4-hydroxybutyric acid has been researched along with 1,4-butanediol in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 10 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bourguignon, JJ; Charlier, B; Hechler, V; Maitre, M; Schmitt, M; Schoenfelder, A; Wermuth, CG | 1 |
| Byers, KL; Duer, WC; Martin, JV | 1 |
| Dahlén, J; Vriesman, T | 1 |
| Baud, FJ; Fompeydie, D; Garnier, R; Mégarbane, B | 1 |
| Carai, MA; Castelli, MP; Cignarella, G; Colombo, G; Gessa, GL; Mocci, I; Reali, R; Serra, S | 1 |
| Desai, MC; Maher, TJ; Quang, LS; Shannon, MW; Woolf, AD | 1 |
| Atzeri, S; Carai, MA; Colombo, G; Gessa, GL; Lobina, C; Maccioni, P; Maher, TJ; Orrù, A; Quang, LS | 1 |
| Gibson, KM; Snead, OC | 1 |
| Boyer, EW; Desai, MC; Law, T; Levy, HL; Maher, TJ; Quang, LS; Shannon, MW; Woolf, AD | 1 |
| Dutra-Filho, CS; Magnusson, AS; Mescka, CP; Oliveira, AS; Pederzolli, CD; Sgaravatti, AM; Sgarbi, MB; Wajner, M; Wannmacher, CM; Wyse, AT; Zanin, F | 1 |
| Beike, J; Bender, K; Jübner, M; Käferstein, H; Lenz, D; Rothschild, MA; Wintermeyer, A | 1 |
| Chen, GQ; Chen, JC; Meng, DC; Shi, ZY; Wu, Q; Zhou, Q | 1 |
| Chen, G; Zhang, X | 1 |
| Dematteis, M; Mallaret, M; Pennel, L | 1 |
| Goodwin, AK; Kaminski, BJ; Weerts, EM | 1 |
| Bartolucci, G; Frediani, P; Rosi, L | 1 |
| Brunt, TM; van Amsterdam, JG; van den Brink, W | 1 |
| Cui, XP; Shen, BH; Shi, Y; Xiang, P | 1 |
| Archer, JR; Dargan, PI; Lambert, WE; Sadones, N; Stove, CP; Van Bever, E; Van Bortel, L; Wood, DM | 1 |
| Castro, AL; Dias, AS; Franco, JM; Melo, P; Tarelho, S; Teixeira, HM | 1 |
3 review(s) available for 4-hydroxybutyric acid and 1,4-butanediol
| Article | Year |
|---|---|
Gamma-hydroxybutyric acid.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Humans; Hydroxybutyrates; Receptors, Cell Surface; Receptors, Dopamine; Receptors, GABA; Substance Withdrawal Syndrome; Substance-Related Disorders | 2005 |
[Current knowledge on gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL) and 1 ,4-butanediol (1,4-BD)].
Topics: 4-Butyrolactone; Butylene Glycols; Humans; Hydroxybutyrates; Illicit Drugs; Knowledge; Models, Biological; Substance-Related Disorders | 2012 |
GHB, GBL and 1,4-BD addiction.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Humans; Hydroxybutyrates; Substance-Related Disorders | 2014 |
17 other study(ies) available for 4-hydroxybutyric acid and 1,4-butanediol
| Article | Year |
|---|---|
Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies.
Topics: Animals; Binding Sites; Brain; Hydroxybutyrates; In Vitro Techniques; Rats; Structure-Activity Relationship | 1988 |
Application of a convenient extraction procedure to analyze gamma-hydroxybutyric acid in fatalities involving gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol.
Topics: 4-Butyrolactone; Autopsy; Butylene Glycols; Chemistry Techniques, Analytical; Humans; Hydroxybutyrates; Poisoning; Solvents; Tissue Distribution | 2001 |
Simultaneous analysis of gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol by micellar electrokinetic chromatography.
Topics: 4-Butyrolactone; Butylene Glycols; Chromatography, Micellar Electrokinetic Capillary; Hydroxybutyrates; Solvents | 2002 |
Treatment of a 1,4-butanediol poisoning with fomepizole.
Topics: Adult; Antidotes; Butylene Glycols; Coma; Fomepizole; Humans; Hydroxybutyrates; Infusions, Intravenous; Male; Pyrazoles; Seizures; Solvents; Substance-Related Disorders; Treatment Outcome | 2002 |
Central effects of 1,4-butanediol are mediated by GABA(B) receptors via its conversion into gamma-hydroxybutyric acid.
