4-iodoclonidine and clonidine

4-iodoclonidine has been researched along with clonidine in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (3.23)	18.7374
1990's	18 (58.06)	18.2507
2000's	10 (32.26)	29.6817
2010's	2 (6.45)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Counsell, RE; Neubig, R; Van Dort, M	1
DeLannoy, I; Dukat, M; Glennon, RA; Law, H; MacLean, N; Prisinzano, T; Slassi, A	1
Agbaba, D; Filipic, S; Nikolic, K	1
Agbaba, D; Azzali, E; Costantino, G; Glisic, S; Laurila, JM; Nikolic, K; Perovic, V; Pieroni, M; Radi, M; Scheinin, M; Srdic-Rajic, T; Tassini, S; Veljkovic, N; Vucicevic, J	1
Gerhardt, MA; Neubig, RR; Wade, SM	1
Baron, BM; Siegel, BW	1
Dreshaj, I; Ernsberger, P; Haxhiu, MA; Schäfer, SG	1
Carrière, S; Chan, JS; Delalandre, A; Lachance, S; Wang, TT	1
Haque, M; Kulkarni, RN; MacDermot, J; Olmos, G	1
Muskardin, DT; Wallace, DR; Zahniser, NR	1
Alburges, ME; Bylund, DB; Pundt, LL; Wamsley, JK	1
Jin, Y; Verstappen, A; Yorio, T	1
Piletz, JE; Sletten, K	1
Christen, MO; Damon, TH; Ernsberger, P; Graff, LM; Schäfer, SG	1
Chikkala, DN; Piletz, JE; Zhu, H	1
Benedetto, N; Ferrara, C; Folgore, A; Galdiero, F; Molitierno, M	1
Ernsberger, P; Shen, IH	1
Halaris, A; Piletz, JE; Zhu, H	1
Ernsberger, P; Kou, YR; Prabhakar, NR	1
Bousquet, P; Dontenwill, M; Greney, H; Heemskerk, FM; Vonthron, C	1
Dilley, G; Klimek, V; Luker, SN; Meltzer, HY; Ordway, GA; Overholser, JC; Rajkowska, G; Stockmeier, CA	1
Krause, T; Paris, A; Scholz, J; Steinfath, M; Tonner, PH; von Knobelsdorff, G; Wappler, F	1
Baldwin, J; Chang, CH; Ernsberger, P; Gold, G; Ivanov, TR; Jones, JC; Pickard, RT; Piletz, JE; Reis, DJ; Roth, B; Sharp, JD; Zhu, H	1
Boundy, VA; Cincotta, AH	1
Halbreich, U; Piletz, JE	1
Carrière, S; Chan, JS; Chen, X; Wang, TT; Zhang, SL	1
Ali, J; Halaris, A; Lindsay De Vane, C; Nasrallah, A; Piletz, JE; Zhu, H	1
Klimek, V; May, W; Ordway, GA; Schenk, J; Stockmeier, CA	1
Bein, B; Brand, PA; Höcker, J; Ohnesorge, H; Scholz, J; Tonner, PH; Weber, B	1
Bein, B; Böhm, R; Gruenewald, M; Höcker, J; Meybohm, P; Ohnesorge, H; Renner, J; Scholz, J	1
Apostolova, E; Kokova, V; Peychev, L; Zagorchev, P	1

Reviews

1 review(s) available for 4-iodoclonidine and clonidine

Article	Year
Catecholamines and angiotensinogen gene expression in kidney proximal tubular cells. Molecular and cellular biochemistry, 2000, Volume: 212, Issue:1-2 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Angiotensinogen; Animals; Cell Line; Clonidine; Gene Expression Regulation; Human Growth Hormone; Humans; Isoproterenol; Kidney Tubules, Proximal; Norepinephrine; Opossums; Phenylephrine; Rats; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate	2000

Article

Year

Catecholamines and angiotensinogen gene expression in kidney proximal tubular cells.

