Page last updated: 2024-09-03

4-hydroxymephenytoin and mephenytoin

4-hydroxymephenytoin has been researched along with mephenytoin in 33 studies

Compound Research Comparison

Studies (4-hydroxymephenytoin)	Trials (4-hydroxymephenytoin)	Recent Studies (post-2010) (4-hydroxymephenytoin)	Studies (mephenytoin)	Trials (mephenytoin)	Recent Studies (post-2010) (mephenytoin)
36	5	0	580	35	32

Protein Interaction Comparison

Protein	Taxonomy	4-hydroxymephenytoin (IC50)	mephenytoin (IC50)
Cytochrome P450 2C19	Homo sapiens (human)		1.185

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (12.12)	18.7374
1990's	19 (57.58)	18.2507
2000's	10 (30.30)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chiba, K; Ishizaki, T; Jang, IJ; Kusaka, M; Shin, JG; Shin, SG; Sohn, DR	1
Horsmans, Y; Lannes, D; Larrey, D; Letteron, P; Loeper, J; Pessayre, D; Tinel, M	1
Anthony, LB; Wilkinson, GR; Wood, AJ; Zhou, HH	1
Dulac, H; Jacqz, E; Mathieu, H	1
Branch, RA; Küpfer, A	1
Aslanian, WS; Branch, RA; McAllister, CB; Wedlund, PJ; Wilkinson, GR	1
Branch, RA; Küpfer, A; Patwardhan, R; Preisig, R; Schenker, S; Ward, S	1
Huang, SL; Xie, HG; Zhou, HH	1
Flockhart, DA; Hadidi, HF; Idle, JR; Irshaid, YM; Woosley, RL	1
Caslavska, J; Desiderio, C; Hufschmid, E; Theurillat, R; Thormann, W; Wolfisberg, H	1
Cheng, YS; Ding, DY; Ruan, ZR	1
Desiderio, C; Fanali, S; Küpfer, A; Thormann, W	1
Chiba, K; Ishizaki, T; Kobayashi, K; Manabe, K; Takayama, Y; Tani, M	1
Kunze, KL; Rettie, AE; Storch, E; Trager, WF; Wienkers, LC; Wurden, CJ	1
Wedlund, PJ; Wilkinson, GR	1
Chiba, K; Hakusui, H; Ishizaki, T; Kaneko, S; Kato, K; Ohkubo, T; Otani, K; Sudo, K; Sugawara, K; Tanaka, M	1
Bajpai, M; Levy, RH; Roskos, LK; Shen, DD	1
Hakusui, H; Ishizaki, T; Kaneko, S; Ohkubo, T; Otani, K; Ryokawa, Y; Sugawara, K; Suzuki, A; Tanaka, M; Yamamori, S	1
Feng, HJ; Huang, SL; Wang, W; Zhou, HH	1
Adedoyin, A; Arns, PA; Branch, RA; Richards, WO; Wilkinson, GR	1
Huang, SL; Jiang, CH; Liu, JH; Wu, JX; Xie, HG; Xu, ZH; Zhou, HH	1
Bochner, F; Coller, JK; Somogyi, AA	1
Baker, GB; Coutts, RT; Salsali, M	1
Feldman, AM; Frye, CS; Frye, RF; Schneider, VM	1
Kalhorn, TF; Lakehal, F; Levy, RH; Wurden, CJ	1
Chen, XP; Huang, SL; Huang, Z; Ou-Yang, DS; Tan, ZR; Zhou, HH	1
Bell, AR; Crewe, HK; Graham, MJ; Lennard, MS; Moorcraft, CL; Walker, L; Whittaker, EF	1
Kharasch, ED; Kunze, KL; Levy, RH; Trager, WF; Yao, C	1
Ashton, M; Jansson, B; Simonsson, US	1
Abd El-Aty, AM; An, W; Chen, GL; Li, Q; Li, Z; Liu, J; Tang, ZR; Wang, D; Wang, LS; Wu, J; Zhou, G; Zhou, HH; Zhu, B	1
Fuhr, U; Harlfinger, S; Kasel, D; Klaassen, T	1
Elsherbiny, D; Jansson, B; Simonsson, US	1
Branch, RA; Chaves-Gnecco, D; Frye, RF; Matzke, GR; Rabinovitz, M; Shaikh, OS; Zgheib, NK	1

