4-desmethoxyverapamil has been researched along with verapamil in 74 studies
| Studies (4-desmethoxyverapamil) | Trials (4-desmethoxyverapamil) | Recent Studies (post-2010) (4-desmethoxyverapamil) | Studies (verapamil) | Trials (verapamil) | Recent Studies (post-2010) (verapamil) |
|---|---|---|---|---|---|
| 76 | 0 | 1 | 17,621 | 1,527 | 2,067 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (54.05) | 18.7374 |
| 1990's | 31 (41.89) | 18.2507 |
| 2000's | 2 (2.70) | 29.6817 |
| 2010's | 1 (1.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Catterall, WA; Hockerman, GH; Johnson, BD; Scheuer, T | 2 |
| Drímal, J | 1 |
| Catterall, WA; Gartside, CL; Hauschka, SD; Morton, M; Scheuer, T; Sculptoreanu, A | 1 |
| Heym, J; McLean, S; Schmidt, AW | 1 |
| Glossmann, H; Knaus, HG; Staudinger, R | 1 |
| Mironneau, C; Mironneau, J; Rakotoarisoa, L; Sayet, I | 2 |
| Rampe, D; Triggle, DJ; Zheng, W | 1 |
| Koek, L; Melvin, JE; Zhang, GH | 1 |
| Glossmann, H; Mühlbacher, J; Staudinger, R; Zech, C | 1 |
| Bkaily, G; Carrier, D; Jacques, D; Sculptoreanu, A; Sperelakis, N; Vigneault, D; Yamamoto, T | 1 |
| Beaufort, P; Chatelain, P; Clinet, M; Laruel, R; Meysmans, L; Nokin, P | 1 |
| Dacquet, C; Mironneau, C; Mironneau, J; Rakotoarisoa, L; Sayet, I | 1 |
| Butler, BT; Collins, R; Piascik, MT | 1 |
| Glossmann, H; Knaus, HG; Romanin, C; Scheffauer, F; Schindler, HG | 1 |
| Bkaily, G; Jacques, D; Jasmin, G; Peyrow, M; Prochek, L; Sculptoreanu, A; Tautu, C; Yamamoto, T | 1 |
| Hosey, MM; McMahon, KK; Ptasienski, J | 1 |
| Ferry, DR; Glossmann, H; Goll, A; Schober, M; Striessnig, J | 2 |
| Glossmann, H; Goll, A; Moosburger, K; Striessnig, J | 1 |
| Fosset, M; Galizzi, JP; Laduron, P; Lazdunski, M; Romey, G | 1 |
| Barhanin, J; Borsotto, M; Fosset, M; Galizzi, JP; Lazdunski, M; Renaud, JF; Romey, G; Schmid, A | 1 |
| Cornwell, MM; Gottesman, MM; Pastan, I | 1 |
| Cervera, P; Lazdunski, M; Mourre, C | 1 |
| Hofmann, F; Nastainczyk, W; Sieber, M; Wernet, W; Zubor, V | 1 |
| Fosset, M; Galizzi, JP; Lazdunski, M; Qar, J | 1 |
| Glossmann, H; Hymel, L; Schindler, H; Striessnig, J | 1 |
| Guggino, SE; Hester, LD; Sacktor, B; Snowman, AM; Snyder, SH; Wagner, JA | 1 |
| Dillon, JS; Nayler, WG | 1 |
| Holck, M; Osterrieder, W | 1 |
| Donowitz, M; Homaidan, FR; Sharp, GW; Weiland, GA | 1 |
| Dillon, JS; Gu, XH; Nayler, WG | 1 |
| Claessens, MT; Ervasti, JM; Louis, CF; Mickelson, JR | 1 |
| Dillon, JS; Gu, XH; Liu, JJ; Nayler, WG | 1 |
| Frelin, C; Lazdunski, M; Vigne, P | 1 |
| Hudecová, S; Krizanová, O; Orlický, J; Zachar, J | 1 |
| Dacquet, C; Loirand, G; Mironneau, C; Mironneau, J; Pacaud, P; Rakotoarisoa, L; Sayet, I | 1 |
| Carvalho, AP; Carvalho, CM; Leysen, JE; Lima, MP; Oliveira, CR | 1 |
