4-hydroxymidazolam has been researched along with midazolam in 26 studies
| Studies (4-hydroxymidazolam) | Trials (4-hydroxymidazolam) | Recent Studies (post-2010) (4-hydroxymidazolam) | Studies (midazolam) | Trials (midazolam) | Recent Studies (post-2010) (midazolam) |
|---|---|---|---|---|---|
| 26 | 2 | 6 | 9,834 | 3,191 | 3,301 |
| Protein | Taxonomy | 4-hydroxymidazolam (IC50) | midazolam (IC50) |
|---|---|---|---|
| Cytochrome P450 3A4 | Homo sapiens (human) | 2.7427 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.85) | 18.7374 |
| 1990's | 6 (23.08) | 18.2507 |
| 2000's | 10 (38.46) | 29.6817 |
| 2010's | 8 (30.77) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Katoh, M; Nakajima, M; Yamazaki, H; Yokoi, T | 1 |
| Falk, JL; Lau, CE; Tang, M; Vigorito, M | 1 |
| Dayer, P; Gascon, MP | 1 |
| Arendt, RM; Garland, WA; Greenblatt, DJ | 1 |
| Donati, F; Mastey, V; Panneton, AC; Varin, F | 1 |
| Gorski, JC; Hall, SD; Jones, DR; VandenBranden, M; Wrighton, SA | 1 |
| Bush, E; Ghosal, A; Moore, D; Satoh, H; Thomas, PE | 1 |
| Banditt, P; Martens, J | 1 |
| Chen, YL; Eerkes, A; Jiang, X; Magis, L; Naidong, W; Shou, WZ; Tang, YQ | 1 |
| Akiyama, TE; Cheung, C; Elizondo, G; Feigenbaum, L; Gonzalez, FJ; Granvil, CP; Krausz, KW; Yu, AM | 1 |
| Baumann, P; Bouchoux, G; Eap, CB; Powell Golay, K | 1 |
| Aubert, AC; Baumann, P; Bleiber, G; Buclin, T; Cucchia, G; Eap, CB; Golay, KP; Hustert, E; Kerb, R; Telenti, A; Zullino, D | 1 |
| Aubert, AC; Baumann, P; Bleiber, G; Buclin, T; Eap, CB; Golay, KP; Hustert, E; Kerb, R; Telenti, A | 1 |
| Allen, KE; Cameron, MD; Campbell, AP; Kunze, KL; Nelson, SD; Roberts, AG; Schuman, JT; Wen, B | 1 |
| Calderon, PB; Verbeeck, RK; Wauthier, V | 1 |
| Haschke, M; Krähenbühl, S; Link, B; Wenk, M | 1 |
| Jeong, HE; Kang, W; Lee, SJ; Lee, SS; Liu, KH; Park, YJ; Ryu, JY; Shin, CM; Shin, JG; Shon, JH; Sunwoo, YE | 1 |
| Galinsky, RE; Hall, SD; Jones, DR; Kimura, RE; Quinney, SK; Zhang, X | 1 |
| Akhlaghi, F; Chitnis, SD; Dostalek, M; Ionita, IA; Macwan, JS | 1 |
| Bae, SK; Choi, CS; Choi, YK; Liu, KH; Seo, KA; Shin, JG | 1 |
| de Jonge, H; de Loor, H; Kuypers, DR; Vanrenterghem, Y; Verbeke, K | 1 |
| Atkins, WM; Halpert, JR; Nelson, SD; Roberts, AG; Thummel, KT; Yang, J | 1 |
| Atkins, WM; Isoherranen, N; Paine, MF; Thummel, KE; Yang, J | 1 |
| Clark, RD; Fraczkiewicz, R; Waldman, M | 1 |
| He, F; Huang, S; Liu, M; Xia, C; Xiong, Y; Zeng, C; Zhang, H; Zhang, W | 1 |
| DuBois, B; Mehvar, R; Venkatapura Chandrashekar, D | 1 |
2 trial(s) available for 4-hydroxymidazolam and midazolam
| Article | Year |
|---|---|
Oral administration of a low dose of midazolam (75 microg) as an in vivo probe for CYP3A activity.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Enzyme Induction; Female; Humans; Ketoconazole; Male; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating | 2004 |
Pharmacokinetics of midazolam in CYP3A4- and CYP3A5-genotyped subjects.