Molecular and cellular biochemistry, 2000, Volume: 212, Issue:1-2

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Angiotensinogen; Animals; Cell Line; Clonidine; Gene Expression Regulation; Human Growth Hormone; Humans; Isoproterenol; Kidney Tubules, Proximal; Norepinephrine; Opossums; Phenylephrine; Rats; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate

2000

Trials

2 trial(s) available for 4-iodoclonidine and clonidine

Article	Year
Imidazoline and alpha(2a)-adrenoceptor binding sites in postmenopausal women before and after estrogen replacement therapy. Biological psychiatry, 2000, Nov-01, Volume: 48, Issue:9 Topics: Adult; Affinity Labels; Binding Sites; Blood Platelets; Clonidine; Depressive Disorder; Down-Regulation; Estrogen Replacement Therapy; Female; Humans; Imidazoline Receptors; Iodine Radioisotopes; Luteinizing Hormone; Menopause; Middle Aged; Postmenopause; Radioligand Assay; Receptors, Adrenergic, alpha-2; Receptors, Drug	2000
Down-regulation of platelet imidazoline-1-binding sites after bupropion treatment. The international journal of neuropsychopharmacology, 2002, Volume: 5, Issue:1 Topics: Antidepressive Agents, Second-Generation; Binding Sites; Blood Platelets; Bupropion; Clonidine; Depressive Disorder; Dose-Response Relationship, Drug; Down-Regulation; Humans; Imidazoline Receptors; Psychiatric Status Rating Scales; Receptors, Drug; Time Factors	2002

Article

Year

Imidazoline and alpha(2a)-adrenoceptor binding sites in postmenopausal women before and after estrogen replacement therapy.

Biological psychiatry, 2000, Nov-01, Volume: 48, Issue:9

Topics: Adult; Affinity Labels; Binding Sites; Blood Platelets; Clonidine; Depressive Disorder; Down-Regulation; Estrogen Replacement Therapy; Female; Humans; Imidazoline Receptors; Iodine Radioisotopes; Luteinizing Hormone; Menopause; Middle Aged; Postmenopause; Radioligand Assay; Receptors, Adrenergic, alpha-2; Receptors, Drug

2000

Down-regulation of platelet imidazoline-1-binding sites after bupropion treatment.

The international journal of neuropsychopharmacology, 2002, Volume: 5, Issue:1

Topics: Antidepressive Agents, Second-Generation; Binding Sites; Blood Platelets; Bupropion; Clonidine; Depressive Disorder; Dose-Response Relationship, Drug; Down-Regulation; Humans; Imidazoline Receptors; Psychiatric Status Rating Scales; Receptors, Drug; Time Factors