| Atrakchi, AH; Kunysz, E; Michel, AD | 1 |
| Haase, H; Vetter, R; Wallukat, G; Will, H | 1 |
| Glossmann, H; Knaus, HG; Koza, A; Striessnig, J | 1 |
| Garcia, L; Lazdunski, M; Rieger, F; Romey, G | 1 |
| Carmi, R; Rehavi, M; Weizman, A | 1 |
| Barhanin, J; Henning, R; Lazdunski, M; Lerch, U; Oekonomopulos, R; Qar, J; Romey, G; Urbach, H | 1 |
| Flockerzi, V; Hofmann, F; Oeken, J; Ruth, P; von Nettelbladt, E | 1 |
| Fosset, M; Galizzi, JP; Lazdunski, M | 1 |
| Barhanin, J; Borsotto, M; Fosset, M; Galizzi, JP; Lazdunski, M | 1 |
| Flockerzi, V; Hofmann, F; Oeken, HJ; Ruth, P; von Nettelbladt, E; Zimmer, M | 1 |
| Reynolds, IJ; Snowman, AM; Snyder, SH | 1 |
| Barlier, S; Colin, DA; Couraud, F; Dayanithi, G; Kretz-Zaepfel, M; Martin-Moutot, N; Nordmann, JJ | 1 |
| Bkaily, G; Jacques, D; Payet, MD; Sculptoreanu, A; Sperelakis, N; Yamamoto, T | 1 |
| Nawrath, H; Raschack, M | 1 |
| Bradford, HF; White, EJ | 1 |
| Bruns, C; Marmé, D; Osswald, H | 1 |
| Carvalho, AP; Carvalho, CM; Santos, SV | 1 |
| Ferry, DR; Gadow, C; Glossmann, H; Goll, A | 1 |
| Anderson, K; Meissner, G | 1 |
| Carvalho, CM; Lopes, MC; Santos, DL | 1 |
| Daniele, E; Lograno, MD; Pirrelli, A; Vulpis, V | 1 |
| Lombet, A; Spedding, M | 1 |
| Bryce, DK; Desai, MC; Heym, J; Longo, KP; McLean, S; Rosen, T; Schmidt, AW; Snider, RM | 1 |
| Boksa, P; Quirion, R; Sen, AP | 1 |
| Degtiar, VE; Döring, F; Glossman, H; Grabner, M; Hering, S; Striessnig, J | 1 |
| Hagiwara, M; Nagao, T; Shimasue, K; Urushidani, T | 1 |
| Bochkov, VN; Ratner, EI; Tkachuk, VA | 1 |
| Aczel, S; Berjukov, S; Beyer, B; Dichtl, M; Hering, S; Kimball, SD; Striessnig, J | 1 |
| Abu Khoudoud, OR; Bikhazi, AB; Bitar, KM; el-Kasti, MM; Ibrahim, MZ; Kreydiyyeh, SI; Saleh, RS | 1 |
| Adachi-Akahane, S; Hagiwara, M; Nagao, T | 1 |
| Abbott, MR; Catterall, WA; Hockerman, GH; Johnson, BD; Scheuer, T | 1 |
| Kanellopoulos, A; Lenz, G; Mühlbauer, B | 1 |
| El Bardai, S; Hamaide, MC; Lyoussi, B; Morel, N; Quetin-Leclercq, J; Wibo, M | 1 |
| Beyl, S; Guy, RH; Hering, S; Hohaus, A; Kudrnac, M; Stary, A; Timin, EN | 1 |
| Bergson, P; Duban, ME; Hanck, DA; Lee, SP; Lipkind, G | 1 |
74 other study(ies) available for 4-desmethoxyverapamil and verapamil
| Article | Year |
|---|---|
Distinct effects of mutations in transmembrane segment IVS6 on block of L-type calcium channels by structurally similar phenylalkylamines.
Topics: Amino Acid Sequence; Aniline Compounds; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Electrophysiology; Gallopamil; Kinetics; Molecular Sequence Data; Mutation; Protein Structure, Secondary; Structure-Activity Relationship; Verapamil | 1996 |
Modulation of high affinity phenylalkylamine binding sites on cultured human embryonal vascular smooth muscle cells.
