4-hydroxy-2-nonenal has been researched along with malic-acid* in 1 studies
1 other study(ies) available for 4-hydroxy-2-nonenal and malic-acid
| Article | Year |
|---|---|
The cytotoxic lipid peroxidation product, 4-hydroxy-2-nonenal, specifically inhibits decarboxylating dehydrogenases in the matrix of plant mitochondria.
4-Hydroxy-2-nonenal (HNE), a cytotoxic product of lipid peroxidation, inhibits O(2) consumption by potato tuber mitochondria. 2-Oxoglutarate dehydrogenase (OGDC), pyruvate dehydrogenase complex (PDC) (both 80% inhibited) and NAD-malic enzyme (50% inhibited) are its major targets. Mitochondrial proteins identified by reaction with antibodies raised to lipoic acid lost this antigenicity following HNE treatment. These proteins were identified as acetyltransferases of PDC (78 kDa and 55 kDa), succinyltransferases of OGDC (50 kDa and 48 kDa) and glycine decarboxylase H protein (17 kDa). The significance of the effect of these inhibitions on the impact of lipid peroxidation and plant respiratory functions is discussed. Topics: Acyltransferases; Aldehydes; Amino Acid Oxidoreductases; Antibodies; Cell Respiration; Glycine Decarboxylase Complex H-Protein; Glycine Dehydrogenase (Decarboxylating); Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Kinetics; Lipid Peroxidation; Malate Dehydrogenase; Malates; Mitochondria; Molecular Weight; Oxidoreductases; Oxygen; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Solanum tuberosum; Succinic Acid; Thioctic Acid | 2000 |