic Fluid; Cystic Fibrosis; Female; Heterozygote; Humans; Hymecromone; Pregnancy; Pregnancy Trimester, Second; Prenatal Diagnosis

1981
Effect of soluble tissue factor on the kinetic mechanism of factor VIIa: enhancement of p-guanidinobenzoate substrate hydrolysis.
    Biochemistry, 1996, Jun-04, Volume: 35, Issue:22

    Topics: Allosteric Regulation; Binding Sites; Factor VIIa; Humans; Hydrolysis; Hymecromone; Kinetics; Models, Chemical; Protein Binding; Recombinant Proteins; Solubility; Spectrometry, Fluorescence; Thromboplastin

1996
Dansyl fluoride, a fluorescent inhibitor for the location of tumour cells in human tissues.
    Journal of enzyme inhibition, 1996, Volume: 10, Issue:3

    Topics: Aminacrine; Binding Sites; Carboxylic Ester Hydrolases; Colonic Neoplasms; Coloring Agents; Dansyl Compounds; Endopeptidases; Enzyme Activation; Histocytochemistry; Humans; Hydroxylamine; Hydroxylamines; Hymecromone; Isoenzymes; Lung Neoplasms; Microscopy, Fluorescence; Serine Proteinase Inhibitors; Sodium Dodecyl Sulfate; Spectrometry, Fluorescence

1996
Location of tumour cells in colon tissue by Texas red labelled pentosan polysulphate, an inhibitor of a cell surface protease.
    Journal of enzyme inhibition, 1996, Volume: 10, Issue:3

    Topics: Carboxylic Ester Hydrolases; Cell Membrane; Chromatography, Affinity; Colonic Neoplasms; Dansyl Compounds; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Fluorescent Dyes; Heparin; Humans; Hymecromone; Isoenzymes; Kinetics; Microscopy, Fluorescence; Pentosan Sulfuric Polyester; Protease Inhibitors; Protein Conformation; Suramin; Trypan Blue; Xanthenes

1996
Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor.
    Biological chemistry, 2003, Volume: 384, Issue:12

    Topics: Benzamidines; Binding Sites; Binding, Competitive; Cross-Linking Reagents; Dioxoles; Fluorescent Dyes; Guanidines; Humans; Hymecromone; Kinetics; Osmolar Concentration; Protein Binding; Recombinant Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Spectrometry, Fluorescence; Sulfones; Thermodynamics; Tryptases

2003
Thermodynamic analysis reveals structural rearrangement during the acylation step in human trypsin 4 on 4-methylumbelliferyl 4-guanidinobenzoate substrate analogue.
    The Journal of biological chemistry, 2006, May-05, Volume: 281, Issue:18

    Topics: Acylation; Brain; Entropy; Glycine; Hot Temperature; Humans; Hydrolysis; Hymecromone; Kinetics; Molecular Conformation; Mutation; Thermodynamics; Time Factors; Trypsin

2006