Page last updated: 2024-08-26

4-hydroxydebrisoquin and debrisoquin

4-hydroxydebrisoquin has been researched along with debrisoquin in 81 studies

Research

Studies (81)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (44.44)	18.7374
1990's	31 (38.27)	18.2507
2000's	12 (14.81)	29.6817
2010's	2 (2.47)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bertilsson, L; Du, YL; Iselius, L; Kuang, TY; Liao, XM; Liu, Y; Lou, YQ; Reviriego, J; Sjöqvist, F; Wang, KY	1
Jenner, PG; Lledo, P; Marsden, CD; Quinn, NP; Steiger, MJ; Turner, P	1
Ho, JW; Moody, DE	1
Allegre, F; Boucherat, M; Clapot, P; Daumas, L; Francois, B; Pinatel, H; Sabot, JF; Vermeulen, E	1
Chernozemsky, IN; Idle, JR; Nikolov, IG	1
Idle, JR; Pontin, J; Sardas, S	1
McLean, S; Veronese, ME	1
Kuang, TY; Liao, XM; Lou, YQ; Wang, KY; Zhang, Y	1
al-Sereiti, MR; Edeki, T; Lledo, P; Turner, P	1
Franke, G; Hanke, W; Siegmund, W; Wilke, A; Zschiesche, M	1
Jiang, WD; Xu, XM	1
Huupponen, R; Kallio, J; Viikari, J	1
Allain, H; Bentué-Ferrer, D; Brunet-Bourgin, F; Meillard, MN; Morel, G	1
Biola Mabadeje, AF; Boobis, AR; Davies, DS; Murray, S; Speirs, CJ	1
Kallio, J	1
Arias, TD; Inaba, T; Jackson, PR; Jorge, LF	1
Johnson, KA; Kolatkar, V; Straka, RJ	1
Horai, Y; Ishikawa, K; Ishizaki, T; Taga, J	1
Lee, EJ; Patamasucon, P; Wanwimolruk, S	1
Du, YL; Lou, YQ	1
Bechtel, P; Bertschy, G; Derenne, F; Joanne, C; Vandel, S; Volmat, R	1
Bertilsson, L; Buemi, AL; Sanz, E; Spina, E	1
Alván, G; Seideman, P	1
Avenant, J; Moncrieff, J; Sommers, DK	2
Ayesh, R; Bale, S; Caporaso, N; Hetzel, M; Idle, J; Pickle, LW	1
Mellström, B	1
Fleming, JJ; McBurney, A; McGourty, JC; Silas, JH; Ward, JW	1
Benitez, J; Buemi, AL; Caputi, AP; Cobaleda, J; Garcia, MA; Llerena, A; Piña, B; Spina, E	1
Deshayes, S; Galteau, MM; Mothe, O; Siest, G; Vincent-Viry, M	1
Altenbern, D; Dai, GH; Oates, J; Roden, DM; Wang, T; Wilkinson, GR; Woosley, RL	1
Moncrieff, J	1
Lee, EJ	1
Huupponen, R; Iisalo, E; Kallio, J; Lindberg, R	1
Eichelbaum, M; Fischer, C; Meese, CO	1
Chan, K	1
Benítez, J; Cobaleda, J; LLerena, A	1
Amery, WK; Caers, LI; Davies, PT; Heykants, J; Rose, FC; Steiner, TJ; Woestenborghs, R	1
Ayesh, R; Brostoff, J; Mitchell, SC; Scadding, GK; Smith, RL; Waring, RH	1
Eichelbaum, M; Meese, CO; Thalheimer, P	1
Decolin, D; Motassim, N; Nicolas, A; Siest, G	1
