4-hydroxyestradiol and carbene

4-hydroxyestradiol has been researched along with carbene* in 1 studies

Other Studies

1 other study(ies) available for 4-hydroxyestradiol and carbene

Article	Year
Selective synthesis of 4-methoxyestrogen from 4-hydroxyestrogen. Steroids, 2001, Volume: 66, Issue:8 The introduction of an oxygen atom into the C-6 position of 4-hydroxyestrogen allowed for the selective methylation of the two phenolic hydroxyl groups. When the 6-oxo derivative of 4-hydroxyestrone was benzylated in ethanol, only the 3-monobenzyl ether was obtained without formation of the 4-monobenzyl ether. Moreover, the 6-carbonyl group was further reduced to methylene almost quantitatively in the reaction of 4-acetoxy-6-oxoestrone 3-benzyl ether derivative with sodium borohydride. Therefore, 4-methoxyestrogen was synthesized by essentially combining these two reactions. Topics: Estradiol; Estrogens; Estrogens, Catechol; Hydrocarbons; Methane; Methylation; Temperature	2001

Article

Year

Selective synthesis of 4-methoxyestrogen from 4-hydroxyestrogen.

Steroids, 2001, Volume: 66, Issue:8

The introduction of an oxygen atom into the C-6 position of 4-hydroxyestrogen allowed for the selective methylation of the two phenolic hydroxyl groups. When the 6-oxo derivative of 4-hydroxyestrone was benzylated in ethanol, only the 3-monobenzyl ether was obtained without formation of the 4-monobenzyl ether. Moreover, the 6-carbonyl group was further reduced to methylene almost quantitatively in the reaction of 4-acetoxy-6-oxoestrone 3-benzyl ether derivative with sodium borohydride. Therefore, 4-methoxyestrogen was synthesized by essentially combining these two reactions.

Topics: Estradiol; Estrogens; Estrogens, Catechol; Hydrocarbons; Methane; Methylation; Temperature

2001