Compounds > 4-hydroxybutyric acid

Page last updated: 2024-08-21

4-hydroxybutyric acid and ncs 382

4-hydroxybutyric acid has been researched along with ncs 382 in 17 studies

Research

Studies (17)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	11 (64.71)	29.6817
2010's	5 (29.41)	24.3611
2020's	1 (5.88)	2.80

Authors

Authors	Studies
Bourguignon, JJ; Didier, B; Schmitt, M	1
Castelli, MP; Gessa, GL; Gommerendagger, W; Langlois, X; Leysen, JE; Luyten, WH; Mocci, I	1
Brunetti, G; Carai, MA; Cignarella, G; Colombo, G; Gessa, GL; Mastinu, S; Melis, S; Minardi, G; Pistuddi, AM; Serra, S; Solinas, C; Vacca, G	1
Bortolato, M; Carta, G; Gessa, GL; Nava, F	1
Agabio, R; Carai, MA; Colombo, G; Gessa, GL; Lobina, C; Reali, R; Vacca, G	1
Frazer, A; Gould, GG; Mehta, AK; Ticku, MK	1
Antonelli, T; Carai, MA; Carta, F; Castelli, MP; Cignarella, G; Ferraro, L; Gessa, GL; Mocci, I; Tanganelli, S	1
Crunelli, V; Gervasi, N; Hughes, SW; Leresche, N; Monnier, Z; Paupardin-Tritsch, D; Vincent, P	1
Dimitrijevic, N; Dzitoyeva, S; Imbesi, M; Manev, H; Satta, R; Yildiz, S	1
Dörnyei, G; Fekete, EK; Kardos, J; Moldvai, I; Molnár, T; Simon, A; Temesvári-Major, E; Visy, J	1
Mehta, AK; Ticku, MK	1
Bräuner-Osborne, H; Clausen, RP; Frølund, B; Høg, S; Knudsen, GM; Martiny, L; Pedersen, MH; Sabbatini, P; Wellendorph, P	1
Absalom, N; Bay, T; Bräuner-Osborne, H; Chebib, M; Clausen, RP; Eghorn, LF; Frølund, B; Karim, N; Knudsen, GM; Olsen, JV; Villumsen, IS; Wellendorph, P	1
Bay, T; Bundgaard, C; Clausen, RP; Frølund, B; Kehler, J; Marek, A; Pedersen, MH; Vogensen, SB; Wellendorph, P	1
Bay, T; Eghorn, LF; Frølund, B; Higgins, D; Hoestgaard-Jensen, K; Kongstad, KT; Wellendorph, P	1
Ainslie, GR; Gibson, KM; McConnell, A; Roullet, JB; Vogel, KR	1
Belew, ZM; Crocoll, C; Griem-Krey, N; Nour-Eldin, HH; Pedersen, SF; Thiesen, L; Wellendorph, P	1

Reviews

1 review(s) available for 4-hydroxybutyric acid and ncs 382

Article	Year
Design and structure-activity relationship analysis of ligands of gamma-hydroxybutyric acid receptors. Alcohol (Fayetteville, N.Y.), 2000, Volume: 20, Issue:3 Topics: Benzocycloheptenes; Drug Design; Humans; Hydroxybutyrates; Ligands; Molecular Conformation; Molecular Structure; Receptors, Cell Surface; Structure-Activity Relationship; Tritium	2000

