Page last updated: 2024-08-23

4-ipomeanol and nadp

4-ipomeanol has been researched along with nadp in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19903 (50.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Boyd, MR; Burka, LT; Sasame, HA; Wilson, BJ1
Boyd, MR; Philpot, RM; Slaughter, SR; Statham, CN1
Boyd, MR; Franklin, RB; Sasame, HA1
Alvarez-Diez, TM; Zheng, J1
Baer, BR; Henne, KR; Rettie, AE1
Burka, LT; Chen, LJ; DeRose, EF1

Other Studies

6 other study(ies) available for 4-ipomeanol and nadp

ArticleYear
In vitro studies on the metabolic activation of the pulmonary toxin, 4-ipomeanol, by rat lung and liver microsomes.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 207, Issue:3

    Topics: Alkylation; Animals; Biotransformation; Enzyme Induction; Epoxide Hydrolases; Furans; Glutathione; In Vitro Techniques; Kinetics; Lung; Male; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; NADP; Rats; Subcellular Fractions; Terpenes; Toxins, Biological

1978
Covalent binding of metabolites of 4-ipomeanol to rabbit pulmonary and hepatic microsomal proteins and to the enzymes of the pulmonary cytochrome P-450-dependent monooxygenase system.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:1

    Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Fluoroscopy; In Vitro Techniques; Lung; Microsomes; Microsomes, Liver; NADP; Oxygenases; Protein Binding; Rabbits; Terpenes; Toxins, Biological

1983
Comparison of ratios of covalent binding to total metabolism of the pulmonary toxin, 4-ipomeanol, in vitro in pulmonary and hepatic microsomes, and the effects of pretreatments with phenobarbital or 3-methylcholanthrene.
    Biochemical and biophysical research communications, 1980, Apr-29, Volume: 93, Issue:4

    Topics: Alkylating Agents; Animals; Biotransformation; Furans; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Rats; Terpenes

1980
Mechanism-based inactivation of cytochrome P450 3A4 by 4-ipomeanol.
    Chemical research in toxicology, 2004, Volume: 17, Issue:2

    Topics: Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Microsomes, Liver; NADP; Substrate Specificity; Terpenes

2004
Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate.
    Chemical research in toxicology, 2005, Volume: 18, Issue:5

    Topics: Acetylcysteine; Aldehydes; Animals; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 Enzyme System; Glutathione; Humans; Liver; Lung; Lysine; NADP; Pyrroles; Rabbits; Spectrometry, Mass, Electrospray Ionization; Terpenes

2005
Metabolism of furans in vitro: ipomeanine and 4-ipomeanol.
    Chemical research in toxicology, 2006, Volume: 19, Issue:10

    Topics: Acetylation; Animals; Cysteine; Furans; Glutathione; Glycine; Methylation; Microsomes; Molecular Structure; NADP; Oxidation-Reduction; Rats; Rats, Inbred F344; Terpenes

2006
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