Trials

5 trial(s) available for 4-hydroxymephenytoin and mephenytoin

Article	Year
S-mephenytoin hydroxylation phenotypes in a Jordanian population. Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:5 Topics: Adolescent; Adult; Anticonvulsants; Debrisoquin; Female; Gene Frequency; Humans; Hydroxylation; Jordan; Male; Mephenytoin; Metabolism; Middle Aged; Phenotype; Prevalence; Sympatholytics	1995
Screening for hydroxylation and acetylation polymorphisms in man via simultaneous analysis of urinary metabolites of mephenytoin, dextromethorphan and caffeine by capillary electrophoretic procedures. Journal of chromatography. B, Biomedical applications, 1994, Jun-03, Volume: 656, Issue:1 Topics: Acetylation; Adult; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Dextromethorphan; Electrophoresis, Polyacrylamide Gel; Humans; Hydroxylation; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic	1994
Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6. Clinical pharmacology and therapeutics, 1998, Volume: 64, Issue:1 Topics: Adult; Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Liver Diseases; Male; Mephenytoin; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Stereoisomerism; Sympatholytics	1998
The influence of St John's Wort on CYP2C19 activity with respect to genotype. Journal of clinical pharmacology, 2004, Volume: 44, Issue:6 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Genotype; Humans; Hypericum; Male; Mephenytoin; Mixed Function Oxygenases; Plant Extracts; Polymorphism, Genetic	2004
Liver disease selectively modulates cytochrome P450--mediated metabolism. Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:3 Topics: Administration, Oral; Adult; Anticonvulsants; Antihypertensive Agents; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Isoenzymes; Liver Diseases; Male; Mephenytoin; Middle Aged; Muscle Relaxants, Central; Phosphodiesterase Inhibitors; Severity of Illness Index; Theophylline	2006

