Compounds > 4-methyl-4-aza-3-oxopregnane-20-carboxylate

Page last updated: 2024-09-04

4-methyl-4-aza-3-oxopregnane-20-carboxylate and dihydrotestosterone

4-methyl-4-aza-3-oxopregnane-20-carboxylate has been researched along with dihydrotestosterone in 6 studies

Compound Research Comparison

Studies (4-methyl-4-aza-3-oxopregnane-20-carboxylate)	Trials (4-methyl-4-aza-3-oxopregnane-20-carboxylate)	Recent Studies (post-2010) (4-methyl-4-aza-3-oxopregnane-20-carboxylate)	Studies (dihydrotestosterone)	Trials (dihydrotestosterone)	Recent Studies (post-2010) (dihydrotestosterone)
12	0	0	9,325	307	1,517

Protein Interaction Comparison

Protein	Taxonomy	4-methyl-4-aza-3-oxopregnane-20-carboxylate (IC50)	dihydrotestosterone (IC50)
Plasma kallikrein	Homo sapiens (human)		0.0031
Glucocorticoid receptor	Homo sapiens (human)		0.54
Sex hormone-binding globulin	Homo sapiens (human)		0.0038
Progesterone receptor	Oryctolagus cuniculus (rabbit)		0.44
Progesterone receptor	Homo sapiens (human)		7.3
Mineralocorticoid receptor	Homo sapiens (human)		0.36
Sex hormone-binding globulin	Rattus norvegicus (Norway rat)		0.023
Androgen receptor	Homo sapiens (human)		0.0048
Androgen receptor	Rattus norvegicus (Norway rat)		0.4041
Androgen receptor	Mus musculus (house mouse)		0.001
Mineralocorticoid receptor	Rattus norvegicus (Norway rat)		2.1
Testosterone 17-beta-dehydrogenase 3	Homo sapiens (human)		0.0026

Research

Studies (6)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (50.00)	18.7374
1990's	3 (50.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lemmi, CA; Ngyuen, MM; Rajfer, J	1
Murono, EP	1
Kadohama, N; Karr, JP; Kim, U; Murphy, GP; Sandberg, AA; Wakisaka, M	1
Kadohama, N; Karr, JP; Murphy, GP; Sandberg, AA	1
Brooks, JR; Liang, T; Rasmusson, GH	1
Ahmed, S; Denison, S	1

Other Studies

6 other study(ies) available for 4-methyl-4-aza-3-oxopregnane-20-carboxylate and dihydrotestosterone

Article	Year
Effect of 5-alpha-reductase inhibitor, 4-MAPC, on testicular descent in male rat. The Journal of urology, 1991, Volume: 145, Issue:5 Topics: 5-alpha Reductase Inhibitors; Animals; Animals, Newborn; Azasteroids; Dihydrotestosterone; Male; Pregnanes; Rats; Rats, Inbred Strains; Testis; Testosterone	1991
Differential regulation of steroidogenic enzymes metabolizing testosterone or dihydrotestosterone by human chorionic gonadotropin in cultured rat neonatal interstitial cells. Acta endocrinologica, 1990, Volume: 122, Issue:3 Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Animals, Newborn; Azasteroids; Cells, Cultured; Chorionic Gonadotropin; Dihydrotestosterone; Leydig Cells; Male; Pregnanes; Rats; Rats, Inbred Strains; Testosterone	1990
Retardation of prostate tumor progression in the Noble rat by 4-methyl-4-aza-steroidal inhibitors of 5 alpha-reductase. Journal of the National Cancer Institute, 1985, Volume: 74, Issue:2 Topics: 5-alpha Reductase Inhibitors; Animals; Azasteroids; Castration; Dihydrotestosterone; Male; Organ Size; Oxidoreductases; Pregnanes; Prostate; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Steroids, Heterocyclic	1985
Selective inhibition of prostatic tumor 5 alpha-reductase by a 4-methyl-4-azasteroid. Cancer research, 1984, Volume: 44, Issue:11 Topics: 5-alpha Reductase Inhibitors; Animals; Azasteroids; Cell Nucleus; Cytosol; Dihydrotestosterone; Humans; Kinetics; Male; Organ Culture Techniques; Oxidoreductases; Pregnanes; Prostate; Prostatic Neoplasms; Rats; Rats, Inbred WF; Steroids, Heterocyclic; Testosterone	1984
12. Androgens: Pharmacodynamics and antagonists. Biochemical and biological studies with 4-aza-steroidal 5 alpha-reductase inhibitors. Journal of steroid biochemistry, 1983, Volume: 19, Issue:1A Topics: 5-alpha Reductase Inhibitors; Animals; Azasteroids; Binding, Competitive; Dihydrotestosterone; Kinetics; Male; Oxidoreductases; Pregnanes; Prostate; Rats; Receptors, Androgen; Steroids, Heterocyclic; Structure-Activity Relationship	1983
Mechanism based representation of the active site of 5 alpha-reductase (5AR). Bioorganic & medicinal chemistry letters, 1998, Sep-22, Volume: 8, Issue:18 Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Azasteroids; Binding Sites; Dihydrotestosterone; Enzyme Inhibitors; Finasteride; Models, Chemical; Models, Molecular; NADP; Pregnanes; Structure-Activity Relationship; Testosterone	1998