Harper, PG; Philip, PA; Rogers, HJ	1
Gachályi, B; Róna, K; Vereczkey, L	1
Harman, PJ; Mashford, ML; Westwood, BE	1
Dixon, ST; Harrison, PM; McLean, AJ; Tonkin, AM	1
Bertilsson, L; Mellström, B; Säwe, J; Sjöqvist, F	1
Rawlins, MD	1
Eichelbaum, M; Idle, JR; Oates, NS; Smith, RL; Woolhouse, NM	1
Strecker, M; Wolff, T	1
Branch, RA; Goto, F; Jacqz, E; McAllister, CB; Nakamura, K; Ray, WA; Wilkinson, GR	1
Birgersson, C; Ericsson, O; Mellström, B; Sjöqvist, F; Spina, E; Steiner, E; von Bahr, C	1
Aslanian, WS; Branch, RA; McAllister, CB; Wedlund, PJ; Wilkinson, GR	1
Karlaganis, G; Küpfer, A; Preisig, R	1
Aberg-Wistedt, A; Bertilsson, L	1
Idle, JR; Lancaster, R; Shah, RR; Sloan, TP; Smith, RL	1
Chapman, PH; Idle, JR; Rawlins, MD; Ritchie, JC; Shuster, S; Smith, RL	1
Clements, DG; Mitchell, SC; Shah, RR; Smith, RL	1
Johnston, A; Lledó, P; Pearson, RM; Turner, P; Walker, S	1
Bertilsson, L; Dahl, ML; Eichelbaum, M; Ingelman-Sundberg, M; Johansson, I; Meese, CO; Säwe, J; Yue, QY	1
Basci, NE; Bozkurt, A; Isimer, A; Kayaalp, SO; Sayal, A	1
Basci, NE; Bozkurt, A; Isimer, A; Kayaalp, SO	1
Branch, RA; Frye, RF	1
Lanz, M; Theurillat, R; Thormann, W	1
Cerqueira, PM; Cesarino, EJ; Lanchote, VL; Mateus, FH; Mere, Y; Santos, SR	1
Boucher, JL; Clement, B; Harsdorf, A; Mansuy, D	1
Andersson, K; Bertilsson, L; Dahl, M; Dalén, P	1
Auler, JO; Breimer, DD; Carmona, MJ; Lanchote, VL; Mateus, FH; Pereira, VA; Santos, SR	1
Bertilsson, L; Svensson, JO	1
Lennard, MS; Sijumbil, G; Simooya, OO; Tucker, GT	1
Hussein, A; Ismail, R; Nizam Isa, M; Teh, LK	1
Bonato, PS; Cerqueira, PM; Cesarino, EJ; Lanchote, VL; Mateus, FH	1
Andersson, K; Bertilsson, L; Härtter, S; Laine, K; Svensson, JO; Tybring, G; Widén, J	1
Hashimoto, Y; Hasunuma, M; Okabe, H	1
Berecz, R; Cáceres, MC; Cobaleda, J; Dorado, P; González, I; Llerena, A	1
Cerqueira, PM; Coelho, EB; Geleilete, TJ; Goldman, GH; Lanchote, VL	1
Chen, C; Gonzalez, FJ; Idle, JR; Krausz, KW; McPhail, KL; Perlík, F; Slanar, O; Slavík, J; Zabriskie, TM; Zhen, Y	1
Katoh, M; Nakajima, M; Sawada, T; Soeno, Y; Tateno, C; Yokoi, T; Yoshizato, K	1
Burm, AG; Ekström, GY; Huledal, GA; Kruit, M; Stienstra, R; van Kleef, JW; Veering, BT; Wink, J	1
Katoh, M; Tateno, C; Yokoi, T; Yoshizato, K	1
Chen, L; Gai, Z; He, L; Qin, S; Wu, Z; Xu, Q; Yang, L; Zhang, X	1
Corado, CR; Knych, HK; McKemie, DS	1