Other Studies

28 other study(ies) available for 4-hydroxymephenytoin and mephenytoin

Article	Year
Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:2 Topics: Adult; Asian People; Creatinine; Diazepam; Female; Humans; Hydroxylation; Korea; Male; Mephenytoin; Mixed Function Oxygenases; Nordazepam; Phenotype; Polymorphism, Genetic	1992
Nilutamide inhibits mephenytoin 4-hydroxylation in untreated male rats and in human liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 1991, Volume: 21, Issue:12 Topics: Androgen Antagonists; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Ferricyanides; Humans; Hydroxylation; Imidazoles; Imidazolidines; Male; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Troleandomycin	1991
Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin. British journal of clinical pharmacology, 1990, Volume: 30, Issue:3 Topics: Adult; Female; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Phenotype; Rifampin	1990
Phenotyping polymorphic drug metabolism in the French Caucasian population. European journal of clinical pharmacology, 1988, Volume: 35, Issue:2 Topics: Adult; Dextromethorphan; Female; France; Humans; Hydantoins; Levorphanol; Male; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic; White People	1988
Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation. Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:4 Topics: Administration, Oral; Chromatography, High Pressure Liquid; Humans; Hydantoins; Hydroxylation; Mephenytoin; Mephobarbital; Phenotype; Stereoisomerism	1985
Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism. Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Chromatography, High Pressure Liquid; Debrisoquin; Female; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic; Tennessee; White People	1984
Stereoselective metabolism and pharmacogenetic control of 5-phenyl-5-ethylhydantoin (nirvanol) in humans. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:1 Topics: Adolescent; Adult; Anticonvulsants; Half-Life; Humans; Hydantoins; Male; Mephenytoin; Stereoisomerism; Time Factors	1984
High-performance liquid chromatographic determination of urinary 4'-hydroxymephenytoin, a metabolic marker for the hepatic enzyme CYP2C19, in humans. Journal of chromatography. B, Biomedical applications, 1995, Jun-09, Volume: 668, Issue:1 Topics: Aryl Hydrocarbon Hydroxylases; Biomarkers; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; Liver; Mephenytoin; Mixed Function Oxygenases; Reproducibility of Results; Spectrophotometry, Ultraviolet	1995
[Determination of mephenytoin and 4'-hydroxymephenytoin in urine by high performance liquid chromatography]. Yao xue xue bao = Acta pharmaceutica Sinica, 1994, Volume: 29, Issue:8 Topics: Chromatography, High Pressure Liquid; Humans; Mephenytoin	1994
Analysis of mephenytoin, 4-hydroxymephenytoin and 4-hydroxyphenytoin enantiomers in human urine by cyclodextrin micellar electrokinetic capillary chromatography: simple determination of a hydroxylation polymorphism in man. Electrophoresis, 1994, Volume: 15, Issue:1 Topics: Buffers; Capillary Action; Chromatography; Cyclodextrins; Humans; Hydroxylation; Kinetics; Mephenytoin; Micelles; Phenytoin; Stereoisomerism	1994
Development and preliminary application of a simple assay of S-mephenytoin 4-hydroxylase activity in human liver microsomes. European journal of clinical pharmacology, 1993, Volume: 44, Issue:6 Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Polymorphism, Genetic	1993
Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:5 Topics: Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fluconazole; Humans; Hydroxylation; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Theophylline; Tranylcypromine; Warfarin	1996
In vivo and in vitro measurement of CYP2C19 activity. Methods in enzymology, 1996, Volume: 272 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Mephenytoin; Mixed Function Oxygenases; Omeprazole; Phenotype; Polymorphism, Genetic; Stereoisomerism; Substrate Specificity	1996
Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test. Journal of chromatography. B, Biomedical applications, 1996, Feb-09, Volume: 676, Issue:1 Topics: Adult; Animals; Anticonvulsants; Calibration; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Indicators and Reagents; Male; Mephenytoin; Phenotype; Rats; Solutions	1996
Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:12 Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Phenytoin; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	1996
Metabolic disposition of pantoprazole, a proton pump inhibitor, in relation to S-mephenytoin 4'-hydroxylation phenotype and genotype. Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:6 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Half-Life; Humans; Japan; Male; Mephenytoin; Metabolic Clearance Rate; Mixed Function Oxygenases; Omeprazole; Pantoprazole; Proton Pump Inhibitors; Sulfoxides	1997
The induction effect of rifampicin on activity of mephenytoin 4'-hydroxylase related to M1 mutation of CYP2C19 and gene dose. British journal of clinical pharmacology, 1998, Volume: 45, Issue:1 Topics: Adult; Antibiotics, Antitubercular; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Hydroxylation; Male; Mephenytoin; Mixed Function Oxygenases; Mutation; Rifampin; Stereoisomerism	1998
No correlation between side-chain of propranolol oxidation and S-mephenytoin 4'-hydroxylase activity. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1997, Volume: 18, Issue:3 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Female; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Oxidation-Reduction; Propranolol	1997
Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms. British journal of clinical pharmacology, 1999, Volume: 48, Issue:2 Topics: Adult; Aged; Antibodies, Monoclonal; Anticonvulsants; Antimetabolites; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Folic Acid Antagonists; Genotype; Humans; In Vitro Techniques; Isoenzymes; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Oxidation-Reduction; Proguanil; Triazines	1999
Analysis of dextrorphan, a metabolite of dextromethorphan, using gas chromatography with electron-capture detection. Journal of pharmacological and toxicological methods, 1999, Volume: 41, Issue:4 Topics: Benzoates; Chromatography, Gas; Dextrorphan; Drug Stability; Humans; In Vitro Techniques; Mephenytoin; Microsomes, Liver; Oxidation-Reduction; Solubility	1999
Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure. Journal of cardiac failure, 2002, Volume: 8, Issue:5 Topics: Adult; Aged; Biomarkers; Cytochrome P-450 Enzyme System; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Genetic Markers; Genotype; Heart Failure; Humans; Interleukin-6; Male; Mephenytoin; Middle Aged; Mutation; Phenotype; Polymorphism, Genetic; Prevalence; Statistics as Topic; Tumor Necrosis Factor-alpha	2002
Carbamazepine and oxcarbazepine decrease phenytoin metabolism through inhibition of CYP2C19. Epilepsy research, 2002, Volume: 52, Issue:2 Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Chlorophyll; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Liver; Mephenytoin; Microsomes; Mixed Function Oxygenases; Oxcarbazepine; Phenytoin; Recombinant Proteins	2002
Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects. Clinical pharmacology and therapeutics, 2003, Volume: 73, Issue:3 Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Asian People; Aspirin; Caffeine; China; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Isoenzymes; Male; Mephenytoin; Metoprolol; Midazolam; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenotype; Reference Values; Theophylline	2003
mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates. Xenobiotica; the fate of foreign compounds in biological systems, 2003, Volume: 33, Issue:3 Topics: Algorithms; Animals; Cytochrome P-450 Enzyme System; Dextromethorphan; Dogs; Female; Humans; Isoenzymes; Kinetics; Liver; Male; Mephenytoin; Microsomes, Liver; Omeprazole; Protein Biosynthesis; RNA, Messenger; Warfarin	2003
Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:5 Topics: Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fluvoxamine; Humans; In Vitro Techniques; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Time Factors	2003
Simultaneous enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4'-hydroxymephenytoin in human plasma by liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003, Jul-05, Volume: 791, Issue:1-2 Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Humans; Mephenytoin; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism	2003
Quantification of mephenytoin and its metabolites 4'-hydroxymephenytoin and nirvanol in human urine using a simple sample processing method. Rapid communications in mass spectrometry : RCM, 2004, Volume: 18, Issue:15 Topics: Aryl Hydrocarbon Hydroxylases; Calibration; Chromatography, Liquid; Cytochrome P-450 CYP2C19; Humans; Male; Mass Spectrometry; Mephenytoin; Mixed Function Oxygenases; Molecular Structure; Reference Standards; Reproducibility of Results; Sensitivity and Specificity	2004
Enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4'-hydroxymephenytoin in human plasma and urine by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 2006, Volume: 20, Issue:3 Topics: Chromatography, Liquid; Humans; Mass Spectrometry; Mephenytoin; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism	2006