Compounds > 4-desmethoxyverapamil
Page last updated: 2024-09-02

4-desmethoxyverapamil and bepridil

4-desmethoxyverapamil has been researched along with bepridil in 4 studies

Compound Research Comparison

Studies
(4-desmethoxyverapamil)		Trials
(4-desmethoxyverapamil)		Recent Studies (post-2010)
(4-desmethoxyverapamil)		Studies
(bepridil)		Trials
(bepridil)		Recent Studies (post-2010) (bepridil)
76017987094

Protein Interaction Comparison

ProteinTaxonomy4-desmethoxyverapamil (IC50)bepridil (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)1.4
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)1
Lethal factorBacillus anthracis4.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.5184
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)1
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)1.2
Sodium channel protein type 5 subunit alphaHomo sapiens (human)3.7

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19904 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barhanin, J; Borsotto, M; Fosset, M; Galizzi, JP; Lazdunski, M; Renaud, JF; Romey, G; Schmid, A1
Barhanin, J; Henning, R; Lazdunski, M; Lerch, U; Oekonomopulos, R; Qar, J; Romey, G; Urbach, H1
Fosset, M; Galizzi, JP; Lazdunski, M1
Barhanin, J; Borsotto, M; Fosset, M; Galizzi, JP; Lazdunski, M1

Other Studies

4 other study(ies) available for 4-desmethoxyverapamil and bepridil

ArticleYear
Dihydropyridine-sensitive Ca2+ channels: molecular properties of interaction with Ca2+ channel blockers, purification, subunit structure, and differentiation.
    Journal of cardiovascular pharmacology, 1986, Volume: 8 Suppl 8

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Affinity Labels; Animals; Bepridil; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Chick Embryo; Cholic Acids; Diltiazem; Ion Channels; Isradipine; Kinetics; Macromolecular Substances; Molecular Weight; Muscles; Myocardial Contraction; Oxadiazoles; Pyridines; Pyrrolidines; Receptors, Nicotinic; Verapamil

1986
A novel high affinity class of Ca2+ channel blockers.
    Molecular pharmacology, 1988, Volume: 33, Issue:4

    Topics: Animals; Bepridil; Binding Sites; Calcium Channel Blockers; Cell Line; Dihydropyridines; Fluspirilene; Isradipine; Kinetics; Muscles; Oxadiazoles; Piperidines; Pyrrolidines; Rabbits; Rats; Structure-Activity Relationship; Thiazines; Verapamil

1988
Characterization of the Ca2+ coordination site regulating binding of Ca2+ channel inhibitors d-cis-diltiazem, (+/-)bepridil and (-)desmethoxyverapamil to their receptor site in skeletal muscle transverse tubule membranes.
    Biochemical and biophysical research communications, 1985, Oct-15, Volume: 132, Issue:1

    Topics: Barium; Benzazepines; Bepridil; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Gallopamil; Kinetics; Magnesium; Membranes; Microtubules; Muscles; Pyrrolidines; Receptors, Nicotinic; Strontium; Verapamil

1985
Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes.
    The Journal of biological chemistry, 1986, Jan-25, Volume: 261, Issue:3

    Topics: Affinity Labels; Animals; Autoradiography; Benzazepines; Bepridil; Binding, Competitive; Calcium Channels; Diltiazem; Isradipine; Kinetics; Muscles; Oxadiazoles; Photochemistry; Pyrrolidines; Rabbits; Receptors, Nicotinic; Verapamil

1986