4-hydroxybutyric acid has been researched along with 4-butyrolactone in 47 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (8.51) | 18.7374 |
1990's | 2 (4.26) | 18.2507 |
2000's | 15 (31.91) | 29.6817 |
2010's | 21 (44.68) | 24.3611 |
2020's | 5 (10.64) | 2.80 |
Authors | Studies |
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Bourguignon, JJ; Charlier, B; Hechler, V; Maitre, M; Schmitt, M; Schoenfelder, A; Wermuth, CG | 1 |
Basaki, Y; Chikahisa, L; Hashimoto, A; Miyadera, K; Okabe, S; Wierzba, K; Yamada, Y; Yonekura, K | 1 |
Davis, LG | 1 |
Banerjee, PK; Hu, RQ; Snead, OC | 1 |
Ferrara, SD; Frison, G; Maietti, S; Tedeschi, L | 1 |
Byers, KL; Duer, WC; Martin, JV | 1 |
Ciolino, LA; Machal, AC; McCauley, HA; Mesmer, MZ; Mohrhaus, AS; Satzger, RD | 1 |
Dahlén, J; Vriesman, T | 1 |
BESSMAN, SP; SKOLNIK, SJ | 1 |
GIARMAN, NJ; ROTH, RH | 2 |
Cho, BP; Del Signore, AG; McGregor, M | 1 |
Gibson, KM; Snead, OC | 1 |
Carai, MA; Colombo, G; Gessa, GL; Lobina, C; Maccioni, P; Maher, TJ; Orru, A; Quang, LS | 1 |
Huang, ZP; Zhang, SY | 1 |
Maher, TJ; Towiwat, P; Unchern, S; Werawattanachai, N | 1 |
Efe, C; Straathof, AJ; van der Wielen, LA | 1 |
Emi, Y; Fukui, Y; Kakeji, Y; Maehara, Y; Oki, E; Sumiyoshi, Y | 1 |
Kröner, L; Lenz, D; Rothschild, MA | 1 |
Brewster, VL; Edwards, HG; Hargreaves, MD; Munshi, T | 1 |
Aronsen, L; Fuskevåg, OM; Raknes, G | 1 |
Gibson, KM; Jakobs, C; Jansen, EE; Mulder, MF; Roos, B; Wamelink, MM | 1 |
Burke, LM; Castell, LM; Manore, M; Meeusen, R; Moran, S; Naylor, MJ; Popple, AD; Roelands, B; Stear, SJ | 1 |
Champeil, E; Decatur, J; Lesar, CT; Lukasiewicz, E | 1 |
Dematteis, M; Mallaret, M; Pennel, L | 1 |
Goodwin, AK; Kaminski, BJ; Weerts, EM | 1 |
Brewster, VL; Edwards, HG; Hargreaves, MD; Jilani, SK; Munshi, T; Scowen, IJ | 1 |
Bartolucci, G; Frediani, P; Rosi, L | 1 |
Auwärter, V; Hari, Y; König, S; Schröck, A; Schürch, S; Weinmann, W | 1 |
Brunt, TM; van Amsterdam, JG; van den Brink, W | 1 |
Choi, S; Kim, HU; Kim, TY; Kim, WJ; Lee, MH; Lee, SY | 1 |
Lundahl, MK; Norbergh, KG; Olovsson, KJ; Rönngren, Y | 1 |
Braunegg, G; Fasl, H; Hermann-Krauss, C; Koller, M; Muhr, A; Stelzer, F | 1 |
Ingels, AS; Lambert, WE; Samyn, N; Stove, CP; Wille, SM | 1 |
Brunt, T; Pennings, E; van Amsterdam, J; van den Brink, W | 1 |
Kawase, T; Oida, T; Okada, K | 1 |
Cui, XP; Shen, BH; Shi, Y; Xiang, P | 1 |
Busardò, FP; Kyriakou, C; Marchei, E; Pacifici, R; Pedersen, DS; Pichini, S | 1 |
Free, C; Hickson, F; Kohli, M; Reid, D; Weatherburn, P | 1 |
Castro, AL; Dias, AS; Franco, JM; Melo, P; Tarelho, S; Teixeira, HM | 1 |
Bolino, G; Busardò, FP; Giorgetti, R; Pellegrini, M; Pichini, S; Varì, MR | 1 |
Beier, N; Krämer, M; Küting, T; Madea, B | 1 |
Davis, KE; Goodpaster, JV; Hickey, LD | 1 |
Chao, YL; Chen, GY; Chen, JY; Chen, LY; Fang, CC; Mou, CW; Weng, TI | 1 |
Blakeslee, K; Kharel, MK; Osinaga, FO; Victor Hsia, S; Waguespack, Y | 1 |
Gao, ZX; Luo, QZ; Pei, MQ; Wang, HJ; Yue, X; Zhang, L | 1 |
6 review(s) available for 4-hydroxybutyric acid and 4-butyrolactone
Article | Year |
---|---|
Gamma-hydroxybutyric acid.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Humans; Hydroxybutyrates; Receptors, Cell Surface; Receptors, Dopamine; Receptors, GABA; Substance Withdrawal Syndrome; Substance-Related Disorders | 2005 |
BJSM reviews: A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--Part 16.