Topics: Binding Sites; Calcium Channels; Cells, Cultured; Diltiazem; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Isoproterenol; Kinetics; Magnesium; Muscle, Smooth, Vascular; Potassium; Verapamil | 1992 |
Tetrodotoxin-insensitive sodium channels in a cardiac cell line from a transgenic mouse.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Line; Cell Membrane; Cyclic AMP; Electric Conductivity; Isoproterenol; Kinetics; Membrane Potentials; Mice; Mice, Transgenic; Myocardium; Protein Kinases; Sodium Channels; Tetrodotoxin; Verapamil | 1992 |
The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Brain; Calcium Channels; Diltiazem; Drug Interactions; Guinea Pigs; Heart; Nitrendipine; Radioligand Assay; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Tritium; Verapamil | 1992 |
Positive heterotropic allosteric regulators of dihydropyridine binding increase the Ca2+ affinity of the L-type Ca2+ channel. Stereoselective reversal by the novel Ca2+ antagonist BM 20.1140.
Topics: Alkaloids; Allosteric Regulation; Animals; Benzothiazoles; Benzylisoquinolines; Binding Sites; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cerebral Cortex; Diltiazem; Guinea Pigs; Isomerism; Isradipine; Kinetics; Macromolecular Substances; Models, Theoretical; Muscles; Oxadiazoles; Pyridines; Pyrrolidines; Rabbits; Thiazoles; Verapamil | 1991 |
Guanine nucleotide-binding proteins modulate desmethoxyverapamil binding to calcium channels in vascular smooth muscle.
Topics: Animals; Calcium Channels; GTP-Binding Proteins; Horses; Isometric Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phorbol Esters; Rats; Vasoconstriction; Verapamil | 1991 |
Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Isradipine; Male; Myocardium; Potassium; Pyrroles; Radioligand Assay; Rats; Vasoconstriction; Verapamil | 1991 |
A capacitative Ca2+ influx is required for sustained fluid secretion in sublingual mucous acini.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bumetanide; Calcium; Calcium Channel Blockers; Chlorides; Electric Conductivity; Kinetics; Male; Mouth Mucosa; Potassium; Rats; Sodium; Sublingual Gland; Verapamil | 1991 |
Novel sites for phenylalkylamines: characterisation of a sodium-sensitive drug receptor with (-)-[3H]emopamil.
Topics: Animals; Binding Sites; Cations; Cerebral Cortex; Dihydropyridines; Guinea Pigs; Liver; Male; Receptors, Drug; Tissue Distribution; Tritium; Verapamil | 1991 |
Apamin, a highly potent blocker of the TTX- and Mn2(+)-insensitive fast transient Na+ current in young embryonic heart.
Topics: Action Potentials; Animals; Apamin; Barium; Calcium; Cell Membrane Permeability; Chick Embryo; Electric Conductivity; Heart; Lithium; Manganese; Myocardium; Nifedipine; Sodium; Tetrodotoxin; Verapamil | 1991 |
SR 33557, a novel calcium entry blocker. II. Interactions with 1,4-dihydropyridine, phenylalkylamine and benzothiazepine binding sites in rat heart sarcolemmal membranes.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Indolizines; Isradipine; Male; Myocardium; Oxadiazoles; Phenethylamines; Radioligand Assay; Rats; Rats, Inbred Strains; Sarcolemma; Verapamil | 1990 |
Interactions of spironolactone with (+)-[3H]-isradipine and (-)-[3H]-desmethoxyverapamil binding sites in vascular smooth muscle.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Cell Membrane; Horses; In Vitro Techniques; Isradipine; Ligands; Muscle, Smooth, Vascular; Portal Vein; Progesterone; Pyridines; Spironolactone; Verapamil | 1990 |
Stereoselective and nonstereoselective inhibition exhibited by the enantiomers of verapamil.
