4-hydroxy-2-nonenal and xanthorrhizol

4-hydroxy-2-nonenal has been researched along with xanthorrhizol* in 1 studies

Other Studies

1 other study(ies) available for 4-hydroxy-2-nonenal and xanthorrhizol

Article	Year
The antioxidant xanthorrhizol prevents amyloid-β-induced oxidative modification and inactivation of neprilysin. Bioscience reports, 2018, 02-28, Volume: 38, Issue:1 Activity of neprilysin (NEP), the major protease which cleaves amyloid-β peptide (Aβ), is reportedly reduced in the brains of patients with Alzheimer's disease (AD). Accumulation of Aβ generates reactive oxygen species (ROS) such as 4-hydroxynonenal (HNE), and then reduces activities of Aβ-degrading enzymes including NEP. Xanthorrhizol (Xan), a natural sesquiterpenoid, has been reported to possess antioxidant and anti-inflammatory properties. The present study examined the effects of Xan on HNE- or oligomeric Aβ Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Brain; Cell Line; Humans; Neprilysin; Neuroblastoma; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Phenols; Reactive Oxygen Species	2018

Article

Year

The antioxidant xanthorrhizol prevents amyloid-β-induced oxidative modification and inactivation of neprilysin.

Bioscience reports, 2018, 02-28, Volume: 38, Issue:1

Activity of neprilysin (NEP), the major protease which cleaves amyloid-β peptide (Aβ), is reportedly reduced in the brains of patients with Alzheimer's disease (AD). Accumulation of Aβ generates reactive oxygen species (ROS) such as 4-hydroxynonenal (HNE), and then reduces activities of Aβ-degrading enzymes including NEP. Xanthorrhizol (Xan), a natural sesquiterpenoid, has been reported to possess antioxidant and anti-inflammatory properties. The present study examined the effects of Xan on HNE- or oligomeric Aβ

Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Brain; Cell Line; Humans; Neprilysin; Neuroblastoma; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Phenols; Reactive Oxygen Species

2018