Other Studies

16 other study(ies) available for 4-hydroxybutyric acid and ncs 382

Article	Year
Quantitative autoradiographic distribution of gamma-hydroxybutyric acid binding sites in human and monkey brain. Brain research. Molecular brain research, 2000, May-31, Volume: 78, Issue:1-2 Topics: Aged; Animals; Anticonvulsants; Autoradiography; Benzocycloheptenes; Binding, Competitive; Cerebral Cortex; Humans; Hydroxybutyrates; Male; Middle Aged; Radioligand Assay; Saimiri; Species Specificity; Tritium	2000
Role of GABA(B) receptors in the sedative/hypnotic effect of gamma-hydroxybutyric acid. European journal of pharmacology, 2001, Oct-12, Volume: 428, Issue:3 Topics: Animals; Anticonvulsants; Baclofen; Benzocycloheptenes; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Hydroxybutyrates; Hypnotics and Sedatives; Male; Mice; Mice, Inbred DBA; Morpholines; Receptors, GABA-B; Reflex	2001
gamma-Hydroxybutyric acid and baclofen decrease extracellular acetylcholine levels in the hippocampus via GABA(B) receptors. European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3 Topics: Acetylcholine; Animals; Anticonvulsants; Baclofen; Benzocycloheptenes; Dose-Response Relationship, Drug; Extracellular Space; GABA Agonists; GABA Antagonists; Hippocampus; Hydroxybutyrates; Male; Morpholines; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Time Factors	2001
GABA(B)-receptor mediation of the inhibitory effect of gamma-hydroxybutyric acid on intestinal motility in mice. Life sciences, 2002, May-10, Volume: 70, Issue:25 Topics: Animals; Benzocycloheptenes; Dose-Response Relationship, Drug; GABA-B Receptor Antagonists; Gastrointestinal Motility; Hydroxybutyrates; Male; Mice; Mice, Inbred Strains; Morpholines; Receptors, GABA-B	2002
Quantitative autoradiographic analysis of the new radioligand [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid ([(3)H]NCS-382) at gamma-hydroxybutyric acid (GHB) binding sites in rat brain. Brain research, 2003, Jul-25, Volume: 979, Issue:1-2 Topics: Animals; Autoradiography; Benzocycloheptenes; Binding, Competitive; Brain; Hydroxybutyrates; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, GABA; Tritium	2003
Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of gamma-hydroxybutyric acid. Journal of neurochemistry, 2003, Volume: 87, Issue:3 Topics: Animals; Autoradiography; Benzocycloheptenes; Binding, Competitive; Brain Chemistry; Extracellular Space; GABA Antagonists; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Hydroxybutyrates; Hypnotics and Sedatives; Ligands; Male; Mice; Mice, Inbred DBA; Microdialysis; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Reflex	2003
Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Dec-10, Volume: 23, Issue:36 Topics: Afferent Pathways; Animals; Benzocycloheptenes; Cells, Cultured; Electric Conductivity; Epilepsy, Absence; Evoked Potentials; Excitatory Postsynaptic Potentials; GABA-B Receptor Agonists; Hydroxybutyrates; Neural Inhibition; Neurons, Afferent; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, GABA-B; Synaptic Transmission; Thalamus	2003
Drosophila GABA(B) receptors are involved in behavioral effects of gamma-hydroxybutyric acid (GHB). European journal of pharmacology, 2005, Sep-20, Volume: 519, Issue:3 Topics: Animals; Behavior, Animal; Benzocycloheptenes; Dose-Response Relationship, Drug; Drosophila melanogaster; Drug Interactions; Ethanol; GABA-B Receptor Antagonists; Hydroxybutyrates; Male; Motor Activity; Mutation; Organophosphorus Compounds; Receptors, GABA-B; RNA Interference; RNA, Double-Stranded; Time Factors	2005
Validation of high-affinity binding sites for succinic acid through distinguishable binding of gamma-hydroxybutyric acid receptor-specific NCS 382 antipodes. Bioorganic & medicinal chemistry letters, 2008, Dec-01, Volume: 18, Issue:23 Topics: Animals; Benzocycloheptenes; Binding Sites; Binding, Competitive; Brain; Hydroxybutyrates; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Stereoisomerism; Succinic Acid	2008
Characterization and pharmacology of the GHB receptor. Annals of the New York Academy of Sciences, 2008, Volume: 1139 Topics: Animals; Anticonvulsants; Autoradiography; Benzocycloheptenes; Binding Sites; Brain; Hydroxybutyrates; Male; Mice; Mice, Knockout; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Succinate-Semialdehyde Dehydrogenase; Tritium	2008
Novel radioiodinated {gamma}-hydroxybutyric acid analogues for radiolabeling and Photolinking of high-affinity {gamma}-hydroxybutyric acid binding sites. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:2 Topics: Affinity Labels; Animals; Autoradiography; Azides; Benzocycloheptenes; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Hydroxybutyrates; In Vitro Techniques; Iodine Radioisotopes; Ligands; Molecular Structure; Phenylbutyrates; Photoaffinity Labels; Protein Binding; Radioligand Assay; Rats; Receptors, GABA-B	2010
α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). Proceedings of the National Academy of Sciences of the United States of America, 2012, Aug-14, Volume: 109, Issue:33 Topics: Animals; Benzocycloheptenes; Binding Sites; Brain; Electrodes; Humans; Hydroxybutyrates; Mice; Mice, Knockout; Patch-Clamp Techniques; Photoaffinity Labels; Point Mutation; Protein Binding; Protein Subunits; Proteomics; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis	2012
New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites. Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20 Topics: Animals; Benzocycloheptenes; Binding Sites; Binding, Competitive; Brain; Carboxylic Acids; Cell Line; Central Nervous System; Cyclopentanes; Drug Stability; gamma-Aminobutyric Acid; Hydroxybutyrates; Kinetics; Ligands; Male; Models, Chemical; Molecular Structure; Radioligand Assay; Rats; Rats, Sprague-Dawley; Synaptic Membranes; Tritium	2013
Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin. European journal of pharmacology, 2014, Oct-05, Volume: 740 Topics: Animals; Benzocycloheptenes; Binding Sites; Catechin; Female; Hydroxybutyrates; Oocytes; Pyrimidines; Receptors, GABA-A; Thiones; Xenopus laevis	2014
In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding. Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 40 Topics: Benzocycloheptenes; Cell Survival; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatocytes; Humans; Hydroxybutyrates; Microsomes, Liver; Receptors, Cell Surface	2017
The γ-hydroxybutyric acid (GHB) analogue NCS-382 is a substrate for both monocarboxylate transporters subtypes 1 and 4. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020, Feb-15, Volume: 143 Topics: Animals; Benzocycloheptenes; Cell Line; Humans; Hydroxybutyrates; Ligands; Monocarboxylic Acid Transporters; Muscle Proteins; Oocytes; Symporters; Xenopus laevis	2020