Reviews

1 review(s) available for 4-hydroxydebrisoquin and debrisoquin

Article	Year
Chimeric mice with humanized liver. Toxicology, 2008, Apr-03, Volume: 246, Issue:1 Topics: Adrenergic Agents; Animals; Anti-Bacterial Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cefmetazole; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Liver; Male; Mice; Mixed Function Oxygenases; Models, Biological; Polymorphism, Genetic; Species Specificity; Transplantation Chimera	2008

Article

Year

Chimeric mice with humanized liver.

Toxicology, 2008, Apr-03, Volume: 246, Issue:1

Topics: Adrenergic Agents; Animals; Anti-Bacterial Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cefmetazole; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Liver; Male; Mice; Mixed Function Oxygenases; Models, Biological; Polymorphism, Genetic; Species Specificity; Transplantation Chimera

2008

Trials

10 trial(s) available for 4-hydroxydebrisoquin and debrisoquin

Article	Year
Poor sulphoxidation ability in patients with food sensitivity. BMJ (Clinical research ed.), 1988, Jul-09, Volume: 297, Issue:6641 Topics: Adult; Aged; Carbocysteine; Carbon; Debrisoquin; Female; Food Hypersensitivity; Humans; Male; Middle Aged; Sulfur	1988
Changes in debrisoquine hydroxylation capacity following liver surgery. Human & experimental toxicology, 1994, Volume: 13, Issue:8 Topics: Adult; Debrisoquin; Female; Humans; Hydroxylation; Liver Transplantation; Male; Middle Aged; Portacaval Shunt, Surgical	1994
Enantioselectivity in the steady-state pharmacokinetics of metoprolol in hypertensive patients. Chirality, 1999, Volume: 11, Issue:7 Topics: Adult; Aged; Antihypertensive Agents; Area Under Curve; Debrisoquin; Female; Half-Life; Humans; Hypertension; Male; Metoprolol; Middle Aged; Phenotype; Stereoisomerism	1999
Inhibition of debrisoquine hydroxylation with quinidine in subjects with three or more functional CYP2D6 genes. British journal of clinical pharmacology, 2000, Volume: 49, Issue:2 Topics: Administration, Oral; Adult; Alleles; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Dosage; Genotype; Humans; Hydroxylation; Male; Quinidine	2000
Halofantrine and chloroquine inhibit CYP2D6 activity in healthy Zambians. British journal of clinical pharmacology, 1998, Volume: 45, Issue:3 Topics: Administration, Oral; Adult; Antimalarials; Black People; Chloroquine; Chromatography, Gas; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Humans; Liver; Male; Phenanthrenes; Zambia	1998
Enantioselectivity of debrisoquine 4-hydroxylation in Brazilian Caucasian hypertensive patients phenotyped as extensive metabolizers. Journal of chromatography. B, Biomedical sciences and applications, 2000, Dec-01, Volume: 749, Issue:2 Topics: Adult; Aged; Antihypertensive Agents; Brazil; Calibration; Chromatography, High Pressure Liquid; Debrisoquin; Female; Humans; Hypertension; Male; Middle Aged; Molecular Conformation; Phenotype; Reproducibility of Results; White People	2000
Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test. Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:4 Topics: Adult; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Female; Humans; Hypotension, Orthostatic; Male; Middle Aged; Mixed Function Oxygenases; Nortriptyline; Paroxetine; Phenotype; Tremor; Xerostomia	2001
Influence of chronic renal failure on stereoselective metoprolol metabolism in hypertensive patients. Journal of clinical pharmacology, 2005, Volume: 45, Issue:12 Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Metoprolol; Middle Aged; Mutation; Stereoisomerism	2005
3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:9 Topics: Adult; Animals; Antihypertensive Agents; Biotransformation; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Gas Chromatography-Mass Spectrometry; Genetic Variation; Genotype; Glucuronides; Humans; Hydro-Lyases; Hydroxylation; Male; Microsomes, Liver; Phenotype	2006
The effect of a long term epidural infusion of ropivacaine on CYP2D6 activity. Anesthesia and analgesia, 2008, Volume: 106, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Amides; Analgesia, Epidural; Anesthetics, Local; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; Infusions, Parenteral; Liver; Middle Aged; Netherlands; Ropivacaine; Substrate Specificity; Sweden; Time Factors; Treatment Outcome	2008