Topics: Area Under Curve; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Genotype; Humans; Male; Midazolam | 2004 |
24 other study(ies) available for 4-hydroxymidazolam and midazolam
| Article | Year |
|---|---|
Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport.
Topics: Amiodarone; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Daunorubicin; Digoxin; Enzyme Inhibitors; GABA Modulators; Gonadal Steroid Hormones; Humans; LLC-PK1 Cells; Midazolam; Mixed Function Oxygenases; Nifedipine; Phthalazines; Swine; Testosterone | 2001 |
Midazolam withdrawal and discriminative motor control: effects of FG 7142 and Ro 15-1788.
Topics: Animals; Brain Chemistry; Carbolines; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking Behavior; Flumazenil; GABA-A Receptor Antagonists; Male; Midazolam; Rats; Reinforcement Schedule; Substance Withdrawal Syndrome; Substance-Related Disorders | 1991 |
In vitro forecasting of drugs which may interfere with the biotransformation of midazolam.
Topics: Biotransformation; Debrisoquin; Humans; Hydroxylation; Male; Microsomes, Liver; Midazolam; Middle Aged; Time Factors | 1991 |
Quantitation by gas chromatography of the 1- and 4-hydroxy metabolites of midazolam in human plasma.
Topics: Benzodiazepines; Chromatography, Gas; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Kinetics; Midazolam | 1984 |
Determination of midazolam and two of its metabolites in human plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Hydroxylation; Midazolam; Sensitivity and Specificity | 1994 |
Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.
Topics: Biotransformation; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Fetus; Humans; Isoenzymes; Kinetics; Microsomes, Liver; Midazolam; Mixed Function Oxygenases | 1994 |
Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450.
Topics: Anesthetics, Intravenous; Animals; Anti-Anxiety Agents; Antibodies; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 1996 |
Simultaneous determination of midazolam and its metabolites 1-hydroxymidazolam and 4-hydroxymidazolam in human serum using gas chromatography-mass spectrometry.
Topics: Anesthetics, Intravenous; Gas Chromatography-Mass Spectrometry; Humans; Hypnotics and Sedatives; Midazolam; Sensitivity and Specificity | 1997 |
Ultrafast liquid chromatography/tandem mass spectrometry bioanalysis of polar analytes using packed silica columns.
Topics: Animals; Chromatography, Liquid; Humans; Macaca fascicularis; Midazolam; Morphine; Morphine Derivatives; Reproducibility of Results; Sensitivity and Specificity; Silicon Dioxide; Solvents; Spectrum Analysis | 2002 |
Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Blotting, Southern; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Inhibitors; Half-Life; Humans; In Vitro Techniques; Intestine, Small; Ketoconazole; Male; Mice; Mice, Transgenic; Microsomes; Midazolam; Polymerase Chain Reaction; Rifampin; Time Factors | 2003 |
Determination of picogram levels of midazolam, and 1- and 4-hydroxymidazolam in human plasma by gas chromatography-negative chemical ionization-mass spectrometry.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Midazolam; Reproducibility of Results | 2004 |
Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study.
Topics: Benzoflavones; Binding Sites; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Heme; Kinetics; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Midazolam; Protons; Testosterone | 2005 |
Decreased CYP3A2 expression and activity in senescent male Wistar rats: is there a role for HNF4alpha?
