4-methylene-2-octyl-5-oxo-3-oxolanecarboxylic-acid has been researched along with pantolactone* in 1 studies
1 other study(ies) available for 4-methylene-2-octyl-5-oxo-3-oxolanecarboxylic-acid and pantolactone
| Article | Year |
|---|---|
Synthesis, biological activities, and docking studies of d-pantolactone derivatives as novel FAS inhibitors.
A novel series of fatty acid synthase (FAS) inhibitors with D-(-)-pantolactone moiety and potential utility for the treatment of obesity were designed, synthesized and characterized, in which the structure of compound 3k was further confirmed by single X-ray diffraction. The mouse FAS inhibitory activity of synthesized compounds was evaluated. Major synthesized compounds (except 3g, 3i, 3k, 3l, and 3n) exhibited moderate FAS inhibitory properties with IC Topics: 4-Butyrolactone; Dose-Response Relationship, Drug; Enzyme Inhibitors; fas Receptor; Hep G2 Cells; Humans; Lipids; Molecular Docking Simulation; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |