4-desacetylvinblastine-3-carboxhydrazide and folic acid

4-desacetylvinblastine-3-carboxhydrazide has been researched along with folic acid in 3 studies

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (66.67)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Howard, SJ; Kleindl, PJ; Leamon, CP; Santhapuram, HK; Stanford, KM; Vlahov, IR	1
Klein, PJ; Leamon, CP; Li, J; LoRusso, P; Messmann, RA; Morgenstern, D; Sausville, EA	1
Diop-Bove, N; Goldman, ID; Zhao, R	1

Trials

1 trial(s) available for 4-desacetylvinblastine-3-carboxhydrazide and folic acid

Article	Year
Clinical pharmacokinetics and exposure-toxicity relationship of a folate-Vinca alkaloid conjugate EC145 in cancer patients. Journal of clinical pharmacology, 2009, Volume: 49, Issue:12 Topics: Adult; Aged; Body Surface Area; Carrier Proteins; Constipation; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Nonlinear Dynamics; Peripheral Nervous System Diseases; Receptors, Cell Surface; Vinblastine; Vinca Alkaloids	2009

Article

Year

Clinical pharmacokinetics and exposure-toxicity relationship of a folate-Vinca alkaloid conjugate EC145 in cancer patients.

Journal of clinical pharmacology, 2009, Volume: 49, Issue:12

Topics: Adult; Aged; Body Surface Area; Carrier Proteins; Constipation; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Nonlinear Dynamics; Peripheral Nervous System Diseases; Receptors, Cell Surface; Vinblastine; Vinca Alkaloids

2009

Other Studies

2 other study(ies) available for 4-desacetylvinblastine-3-carboxhydrazide and folic acid

Article	Year
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide. Bioorganic & medicinal chemistry letters, 2006, Oct-01, Volume: 16, Issue:19 Topics: Antineoplastic Agents; Disulfides; Drug Delivery Systems; Drug Design; Folic Acid; Solubility; Structure-Activity Relationship; Vinblastine	2006
Enhanced receptor-mediated endocytosis and cytotoxicity of a folic acid-desacetylvinblastine monohydrazide conjugate in a pemetrexed-resistant cell line lacking folate-specific facilitative carriers but with increased folate receptor expression. Molecular pharmacology, 2014, Volume: 85, Issue:2 Topics: Antineoplastic Agents; Cells, Cultured; Drug Resistance, Neoplasm; Endocytosis; Folic Acid; Folic Acid Antagonists; Folic Acid Transporters; Glutamates; Guanine; Humans; Pemetrexed; Proton-Coupled Folate Transporter; Vinblastine	2014

Article

Year

Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide.

Bioorganic & medicinal chemistry letters, 2006, Oct-01, Volume: 16, Issue:19

Topics: Antineoplastic Agents; Disulfides; Drug Delivery Systems; Drug Design; Folic Acid; Solubility; Structure-Activity Relationship; Vinblastine

2006

Enhanced receptor-mediated endocytosis and cytotoxicity of a folic acid-desacetylvinblastine monohydrazide conjugate in a pemetrexed-resistant cell line lacking folate-specific facilitative carriers but with increased folate receptor expression.

Molecular pharmacology, 2014, Volume: 85, Issue:2

Topics: Antineoplastic Agents; Cells, Cultured; Drug Resistance, Neoplasm; Endocytosis; Folic Acid; Folic Acid Antagonists; Folic Acid Transporters; Glutamates; Guanine; Humans; Pemetrexed; Proton-Coupled Folate Transporter; Vinblastine

2014