4-hydroxyantipyrine has been researched along with edaravone in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (54.29) | 18.7374 |
| 1990's | 15 (42.86) | 18.2507 |
| 2000's | 1 (2.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Belwon, S; Dengler, HJ; Edeki, T; Funke, C; Lindecken, KD; Robertz-Vaupel, GM | 1 |
| Abul-Hajj, Y; Awni, WM; St Peter, JV | 1 |
| Edwards, DJ; Krakovsky, DJ; Rybak, MJ; Steinberg, JD; Waite, NM; Warbasse, LH | 1 |
| Advenier, C; Cordonnier, P; Naline, E; Palette, C; Pays, M | 1 |
| Khlopushina, TG; Rybina, IV; Seredenin, SB; Zherdev, VP | 1 |
| Van Bezooijen, CF; Van Geel, CA | 1 |
| Brendel, E; de Mey, C; Meineke, I | 1 |
| Awni, WM; St Peter, JV | 1 |
| Imai, Y; Inada, M; Inui, Y; Ito, N; Kawata, S; Matsuda, Y; Miyoshi, S; Noda, S; Saitoh, R; Tamura, S | 1 |
| Houston, JB; Shaw, PN | 1 |
| Breimer, DD; Janssens, AR; Koch, CW; Spoelstra, P; Teunissen, MW; van Duijn, W; Weeda, B | 1 |
| Browne, TR; Greenblatt, DJ; LeDuc, BW; Mikati, MA; Pylilo, RJ; Szabo, GK | 1 |
| Chenery, RJ; Jennings, P; Mason, PA; Norman, SJ; Oldham, HG; Standring, P | 1 |
| Bach, D; Blevins, R; Edwards, DJ; Kerner, N; Rubenfire, M | 1 |
| Chiba, K; Ishizaki, T; Kubota, K; Nakagawa, A; Nakamura, K; Takagi, A | 1 |
| Back, DJ; Breckenridge, AM; Howells, RE; Rivière, JH | 1 |
| Breimer, DD; Kampf, D; Roots, I; Teunissen, MW; Vermeulen, NP | 1 |
| Pilsgaard, H; Poulsen, HE | 1 |
| Breimer, DD; Teunissen, MW; Vinnars, E; Wahlén, A | 1 |
| Breimer, DD; Joeres, RP; Teunissen, MW; Vermeulen, NP | 1 |
| Chiba, K; Ishizaki, T; Nakagawa, A; Nakamura, K | 1 |
| Inaba, T; Kalow, W; Tang, BK; Uchino, H | 1 |
| Blair, IA; Boobis, AR; Brodie, MJ; Davies, DS; Kahn, GC | 1 |
| Dengler, HJ; Eichelbaum, M; Sonntag, B | 1 |
| Fischer, NE; Inaba, T | 1 |
| Ali, HA; Ali, MA; Døssing, M; el-Yazigi, A; Ernst, P; Khan, B; Raines, DA; Saour, J; Sieck, JO | 1 |
| Ali, HA; Døssing, M; el-Yazigi, A; Ernst, P; Raines, DA; Saour, J; Sieck, JO | 1 |
| Cosme, J; Eichelbaum, M; Engel, G; Heidemann, H; Hofmann, U | 1 |
| Janus, K; Suszycka, J | 2 |
| Sharer, JE; Wrighton, SA | 1 |
| Janus, K; Muszczynski, Z; Suszycka, J | 1 |
| Lanchote, VL; Ping, WC; Santos, SR | 1 |
| Almar, M; González-Gallego, J; González-Sastre, M; Jorquera, F; Pozuelo, M; Sansegundo, D | 1 |
| Bayón, JE; Ferre, I; González-Gallego, J; Jiang, SX; Mao, XZ | 1 |
2 trial(s) available for 4-hydroxyantipyrine and edaravone
| Article | Year |
|---|---|
Influence of subject age on the inhibition of oxidative metabolism by ciprofloxacin.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antipyrine; Ciprofloxacin; Edaravone; Female; Humans; Male; Oxidation-Reduction; Prospective Studies | 1991 |
Elimination studies of antipyrine and its metabolites in healthy Saudi Arabians.
