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4-ethylthymine and thymine

4-ethylthymine has been researched along with thymine in 22 studies

*Thymine: One of four constituent bases of DNA. [MeSH]

*Thymine: One of four constituent bases of DNA. [MeSH]

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199010 (45.45)18.7374
1990's11 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (4.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Eberle, G; Huh, NH; Kang, HI; Konishi, C; Kuroki, T; Rajewsky, MF1
Goldmacher, VS1
Bronstein, SM; Skopek, TR; Swenberg, JA1
Eritja, R; Fernandez-Forner, D; Ikuta, S; Palom, Y; Pedroso, E1
Berns, AJ; Bleeker, MJ; Brugghe, HF; Klein, JC; Lutgerink, JT; van Boom, JH; van den Elst, H; van der Marel, GA; van Dijk, WJ; Westra, JG1
D'Ambrosio, SM; Wani, AA; Wani, G1
Huh, NH; Kuroki, T; Rajewsky, MF; Satoh, MS; Shiga, J1
Duran, HL; Wani, AA1
Rajewsky, MF; Samson, L; Thomale, J1
Huh, N; Kuroki, T; Satoh, MS; Shiga, J1
Annan, R; Fisher, D; Giese, R; Kresbach, G; Minnetian, O; Rogers, E; Saha, M; Vouros, P1
Burns, PA; Glickman, BW; Gordon, AJ; Kunsmann, K1
Bhattacharyya, A; Pal, BC1
Boucheron, J; Deal, F; Richardson, FC; Swenberg, JA; Tyeryar, L1
De Brij, RJ; De Graaf, A; Den Engelse, L; Menkveld, GJ1
Huh, N; Rajewsky, MF1
Huh, N; Kang, H; Konishi, C; Kuroki, T2
Arezina, J; Musarrat, J; Uddin, S; Wani, AA1
Bleeker, MJ; Brugghe, HF; Klein, JC; Kriek, E; Margison, GP; Rafferty, JA; Roelen, HC; van Boom, JH; van den Elst, H; van der Marel, GA1
Dosanjh, MK; Eritja, R; Menichini, P; Singer, B1
Katanić, J; Matić, S; Mihailović, V; Mladenović, M; Solujić, S; Stanić, S; Stanković, N1

Other Studies

22 other study(ies) available for 4-ethylthymine and thymine

ArticleYear
Highly sensitive, specific detection of O6-methylguanine, O4-methylthymine, and O4-ethylthymine by the combination of high-performance liquid chromatography prefractionation, 32P postlabeling, and immunoprecipitation.
    Cancer research, 1992, Oct-01, Volume: 52, Issue:19

    Topics: Chromatography, High Pressure Liquid; DNA; Guanosine; Humans; Hydrolysis; Isotope Labeling; Leukocytes; Liver; Phosphorus Radioisotopes; Precipitin Tests; Sensitivity and Specificity; Thymine; Time Factors

1992
Re: S. M. Bronstein et al. Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells. Cancer Res., 52: 2008-2011, 1992.
    Cancer research, 1992, Dec-15, Volume: 52, Issue:24

    Topics: Cells, Cultured; DNA Repair; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Thymine

1992
Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells.
    Cancer research, 1992, Apr-01, Volume: 52, Issue:7

    Topics: B-Lymphocytes; Cell Line; DNA Repair; Ethylnitrosourea; Guanine; Humans; Kinetics; Methyltransferases; Models, Biological; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidine Dimers; Substrate Specificity; Thymine; Time Factors

1992
Synthesis and characterization of oligodeoxynucleotides containing the mutagenic base analogue 4-O-ethylthymine.
    Nucleic acids research, 1990, Oct-11, Volume: 18, Issue:19

    Topics: Base Sequence; Molecular Sequence Data; Molecular Structure; Mutation; Oligodeoxyribonucleotides; Thymine

1990
Use of shuttle vectors to study the molecular processing of defined carcinogen-induced DNA damage: mutagenicity of single O4-ethylthymine adducts in HeLa cells.
    Nucleic acids research, 1990, Jul-25, Volume: 18, Issue:14

    Topics: Base Sequence; Carcinogens; Cell Line; DNA Damage; DNA Replication; Genetic Vectors; HeLa Cells; Humans; Kinetics; Molecular Sequence Data; Mutagenicity Tests; Mutation; Oligodeoxyribonucleotides; Thymine; Transfection

1990
A human DNA repair activity specific for O4-ethylthymine: identification and partial characterization.
    Carcinogenesis, 1990, Volume: 11, Issue:8

    Topics: Brain; Culture Techniques; DNA Repair; Humans; Kidney; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Thymine

1990
Immunoanalytical detection of O4-ethylthymine in liver DNA of individuals with or without malignant tumors.
    Cancer research, 1989, Jan-01, Volume: 49, Issue:1

    Topics: Adolescent; Adult; Aged; Alkylation; Chromatography, High Pressure Liquid; DNA; Female; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Thymine

1989
Site-specific gap-misrepair mutagenesis by O4-ethylthymine.
    Biochimica et biophysica acta, 1987, Jan-28, Volume: 908, Issue:1

    Topics: Alkyl and Aryl Transferases; Deoxycytosine Nucleotides; DNA Repair; DNA Restriction Enzymes; DNA-Directed DNA Polymerase; Escherichia coli; Mutation; Plasmids; Thymine; Thymine Nucleotides; Transferases