Topics: Anesthesia; Animals; Blood Pressure; Brain; Calcium Channels; In Vitro Techniques; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Chloride; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Stereoisomerism; Verapamil | 1990 |
Heparin binds with high affinity to voltage-dependent L-type Ca2+ channels. Evidence for an agonistic action.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Calcium Channels; Carps; Cell Membrane; Cerebral Cortex; Dihydropyridines; Diltiazem; Electric Conductivity; Guinea Pigs; Heparin; Isradipine; Molecular Sequence Data; Muscles; Myocardium; Nicotinic Antagonists; Oxadiazoles; Polyelectrolytes; Polymers; Rabbits; Receptors, Nicotinic; Stereoisomerism; Verapamil | 1990 |
A tetrodotoxin- and Mn2(+)-insensitive Na+ current in Duchenne muscular dystrophy.
Topics: Adolescent; Calcium Channel Blockers; Calcium Channels; Child; Child, Preschool; Culture Techniques; Electrophysiology; Humans; Manganese; Muscles; Muscular Dystrophies; Sodium Channels; Tetrodotoxin; Verapamil | 1990 |
Selective modulation by membrane potential of desmethoxyverapamil binding to calcium channels in rat portal vein.
Topics: Animals; Barium; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Isradipine; Kinetics; Membrane Potentials; Muscle, Smooth, Vascular; Portal Vein; Pyridines; Rats; Strontium; Verapamil | 1990 |
High and low affinity states of the dihydropyridine and phenylalkylamine receptors on the cardiac calcium channel and their interconversion by divalent cations.
Topics: Animals; Calcium; Cations, Divalent; Chickens; Dihydropyridines; Heart; Ion Channels; Isradipine; Magnesium; Myocardium; Nifedipine; Nitrendipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1985 |
Calcium channels: basic properties as revealed by radioligand binding studies.
Topics: Affinity Labels; Animals; Azides; Binding Sites; Binding, Competitive; Brain; Calcium; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Iodobenzenes; Ion Channels; Molecular Weight; Muscles; Neurilemma; Photochemistry; Pyridines; Sarcolemma; Verapamil | 1985 |
Purified calcium channels have three allosterically coupled drug receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Amines; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Guinea Pigs; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1986 |
Neuroleptics of the diphenylbutylpiperidine series are potent calcium channel inhibitors.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Calcium Channel Blockers; Fluspirilene; In Vitro Techniques; Ion Channels; Membrane Potentials; Muscles; Rabbits; Spiro Compounds; Structure-Activity Relationship; Verapamil | 1986 |
Dihydropyridine-sensitive Ca2+ channels: molecular properties of interaction with Ca2+ channel blockers, purification, subunit structure, and differentiation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Affinity Labels; Animals; Bepridil; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Chick Embryo; Cholic Acids; Diltiazem; Ion Channels; Isradipine; Kinetics; Macromolecular Substances; Molecular Weight; Muscles; Myocardial Contraction; Oxadiazoles; Pyridines; Pyrrolidines; Receptors, Nicotinic; Verapamil | 1986 |
Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Carcinoma; Cell Line; Diltiazem; Drug Resistance; Glycoproteins; Humans; Nitrendipine; Quinidine; Verapamil; Vinblastine | 1987 |
Autoradiographic analysis in rat brain of the postnatal ontogeny of voltage-dependent Na+ channels, Ca2+-dependent K+ channels and slow Ca2+ channels identified as receptors for tetrodotoxin, apamin and (-)-desmethoxyverapamil.
Topics: Animals; Autoradiography; Brain; Calcium; Carrier Proteins; Ion Channels; Potassium; Potassium Channels; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Sodium; Sodium Channels; Verapamil | 1987 |
The 165-kDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel.
Topics: Affinity Labels; Animals; Azides; Calcium; Calcium Channels; Dihydropyridines; Ion Channels; Isradipine; Kinetics; Molecular Weight; Muscles; Oxadiazoles; Pyridines; Rabbits; Receptors, Nicotinic; Verapamil | 1987 |
Receptors for diphenylbutylpiperidine neuroleptics in brain, cardiac, and smooth muscle membranes. Relationship with receptors for 1,4-dihydropyridines and phenylalkylamines and with Ca2+ channel blockade.
Topics: Animals; Antipsychotic Agents; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Fluspirilene; In Vitro Techniques; Intracellular Membranes; Ion Channels; Kinetics; Muscle, Smooth; Myocardium; Rabbits; Receptors, Dopamine; Receptors, Nicotinic; Verapamil | 1987 |
Purification and reconstitution of calcium channel drug-receptor sites.
Topics: Affinity Labels; Animals; Azides; Calcium; Calcium Channels; Dihydropyridines; Guinea Pigs; Ion Channels; Muscles; Receptors, Drug; Receptors, Nicotinic; Verapamil | 1988 |
Phenylalkylamine-sensitive calcium channels in osteoblast-like osteosarcoma cells. Characterization by ligand binding and single channel recordings.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Cations, Monovalent; Cell Line; Ion Channels; Kinetics; Membrane Potentials; Osteoblasts; Osteosarcoma; Receptors, Nicotinic; Verapamil | 1988 |
The Ca2+ -antagonist and binding properties of the phenylalkylamine, anipamil.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Chloride; Electric Stimulation; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Propylamines; Rats; Rats, Inbred Strains; Verapamil | 1988 |
In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with potent vasodilator but weak inotropic action.
Topics: Animals; Benzimidazoles; Calcium Channel Blockers; Coronary Circulation; Electric Stimulation; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Mibefradil; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Naphthalenes; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes; Vasodilator Agents; Verapamil | 1989 |
Two calcium channels in basolateral membranes of rabbit ileal epithelial cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Chlorides; Diltiazem; Egtazic Acid; Electric Conductivity; Epithelium; Ileum; Male; Nifedipine; Nitrendipine; Rabbits; Sodium; Verapamil | 1989 |
Effect of age and of hypertrophy on cardiac Ca2+ antagonist binding sites.
Topics: Aging; Animals; Blood Pressure; Body Weight; Calcium Channels; Cardiomegaly; Cell Membrane; Dihydropyridines; Indicators and Reagents; Isradipine; Male; Myocardium; Oxadiazoles; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Nicotinic; Time Factors; Verapamil | 1989 |
Altered transverse tubule dihydropyridine receptor binding in malignant hyperthermia.
Topics: Adenosine Triphosphatases; Animals; Calcium Channels; Kinetics; Malignant Hyperthermia; Muscles; Nitrendipine; Organelles; Ouabain; Receptors, Nicotinic; Reference Values; Sodium-Potassium-Exchanging ATPase; Swine; Swine Diseases; Verapamil | 1989 |
The failure of endothelin to displace bound, radioactively-labelled, calcium antagonists (PN 200/110, D888 and diltiazem).
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Diltiazem; Endothelins; Female; In Vitro Techniques; Isradipine; Oxadiazoles; Peptides; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Verapamil | 1989 |
The inotropic effect of endothelin-1 on rat atria involves hydrolysis of phosphatidylinositol.
Topics: Animals; Cyclic AMP; Endothelins; Endothelium, Vascular; Enzyme Activation; Guinea Pigs; Heart Atria; Humans; Hydrolysis; In Vitro Techniques; Inositol Phosphates; Kinetics; Male; Myocardial Contraction; Peptides; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Inbred Strains; Stimulation, Chemical; Verapamil | 1989 |
Is Ca2+ antagonists binding protein from cytosolic fraction the precursor of alpha 1-subunit of Ca2+ channel?
Topics: Affinity Labels; Animals; Antibodies; Azides; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cytoplasm; Dihydropyridines; In Vitro Techniques; Isradipine; Muscles; Oxadiazoles; Protein Precursors; Rabbits; Radioligand Assay; Receptors, Nicotinic; Ultraviolet Rays; Verapamil | 1989 |
Desmethoxyverapamil-sensitive calcium channels in rat portal vein smooth muscle.
Topics: Animals; Calcium Channels; Diltiazem; In Vitro Techniques; Membranes; Muscle, Smooth, Vascular; Nicardipine; Portal Vein; Rats; Rats, Inbred Strains; Verapamil | 1989 |
Partition of Ca2+ antagonists in brain plasma membranes.
Topics: Animals; Brain; Calcium Channel Blockers; Flunarizine; Kinetics; Liposomes; Nitrendipine; Sheep; Synaptic Membranes; Verapamil | 1989 |
Pharmacology of (-) [3H]D888 (desmethoxyverapamil) binding sites in rat skeletal membranes.