Topics: 4-Butyrolactone; Animals; Athletic Performance; Coumaric Acids; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; gamma-Aminobutyric Acid; Humans; Hydroxybutyrates; Hypolipidemic Agents; Muscle, Skeletal; Phenylpropionates; Rats | 2011 |
[Current knowledge on gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL) and 1 ,4-butanediol (1,4-BD)].
Topics: 4-Butyrolactone; Butylene Glycols; Humans; Hydroxybutyrates; Illicit Drugs; Knowledge; Models, Biological; Substance-Related Disorders | 2012 |
GHB, GBL and 1,4-BD addiction.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Humans; Hydroxybutyrates; Substance-Related Disorders | 2014 |
Screening and confirmation methods for GHB determination in biological fluids.
Topics: 4-Butyrolactone; Body Fluids; Calorimetry; Chromatography, Gas; Chromatography, Liquid; Electrophoresis, Capillary; Filtration; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybutyrates; Mass Spectrometry; Molecular Weight; Solid Phase Extraction; Substance Abuse Detection; Tandem Mass Spectrometry | 2014 |
Risk assessment of GBL as a substitute for the illicit drug GHB in the Netherlands. A comparison of the risks of GBL versus GHB.
Topics: 4-Butyrolactone; Animals; Drug Overdose; Europe; Humans; Hydroxybutyrates; Illicit Drugs; Netherlands; Risk; Risk Assessment | 2014 |
41 other study(ies) available for 4-hydroxybutyric acid and 4-butyrolactone
Article | Year |
---|---|
Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies.
Topics: Animals; Binding Sites; Brain; Hydroxybutyrates; In Vitro Techniques; Rats; Structure-Activity Relationship | 1988 |
UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice.
Topics: 4-Butyrolactone; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell Division; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Hydroxybutyrates; Kidney Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neovascularization, Pathologic; Tegafur; Tumor Cells, Cultured; Uracil | 1999 |
Fatalities attributed to GHB and related compounds.
Topics: 4-Butyrolactone; Adult; Ethanol; Fatal Outcome; Female; GABA Modulators; Humans; Hydroxybutyrates; Male; Respiration | 1999 |
Regulation of gamma-aminobutyric acid (GABA) release in cerebral cortex in the gamma-hydroxybutyric acid (GHB) model of absence seizures in rat.
Topics: 4-Butyrolactone; Animals; Cerebral Cortex; Electroencephalography; Epilepsy, Absence; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hydroxybutyrates; Male; Microdialysis; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Solvents; Thalamus | 2000 |
Determination of gamma-hydroxybutyric acid (GHB) in plasma and urine by headspace solid-phase microextraction and gas chromatography/positive ion chemical ionization mass spectrometry.
Topics: 4-Butyrolactone; Calibration; Drug Monitoring; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Reference Standards; Sensitivity and Specificity; Temperature | 2000 |
Application of a convenient extraction procedure to analyze gamma-hydroxybutyric acid in fatalities involving gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol.
Topics: 4-Butyrolactone; Autopsy; Butylene Glycols; Chemistry Techniques, Analytical; Humans; Hydroxybutyrates; Poisoning; Solvents; Tissue Distribution | 2001 |
The chemical interconversion of GHB and GBL: forensic issues and implications.
