Compounds > 4-hydroxycyclophosphamide

Page last updated: 2024-08-26

4-hydroxycyclophosphamide and acrolein

4-hydroxycyclophosphamide has been researched along with acrolein in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (50.00)	18.7374
1990's	4 (33.33)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (8.33)	24.3611
2020's	1 (8.33)	2.80

Authors

Authors	Studies
Brock, N	1
Little, SA; Mirkes, PE	1
Borch, RF; Low, JE; Sladek, NE	2
Bielicki, L; Hohorst, HJ; Voelcker, G	1
Hales, BF	1
Borch, RF; Bratt, PM; Coveney, JR; Low, JE; Powers, JF; Sladek, NE; Smith, PC	1
DeLeve, LD	1
Kalhorn, TF; Ren, S; Slattery, JT	1
Ren, S; Slatterly, JT	1
Kawano, Y; Kurauchi, K; Miyahara, E; Nishikawa, T; Okamoto, Y	1
Araújo, AM; Bastos, ML; Carvalho, F; Costa, VM; Dionísio, F; Duarte-Araújo, M; Guedes de Pinho, P	1

Other Studies

12 other study(ies) available for 4-hydroxycyclophosphamide and acrolein

Article	Year
Comparative pharmacologic study in vitro and in vivo with cyclophosphamide (NSC-26271), cyclophosphamide metabolites, and plain nitrogen mustard compounds. Cancer treatment reports, 1976, Volume: 60, Issue:4 Topics: Acrolein; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chlorides; Cyclophosphamide; In Vitro Techniques; Lethal Dose 50; Mammals; Methylation; Nitrogen Mustard Compounds; Rats; Sarcoma, Yoshida; Solutions; Structure-Activity Relationship	1976
Relationship of DNA damage and embryotoxicity induced by 4-hydroperoxydechlorocyclophosphamide in postimplantation rat embryos. Teratology, 1990, Volume: 41, Issue:2 Topics: Acrolein; Animals; Cyclophosphamide; DNA Damage; Dose-Response Relationship, Drug; Embryo Implantation; Embryo, Mammalian; Female; Glutathione; In Vitro Techniques; Phosphoramide Mustards; Rats; Rats, Inbred Strains	1990
Further studies on the conversion of 4-hydroxyoxazaphosphorines to reactive mustards and acrolein in inorganic buffers. Cancer research, 1983, Volume: 43, Issue:12 Pt 1 Topics: Acrolein; Aldehydes; Buffers; Chemical Phenomena; Chemistry; Cyclophosphamide; Hydrogen-Ion Concentration; Ifosfamide; Kinetics; Nitrogen Mustard Compounds; Osmolar Concentration; Structure-Activity Relationship; Temperature	1983
Activated cyclophosphamide: an enzyme-mechanism-based suicide inactivator of DNA polymerase/3'-5' exonuclease. Journal of cancer research and clinical oncology, 1984, Volume: 107, Issue:3 Topics: Acrolein; Alkylation; Animals; Biotransformation; Cyclophosphamide; DNA Polymerase I; Exodeoxyribonuclease V; Exodeoxyribonucleases; Humans	1984
Comparison of the mutagenicity and teratogenicity of cyclophosphamide and its active metabolites, 4-hydroxycyclophosphamide, phosphoramide mustard, and acrolein. Cancer research, 1982, Volume: 42, Issue:8 Topics: Acrolein; Aldehydes; Animals; Cyclophosphamide; Drug Evaluation, Preclinical; Embryo, Mammalian; Female; Mutagenicity Tests; Mutagens; Mutation; Phosphoramide Mustards; Pregnancy; Rats; Rats, Inbred Strains; Salmonella typhimurium; Structure-Activity Relationship; Teratogens	1982
Conversion of 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide to phosphoramide mustard and acrolein mediated by bifunctional catalysis. Cancer research, 1982, Volume: 42, Issue:3 Topics: Acrolein; Biotransformation; Buffers; Chemical Phenomena; Chemistry; Cyclophosphamide; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; Magnetic Resonance Spectroscopy; Phosphoramide Mustards	1982
Influence of diuretics on urinary general base catalytic activity and cyclophosphamide-induced bladder toxicity. Cancer treatment reports, 1982, Volume: 66, Issue:11 Topics: Acrolein; Animals; Cyclophosphamide; Diuretics; Female; Hydrogen-Ion Concentration; Injections, Intraperitoneal; Male; Organ Size; Rats; Rats, Inbred Strains; Spleen; Urinary Bladder	1982
Cellular target of cyclophosphamide toxicity in the murine liver: role of glutathione and site of metabolic activation. Hepatology (Baltimore, Md.), 1996, Volume: 24, Issue:4 Topics: Acrolein; Animals; Biotransformation; Coculture Techniques; Cyclophosphamide; Dose-Response Relationship, Drug; Endothelium; Glutathione; Hepatic Veno-Occlusive Disease; Immunosuppressive Agents; Liver; Male; Methionine; Mice; Mice, Inbred C3H; Serine; Time Factors	1996
Inhibition of human aldehyde dehydrogenase 1 by the 4-hydroxycyclophosphamide degradation product acrolein. Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:1 Topics: Acrolein; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Cyclophosphamide; Cytosol; Enzyme Inhibitors; Humans; Isoenzymes; Liver; Retinal Dehydrogenase	1999
Inhibition of carboxyethylphosphoramide mustard formation from 4-hydroxycyclophosphamide by carmustine. AAPS pharmSci, 1999, Volume: 1, Issue:3 Topics: Acrolein; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Enzyme Inhibitors; Humans; In Vitro Techniques; Isocyanates; Isoenzymes; Liver; Phosphoramide Mustards; Retinal Dehydrogenase	1999
Role of metabolites of cyclophosphamide in cardiotoxicity. BMC research notes, 2017, Aug-14, Volume: 10, Issue:1 Topics: Acetylcysteine; Acrolein; Aldehyde Dehydrogenase; Animals; Apoptosis; Cardiotoxicity; Cardiotoxins; Cell Line; Cell Survival; Cyclophosphamide; Free Radical Scavengers; Immunosuppressive Agents; Myocytes, Cardiac; Phosphoramide Mustards; Rats; Reactive Oxygen Species	2017
Cardiotoxicity of cyclophosphamide's metabolites: an in vitro metabolomics approach in AC16 human cardiomyocytes. Archives of toxicology, 2022, Volume: 96, Issue:2 Topics: Acrolein; Antineoplastic Agents; Cardiotoxicity; Cell Line; Cyclophosphamide; Dose-Response Relationship, Drug; Humans; Immunosuppressive Agents; Metabolomics; Myocytes, Cardiac	2022