Other Studies

70 other study(ies) available for 4-hydroxydebrisoquin and debrisoquin

Article	Year
Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin. Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:4 Topics: China; Chromatography, Gas; Debrisoquin; Humans; Hydroxylation; Mephenytoin; Phenotype; Polymorphism, Genetic; Sweden	1992
Debrisoquine hydroxylation in Parkinson's disease. Acta neurologica Scandinavica, 1992, Volume: 86, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Neurologic Examination; Parkinson Disease	1992
Gas chromatography/mass spectrometry assays for the determination of debrisoquine and sparteine metabolites in microsomal fractions of rat liver. Analytical biochemistry, 1992, Volume: 203, Issue:2 Topics: Animals; Cytochrome P-450 Enzyme System; Debrisoquin; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Male; Microsomes, Liver; Polymorphism, Genetic; Rats; Rats, Sprague-Dawley; Sparteine	1992
Determination of debrisoquine and metabolites in human urine by gas chromatography-mass spectrometry. Journal of chromatography, 1991, Sep-18, Volume: 570, Issue:1 Topics: Debrisoquin; Gas Chromatography-Mass Spectrometry; Humans; Kidney Failure, Chronic; Reference Values; Reproducibility of Results	1991
Genetic predisposition to Balkan endemic nephropathy: ability to hydroxylate debrisoquine as a host risk factor. IARC scientific publications, 1991, Issue:115 Topics: Adult; Aged; Balkan Nephropathy; Bulgaria; Carcinoma, Transitional Cell; Case-Control Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Disease Susceptibility; Female; Genetic Predisposition to Disease; Humans; Hydroxylation; Male; Middle Aged; Mixed Function Oxygenases; Oxidation-Reduction; Risk Factors; Urologic Neoplasms	1991
Polymorphic 4-hydroxylation of debrisoquine in a Turkish population. Pharmacogenetics, 1991, Volume: 1, Issue:2 Topics: Adult; Debrisoquin; Female; Humans; Hydroxylation; Male; Middle Aged; Oxidation-Reduction; Polymorphism, Genetic; Turkey	1991
Debrisoquine oxidation polymorphism in a Tasmanian population. European journal of clinical pharmacology, 1991, Volume: 40, Issue:5 Topics: Adolescent; Adult; Australia; Debrisoquin; Female; Humans; Male; Oxidation-Reduction; Polymorphism, Genetic; White People	1991
[Study on the frequency distribution of debrisoquine hydroxylation deficiency in Chinese healthy Zang and Wei volunteers]. Yao xue xue bao = Acta pharmaceutica Sinica, 1991, Volume: 26, Issue:4 Topics: Adolescent; Adult; Asian People; China; Debrisoquin; Ethnicity; Female; Humans; Hydroxylation; Male; Middle Aged; Polymorphism, Genetic; White People	1991
The effects of timolol on intraocular pressure and exercise heart rate in poor and extensive debrisoquine metabolizers. International journal of clinical pharmacology research, 1990, Volume: 10, Issue:6 Topics: Adult; Debrisoquin; Electrocardiography; Exercise; Female; Heart Rate; Humans; Intraocular Pressure; Male; Phenotype; Timolol	1990
Oxidation phenotyping with debrisoquine in Germany (East). Die Pharmazie, 1990, Volume: 45, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Debrisoquin; Female; Germany; Humans; Male; Middle Aged; Oxidation-Reduction; Phenotype; Spectrophotometry, Ultraviolet	1990
Debrisoquine hydroxylation and sulfamethazine acetylation in a Chinese population. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:5 Topics: Acetylation; Adolescent; Adult; Asian People; China; Chromatography, High Pressure Liquid; Debrisoquin; Female; Humans; Hydroxylation; Male; Phenotype; Sulfamethazine	1990
Debrisoquine hydroxylation polymorphism in diabetic patients. Diabetes research (Edinburgh, Scotland), 1990, Volume: 15, Issue:3 Topics: Adult; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Debrisoquin; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gene Frequency; Glycated Hemoglobin; Humans; Hydroxylation; Middle Aged; Polymorphism, Genetic; Reference Values; Triglycerides	1990
[Hydroxylation of debrisoquin in Parkinson's disease]. Presse medicale (Paris, France : 1983), 1990, May-19, Volume: 19, Issue:20 Topics: Adult; Aged; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Male; Middle Aged; Parkinson Disease; Reference Values	1990
Debrisoquine oxidation phenotype and susceptibility to lung cancer. British journal of clinical pharmacology, 1990, Volume: 29, Issue:1 Topics: Adenocarcinoma; Aged; Aged, 80 and over; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Debrisoquin; Female; Humans; Isoquinolines; Lung Neoplasms; Male; Middle Aged; Oxidation-Reduction; Phenotype; Risk; Smoking	1990