Topics: Administration, Oral; Adolescent; Adult; Antipyrine; Asian People; Black People; Chromatography, High Pressure Liquid; Edaravone; Female; Humans; Male; Metabolic Clearance Rate; Saudi Arabia; White People | 1994 |
33 other study(ies) available for 4-hydroxyantipyrine and edaravone
| Article | Year |
|---|---|
Disposition of antipyrine in patients with extensive metastatic liver disease.
Topics: Adenocarcinoma; Aged; Antipyrine; Colorectal Neoplasms; Edaravone; Female; Humans; Liver Neoplasms; Male; Middle Aged | 1992 |
The pharmacokinetics of antipyrine and three of its metabolites in the rabbit: intravenous administration of pure metabolites.
Topics: Animals; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Injections, Intravenous; Male; Mass Spectrometry; Rabbits | 1991 |
High-performance liquid chromatographic method for the determination of the three main oxidative and 3-carboxylic antipyrine metabolites in human urine.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Humans; Indicators and Reagents; Oxidation-Reduction | 1991 |
[The determination of the oxidation phenotype in inbred C57Bl/6 and BALB/c mice].
Topics: Animals; Antipyrine; Chromatography, Gas; Edaravone; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oxidation-Reduction; Phenotype; Time Factors | 1990 |
The effect of age on the oxidative metabolism of antipyrine by uninduced microsomal fractions of rat liver.
Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Edaravone; In Vitro Techniques; Isoenzymes; Kinetics; Male; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Inbred BN | 1990 |
Assay of antipyrine and its main metabolites 3-hydroxymethylantipyrine, norantipyrine and 4-hydroxyantipyrine in urine.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Glucuronidase; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Spectrophotometry, Ultraviolet | 1989 |
Modified high-performance liquid chromatographic assay for antipyrine and its three major metabolites in urine.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Humans | 1989 |
[Alterations of urinary excretion of antipyrine metabolites in patients with cirrhosis of the liver].
Topics: Antipyrine; Carcinoma, Hepatocellular; Edaravone; Female; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged | 1987 |
Temporal effects on antipyrine metabolite kinetics in Aroclor 1254-treated rats.
Topics: Animals; Antipyrine; Aroclors; Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Edaravone; Enzyme Induction; Half-Life; Injections, Intraperitoneal; Kinetics; Liver; Male; Rats; Rats, Inbred Strains | 1986 |
Antipyrine clearance and metabolite formation: the influence of liver volume and smoking.
Topics: Adult; Antipyrine; Cytochrome P-450 Enzyme System; Edaravone; Female; Humans; Kinetics; Liver; Male; Middle Aged; Organ Size; Smoking | 1986 |
Improved high-performance liquid chromatographic assay of antipyrine, hydroxymethylantipyrine, 4-hydroxyantipyrine and norantipyrine in urine.
Topics: Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Reference Standards | 1988 |
Antipyrine metabolism in cultured rat hepatocytes.
Topics: Animals; Antipyrine; Cells, Cultured; Chloramphenicol; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Edaravone; Isoenzymes; Kinetics; Liver; Male; Rats; Rats, Inbred Strains | 1987 |
The effect of verapamil on antipyrine pharmacokinetics and metabolism in man.
Topics: Adult; Antipyrine; Drug Interactions; Edaravone; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Verapamil | 1986 |
Antipyrine clearance and metabolism in patients with psoriasis.
Topics: Aged; Aged, 80 and over; Antipyrine; Aryl Hydrocarbon Hydroxylases; Edaravone; Female; Half-Life; Humans; Male; Middle Aged; Psoriasis; Saliva; Smoking | 1986 |
The pharmacokinetics of mefloquine in man: lack of effect of mefloquine on antipyrine metabolism.
Topics: Adult; Antimalarials; Antipyrine; Chromatography, High Pressure Liquid; Drug Interactions; Edaravone; Humans; Kinetics; Male; Mefloquine; Metabolic Clearance Rate; Quinolines; Saliva | 1985 |
Antipyrine metabolite formation and excretion in patients with chronic renal failure.
Topics: Adult; Aged; Antipyrine; Edaravone; Female; Half-Life; Humans; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Time Factors | 1985 |
Antipyrine metabolism during hepatic regeneration in the rat.
