4-hydroxy-2-nonenal and trimethyltin

4-hydroxy-2-nonenal has been researched along with trimethyltin* in 1 studies

Other Studies

1 other study(ies) available for 4-hydroxy-2-nonenal and trimethyltin

Article	Year
Distribution and time-course of 4-hydroxynonenal, heat shock protein 110/105 family members and cyclooxygenase-2 expression in the hippocampus of rat during trimethyltin-induced neurodegeneration. Neurochemical research, 2011, Volume: 36, Issue:8 Trimethyltin (TMT), an organotin compound considered a useful tool to obtain an experimental model of neurodegeneration, exhibits neurotoxicant effects selectively localised in the limbic system and especially in the hippocampus, which are different in the rat and in mice. In the rat hippocampus, we investigated the expression of aldehyde 4-hydroxynonenal, a major bioactive marker of membrane lipid peroxidation, heat shock protein (HSP) 110/105 family members, markers of oxidative stress, and the neuroinflammatory marker cyclooxygenase-2 after TMT-intoxication at various time points after treatment. Our data show that TMT-induced neurodegeneration in the rat hippocampus is associated specifically with oxidative stress and lipid peroxidation, but not with HSP expression, indicating species-specific differences in the neurotoxicity of TMT between rats and mice. Topics: Aldehydes; Animals; Biomarkers; Cyclooxygenase 2; Cysteine Proteinase Inhibitors; Female; Hippocampus; HSP110 Heat-Shock Proteins; Mice; Nerve Degeneration; Rats; Rats, Wistar; Trimethyltin Compounds	2011

Article

Year

Distribution and time-course of 4-hydroxynonenal, heat shock protein 110/105 family members and cyclooxygenase-2 expression in the hippocampus of rat during trimethyltin-induced neurodegeneration.

Neurochemical research, 2011, Volume: 36, Issue:8

Trimethyltin (TMT), an organotin compound considered a useful tool to obtain an experimental model of neurodegeneration, exhibits neurotoxicant effects selectively localised in the limbic system and especially in the hippocampus, which are different in the rat and in mice. In the rat hippocampus, we investigated the expression of aldehyde 4-hydroxynonenal, a major bioactive marker of membrane lipid peroxidation, heat shock protein (HSP) 110/105 family members, markers of oxidative stress, and the neuroinflammatory marker cyclooxygenase-2 after TMT-intoxication at various time points after treatment. Our data show that TMT-induced neurodegeneration in the rat hippocampus is associated specifically with oxidative stress and lipid peroxidation, but not with HSP expression, indicating species-specific differences in the neurotoxicity of TMT between rats and mice.

Topics: Aldehydes; Animals; Biomarkers; Cyclooxygenase 2; Cysteine Proteinase Inhibitors; Female; Hippocampus; HSP110 Heat-Shock Proteins; Mice; Nerve Degeneration; Rats; Rats, Wistar; Trimethyltin Compounds

2011