The effect of urine pH on debrisoquine phenotyping: application of an HPLC-method. International journal of clinical pharmacology, therapy, and toxicology, 1990, Volume: 28, Issue:5 Topics: Administration, Oral; Adult; Ammonium Chloride; Bicarbonates; Chromatography, High Pressure Liquid; Debrisoquin; Female; Humans; Hydrogen-Ion Concentration; Isoquinolines; Male; Phenotype; Sodium; Sodium Bicarbonate; Time Factors	1990
Unimodal distribution of the metabolic ratio for debrisoquine in Cuna Amerindians of Panama. British journal of clinical pharmacology, 1990, Volume: 30, Issue:2 Topics: Debrisoquin; Humans; Indians, Central American; Panama; Statistics as Topic	1990
Improved selectivity of a high-performance liquid chromatography assay for debrisoquine and its 4-hydroxy metabolite from urine. Therapeutic drug monitoring, 1990, Volume: 12, Issue:5 Topics: Chromatography, High Pressure Liquid; Debrisoquin; Humans	1990
Correlations among the metabolic ratios of three test probes (metoprolol, debrisoquine and sparteine) for genetically determined oxidation polymorphism in a Japanese population. British journal of clinical pharmacology, 1990, Volume: 29, Issue:1 Topics: Adolescent; Adult; Debrisoquin; Female; Humans; Isoquinolines; Japan; Male; Metoprolol; Middle Aged; Oxidation-Reduction; Polymorphism, Genetic; Sparteine	1990
Evidence for the polymorphic oxidation of debrisoquine in the Thai population. British journal of clinical pharmacology, 1990, Volume: 29, Issue:2 Topics: Adolescent; Adult; Debrisoquin; Female; Humans; Isoquinolines; Male; Middle Aged; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Sex Factors; Smoking; Thailand	1990
Polymorphism of debrisoquine 4-hydroxylation and family studies of poor metabolizers in Chinese population. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:1 Topics: Adolescent; Adult; Asian People; China; Debrisoquin; Female; Humans; Incidence; Isoquinolines; Male; Metabolism, Inborn Errors; Pedigree; Polymorphism, Genetic	1990
Debrisoquine oxidative phenotyping and psychiatric drug treatment. European journal of clinical pharmacology, 1989, Volume: 36, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Debrisoquin; Depressive Disorder; Drug Interactions; Female; Humans; Hydroxylation; Isoquinolines; Male; Middle Aged; Oxidation-Reduction; Phenotype	1989
Diazepam treatment does not influence the debrisoquine or mephenytoin hydroxylation phenotyping tests. Therapeutic drug monitoring, 1989, Volume: 11, Issue:6 Topics: Adult; Debrisoquin; Diazepam; Drug Interactions; Humans; Hydantoins; Hydroxylation; Isoquinolines; Male; Mephenytoin; Middle Aged; Phenotype	1989
Debrisoquine hydroxylation phenotype in SLE patients. Scandinavian journal of rheumatology, 1989, Volume: 18, Issue:1 Topics: Debrisoquin; Humans; Hydroxylation; Isoquinolines; Lupus Erythematosus, Systemic; Phenotype	1989
Metoprolol alpha-hydroxylation polymorphism in the San Bushmen of southern Africa. Human toxicology, 1989, Volume: 8, Issue:1 Topics: Black People; Debrisoquin; Humans; Hydroxylation; Male; Metoprolol; Nigeria; Polymorphism, Genetic; South Africa; White People	1989
The distribution of debrisoquine metabolic phenotypes and implications for the suggested association with lung cancer risk. Genetic epidemiology, 1989, Volume: 6, Issue:4 Topics: Chromatography, Gas; Data Interpretation, Statistical; Debrisoquin; Gene Frequency; Genetic Predisposition to Disease; Humans; Isoquinolines; Lung Neoplasms; Phenotype; Risk Factors	1989
High-performance liquid chromatographic quantitation of 4-hydroxydebrisoquine in microsomal incubates by use of silica columns, aqueous mobile phase and automated column switching. Journal of chromatography, 1988, Feb-26, Volume: 424, Issue:2 Topics: Adult; Chromatography, High Pressure Liquid; Debrisoquin; Humans; Isoquinolines; Microsomes, Liver; Silicon Dioxide; Spectrophotometry, Ultraviolet	1988
Pharmacokinetics and beta-blocking effects of timolol in poor and extensive metabolizers of debrisoquin. Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:4 Topics: Absorption; Administration, Oral; Adrenergic beta-Antagonists; Adult; Biotransformation; Chromatography, High Pressure Liquid; Debrisoquin; Heart Rate; Humans; Isoquinolines; Kinetics; Male; Middle Aged; Phenotype; Physical Exertion; Timolol	1985
Debrisoquine oxidation in schizophrenic patients treated with neuroleptics. Pharmacological research communications, 1988, Volume: 20, Issue:12 Topics: Adult; Aged; Antipsychotic Agents; Chlorpromazine; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Male; Methotrimeprazine; Middle Aged; Oxidation-Reduction; Schizophrenia; Thioridazine	1988
