4-hydroxymexiletine has been researched along with mexiletine in 6 studies
*Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties. [MeSH]
*Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Filipek, M; Paczkowski, D; Podleśny, J | 1 |
| Gilbert, M; Grech-Bélanger, O; LeBlanc, PP; Turgeon, J | 1 |
| Coutts, RT; Foster, RT; Freitag, DG; Pasutto, FM | 1 |
| Coutts, RT; Foster, RT; Freitag, DG; Pasutto, FM; Pickard, MA | 1 |
| Carocci, A; Catalano, A; Conte Camerino, D; De Bellis, M; De Luca, A; Desaphy, JF; Fracchiolla, G; Franchini, C; Lentini, G; Tortorella, V | 1 |
| Coelho, EB; Godoy, AL; Lanchote, VL; Marques, MP; Parisi, CC | 1 |
6 other study(ies) available for 4-hydroxymexiletine and mexiletine
| Article | Year |
|---|---|
High-performance liquid chromatographic method for the determination of p-hydroxylated and hydroxymethylated metabolites of mexiletine in human serum.
Topics: Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Mexiletine; Solutions; Spectrophotometry, Ultraviolet | 1988 |
Effect of cigarette smoking on mexiletine kinetics.
Topics: Adult; Female; Humans; Kinetics; Male; Mexiletine; Propylamines; Smoking; Time Factors | 1985 |
High-performance liquid chromatographic method for resolving the enantiomers of mexiletine and two major metabolites isolated from microbial fermentation media.
Topics: Chromatography, High Pressure Liquid; Culture Media; Fermentation; Indicators and Reagents; Mexiletine; Mucorales; Stereoisomerism | 1993 |
Stereoselective metabolism of rac-mexiletine by the fungus Cunninghamella echinulata yields the major human metabolites hydroxymethylmexiletine and p-hydroxymexiletine.
Topics: Anti-Arrhythmia Agents; Culture Media; Fungi; Hydrogen-Ion Concentration; Mexiletine | 1997 |
Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation.
Topics: Animals; Anura; Inhibitory Concentration 50; Mexiletine; Molecular Structure; Muscles; Sodium Channel Blockers; Sodium Channels; Stereoisomerism | 2004 |
Enantioselective determination of mexiletine and its metabolites p-hydroxymexiletine and hydroxymethylmexiletine in rat plasma by normal-phase liquid chromatography-tandem mass spectrometry: application to pharmacokinetics.
Topics: Animals; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Chromatography, Liquid; Culture Media; Drugs, Chinese Herbal; Male; Mass Spectrometry; Mexiletine; Rats; Rats, Wistar; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry | 2009 |