4-hydroxyalprazolam has been researched along with alpha-hydroxyalprazolam in 5 studies
| Studies (4-hydroxyalprazolam) | Trials (4-hydroxyalprazolam) | Recent Studies (post-2010) (4-hydroxyalprazolam) | Studies (alpha-hydroxyalprazolam) | Trials (alpha-hydroxyalprazolam) | Recent Studies (post-2010) (alpha-hydroxyalprazolam) |
|---|---|---|---|---|---|
| 7 | 1 | 2 | 26 | 3 | 9 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Collins, RJ; Gall, M; Kamdar, BV | 1 |
| Allqvist, A; Bertilsson, L; Gustafsson, LL; Mirghani, RA; Svensson, JO; Wennerholm, A | 1 |
| Allqvist, A; Bertilsson, L; Mirghani, RA; Miura, J | 1 |
| Honda, K; Nakamura, T; Shinozuka, T; Tanaka, E; Terada, M | 1 |
| Bertilsson, L; Carrero, JJ; Diczfalusy, U; Heimbürger, O; Lindholm, B; Molanaei, H; Odar-Cederlöf, I; Qureshi, AR; Stenvinkel, P | 1 |
1 trial(s) available for 4-hydroxyalprazolam and alpha-hydroxyalprazolam
| Article | Year |
|---|---|
Alprazolam as a probe for CYP3A using a single blood sample: pharmacokinetics of parent drug, and of alpha- and 4-hydroxy metabolites in healthy subjects.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Oxidoreductases, N-Demethylating | 2005 |
4 other study(ies) available for 4-hydroxyalprazolam and alpha-hydroxyalprazolam
| Article | Year |
|---|---|
Pharmacology of some metabolites of triazolam, alprazolam, and diazepam prepared by a simple, one-step oxidation of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Hydroxylation; Male; Methods; Mice; Oxidation-Reduction; Triazolam; Triazoles | 1978 |
Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers.
Topics: Alprazolam; Anti-Anxiety Agents; Antifungal Agents; Antimalarials; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Inhibitory Concentration 50; Ketoconazole; Mass Spectrometry; Microsomes, Liver; Quinidine; Stereoisomerism | 2007 |
Metabolic interaction between ethanol, high-dose alprazolam and its two main metabolites using human liver microsomes in vitro.
Topics: Alprazolam; Anti-Anxiety Agents; Central Nervous System Depressants; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Forensic Toxicology; Humans; In Vitro Techniques; Microsomes, Liver | 2007 |
Metabolism of alprazolam (a marker of CYP3A4) in hemodialysis patients with persistent inflammation.
Topics: Adult; Aged; Algorithms; Alprazolam; Anti-Anxiety Agents; Biomarkers; Biotransformation; C-Reactive Protein; Cytochrome P-450 CYP3A; Female; Humans; Hydroxycholesterols; Hydroxylation; Male; Middle Aged; Orosomucoid; Renal Dialysis; Renal Insufficiency, Chronic | 2012 |