Compounds > 4-cyano-1-(2-4-dichlorophenyl)-5-(4-methoxyphenyl)-n-(piperidin-1-yl)-1h-pyrazole-3-carboxamide

4-cyano-1-(2-4-dichlorophenyl)-5-(4-methoxyphenyl)-n-(piperidin-1-yl)-1h-pyrazole-3-carboxamide and aniline

4-cyano-1-(2-4-dichlorophenyl)-5-(4-methoxyphenyl)-n-(piperidin-1-yl)-1h-pyrazole-3-carboxamide has been researched along with aniline* in 1 studies

Other Studies

1 other study(ies) available for 4-cyano-1-(2-4-dichlorophenyl)-5-(4-methoxyphenyl)-n-(piperidin-1-yl)-1h-pyrazole-3-carboxamide and aniline

Article	Year
A new high-yield synthetic route to PET CB1 radioligands [11C]OMAR and its analogs. Bioorganic & medicinal chemistry letters, 2012, Jun-01, Volume: 22, Issue:11 OMAR analogs reference standards and their corresponding desmethylated precursors were synthesized from substituted anilines either in 4 and 5 steps with 27-32% and 24-31% yield, or in 3 and 4 steps with 21-30% and 19-28% yield, respectively. [(11)C]OMAR and its analog radioligands were prepared from their desmethylated precursors with [(11)C]CH(3)OTf through O-[(11)C]methylation and isolated by HPLC combined with solid-phase extraction (SPE) in 50-65% radiochemical yields based on [(11)C]CO(2) and decay corrected to end of bombardment (EOB), with 370-740 GBq/μmol specific activity at EOB. Topics: Aniline Compounds; Animals; Brain; Carbon Radioisotopes; Humans; Isotope Labeling; Ligands; Piperidines; Positron-Emission Tomography; Pyrazoles; Radiopharmaceuticals; Receptor, Cannabinoid, CB1; Structure-Activity Relationship	2012

Article

Year

A new high-yield synthetic route to PET CB1 radioligands [11C]OMAR and its analogs.

Bioorganic & medicinal chemistry letters, 2012, Jun-01, Volume: 22, Issue:11

OMAR analogs reference standards and their corresponding desmethylated precursors were synthesized from substituted anilines either in 4 and 5 steps with 27-32% and 24-31% yield, or in 3 and 4 steps with 21-30% and 19-28% yield, respectively. [(11)C]OMAR and its analog radioligands were prepared from their desmethylated precursors with [(11)C]CH(3)OTf through O-[(11)C]methylation and isolated by HPLC combined with solid-phase extraction (SPE) in 50-65% radiochemical yields based on [(11)C]CO(2) and decay corrected to end of bombardment (EOB), with 370-740 GBq/μmol specific activity at EOB.

Topics: Aniline Compounds; Animals; Brain; Carbon Radioisotopes; Humans; Isotope Labeling; Ligands; Piperidines; Positron-Emission Tomography; Pyrazoles; Radiopharmaceuticals; Receptor, Cannabinoid, CB1; Structure-Activity Relationship

2012