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; COUP Transcription Factor II; Cytochrome P-450 CYP3A; DNA; Electrophoretic Mobility Shift Assay; Female; Growth Hormone; Hepatocyte Nuclear Factor 4; Liver; Male; Membrane Proteins; Microsomes, Liver; Midazolam; Protein Processing, Post-Translational; Rats; Rats, Wistar; RNA, Messenger; Sex Factors | 2006 |
Determination of midazolam and its hydroxy metabolites in human plasma and oral fluid by liquid chromatography/electrospray ionization ion trap tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Humans; Hypnotics and Sedatives; Midazolam; Reproducibility of Results; Saliva; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2007 |
The CYP3A4*18 allele, the most frequent coding variant in asian populations, does not significantly affect the midazolam disposition in heterozygous individuals.
Topics: Adult; Anti-Anxiety Agents; Asian People; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gene Frequency; Heterozygote; Humans; Isoenzymes; Kinetics; Korea; Midazolam; NADPH-Ferrihemoprotein Reductase; Polymorphism, Single Nucleotide; Spectrophotometry | 2007 |
Inhibition of CYP3A by erythromycin: in vitro-in vivo correlation in rats.
Topics: Algorithms; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Erythromycin; Gene Expression; Kinetics; Liver; Male; Membrane Proteins; Microsomes, Liver; Midazolam; Models, Biological; Rats; Rats, Sprague-Dawley | 2010 |
Development and validation of a rapid and sensitive assay for simultaneous quantification of midazolam, 1'-hydroxymidazolam, and 4-hydroxymidazolam by liquid chromatography coupled to tandem mass-spectrometry.
Topics: Chromatography, Liquid; Humans; Least-Squares Analysis; Microsomes, Liver; Midazolam; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2010 |
Metabolism of 1'- and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7.
Topics: Chromatography, High Pressure Liquid; Glucuronides; Glucuronosyltransferase; Humans; Hydroxylation; In Vitro Techniques; Metabolic Detoxication, Phase II; Microsomes, Liver; Midazolam; Molecular Structure; Recombinant Proteins; Tandem Mass Spectrometry | 2010 |
A highly sensitive liquid chromatography tandem mass spectrometry method for simultaneous quantification of midazolam, 1'-hydroxymidazolam and 4-hydroxymidazolam in human plasma.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Kidney Transplantation; Midazolam; Nonlinear Dynamics; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2011 |
The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4.
Topics: Algorithms; Anticonvulsants; Biocatalysis; Carbamazepine; Catalytic Domain; Computer Simulation; Cytochrome P-450 CYP3A; Humans; Hydroxylation; Hypnotics and Sedatives; Kinetics; Ligands; Midazolam; Models, Molecular; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Recombinant Proteins | 2011 |
Evidence of CYP3A allosterism in vivo: analysis of interaction between fluconazole and midazolam.
Topics: Allosteric Regulation; Area Under Curve; Biomarkers; Cytochrome P-450 CYP3A; Drug Interactions; Fluconazole; Humans; Midazolam | 2012 |
Tales from the war on error: the art and science of curating QSAR data.
Topics: Chlorpromazine; Cytochrome P-450 Enzyme System; Data Accuracy; Data Curation; Isomerism; Methylergonovine; Midazolam; Molecular Structure; Quantitative Structure-Activity Relationship; Terminology as Topic; Thermodynamics; Transition Temperature | 2015 |
Mechanism of Action of Panaxytriol on Midazolam 1'-Hydroxylation and 4-Hydroxylation Mediated by CYP3A in Liver Microsomes and Rat Primary Hepatocytes.
Topics: Animals; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dexamethasone; Enediynes; Fatty Alcohols; Hepatocytes; Humans; Hydroxylation; Ketoconazole; Microsomes, Liver; Midazolam; Rats; RNA, Messenger | 2015 |
UPLC-MS/MS analysis of the Michaelis-Menten kinetics of CYP3A-mediated midazolam 1'- and 4-hydroxylation in rat brain microsomes.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Kinetics; Male; Microsomes; Midazolam; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2021 |