Hydroxylation of debrisoquine using perfused liver isolated from Sprague Dawley and DA rats: comparison with in-vivo results. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:10 Topics: Animals; Body Weight; Debrisoquin; Female; Hydroxylation; In Vitro Techniques; Indicators and Reagents; Isoquinolines; Liver; Male; Organ Size; Rats; Rats, Inbred Strains	1988
Co-inheritance of the polymorphic metabolism of encainide and debrisoquin. Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:3 Topics: Administration, Oral; Adult; Aged; Anilides; Chromatography, High Pressure Liquid; Debrisoquin; Electrocardiography; Encainide; Female; Half-Life; Humans; Isoquinolines; Kinetics; Male; Middle Aged; Phenotype	1986
Assay of debrisoquine and 4-hydroxydebrisoquine in urine by reversed-phase high-performance liquid chromatography using on-line sample clean-up on a standard isocratic chromatograph. Journal of chromatography, 1988, Jun-24, Volume: 428, Issue:1 Topics: Chromatography, High Pressure Liquid; Debrisoquin; Humans; Indicators and Reagents; Isoquinolines; Spectrophotometry, Ultraviolet	1988
Diurnal effects on debrisoquine hydroxylation phenotyping. European journal of clinical pharmacology, 1988, Volume: 35, Issue:4 Topics: Adult; Circadian Rhythm; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Male; Phenotype; Polymorphism, Genetic	1988
Debrisoquine oxidation in a Finnish population: the effect of oral contraceptives on the metabolic ratio. British journal of clinical pharmacology, 1988, Volume: 26, Issue:6 Topics: Adult; Contraceptives, Oral, Hormonal; Debrisoquin; Female; Finland; Humans; Isoquinolines; Male; Middle Aged; Oxidation-Reduction	1988
Stereoselectivity of the 4-hydroxylation of debrisoquine in man, detected by gas chromatography/mass spectrometry. Biomedical & environmental mass spectrometry, 1988, Jan-15, Volume: 15, Issue:2 Topics: Arsenicals; Biotransformation; Choline; Debrisoquin; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Isoquinolines; Oxidation-Reduction; Stereoisomerism	1988
Comparison of gas chromatographic and high-performance liquid chromatographic assays for the determination of debrisoquine and its 4-hydroxy metabolite in human fluids. Journal of chromatography, 1988, Mar-18, Volume: 425, Issue:2 Topics: Absorption; Administration, Buccal; Chromatography, Gas; Chromatography, High Pressure Liquid; Debrisoquin; Humans; Indicators and Reagents; Isoquinolines; Saliva; Spectrophotometry, Ultraviolet	1988
Debrisoquin oxidation polymorphism in a Spanish population. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:1 Topics: Adolescent; Adult; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Isoenzymes; Isoquinolines; Male; Middle Aged; Oxidation-Reduction; Phenotype; Spain	1988
Polymorphism of the 4-hydroxylation of debrisoquine in the San Bushmen of southern Africa. Human toxicology, 1988, Volume: 7, Issue:3 Topics: Black People; Debrisoquin; Ethnicity; Humans; Hydroxylation; Isoquinolines; Male; Oxidation-Reduction; Polymorphism, Genetic; South Africa	1988
Hepatic cytochrome P450-mediated oxidation function in migraine. Cephalalgia : an international journal of headache, 1988, Volume: 8, Issue:2 Topics: Adult; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Humans; Hydroxylation; Liver; Male; Middle Aged; Migraine Disorders; Oxidation-Reduction	1988
High-performance liquid chromatographic method for the analysis of debrisoquine and its S-(+)- and R-(-)-hydroxy metabolites in urine. Journal of chromatography, 1987, Dec-25, Volume: 423 Topics: Chromatography, High Pressure Liquid; Debrisoquin; Humans; Isoquinolines; Oxidation-Reduction; Phenotype; Reference Standards; Stereoisomerism	1987
Direct determination of debrisoquine and 4-hydroxydebrisoquine using a high-performance liquid chromatographic switching technique. Journal of chromatography, 1987, Aug-07, Volume: 419 Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Debrisoquin; Humans; Indicators and Reagents; Isoquinolines	1987
Acetylation and oxidation phenotypes in malignant lymphoma. Cancer chemotherapy and pharmacology, 1987, Volume: 20, Issue:3 Topics: Acetylation; Adult; Aged; Dapsone; Debrisoquin; Female; Hodgkin Disease; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Male; Middle Aged; Oxidation-Reduction; Phenotype; Polymorphism, Genetic	1987
Liquid chromatographic method for the determination of debrisoquine and its 4-hydroxy metabolite in human urine. Journal of chromatography, 1986, Jun-13, Volume: 378, Issue:2 Topics: Chromatography, High Pressure Liquid; Debrisoquin; Humans; Isoquinolines; Spectrophotometry, Ultraviolet	1986