Topics: Animals; Calcium Channels; In Vitro Techniques; Kinetics; Membranes; Muscles; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Verapamil | 1987 |
Characterization of calcium antagonist receptors in highly purified porcine cardiac sarcolemma.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Heart Rate; In Vitro Techniques; Kinetics; Myocardium; Nitrendipine; Receptors, Nicotinic; Sarcolemma; Swine; Verapamil | 1987 |
Neurotoxic aminoglycoside antibiotics are potent inhibitors of [125I]-Omega-Conotoxin GVIA binding to guinea-pig cerebral cortex membranes.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Calcium Channel Blockers; Cerebral Cortex; Guinea Pigs; Mollusk Venoms; Nervous System; omega-Conotoxin GVIA; Receptors, Neurotransmitter; Verapamil | 1987 |
Targets for calcium channel blockers in mammalian skeletal muscle and their respective functions in excitation-contraction coupling.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Evoked Potentials; Isradipine; Mice; Muscle Contraction; Oxadiazoles; Piperidines; Thiazines; Verapamil | 1988 |
Tricyclic antidepressants and calcium channel blockers: interactions at the (-)-desmethoxyverapamil binding site and the serotonin transporter.
Topics: Animals; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Calcium Channels; Imipramine; In Vitro Techniques; Kinetics; Male; Nitrendipine; Rats; Receptors, Nicotinic; Receptors, Serotonin; Serotonin; Verapamil | 1988 |
A novel high affinity class of Ca2+ channel blockers.
Topics: Animals; Bepridil; Binding Sites; Calcium Channel Blockers; Cell Line; Dihydropyridines; Fluspirilene; Isradipine; Kinetics; Muscles; Oxadiazoles; Piperidines; Pyrrolidines; Rabbits; Rats; Structure-Activity Relationship; Thiazines; Verapamil | 1988 |
Characterization of the binding sites for nimodipine and (-)-desmethoxyverapamil in bovine cardiac sarcolemma.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Chloride; Cattle; Diltiazem; Egtazic Acid; In Vitro Techniques; Kinetics; Myocardium; Nicotinic Acids; Nimodipine; Receptors, Nicotinic; Sarcolemma; Tritium; Verapamil | 1985 |
Characterization of the Ca2+ coordination site regulating binding of Ca2+ channel inhibitors d-cis-diltiazem, (+/-)bepridil and (-)desmethoxyverapamil to their receptor site in skeletal muscle transverse tubule membranes.
Topics: Barium; Benzazepines; Bepridil; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Gallopamil; Kinetics; Magnesium; Membranes; Microtubules; Muscles; Pyrrolidines; Receptors, Nicotinic; Strontium; Verapamil | 1985 |
Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes.
Topics: Affinity Labels; Animals; Autoradiography; Benzazepines; Bepridil; Binding, Competitive; Calcium Channels; Diltiazem; Isradipine; Kinetics; Muscles; Oxadiazoles; Photochemistry; Pyrrolidines; Rabbits; Receptors, Nicotinic; Verapamil | 1986 |
Cardiac sarcoplasmic reticulum contains a low-affinity site for phenylalkylamines.
Topics: Amines; Animals; Binding Sites; Binding, Competitive; Calcium; Calcium Channels; Cattle; Chymotrypsin; Egtazic Acid; Myocardium; Phospholipases A; Phospholipases A2; Receptors, Nicotinic; Sarcoplasmic Reticulum; Stereoisomerism; Type C Phospholipases; Verapamil | 1986 |
(-)-[3H] desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyridines.
Topics: Animals; Brain Chemistry; Calcium; Calcium Channels; Cell Membrane; Dihydropyridines; Female; Isradipine; Kinetics; Male; Muscles; Oxadiazoles; Pyridines; Rabbits; Receptors, Nicotinic; Stereoisomerism; Temperature; Tritium; Verapamil | 1986 |
The calcium channel antagonist omega-conotoxin inhibits secretion from peptidergic nerve terminals.
Topics: Animals; Arginine Vasopressin; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Electric Stimulation; In Vitro Techniques; Kinetics; Male; Mollusk Venoms; Nerve Endings; Nicardipine; omega-Conotoxin GVIA; Pituitary Gland, Posterior; Potassium; Rats; Reference Values; Verapamil | 1988 |
Three types of slow inward currents as distinguished by melittin in 3-day-old embryonic heart.