1987
Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair.
    The EMBO journal, 1988, Volume: 7, Issue:7

    Topics: Alkylation; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Guanine; Kinetics; Methylnitrosourea; Mutation; Thymine

1988
Detection of O4-ethylthymine in human liver DNA.
    IARC scientific publications, 1988, Issue:89

    Topics: Deoxyguanosine; DNA; Environmental Monitoring; Humans; Liver; Liver Neoplasms; Radioimmunoassay; Thymine

1988
Pentafluorobenzylation of alkyl and related DNA base adducts facilitates their determination by electrophore detection.
    IARC scientific publications, 1988, Issue:89

    Topics: Alkylation; DNA; Hydrolysis; Mass Spectrometry; Thymine

1988
Influence of neighboring base sequence on the distribution and repair of N-ethyl-N-nitrosourea-induced lesions in Escherichia coli.
    Cancer research, 1988, Aug-15, Volume: 48, Issue:16

    Topics: Base Sequence; DNA Repair; Escherichia coli; Ethylnitrosourea; Guanine; Methylnitronitrosoguanidine; Mutation; Thymine

1988
Preparation of O4-ethylthymine containing synthetic DNA and its possible repair by E. coli extracts.
    Indian journal of biochemistry & biophysics, 1986, Volume: 23, Issue:6

    Topics: DNA; DNA Repair; Escherichia coli; Thymine

1986
The molecular dosimetry of DNA adducts formed by continuous exposure of rats to alkylating hepatocarcinogens.
    Progress in experimental tumor research, 1987, Volume: 31

    Topics: 1,2-Dimethylhydrazine; Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; Dimethylhydrazines; DNA Damage; Guanine; Liver; Rats; Thymine

1987
O2- and O4-ethylthymine and the ethylphosphotriester dTp(Et)dT are highly persistent DNA modifications in slowly dividing tissues of the ethylnitrosourea-treated rat.
    Carcinogenesis, 1987, Volume: 8, Issue:6

    Topics: Animals; Cell Division; Dinucleoside Phosphates; DNA; DNA Damage; Ethylnitrosourea; Kinetics; Male; Rats; Rats, Inbred Strains; Thymine; Thymine Nucleotides; Tissue Distribution

1987
Enzymatic elimination of O6-ethylguanine and stability of O4-ethylthymine in the DNA of malignant neural cell lines exposed to N-ethyl-N-nitrosourea in culture.
    Carcinogenesis, 1986, Volume: 7, Issue:3

    Topics: Animals; Cells, Cultured; Clone Cells; DNA Repair; Ethylnitrosourea; Guanine; Kinetics; Neurons; Rats; Thymine

1986
Detection of O6-methylguanine, O4-methylthymine and O4-ethylthymine in human liver and peripheral blood leukocyte DNA.
    Carcinogenesis, 1995, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Aged; Autopsy; DNA; DNA Adducts; Female; Guanine; Humans; Leukocytes; Liver; Male; Middle Aged; Thymine

1995
Induction and processing of promutagenic O4-ethylthymine lesion in specific gene segments of plasmid DNA.
    Biochimica et biophysica acta, 1995, Feb-21, Volume: 1260, Issue:3

    Topics: Alkylation; DNA Adducts; DNA Damage; DNA Repair; DNA, Recombinant; Escherichia coli; Ethylnitrosourea; Plasmids; Thymine

1995
Role of nucleotide excision repair in processing of O4-alkylthymines in human cells.
    The Journal of biological chemistry, 1994, Oct-14, Volume: 269, Issue:41

    Topics: Alkyl and Aryl Transferases; Base Sequence; DNA Repair; DNA Replication; Fibroblasts; HeLa Cells; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Simian virus 40; Thymine; Transfection; Transferases; Xeroderma Pigmentosum

1994
A highly sensitive and specific method for quantitation of O-alkylated DNA adducts and its application to the analysis of human tissue DNA.
    Environmental health perspectives, 1993, Volume: 99

    Topics: Alkylating Agents; Alkylation; Chromatography, High Pressure Liquid; DNA; DNA Damage; Guanine; Humans; Leukocytes; Phosphorus Radioisotopes; Precipitin Tests; Sensitivity and Specificity; Thymine

1993
Both O4-methylthymine and O4-ethylthymine preferentially form alkyl T.G pairs that do not block in vitro replication in a defined sequence.
    Carcinogenesis, 1993, Volume: 14, Issue:9

    Topics: Adenosine Triphosphate; Base Composition; Base Sequence; Deoxyguanine Nucleotides; DNA Replication; Guanine; Molecular Sequence Data; Oligonucleotide Probes; Thymine

1993
Combining molecular docking and 3-D pharmacophore generation to enclose the in vivo antigenotoxic activity of naturally occurring aromatic compounds: myricetin, quercetin, rutin, and rosmarinic acid.
    Biochemical pharmacology, 2013, Nov-01, Volume: 86, Issue:9

    Topics: Alkylating Agents; Animals; Antimutagenic Agents; Binding Sites; Catalytic Domain; Cinnamates; Depsides; DNA Damage; Drosophila melanogaster; Ethyl Methanesulfonate; Flavonoids; Guanine; Male; Molecular Docking Simulation; Monte Carlo Method; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Quercetin; Rosmarinic Acid; Rutin; Thymine

2013