2002

Other Studies

28 other study(ies) available for 4-iodoclonidine and clonidine

Article	Year
Radioiodinated p-iodoclonidine: a high-affinity probe for the alpha 2-adrenergic receptor. Journal of medicinal chemistry, 1987, Volume: 30, Issue:7 Topics: Affinity Labels; Clonidine; Humans; Iodine Radioisotopes; Receptors, Adrenergic, alpha	1987
2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Adenylyl Cyclases; Aniline Compounds; Animals; Benzyl Compounds; Humans; Imidazolines; In Vitro Techniques; Ligands; Muscle, Smooth, Vascular; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT1D; Saphenous Vein; Serotonin Receptor Agonists; Structure-Activity Relationship	2004
QSAR study of imidazoline antihypertensive drugs. Bioorganic & medicinal chemistry, 2008, Aug-01, Volume: 16, Issue:15 Topics: Antihypertensive Agents; Binding Sites; Imidazoline Receptors; Imidazolines; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship	2008
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin. Bioorganic & medicinal chemistry, 2016, 07-15, Volume: 24, Issue:14 Topics: Adrenergic alpha-Agonists; Antibiotics, Antineoplastic; Apoptosis; Doxorubicin; Drug Synergism; Humans; K562 Cells; Ligands; Molecular Structure; Oxazoles; Receptors, Adrenergic, alpha-2; Rilmenidine	2016
p-[125I]iodoclonidine is a partial agonist at the alpha 2-adrenergic receptor. Molecular pharmacology, 1990, Volume: 38, Issue:2 Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Blood Platelets; Cell Membrane; Chromatography, Thin Layer; Clonidine; GTP-Binding Proteins; Humans; Iodine Radioisotopes; Kinetics; Platelet Aggregation; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine	1990
p-[125I]iodoclonidine, a novel radiolabeled agonist for studying central alpha 2-adrenergic receptors. Molecular pharmacology, 1990, Volume: 38, Issue:3 Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Cyclic AMP; Guanine Nucleotides; Iodine Radioisotopes; Kinetics; Magnesium; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Structure-Activity Relationship	1990
Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla. Journal of cardiovascular pharmacology, 1994, Volume: 24 Suppl 1 Topics: Adrenergic alpha-Antagonists; Affinity Labels; Animals; Antihypertensive Agents; Benzazepines; Benzofurans; Binding, Competitive; Blood Gas Analysis; Blood Pressure; Blood Pressure Determination; Cattle; Clonidine; Disease Models, Animal; Heart Rate; Hypertension; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Medulla Oblongata; Microinjections; Radioligand Assay; Rats; Rats, Inbred SHR; Receptors, Drug	1994
Alpha-adrenoceptors and angiotensinogen gene expression in opossum kidney cells. Kidney international, 1995, Volume: 48, Issue:1 Topics: Adrenergic alpha-Agonists; Affinity Labels; Alkaloids; Angiotensinogen; Animals; Cells, Cultured; Clonidine; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Kidney Tubules; Opossums; Phenylephrine; Prazosin; Protein Kinase C; Receptors, Adrenergic, alpha; Staurosporine; Tetradecanoylphorbol Acetate; Yohimbine	1995
Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors. European journal of pharmacology, 1994, Sep-01, Volume: 262, Issue:1-2 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Affinity Labels; Animals; Benzofurans; Binding, Competitive; Clonidine; Clorgyline; Diazoxide; Dioxanes; Guanidines; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Insulinoma; Ligands; Pancreatic Neoplasms; Potassium Channels; Rats; Receptors, Drug; Regression Analysis; Software; Tumor Cells, Cultured	1994
Pharmacological characterization of [3H]idazoxan, [3H]RX821002 and p-[125I]iodoclonidine binding to alpha 2-adrenoceptors in rat cerebral cortical membranes. European journal of pharmacology, 1994, Jun-02, Volume: 258, Issue:1-2 Topics: Adrenergic alpha-Antagonists; Affinity Labels; Animals; Binding, Competitive; Cerebral Cortex; Clonidine; Dioxanes; Idazoxan; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2	1994
Alpha 2-agonist binding sites in brain: [125I]para-iodoclonidine versus [3H]para-aminoclonidine. Brain research bulletin, 1993, Volume: 32, Issue:2 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoradiography; Binding, Competitive; Brain; Clonidine; Iodine Radioisotopes; Isoquinolines; Male; Oxymetazoline; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Tritium	1993
Characterization of alpha 2-adrenoceptor binding sites in rabbit ciliary body membranes. Investigative ophthalmology & visual science, 1994, Volume: 35, Issue:5 Topics: Affinity Labels; Animals; Binding, Competitive; Cell Membrane; Ciliary Body; Clonidine; Iodine Radioisotopes; Ligands; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha-2; Sympathomimetics; Yohimbine	1994
Nonadrenergic imidazoline binding sites on human platelets. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3 Topics: Affinity Labels; Binding Sites; Binding, Competitive; Blood Platelets; Cell Membrane; Clonidine; Dioxanes; Humans; Idazoxan; Imidazoline Receptors; Iodine Radioisotopes; Kinetics; Norepinephrine; Receptors, Adrenergic, alpha-2; Receptors, Drug; Tritium	1993
Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for I1-imidazoline sites. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:1 Topics: Adrenal Medulla; Affinity Labels; Animals; Antihypertensive Agents; Binding, Competitive; Cattle; Clonidine; Imidazoles; Imidazoline Receptors; Iodine Radioisotopes; Kidney; Kinetics; Medulla Oblongata; Radioligand Assay; Receptors, Adrenergic, alpha; Receptors, Drug	1993
Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:2 Topics: Animals; Binding Sites; Binding, Competitive; Blood Platelets; CHO Cells; Clonidine; Cricetinae; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Imidazoline Receptors; Naphazoline; Radioligand Assay; Receptors, Adrenergic, alpha-2; Receptors, Drug	1996
