Compounds > 4-hydroxyclomiphene
Page last updated: 2024-09-04

4-hydroxyclomiphene and enclomiphene

4-hydroxyclomiphene has been researched along with enclomiphene in 7 studies

Compound Research Comparison

Studies
(4-hydroxyclomiphene)		Trials
(4-hydroxyclomiphene)		Recent Studies (post-2010)
(4-hydroxyclomiphene)		Studies
(enclomiphene)		Trials
(enclomiphene)		Recent Studies (post-2010) (enclomiphene)
7015,466677804

Protein Interaction Comparison

ProteinTaxonomy4-hydroxyclomiphene (IC50)enclomiphene (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.272
Epidermal growth factor receptorHomo sapiens (human)1.05
Estrogen receptorHomo sapiens (human)0.0046
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)1.669
Tyrosine-protein kinase FynHomo sapiens (human)2.513
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.862
Muscarinic acetylcholine receptor M2Homo sapiens (human)3.628
Muscarinic acetylcholine receptor M4Homo sapiens (human)1.651
Muscarinic acetylcholine receptor M5Homo sapiens (human)1.771
Alpha-2A adrenergic receptorHomo sapiens (human)0.936
Adenosine receptor A3Homo sapiens (human)5.35
Cytochrome P450 2D6Homo sapiens (human)10
Muscarinic acetylcholine receptor M1Homo sapiens (human)1.628
Beta-3 adrenergic receptorHomo sapiens (human)5.673
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)5.35
Alpha-2B adrenergic receptorHomo sapiens (human)1.578
Alpha-2C adrenergic receptorHomo sapiens (human)1.482
Muscarinic acetylcholine receptor M3Homo sapiens (human)2.071
Substance-K receptorHomo sapiens (human)4.525
Prostaglandin G/H synthase 1Homo sapiens (human)0.346
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.862
5-hydroxytryptamine receptor 2AHomo sapiens (human)3.308
5-hydroxytryptamine receptor 2CHomo sapiens (human)1.272
Sodium-dependent serotonin transporterHomo sapiens (human)0.638
D(3) dopamine receptorHomo sapiens (human)1.319
5-hydroxytryptamine receptor 2BHomo sapiens (human)1.363
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)5.35
5-hydroxytryptamine receptor 6Homo sapiens (human)1.522
Sodium-dependent dopamine transporter Homo sapiens (human)0.784
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.029

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19905 (71.43)18.7374
1990's1 (14.29)18.2507
2000's0 (0.00)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Koga, M; Sutherland, RL2
Koga, M; Musgrove, EA; Sutherland, RL1
Musgrove, EA; Sutherland, RL; Wakeling, AE1
Hall, RE; Ruenitz, PC; Sutherland, RL; Watts, CK1
Ruenitz, PC; Sutherland, RL; Watts, CK1
Böhmer, GM; Brauch, H; Ganchev, B; Igel, S; Kerb, R; Mürdter, TE; Schaeffeler, E; Schroth, W; Schwab, M; Turpeinen, M; Zanger, U1

Other Studies

7 other study(ies) available for 4-hydroxyclomiphene and enclomiphene

ArticleYear
Retinoic acid acts synergistically with 1,25-dihydroxyvitamin D3 or antioestrogen to inhibit T-47D human breast cancer cell proliferation.
    The Journal of steroid biochemistry and molecular biology, 1991, Volume: 39, Issue:4A

    Topics: Breast Neoplasms; Calcitriol; Cell Division; Cell Line; Clomiphene; Drug Synergism; Estradiol; Estrogen Antagonists; Female; Humans; Kinetics; Pyrrolidines; Receptors, Calcitriol; Receptors, Estradiol; Receptors, Steroid; Tamoxifen; Thiophenes; Tretinoin

1991
Modulation of the growth-inhibitory effects of progestins and the antiestrogen hydroxyclomiphene on human breast cancer cells by epidermal growth factor and insulin.
    Cancer research, 1989, Jan-01, Volume: 49, Issue:1

    Topics: Breast Neoplasms; Cell Division; Clomiphene; Epidermal Growth Factor; Estrogen Antagonists; Female; Growth Inhibitors; Humans; Insulin; Pregnenediones; Progestins; Tumor Cells, Cultured

1989
Points of action of estrogen antagonists and a calmodulin antagonist within the MCF-7 human breast cancer cell cycle.
    Cancer research, 1989, May-01, Volume: 49, Issue:9

    Topics: Breast Neoplasms; Calmodulin; Cell Cycle; Clomiphene; DNA; Estradiol; Estrogen Antagonists; Female; Humans; Imidazoles; Polyunsaturated Alkamides; Tumor Cells, Cultured

1989
Epidermal growth factor partially reverses the inhibitory effects of antiestrogens on T 47D human breast cancer cell growth.
    Biochemical and biophysical research communications, 1987, Jul-31, Volume: 146, Issue:2

    Topics: Breast Neoplasms; Cell Division; Cell Line; Clomiphene; Epidermal Growth Factor; Estrogen Antagonists; Humans; Pyrrolidines; Tamoxifen; Thiophenes

1987
Mechanisms of growth inhibition by nonsteroidal antioestrogens in human breast cancer cells.
    Journal of steroid biochemistry, 1987, Volume: 27, Issue:4-6

    Topics: Breast Neoplasms; Calmodulin; Cell Division; Clomiphene; Estradiol; Female; Humans; Interphase; Kinetics; Phenothiazines; Receptors, Drug; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured

1987
Definition of two distinct mechanisms of action of antiestrogens on human breast cancer cell proliferation using hydroxytriphenylethylenes with high affinity for the estrogen receptor.
    Biochemical and biophysical research communications, 1986, Oct-30, Volume: 140, Issue:2

    Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; Clomiphene; Estradiol; Estrogen Antagonists; Humans; Receptors, Estrogen; Stilbenes; Tamoxifen

1986
Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites.
    Human molecular genetics, 2012, Mar-01, Volume: 21, Issue:5

    Topics: Biotransformation; Clomiphene; Cytochrome P-450 CYP2D6; Estrogen Antagonists; Female; Genotype; Humans; Microsomes, Liver; Molecular Structure; Polymorphism, Genetic; Receptors, Estrogen; Recombinant Proteins

2012