Liquid chromatographic assay for debrisoquine and 4-hydroxydebrisoquine in urine. Journal of chromatography, 1986, Jan-10, Volume: 374, Issue:1 Topics: Acetylation; Chromatography, Liquid; Debrisoquin; Humans; Isoquinolines; Phenotype; Spectrophotometry, Ultraviolet	1986
Determination of debrisoquine and its 4-hydroxy metabolite in urine by high-performance liquid chromatography. Journal of chromatography, 1986, Jan-10, Volume: 374, Issue:1 Topics: Chromatography, High Pressure Liquid; Debrisoquin; Humans; Isoquinolines	1986
Amitriptyline metabolism: association with debrisoquin hydroxylation in nonsmokers. Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:4 Topics: Administration, Oral; Adult; Amitriptyline; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Nortriptyline; Phenotype	1986
Pharmocogenetic implications of polymorphic debrisoquine hydroxylations. The Quarterly journal of medicine, 1985, Volume: 54, Issue:214 Topics: Cytochrome P-450 Enzyme System; Debrisoquin; Humans; Hydroxylation; Isoquinolines; Polymorphism, Genetic	1985
Dissociation of co-regulatory control of debrisoquin/phenformin and sparteine oxidation in Ghanaians. Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Debrisoquin; Female; Ghana; Humans; Isoquinolines; Kinetics; Male; Middle Aged; Phenformin; Phenotype; Sparteine; White People	1985
Lack of relationship between debrisoquine 4-hydroxylation and other cytochrome P-450 dependent reactions in rat and human liver. Biochemical pharmacology, 1985, Aug-01, Volume: 34, Issue:15 Topics: Animals; Cytochrome P-450 Enzyme System; Debrisoquin; Enzyme Induction; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity	1985
Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations. Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Debrisoquin; Female; Genotype; Humans; Hydantoins; Hydroxylation; Isoquinolines; Japan; Male; Mephenytoin; Middle Aged; Phenotype; Random Allocation; White People	1985
Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes. Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:5 Topics: Adult; Chromatography, High Pressure Liquid; Debrisoquin; Desipramine; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Microsomes, Liver; Middle Aged; Phenotype	1984
Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism. Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Chromatography, High Pressure Liquid; Debrisoquin; Female; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic; Tennessee; White People	1984
Urinary bile acid and bile alcohol excretion does not reflect the genetic polymorphism of debrisoquine hydroxylation. British journal of clinical pharmacology, 1984, Volume: 17, Issue:4 Topics: Adult; Bile Acids and Salts; Cholestanols; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Male; Middle Aged; Phenotype	1984
The debrisoquine hydroxylation test predicts steady-state plasma levels of desipramine. British journal of clinical pharmacology, 1983, Volume: 15, Issue:3 Topics: Debrisoquin; Depression; Desipramine; Humans; Hydroxylation	1983
Genetically determined oxidation capacity and the disposition of debrisoquine. British journal of clinical pharmacology, 1983, Volume: 15, Issue:4 Topics: Administration, Oral; Adult; Biotransformation; Debrisoquin; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Oxidation-Reduction; Phenotype; Time Factors	1983
Polymorphic 4-hydroxylation of debrisoquine in chronic discoid psoriasis. European journal of clinical pharmacology, 1981, Volume: 21, Issue:3 Topics: Administration, Oral; Adult; Debrisoquin; Heme Oxygenase (Decyclizing); Humans; Hydroxylation; Isoquinolines; Mixed Function Oxygenases; Psoriasis	1981
Determination of oxidation phenotype by measurement of propafenone urinary metabolic ratios. Human & experimental toxicology, 1993, Volume: 12, Issue:2 Topics: Adult; Chromatography, Gas; Debrisoquin; Female; Humans; Male; Oxidation-Reduction; Phenotype; Propafenone	1993
Quinidine inhibition of debrisoquine S(+)-4- and 7-hydroxylations in Chinese of different CYP2D6 genotypes. Pharmacogenetics, 1993, Volume: 3, Issue:2 Topics: Asian People; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Debrisoquin; Genotype; Haplotypes; Humans; Hydroxylation; Metabolic Clearance Rate; Mixed Function Oxygenases; Polymorphism, Restriction Fragment Length; Quinidine; Stereoisomerism; White People	1993
