4-hydroxymephenytoin has been researched along with debrisoquin in 4 studies
| Studies (4-hydroxymephenytoin) | Trials (4-hydroxymephenytoin) | Recent Studies (post-2010) (4-hydroxymephenytoin) | Studies (debrisoquin) | Trials (debrisoquin) | Recent Studies (post-2010) (debrisoquin) |
|---|---|---|---|---|---|
| 36 | 5 | 0 | 890 | 89 | 17 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aslanian, WS; Branch, RA; McAllister, CB; Wedlund, PJ; Wilkinson, GR | 1 |
| Flockhart, DA; Hadidi, HF; Idle, JR; Irshaid, YM; Woosley, RL | 1 |
| Adedoyin, A; Arns, PA; Branch, RA; Richards, WO; Wilkinson, GR | 1 |
| Branch, RA; Chaves-Gnecco, D; Frye, RF; Matzke, GR; Rabinovitz, M; Shaikh, OS; Zgheib, NK | 1 |
3 trial(s) available for 4-hydroxymephenytoin and debrisoquin
| Article | Year |
|---|---|
S-mephenytoin hydroxylation phenotypes in a Jordanian population.
Topics: Adolescent; Adult; Anticonvulsants; Debrisoquin; Female; Gene Frequency; Humans; Hydroxylation; Jordan; Male; Mephenytoin; Metabolism; Middle Aged; Phenotype; Prevalence; Sympatholytics | 1995 |
Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6.
Topics: Adult; Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Liver Diseases; Male; Mephenytoin; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Stereoisomerism; Sympatholytics | 1998 |
Liver disease selectively modulates cytochrome P450--mediated metabolism.
Topics: Administration, Oral; Adult; Anticonvulsants; Antihypertensive Agents; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Isoenzymes; Liver Diseases; Male; Mephenytoin; Middle Aged; Muscle Relaxants, Central; Phosphodiesterase Inhibitors; Severity of Illness Index; Theophylline | 2006 |
1 other study(ies) available for 4-hydroxymephenytoin and debrisoquin
| Article | Year |
|---|---|
Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism.
Topics: Administration, Oral; Adolescent; Adult; Chromatography, High Pressure Liquid; Debrisoquin; Female; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic; Tennessee; White People | 1984 |