4-hydroxymephenytoin has been researched along with dextromethorphan in 4 studies
| Studies (4-hydroxymephenytoin) | Trials (4-hydroxymephenytoin) | Recent Studies (post-2010) (4-hydroxymephenytoin) | Studies (dextromethorphan) | Trials (dextromethorphan) | Recent Studies (post-2010) (dextromethorphan) |
|---|---|---|---|---|---|
| 36 | 5 | 0 | 2,020 | 342 | 593 |
| Protein | Taxonomy | 4-hydroxymephenytoin (IC50) | dextromethorphan (IC50) |
|---|---|---|---|
| Sodium channel protein type 1 subunit alpha | Rattus norvegicus (Norway rat) | 1.3 | |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | 1.3 | |
| Sodium channel protein type 3 subunit alpha | Rattus norvegicus (Norway rat) | 1.3 | |
| Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | 5.6 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 2.1768 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.0027 | |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | 0.1236 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dulac, H; Jacqz, E; Mathieu, H | 1 |
| Caslavska, J; Desiderio, C; Hufschmid, E; Theurillat, R; Thormann, W; Wolfisberg, H | 1 |
| Feldman, AM; Frye, CS; Frye, RF; Schneider, VM | 1 |
| Bell, AR; Crewe, HK; Graham, MJ; Lennard, MS; Moorcraft, CL; Walker, L; Whittaker, EF | 1 |
1 trial(s) available for 4-hydroxymephenytoin and dextromethorphan
| Article | Year |
|---|---|
Screening for hydroxylation and acetylation polymorphisms in man via simultaneous analysis of urinary metabolites of mephenytoin, dextromethorphan and caffeine by capillary electrophoretic procedures.
Topics: Acetylation; Adult; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Dextromethorphan; Electrophoresis, Polyacrylamide Gel; Humans; Hydroxylation; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic | 1994 |
3 other study(ies) available for 4-hydroxymephenytoin and dextromethorphan
| Article | Year |
|---|---|
Phenotyping polymorphic drug metabolism in the French Caucasian population.
Topics: Adult; Dextromethorphan; Female; France; Humans; Hydantoins; Levorphanol; Male; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic; White People | 1988 |
Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure.
Topics: Adult; Aged; Biomarkers; Cytochrome P-450 Enzyme System; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Genetic Markers; Genotype; Heart Failure; Humans; Interleukin-6; Male; Mephenytoin; Middle Aged; Mutation; Phenotype; Polymorphism, Genetic; Prevalence; Statistics as Topic; Tumor Necrosis Factor-alpha | 2002 |
mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates.
Topics: Algorithms; Animals; Cytochrome P-450 Enzyme System; Dextromethorphan; Dogs; Female; Humans; Isoenzymes; Kinetics; Liver; Male; Mephenytoin; Microsomes, Liver; Omeprazole; Protein Biosynthesis; RNA, Messenger; Warfarin | 2003 |