Topics: Animals; Bee Venoms; Chick Embryo; Electrophysiology; Heart; Manganese; Melitten; Sodium; Tetrodotoxin; Verapamil | 1988 |
Effects of (-)-desmethoxyverapamil on heart and vascular smooth muscle.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Cats; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Humans; In Vitro Techniques; Muscle, Smooth, Vascular; Myocardial Contraction; Rats; Rats, Inbred Strains; Stereoisomerism; Tritium; Verapamil | 1987 |
Participation of intracellular sites in the action of Ca2+ channel blockers.
Topics: Amino Acids; Animals; Calcium Channel Blockers; Calcium Radioisotopes; Cerebral Cortex; Gallopamil; In Vitro Techniques; Potassium; Rats; Synaptosomes; Verapamil; Veratrine | 1986 |
Stereospecific inhibition of 5-HT-induced increase of intracellular free calcium by (+)- and (-)-desmethoxyverapamil in human platelets.
Topics: Blood Platelets; Calcium; Humans; In Vitro Techniques; Serotonin; Serotonin Antagonists; Stereoisomerism; Verapamil | 1986 |
gamma-Aminobutyric acid release from synaptosomes as influenced by Ca2+ and Ca2+ channel blockers.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cell Membrane; gamma-Aminobutyric Acid; In Vitro Techniques; Nimodipine; Potassium; Sheep; Sodium; Synaptosomes; Verapamil | 1986 |
(-)-[3H]Desmethoxyverapamil, a novel Ca2+ channel probe. Binding characteristics and target size analysis of its receptor in skeletal muscle.
Topics: Animals; Binding Sites; Calcium; Diltiazem; Guinea Pigs; Ion Channels; Kinetics; Muscles; Nicotinic Acids; Nimodipine; Stereoisomerism; Subcellular Fractions; Verapamil | 1984 |
(-)-3H-desmethoxyverapamil labelling of putative calcium channels in brain: autoradiographic distribution and allosteric coupling to 1,4-dihydropyridine and diltiazem binding sites.
Topics: Animals; Autoradiography; Benzazepines; Binding Sites; Brain; Dihydropyridines; Diltiazem; Guinea Pigs; Hippocampus; In Vitro Techniques; Ion Channels; Kinetics; Membranes; Pyridines; Stereoisomerism; Verapamil | 1984 |
Molecular determinants of high affinity phenylalkylamine block of L-type calcium channels.
Topics: Amino Acid Sequence; Animals; Calcium Channels; Ion Channel Gating; Membrane Glycoproteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Rats; Structure-Activity Relationship; Verapamil | 1995 |
T-tubule depolarization-induced SR Ca2+ release is controlled by dihydropyridine receptor- and Ca(2+)-dependent mechanisms in cell homogenates from rabbit skeletal muscle.
Topics: Animals; Calcium; Calcium Channels, L-Type; Egtazic Acid; Electrophysiology; Isradipine; Microtubules; Muscle Proteins; Muscle, Skeletal; Nifedipine; Rabbits; Sarcoplasmic Reticulum; Verapamil | 1995 |
Calcium channel blockers inhibit the (Ca2+ + Mg2+)-ATPase activity and the 125I-calmodulin binding in brain membranes.
Topics: Animals; Autoradiography; Binding Sites; Brain; Ca(2+) Mg(2+)-ATPase; Calcium Channel Blockers; Calmodulin; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Flunarizine; Iodine Radioisotopes; Nitrendipine; Sheep; Stereoisomerism; Synaptic Membranes; Trifluoperazine; Verapamil | 1994 |
Calcium channels in the vascular smooth muscle of spontaneously hypertensive rats.
Topics: Animals; Aorta, Thoracic; Calcium Channels; Hypertension; In Vitro Techniques; Kinetics; Male; Muscle, Smooth, Vascular; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Verapamil | 1993 |
Differential effects of non-peptidic tachykinin receptor antagonists on Ca2+ channels.
