Page last updated: 2024-09-02

4-desmethoxyverapamil and imipramine

4-desmethoxyverapamil has been researched along with imipramine in 1 studies

Compound Research Comparison

Studies (4-desmethoxyverapamil)	Trials (4-desmethoxyverapamil)	Recent Studies (post-2010) (4-desmethoxyverapamil)	Studies (imipramine)	Trials (imipramine)	Recent Studies (post-2010) (imipramine)
76	0	1	10,320	1,359	801

Protein Interaction Comparison

Protein	Taxonomy	imipramine (IC50)
Solute carrier family 22 member 2	Homo sapiens (human)	0.6
Solute carrier family 22 member 1	Homo sapiens (human)	7.95
Voltage-dependent L-type calcium channel subunit alpha-1C	Cavia porcellus (domestic guinea pig)	8.3
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	8.3
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	0.044
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)	0.3
Cytochrome P450 2D6	Homo sapiens (human)	0.0051
D(2) dopamine receptor	Homo sapiens (human)	0.41
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	0.044
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	0.16
Sphingomyelin phosphodiesterase	Homo sapiens (human)	5
D	Rattus norvegicus (Norway rat)	2.0992
D(3) dopamine receptor	Rattus norvegicus (Norway rat)	0.81
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	0.044
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	3.3884
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	3.3884
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	3.3884
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	0.16
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	0.074
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	3.3884
D(1B) dopamine receptor	Rattus norvegicus (Norway rat)	0.81
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	0.22
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	0.044
5-hydroxytryptamine receptor 1D	Rattus norvegicus (Norway rat)	0.044
D(4) dopamine receptor	Rattus norvegicus (Norway rat)	0.81
5-hydroxytryptamine receptor 1F	Rattus norvegicus (Norway rat)	0.044
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	0.044
5-hydroxytryptamine receptor 6	Rattus norvegicus (Norway rat)	0.044
Histamine H1 receptor	Rattus norvegicus (Norway rat)	0.0001
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.0074
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	0.81
5-hydroxytryptamine receptor 7	Rattus norvegicus (Norway rat)	0.044
5-hydroxytryptamine receptor 5A	Rattus norvegicus (Norway rat)	0.044
5-hydroxytryptamine receptor 5B	Rattus norvegicus (Norway rat)	0.044
Histamine H1 receptor	Homo sapiens (human)	0.027
Sodium channel protein type 1 subunit alpha	Homo sapiens (human)	3.6
Sodium channel protein type 4 subunit alpha	Homo sapiens (human)	3.6
5-hydroxytryptamine receptor 3A	Rattus norvegicus (Norway rat)	0.044
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	0.16
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	1.9
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	0.81
Sodium channel protein type 7 subunit alpha	Homo sapiens (human)	3.6
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	8.3
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	3.3913
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	8.3
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	8.3
Sodium channel protein type 5 subunit alpha	Homo sapiens (human)	3.6
Sodium channel protein type 9 subunit alpha	Homo sapiens (human)	3.6
5-hydroxytryptamine receptor 4	Rattus norvegicus (Norway rat)	0.044
Multidrug and toxin extrusion protein 1	Homo sapiens (human)	10
Sodium channel protein type 2 subunit alpha	Homo sapiens (human)	3.6
5-hydroxytryptamine receptor 3B	Rattus norvegicus (Norway rat)	0.044
Sodium channel protein type 3 subunit alpha	Homo sapiens (human)	3.6
Solute carrier family 22 member 2	Rattus norvegicus (Norway rat)	9.9
Sodium channel protein type 11 subunit alpha	Homo sapiens (human)	3.6
Sodium channel protein type 8 subunit alpha	Homo sapiens (human)	3.6
Transporter	Rattus norvegicus (Norway rat)	0.81
Sodium channel protein type 10 subunit alpha	Homo sapiens (human)	3.6

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Carmi, R; Rehavi, M; Weizman, A	1

Other Studies

1 other study(ies) available for 4-desmethoxyverapamil and imipramine

Article	Year
Tricyclic antidepressants and calcium channel blockers: interactions at the (-)-desmethoxyverapamil binding site and the serotonin transporter. European journal of pharmacology, 1988, Oct-11, Volume: 155, Issue:1-2 Topics: Animals; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Calcium Channels; Imipramine; In Vitro Techniques; Kinetics; Male; Nitrendipine; Rats; Receptors, Nicotinic; Receptors, Serotonin; Serotonin; Verapamil	1988

Article

Year

Tricyclic antidepressants and calcium channel blockers: interactions at the (-)-desmethoxyverapamil binding site and the serotonin transporter.

European journal of pharmacology, 1988, Oct-11, Volume: 155, Issue:1-2

Topics: Animals; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Calcium Channels; Imipramine; In Vitro Techniques; Kinetics; Male; Nitrendipine; Rats; Receptors, Nicotinic; Receptors, Serotonin; Serotonin; Verapamil

1988