4-hydroxy-equilenin has been researched along with estrone in 3 studies
| Studies (4-hydroxy-equilenin) | Trials (4-hydroxy-equilenin) | Recent Studies (post-2010) (4-hydroxy-equilenin) | Studies (estrone) | Trials (estrone) | Recent Studies (post-2010) (estrone) |
|---|---|---|---|---|---|
| 32 | 0 | 0 | 10,266 | 432 | 1,372 |
| Protein | Taxonomy | 4-hydroxy-equilenin (IC50) | estrone (IC50) |
|---|---|---|---|
| Estrogen receptor | Homo sapiens (human) | 0.1261 | |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | 6.589 | |
| 17-beta-hydroxysteroid dehydrogenase type 1 | Homo sapiens (human) | 0.4134 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 5.301 | |
| Estrogen receptor beta | Homo sapiens (human) | 0.3743 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blond, SY; Bolton, JL; Chen, Y; Constantinou, AI; Elguindi, EC; Hua, Y; Liu, X; Pisha, E; Shen, L; van Breemen, RB; Zhang, F | 1 |
| Bolton, JL; Constantinou, AI; Lui, X; Pisha, E | 1 |
| Bolton, JL; Chandrasena, ER; Peng, KW; Thatcher, GR; van Breemen, RB; Wang, Z; Yuan, Y | 1 |
3 other study(ies) available for 4-hydroxy-equilenin and estrone
| Article | Year |
|---|---|
A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines.
Topics: Apoptosis; Breast Neoplasms; Cell Survival; Comet Assay; DNA Damage; DNA Fragmentation; DNA, Neoplasm; Dose-Response Relationship, Drug; Epithelial Cells; Equilenin; Estradiol Congeners; Estrogens, Catechol; Female; Humans; Hydroxyestrones; Tumor Cells, Cultured | 2000 |
Evidence that a metabolite of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro.
Topics: Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; DNA Damage; Epidermal Cells; Epidermis; Equilenin; Estradiol Congeners; Fibroblasts; Horses; Hydroxyestrones; Mice; Mice, Inbred C3H; Reactive Oxygen Species | 2001 |
Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cattle; Cell Line, Tumor; Chelating Agents; Copper; Deoxyguanosine; DNA; DNA Damage; DNA, Neoplasm; Equilenin; Estrogens, Catechol; Free Radical Scavengers; Horses; Humans; Hydrogen Peroxide; Hydroxyestrones; Molecular Structure; NADP; Oxidation-Reduction; Reactive Oxygen Species; Structure-Activity Relationship | 2010 |