Topics: Animals; Calcium Channels; Dihydropyridines; In Vitro Techniques; Isradipine; Muscles; Rats; Receptors, Tachykinin; Verapamil | 1994 |
CP-99,994, a nonpeptide antagonist of the tachykinin NK1 receptor.
Topics: Albuterol; Animals; Binding, Competitive; Calcium Channels; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; Kinetics; Lung; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Thiorphan; Verapamil | 1993 |
Brain calcium channel related dihydropyridine and phenylalkylamine binding sites in Alzheimer's, Parkinson's and Huntington's diseases.
Topics: Aged; Alzheimer Disease; Autopsy; Binding Sites; Brain; Calcium; Calcium Channels; Dihydropyridines; Female; Humans; Huntington Disease; Isradipine; Male; Middle Aged; Organ Specificity; Parkinson Disease; Reference Values; Verapamil | 1993 |
Transfer of L-type calcium channel IVS6 segment increases phenylalkylamine sensitivity of alpha1A.
Topics: Amino Acid Sequence; Animals; Calcium Channel Blockers; Calcium Channels; Gallopamil; Molecular Sequence Data; Rabbits; Structure-Activity Relationship; Verapamil; Xenopus laevis | 1996 |
Effects of anandamide and arachidonic acid on specific binding of (+) -PN200-110, diltiazem and (-) -desmethoxyverapamil to L-type Ca2+ channel.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Calcium Channels; Diltiazem; Endocannabinoids; Isradipine; Male; Polyunsaturated Alkamides; Rabbits; Verapamil | 1996 |
Comparison of binding of 3H-desmethoxyverapamil and 3H-mibefradil in vascular smooth muscle and heart membranes. Possible binding of mibefradil to a site distinct from the phenylalkylamine-binding site.
Topics: Animals; Benzimidazoles; Binding Sites; Calcium Channel Blockers; Cattle; Humans; In Vitro Techniques; Membranes; Mibefradil; Muscle, Smooth, Vascular; Myocardium; Tetrahydronaphthalenes; Verapamil | 1996 |
Extra- and intracellular action of quaternary devapamil on muscle L-type Ca(2+)-channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Muscle, Smooth, Vascular; Rabbits; Verapamil | 1996 |
Binding and distribution of three prototype calcium channel blockers in perfused rat liver.
Topics: Animals; Azides; Calcium Channel Blockers; Calcium Channels; Carbon Radioisotopes; Dihydropyridines; Inulin; Isradipine; Liver; Models, Biological; Perfusion; Rats; Rats, Sprague-Dawley; Time Factors; Tritium; Urea; Verapamil | 1997 |
High-affinity binding of DTZ323, a novel derivative of diltiazem, to rabbit skeletal muscle L-type Ca++ channels.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Diltiazem; Isradipine; Male; Muscle, Skeletal; Rabbits; Verapamil | 1997 |
Molecular determinants of high affinity phenylalkylamine block of L-type calcium channels in transmembrane segment IIIS6 and the pore region of the alpha1 subunit.
Topics: Action Potentials; Amino Acid Sequence; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Membrane; Cells, Cultured; Glutamine; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Structure-Activity Relationship; Verapamil | 1997 |
Stereoselective differences in the vasorelaxing effects of S(+) and R(-) ketamine on rat isolated aorta.
Topics: Anesthetics, Dissociative; Animals; Aorta; Calcium; Calcium Channel Blockers; Endothelium, Vascular; Glyburide; In Vitro Techniques; Ketamine; Norepinephrine; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vasodilator Agents; Verapamil | 1998 |
Marrubenol interacts with the phenylalkylamine binding site of the L-type calcium channel.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Diterpenes; Furans; Ileum; In Vitro Techniques; Isradipine; Male; Membranes; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Radioligand Assay; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 2004 |
Probing the architecture of an L-type calcium channel with a charged phenylalkylamine: evidence for a widely open pore and drug trapping.
Topics: Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Humans; Ion Channel Gating; Protein Binding; Protein Conformation; Static Electricity; Verapamil | 2007 |
Verapamil block of T-type calcium channels.
Topics: Calcium Channel Blockers; Calcium Channels, T-Type; Dose-Response Relationship, Drug; Extracellular Space; HEK293 Cells; Humans; Membrane Potentials; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Verapamil | 2011 |