Topics: Animals; Butylene Glycols; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Hydroxybutyrates; Male; Mice; Mice, Inbred DBA; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Sleep | 2002 |
4-methylpyrazole decreases 1,4-butanediol toxicity by blocking its in vivo biotransformation to gamma-hydroxybutyric acid.
Topics: Animals; Biotransformation; Butylene Glycols; Fomepizole; Hydroxybutyrates; Male; Mice; Motor Skills; Pyrazoles; Rotarod Performance Test | 2004 |
Withdrawal syndrome from gamma-hydroxybutyric acid (GHB) and 1,4-butanediol (1,4-BD) in Sardinian alcohol-preferring rats.
Topics: Animals; Butylene Glycols; Disease Models, Animal; GABA-B Receptor Antagonists; Hydroxybutyrates; Male; Morpholines; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 2005 |
Laboratory diagnosis of 1,4-BD and GHB overdose by routine urine organic acid analysis.
Topics: Animals; Butylene Glycols; Chromatography, Gas; Drug Overdose; Emergency Medical Services; Hydroxybutyrates; Male; Mice; Substance Abuse Detection | 2005 |
Effects of 1,4-butanediol administration on oxidative stress in rat brain: study of the neurotoxicity of gamma-hydroxybutyric acid in vivo.
Topics: Animals; Antioxidants; Butylene Glycols; Catalase; Cerebral Cortex; Dose-Response Relationship, Drug; Glutathione Peroxidase; Hydroxybutyrates; Lipid Peroxidation; Luminescence; Neurotoxins; Oxidation-Reduction; Oxidative Stress; Prodrugs; Rats; Rats, Wistar; Statistics, Nonparametric; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2009 |
Inhibition of 1,4-butanediol metabolism in human liver in vitro.
Topics: Adult; Aged; Antidotes; Butylene Glycols; Cimetidine; Disulfiram; Drug Interactions; Ethanol; Female; Fomepizole; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybutyrates; In Vitro Techniques; Liver; Male; Middle Aged; Pyrazoles | 2011 |
Production of 3-hydroxypropionate homopolymer and poly(3-hydroxypropionate-co-4-hydroxybutyrate) copolymer by recombinant Escherichia coli.
Topics: Acyltransferases; Aeromonas hydrophila; Aldehyde Dehydrogenase; Biopolymers; Butylene Glycols; Chloroflexus; Coenzyme A Ligases; Cupriavidus necator; Escherichia coli; Fermentation; Genetic Engineering; Hydro-Lyases; Hydroxybutyrates; Lactic Acid; Polyesters; Promoter Regions, Genetic; Propylene Glycols; Pseudomonas putida | 2011 |
[Enzymes related with NAD synthesis promote conversion of 1,4-butanediol to 4-hydroxybutyrate].
Topics: Amide Synthases; Butylene Glycols; Escherichia coli; Fermentation; Hydroxybutyrates; Pentosyltransferases | 2011 |
Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Cocaine; Dose-Response Relationship, Drug; Hydroxybutyrates; Injections, Intravenous; Male; Papio; Prodrugs; Reinforcement Schedule; Reinforcement, Psychology; Self Administration | 2013 |
Determination of GHB and its precursors (GBL and 1,4-BD) in dietary supplements through the synthesis of their isotopologues and analysis by GC-MS method.
Topics: 4-Butyrolactone; Butylene Glycols; Dietary Supplements; Gas Chromatography-Mass Spectrometry; Hydroxybutyrates; Prodrugs; Reproducibility of Results | 2013 |
[Analysis of GHB and Its Precursors in Urine and Their Forensic Application].
Topics: 4-Butyrolactone; Butylene Glycols; Chromatography, Liquid; Forensic Sciences; Humans; Hydroxybutyrates; Mass Spectrometry; Reproducibility of Results; Tandem Mass Spectrometry | 2015 |
Microwave-assisted on-spot derivatization for gas chromatography-mass spectrometry based determination of polar low molecular weight compounds in dried blood spots.
Topics: 3-Hydroxybutyric Acid; Amines; Butylene Glycols; Calibration; Cyclohexanecarboxylic Acids; Dried Blood Spot Testing; Forensic Toxicology; Gabapentin; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Hydroxybutyrates; Microwaves; Molecular Weight; Specimen Handling | 2016 |
Quantification of GHB and GHB-GLUC in an 1,4-butanediol intoxication: A case report.
Topics: 4-Butyrolactone; Adult; Butylene Glycols; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybutyrates; Male | 2019 |