Topics: 4-Butyrolactone; Beverages; Chromatography, High Pressure Liquid; Drug Stability; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Illicit Drugs; Solutions; Spectroscopy, Fourier Transform Infrared; United States; United States Food and Drug Administration; Water | 2001 |
Simultaneous analysis of gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol by micellar electrokinetic chromatography.
Topics: 4-Butyrolactone; Butylene Glycols; Chromatography, Micellar Electrokinetic Capillary; Hydroxybutyrates; Solvents | 2002 |
GAMMA HYDROXYBUTYRATE AND GAMMA BUTYROLACTONE: CONCENTRATION IN RAT TISSUES DURING ANESTHESIA.
Topics: 4-Butyrolactone; Anesthesia; Anesthetics; Animals; Blood Chemical Analysis; Brain; Butyrates; Heart; Humans; Hydroxybutyrates; Lactones; Liver; Metabolism; Muscles; Rats; Research; Sleep; Sodium Oxybate | 1964 |
DIFFERENTIAL ESTIMATION OF GAMMA-BUTYROLACTONE AND GAMMA-HYDROXYBUTYRIC ACID IN RAT BLOOD AND BRAIN.
Topics: 4-Butyrolactone; Anesthesia; Anesthesia, Intravenous; Animals; Blood Chemical Analysis; Brain; Cats; Chromatography; Dogs; Hydroxybutyrates; Lactones; Neurochemistry; Pharmacology; Rabbits; Rats; Research; Serum Albumin; Serum Albumin, Radio-Iodinated | 1964 |
PRELIMINARY REPORT ON THE METABOLISM OF GAMMA-BUTYROLACTONE AND GAMMA-HYDROXYBUTYRIC ACID.
Topics: 4-Butyrolactone; Biochemical Phenomena; Blood; Brain; Butyrates; Citric Acid Cycle; Edetic Acid; Fatty Acids; Hydroxybutyrates; Lactones; Lipid Metabolism; Liver; Rats; Research; Succinates | 1965 |
1H NMR analysis of GHB and GBL: further findings on the interconversion and a preliminary report on the analysis of GHB in serum and urine.
Topics: 4-Butyrolactone; Calibration; Forensic Medicine; Humans; Hydrogen-Ion Concentration; Hydrolysis; Hydroxybutyrates; Magnetic Resonance Spectroscopy; Sensitivity and Specificity; Solvents; Specimen Handling | 2005 |
Evaluation for the withdrawal syndrome from gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) in different rat lines.
Topics: 4-Butyrolactone; Animals; Behavior, Animal; Butylene Glycols; Female; Hydroxybutyrates; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Substance Withdrawal Syndrome | 2006 |
[A color test for rapid screening of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in drink and urine].
Topics: 4-Butyrolactone; Alcoholic Beverages; Anesthetics; Beverages; Forensic Medicine; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Solvents; Sulfuric Acids | 2006 |
Neuropharmacological profile of tetrahydrofuran in mice.
Topics: 4-Butyrolactone; Animals; Behavior, Animal; Butylene Glycols; Furans; Hydroxybutyrates; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Motor Activity; Receptors, GABA; Substance-Related Disorders | 2007 |
WHO Expert Committee on Drug Dependence.
Topics: 4-Butyrolactone; Advisory Committees; Azabicyclo Compounds; Buprenorphine; Butorphanol; Catha; Dronabinol; Drug and Narcotic Control; Drug Evaluation; Health Services Accessibility; Humans; Hydroxybutyrates; Ketamine; Piperazines; Psychotropic Drugs; Substance-Related Disorders; Thebaine; Tramadol; World Health Organization | 2006 |
Options for biochemical production of 4-hydroxybutyrate and its lactone as a substitute for petrochemical production.
Topics: 4-Butyrolactone; Biochemistry; Bioreactors; Candida; Computer Simulation; Glucose; Hydroxybutyrates; Lactones; Models, Biological; Signal Transduction | 2008 |
Pharmacokinetics of gamma-hydroxybutylic acid (GHB) and gamma-butyrolactone (GBL), the anti-angiogenic metabolites of oral fluoropyrimidine UFT, in patients with gastric cancer.