Effects of alpha-adrenergic agonists on Toxoplasma gondii replication in human umbilical vein endothelial cells. Pathologie-biologie, 1997, Volume: 45, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cells, Cultured; Clonidine; Endothelium, Vascular; Guanabenz; Humans; In Vitro Techniques; Methoxamine; Nitrogen Dioxide; Toxoplasma; Umbilical Veins; Yohimbine	1997
Membrane localization and guanine nucleotide sensitivity of medullary I1-imidazoline binding sites. Neurochemistry international, 1997, Volume: 30, Issue:1 Topics: Affinity Labels; Animals; Binding Sites; Cattle; Cell Fractionation; Cell Membrane; Clonidine; Guanine Nucleotides; Guanylyl Imidodiphosphate; Idazoxan; Imidazoline Receptors; Medulla Oblongata; Receptors, Drug; Tritium	1997
Chronic imipramine treatment downregulates IR1-imidazoline receptors in rat brainstem. Life sciences, 1997, Volume: 61, Issue:19 Topics: Affinity Labels; Animals; Antidepressive Agents, Tricyclic; Binding Sites; Brain Stem; Clonidine; Down-Regulation; Imidazoline Receptors; Imipramine; Iodine Radioisotopes; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug	1997
Carotid body I1-imidazoline receptors: binding, visualization and modulatory function. Respiration physiology, 1998, Volume: 112, Issue:3 Topics: Adrenergic alpha-Agonists; Affinity Labels; Animals; Autoradiography; Carotid Body; Cats; Clonidine; Guanabenz; Hypoxia; Imidazoline Receptors; Iodine Radioisotopes; Membranes; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha-2; Receptors, Drug	1998
Evidence for the existence of imidazoline-specific binding sites in synaptosomal plasma membranes of the bovine brainstem. Journal of neurochemistry, 1998, Volume: 71, Issue:5 Topics: Animals; Binding Sites; Binding, Competitive; Brain Stem; Cattle; Cell Membrane; Clonidine; Imidazoline Receptors; Microscopy, Electron; Receptors, Drug; Subcellular Fractions; Synaptosomes	1998
Brain noradrenergic receptors in major depression and schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 21, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Affinity Labels; Aged; Autoradiography; Brain Chemistry; Clonidine; Depressive Disorder; Female; Hippocampus; Humans; Iodine Radioisotopes; Male; Middle Aged; Norepinephrine; Pindolol; Prefrontal Cortex; Receptors, Adrenergic; Schizophrenia; Suicide	1999
[Interactions of intravenous anesthetics with cerebral alpha-2-adrenoceptors]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1999, Volume: 34, Issue:10 Topics: Adrenergic alpha-Agonists; Affinity Labels; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Autoradiography; Binding, Competitive; Brain; Clonidine; In Vitro Techniques; Ketamine; Propofol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2	1999
Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization. DNA and cell biology, 2000, Volume: 19, Issue:6 Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Blotting, Western; CHO Cells; Clonidine; Cloning, Molecular; COS Cells; Cricetinae; DNA, Complementary; Epinephrine; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Immune Sera; Iodine Radioisotopes; Molecular Sequence Data; Naphazoline; Receptors, Drug; Ruthenium Red; Sequence Tagged Sites; Staining and Labeling; Transfection; Yohimbine	2000
Hypothalamic adrenergic receptor changes in the metabolic syndrome of genetically obese (ob/ob) mice. American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:2 Topics: Animals; Autoradiography; Clonidine; Female; Hypothalamus; In Vitro Techniques; Iodocyanopindolol; Mice; Obesity; Phenethylamines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Reference Values; Tetralones; Tissue Distribution	2000
Elevated agonist binding to alpha2-adrenoceptors in the locus coeruleus in major depression. Biological psychiatry, 2003, Feb-15, Volume: 53, Issue:4 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Affinity Labels; Aged; Autopsy; Autoradiography; Clonidine; Depressive Disorder, Major; Female; Humans; Locus Coeruleus; Male; Middle Aged; Radiopharmaceuticals; Raphe Nuclei; Receptors, Adrenergic, alpha-2	2003
Meperidine, remifentanil and tramadol but not sufentanil interact with alpha(2)-adrenoceptors in alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptor knock out mice brain. European journal of pharmacology, 2008, Mar-17, Volume: 582, Issue:1-3 Topics: Adrenergic alpha-2 Receptor Agonists; Affinity Labels; Analgesics, Opioid; Animals; Autoradiography; Binding, Competitive; Brain; Clonidine; Drug Partial Agonism; Female; In Vitro Techniques; Male; Meperidine; Mice; Mice, Knockout; Piperidines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Remifentanil; Sufentanil; Tramadol	2008
Interaction of morphine but not fentanyl with cerebral alpha2-adrenoceptors in alpha2-adrenoceptor knockout mice. The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:7 Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Animals; Autoradiography; Binding, Competitive; Brain; Clonidine; Drug Partial Agonism; Female; Fentanyl; In Vitro Techniques; Male; Mice; Mice, Knockout; Morphine; Naloxone; Radioligand Assay; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu	2009
Retigabine diminishes the effects of acetylcholine, adrenaline and adrenergic agonists on the spontaneous activity of guinea pig smooth muscle strips in vitro. Autonomic neuroscience : basic & clinical, 2017, Volume: 203 Topics: Acetylcholine; Adrenergic Agonists; Animals; Anthracenes; Carbamates; Cholinergic Agonists; Clonidine; Drug Interactions; Epinephrine; Guinea Pigs; Isoproterenol; KCNQ Potassium Channels; Membrane Potentials; Methoxamine; Muscle Contraction; Muscle, Smooth; Phenylenediamines; Random Allocation; Stomach; Tissue Culture Techniques	2017