Polymorphic debrisoquin metabolism in a Turkish population. Clinical pharmacology and therapeutics, 1994, Volume: 55, Issue:4 Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Debrisoquin; Female; Humans; Male; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Turkey	1994
Determination of debrisoquine and 4-hydroxydebrisoquine in urine by high-performance liquid chromatography with fluorescence detection after solid-phase extraction. Journal of pharmaceutical and biomedical analysis, 1993, Volume: 11, Issue:8 Topics: Acetonitriles; Chromatography, High Pressure Liquid; Debrisoquin; Humans; Phosphates; Polymorphism, Genetic; Sensitivity and Specificity; Spectrometry, Fluorescence	1993
Improved high-performance liquid chromatographic determination of debrisoquine and 4-hydroxydebrisoquine in human urine following direct injection. Journal of chromatography. B, Biomedical applications, 1996, Feb-23, Volume: 677, Issue:1 Topics: Calibration; Chromatography, High Pressure Liquid; Debrisoquin; Humans; Indicators and Reagents; Quality Control; Reproducibility of Results; Spectrometry, Fluorescence	1996
Characterization of stereoselectivity and genetic polymorphism of the debrisoquine hydroxylation in man via analysis of urinary debrisoquine and 4-hydroxydebrisoquine by capillary electrophoresis. Electrophoresis, 1997, Volume: 18, Issue:10 Topics: Debrisoquin; Electrophoresis, Capillary; Humans; Hydroxylation; Male; Molecular Structure; Phenotype; Polymorphism, Genetic; Stereoisomerism	1997
Microsomal formation of nitric oxide and cyanamides from non-physiological N-hydroxyguanidines: N-hydroxydebrisoquine as a model substrate. Biochemical pharmacology, 1999, Aug-01, Volume: 58, Issue:3 Topics: Animals; Catalase; Cyanamide; Cytochrome P-450 Enzyme System; Debrisoquin; Guanidines; Humans; Hydroxylamines; In Vitro Techniques; Microsomes, Liver; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Rabbits; Rats; Rats, Wistar; Reactive Oxygen Species; Subcellular Fractions; Superoxide Dismutase; Urea	1999
A micromethod for quantitation of debrisoquine and 4-hydroxydebrisoquine in urine by liquid chromatography. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2000, Volume: 33, Issue:5 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Fluorometry; Humans; Hydroxylation; Middle Aged; Phenotype; Sensitivity and Specificity; Xenobiotics	2000
Rapid high-performance liquid chromatographic method for determination of debrisoquine and 4-hydroxy-debrisoquine in urine for CYP2D6 phenotyping. Pharmacogenetics, 1999, Volume: 9, Issue:4 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Debrisoquin; Humans; Phenotype; Spectrometry, Fluorescence	1999
CYP2D6 phenotypes among Malays in Malaysia. Journal of clinical pharmacy and therapeutics, 2000, Volume: 25, Issue:5 Topics: Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Debrisoquin; Humans; Malaysia; Oxidation-Reduction; Phenotype; Polymorphism, Genetic	2000
The hepatic and intestinal metabolic activities of P450 in rats with surgery- and drug-induced renal dysfunction. Pharmaceutical research, 2003, Volume: 20, Issue:10 Topics: Animals; Cisplatin; Cytochrome P-450 Enzyme System; Debrisoquin; Glycerol; Hydroxylation; Hydroxytestosterones; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Microsomes, Liver; Nephrectomy; Phenytoin; Rats; Rats, Wistar; Renal Insufficiency	2003
Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship. Clinical chemistry and laboratory medicine, 2005, Volume: 43, Issue:3 Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Genotype; Humans; Hydroxylation; Male; Middle Aged; Phenotype; Reference Values	2005
In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver. Journal of pharmaceutical sciences, 2007, Volume: 96, Issue:2 Topics: Adrenergic Agents; Animals; Chimera; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Drug Interactions; Humans; Infant; Liver; Male; Mice; Mice, SCID; Models, Animal; Paroxetine; Quinidine; Urokinase-Type Plasminogen Activator	2007
Functional characterization of CYP2D6 novel allelic variants identified in the Chinese Han population. Pharmacogenomics, 2016, Volume: 17, Issue:2 Topics: Alleles; Asian People; Cytochrome P-450 CYP2D6; Debrisoquin; Genetic Variation; Humans; Recombinant Proteins; Saccharomyces cerevisiae	2016
Dextromethorphan and debrisoquine metabolism and polymorphism of the gene for cytochrome P450 isozyme 2D50 in Thoroughbreds. American journal of veterinary research, 2016, Volume: 77, Issue:9 Topics: Animals; Cytochrome P-450 Enzyme System; Debrisoquin; Dextromethorphan; Female; Horses; Isoenzymes; Male; Polymorphism, Single Nucleotide	2016