Topics: 4-Butyrolactone; Administration, Oral; Aged; Angiogenesis Inhibitors; Antineoplastic Agents; Drug Combinations; Female; Humans; Hydroxybutyrates; Male; Middle Aged; Stomach Neoplasms; Tegafur; Uracil | 2007 |
Intoxications due to ingestion of gamma-butyrolactone: organ distribution of gamma-hydroxybutyric acid and gamma-butyrolactone.
Topics: 4-Butyrolactone; Adult; Brain; Female; Humans; Hydroxybutyrates; Male; Muscle, Skeletal; Substance-Related Disorders; Tissue Distribution | 2008 |
Identification of the date-rape drug GHB and its precursor GBL by Raman spectroscopy.
Topics: 4-Butyrolactone; Beverages; Hydroxybutyrates; Limit of Detection; Spectrum Analysis, Raman; Substance Abuse Detection | 2009 |
Urinary concentrations of gamma-hydroxybutyric acid and related compounds in pregnancy.
Topics: 3-Hydroxybutyric Acid; 4-Butyrolactone; Chromatography, Liquid; Cross-Sectional Studies; False Positive Reactions; Female; Forensic Toxicology; Humans; Hydroxybutyrates; Pregnancy; Reference Values; Reproducibility of Results; Tandem Mass Spectrometry | 2010 |
4-Hydroxybutyric aciduria associated with catheter usage: a diagnostic pitfall in the identification of SSADH deficiency.
Topics: 4-Butyrolactone; Amino Acid Metabolism, Inborn Errors; Catheters; Developmental Disabilities; Female; Humans; Hydroxybutyrates; Infant; Infant, Newborn; Maple Syrup Urine Disease; Succinate-Semialdehyde Dehydrogenase | 2011 |
Report on the analysis of common beverages spiked with gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) using NMR and the PURGE solvent-suppression technique.
Topics: 4-Butyrolactone; Alcoholic Beverages; Beverages; Forensic Toxicology; Humans; Hydroxybutyrates; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Sampling Studies; Sensitivity and Specificity; Solvents | 2011 |
Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Cocaine; Dose-Response Relationship, Drug; Hydroxybutyrates; Injections, Intravenous; Male; Papio; Prodrugs; Reinforcement Schedule; Reinforcement, Psychology; Self Administration | 2013 |
Monitoring of the interconversion of gamma-butyrolactone (GBL) to gamma hydroxybutyric acid (GHB) by Raman spectroscopy.
Topics: 4-Butyrolactone; Alcoholic Beverages; Carbonated Beverages; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Illicit Drugs; Rape; Spectrum Analysis, Raman; Substance Abuse Detection | 2013 |
Determination of GHB and its precursors (GBL and 1,4-BD) in dietary supplements through the synthesis of their isotopologues and analysis by GC-MS method.
Topics: 4-Butyrolactone; Butylene Glycols; Dietary Supplements; Gas Chromatography-Mass Spectrometry; Hydroxybutyrates; Prodrugs; Reproducibility of Results | 2013 |
Pharmacokinetics of GHB and detection window in serum and urine after single uptake of a low dose of GBL - an experiment with two volunteers.
Topics: 4-Butyrolactone; Adult; Chromatography, Liquid; Humans; Hydroxybutyrates; Illicit Drugs; Male; Middle Aged; Sodium Oxybate; Tandem Mass Spectrometry | 2014 |
Production of 4-hydroxybutyric acid by metabolically engineered Mannheimia succiniciproducens and its conversion to γ-butyrolactone by acid treatment.
Topics: 4-Butyrolactone; Bacterial Proteins; Hydroxybutyrates; Mannheimia; Metabolic Engineering; Mutation | 2013 |
Nurse's perspectives on care provided for patients with gamma-hydroxybutyric acid and gamma-butyrolactone abuse.
Topics: 4-Butyrolactone; Adult; Female; Hospital Units; Humans; Hydroxybutyrates; Inpatients; Interviews as Topic; Male; Middle Aged; Practice Patterns, Nurses'; Psychiatric Nursing; Scandinavian and Nordic Countries; Substance-Related Disorders | 2014 |
Archaeal production of polyhydroxyalkanoate (PHA) co- and terpolyesters from biodiesel industry-derived by-products.