Topics: Animals; Antipyrine; Edaravone; Female; Liver Diseases; Liver Regeneration; Organ Size; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Influence of alaproclate on antipyrine metabolite formation in man.
Topics: Adult; Alanine; Antipyrine; Biotransformation; Cytochrome P-450 Enzyme System; Edaravone; Half-Life; Humans; Liver; Male; Oxidation-Reduction | 1984 |
Influence of 9-hydroxyellipticine and 3-methylcholanthrene treatment on antipyrine metabolite formation in rats in vivo.
Topics: Alkaloids; Animals; Antipyrine; Edaravone; Ellipticines; Kinetics; Methylcholanthrene; Rats; Rats, Inbred Strains | 1983 |
Automated high-performance liqiud chromatographic method for the determination of antipyrine and its metabolites in urine. Some preliminary results obtained from smokers and non-smokers.
Topics: Adult; Antipyrine; Autoanalysis; Chromatography, High Pressure Liquid; Edaravone; Female; Humans; Male; Smoking | 1982 |
Simultaneous determination of antipyrine, 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norantipyrine in urine by gas chromatography chemical ionization mass spectrometry.
Topics: Antipyrine; Edaravone; Gas Chromatography-Mass Spectrometry; Humans; Reference Standards; Time Factors | 1982 |
A radiometric high-pressure liquid chromatography assay for the simultaneous determination of the three main oxidative metabolites of antipyrine in studies in vitro.
Topics: Animals; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Gas Chromatography-Mass Spectrometry; Humans; Male; Microsomes, Liver; Rats | 1981 |
HPLC determination of antipyrine metabolites.
Topics: Antioxidants; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Humans; Hydrogen-Ion Concentration; Hydrolysis; Time Factors | 1981 |
Antipyrine metabolism in man: simultaneous determination of norantipyrine and 4-hydroxyantipyrine in urine by gas chromatography.
Topics: Adult; Antipyrine; Biotransformation; Chromatography, Gas; Dealkylation; Edaravone; Humans; Hydrolysis; Hydroxylation; Male; Middle Aged | 1980 |
Antipyrine clearance and metabolite excretion in patients with chronic hepatitis C.
Topics: Adult; Antipyrine; Chronic Disease; Edaravone; Female; Hepatitis C; Humans; Male; Middle Aged; Reference Values | 1995 |
Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autoantibodies; Biotransformation; Catalysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Edaravone; Gas Chromatography-Mass Spectrometry; Humans; Microsomes, Liver | 1996 |
Effect of age on the pharmacokinetics of antipyrine in calves.
Topics: Aging; Animals; Antipyrine; Cattle; Edaravone; Female; Half-Life; Metabolic Clearance Rate; Time Factors | 1996 |
Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine.
Topics: Antipyrine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Edaravone; Enzyme Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Oxidoreductases; Regression Analysis | 1996 |
Pharmacokinetics of antipyrine in calves after intravenous and oral administration.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Cattle; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Edaravone; Female; Free Radical Scavengers; Half-Life; Injections, Intravenous; Regression Analysis | 1996 |
The effect of cimetidine on antipyrine metabolism in calves.
Topics: Administration, Oral; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antipyrine; Cattle; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Edaravone; Female; Free Radical Scavengers; Histamine H2 Antagonists; Software | 1997 |
Determination of antipyrine and metabolites in plasma of a patient with mild renal failure.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Chromatography, High Pressure Liquid; Edaravone; Female; Humans; Hypertension; Kidney Failure, Chronic; Metabolic Clearance Rate; Reference Values | 1997 |
The effect of age and sex on metabolism and urinary excretion of antipyrine.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Body Weight; Edaravone; Female; Free Radical Scavengers; Half-Life; Humans; Kidney; Male; Metabolic Clearance Rate; Saliva; Sex Characteristics | 1998 |
Effect of experimental fasciolosis on antipyrine metabolism and clearance in water buffaloes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Helminth; Antipyrine; Aspartate Aminotransferases; Buffaloes; Chromatography, High Pressure Liquid; Edaravone; Enzyme-Linked Immunosorbent Assay; Fascioliasis; Feces; gamma-Glutamyltransferase; Half-Life; Male; Parasite Egg Count | 2000 |