Topics: 3-Hydroxybutyric Acid; 4-Butyrolactone; Biodegradable Plastics; Biofuels; Glycerol; Haloferax mediterranei; Hydroxybutyrates; Pentanoic Acids; Polyesters; Polyhydroxyalkanoates | 2013 |
Novel fluorinated gemini surfactants with γ-butyrolactone segments.
Topics: 4-Butyrolactone; Hot Temperature; Hydroxybutyrates; Micelles; Polymerization; Quaternary Ammonium Compounds; Solutions; Surface Tension; Surface-Active Agents; Water | 2015 |
[Analysis of GHB and Its Precursors in Urine and Their Forensic Application].
Topics: 4-Butyrolactone; Butylene Glycols; Chromatography, Liquid; Forensic Sciences; Humans; Hydroxybutyrates; Mass Spectrometry; Reproducibility of Results; Tandem Mass Spectrometry | 2015 |
Ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) for determination of GHB, precursors and metabolites in different specimens: Application to clinical and forensic cases.
Topics: 4-Butyrolactone; Cerebrospinal Fluid; Chromatography, High Pressure Liquid; Forensic Sciences; gamma-Aminobutyric Acid; Hair; Humans; Hydroxybutyrates; Illicit Drugs; Male; Methanol; Middle Aged; Plasma; Sodium Oxybate; Tandem Mass Spectrometry | 2017 |
Cross-sectional analysis of chemsex drug use and gonorrhoea diagnosis among men who have sex with men in the UK.
Topics: 4-Butyrolactone; Adult; Cross-Sectional Studies; Gonorrhea; Homosexuality, Male; Humans; Hydroxybutyrates; Illicit Drugs; Male; Methamphetamine; Middle Aged; Risk Factors; Substance-Related Disorders; United Kingdom; Young Adult | 2019 |
Quantification of GHB and GHB-GLUC in an 1,4-butanediol intoxication: A case report.
Topics: 4-Butyrolactone; Adult; Butylene Glycols; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybutyrates; Male | 2019 |
A fatal chemsex case involving γ-butyrolactone and 4-methylethcathinone.
Topics: 4-Butyrolactone; Adult; Amphetamines; Autopsy; Central Nervous System Stimulants; Forensic Toxicology; Humans; Hydroxybutyrates; Male; Propiophenones; Substance Abuse Detection | 2019 |
Methyl-4-Hydroxybutyrate and Ethyl-4-Hydroxybutyrate as Potential Markers for Simultaneous Consumption of GHB/GBL and Alcohol: Preliminary Investigations.
Topics: 4-Butyrolactone; Alcoholic Beverages; Ethanol; Hydroxybutyrates; Illicit Drugs; Limit of Detection; Substance Abuse Detection | 2020 |
Detection of ɣ-hydroxybutyric acid (GHB) and ɣ-butyrolactone (GBL) in alcoholic beverages via total vaporization solid-phase microextraction (TV-SPME) and gas chromatography-mass spectrometry.
Topics: 4-Butyrolactone; Alcoholic Beverages; Crime; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybutyrates; Poisoning; Solid Phase Microextraction; Volatilization | 2021 |
Characteristics of patients with analytically confirmed γ-hydroxybutyric acid/γ-butyrolactone (GHB/GBL)-related emergency department visits in Taiwan.
Topics: 4-Butyrolactone; Adult; Emergency Service, Hospital; Female; Humans; Hydroxybutyrates; Male; Retrospective Studies; Sodium Oxybate; Taiwan | 2021 |
Method validation of gamma-Hydroxybutyric acid detection upon Herpes Simplex Virus-Type 1 infection using LC-MRM-MS with 3-nitrophenylhydrazine derivatization.
Topics: 4-Butyrolactone; Animals; Hydroxybutyrates; Phenylhydrazines; Simplexvirus; Sodium Oxybate | 2022 |
Detection of Exogenous γ-Hydroxybutyric Acid in Rat Blood Exosomes.
Topics: 4-Butyrolactone; Animals; Chromatography, Liquid; Exosomes; Hydroxybutyrates; Male; Rats; Rats, Sprague-Dawley; Sodium Oxybate; Tandem Mass Spectrometry | 2022 |