Page last updated: 2024-08-22

4-chlorophenylbiguanide and cycloguanil

4-chlorophenylbiguanide has been researched along with cycloguanil in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19904 (22.22)18.7374
1990's9 (50.00)18.2507
2000's3 (16.67)29.6817
2010's2 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cichero, E; Espinoza, S; Gainetdinov, RR; Tonelli, M1
Cichero, E; Costi, MP; Gazzarrini, S; Loddo, R; Moroni, A; Naesens, L; Santucci, M; Tasso, B; Tonelli, M1
Moody, RR; Ochekpe, NA; Taylor, RB1
Bygbjerg, I; Flachs, H; Hvidberg, EF; Ravn, P; Rønn, A1
Chulay, JD; Sixsmith, DG; Watkins, WM1
Moody, RR; Selkirk, AB; Taylor, RB1
Chiba, K; Darmansjah, I; Ishizaki, T; Kusaka, M; Setiabudy, R1
Breckenridge, AM; Edwards, G; Helsby, NA; Ward, SA1
Brøsen, K; Flachs, H; Skjelbo, E1
Moody, RR; Nosten, F; Taylor, RB; ter Kuile, F; Wangboonskul, J; White, NJ1
Chiba, K; Ishizaki, T; Kusaka, M; Setiabudy, R1
Kolawole, JA; Moody, RR; Taylor, RB1
Brøsen, K; Jeppesen, U; Rasmussen, BB1
Bergqvist, Y; Funding, L; Krysèn, B; Leek, T; Yvell, K1
Bergqvist, Y; Funding, L; Kaneko, A; Krysén, B; Leek, T1
Low, AS; Reid, RG; Taylor, RB1
Gross, AS; Hoskins, JM; Shenfield, GM1
Charman, WN; Chiu, FC; Leveque, NL1

Trials

2 trial(s) available for 4-chlorophenylbiguanide and cycloguanil

ArticleYear
Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide.
    Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:3

    Topics: Administration, Oral; Adult; Antimetabolites; Aryl Hydrocarbon Hydroxylases; Biguanides; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Fluvoxamine; Folic Acid Antagonists; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Proguanil; Selective Serotonin Reuptake Inhibitors; Triazines

1997
Concordance between proguanil phenotype and CYP2C19 genotype in Chinese.
    European journal of clinical pharmacology, 2003, Volume: 59, Issue:8-9

    Topics: Adult; Alleles; Antimetabolites; Aryl Hydrocarbon Hydroxylases; Asian People; Biguanides; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Mixed Function Oxygenases; Phenotype; Proguanil; Triazines

2003

Other Studies

16 other study(ies) available for 4-chlorophenylbiguanide and cycloguanil

ArticleYear
Novel biguanide-based derivatives scouted as TAAR1 agonists: Synthesis, biological evaluation, ADME prediction and molecular docking studies.
    European journal of medicinal chemistry, 2017, Feb-15, Volume: 127

    Topics: Absorption, Physicochemical; Animals; Biguanides; Chemistry Techniques, Synthetic; Computer Simulation; Drug Design; Humans; Mice; Molecular Docking Simulation; Protein Conformation; Receptors, G-Protein-Coupled; Structure-Activity Relationship

2017
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.
    European journal of medicinal chemistry, 2017, Jul-28, Volume: 135

    Topics: Antiviral Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Influenza A Virus, H1N1 Subtype; Influenza B virus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Proguanil; Respiratory Syncytial Viruses; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines

2017
Determination of proguanil and its metabolites cycloguanil and 4-chlorophenylbiguanide in plasma, whole blood and urine by high-performance liquid chromatography.
    Journal of chromatography, 1987, May-15, Volume: 416, Issue:2

    Topics: Biguanides; Chromatography, High Pressure Liquid; Humans; Kinetics; Proguanil; Triazines

1987
Human pharmacokinetics of proguanil and its metabolites.
    Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1987, Volume: 38, Issue:2

    Topics: Adult; Biguanides; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Erythrocytes; Female; Half-Life; Humans; Kinetics; Male; Proguanil; Triazines

1987
The activity of proguanil and its metabolites, cycloguanil and p-chlorophenylbiguanide, against Plasmodium falciparum in vitro.
    Annals of tropical medicine and parasitology, 1984, Volume: 78, Issue:3

    Topics: Animals; Biguanides; Chloroquine; Microbial Sensitivity Tests; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines

1984
High-performance liquid chromatography of proguanil, cycloguanil and 4-chlorophenylbiguanide using hydrophobic pairing ion and its application to serum assay.
    Journal of chromatography, 1980, Jun-13, Volume: 182, Issue:3-4

    Topics: Animals; Biguanides; Cattle; Chromatography, High Pressure Liquid; Humans; Proguanil; Surface-Active Agents; Triazines

1980
Metabolic disposition of proguanil in extensive and poor metabolisers of S-mephenytoin 4'-hydroxylation recruited from an Indonesian population.
    British journal of clinical pharmacology, 1995, Volume: 39, Issue:3

    Topics: Adult; Biguanides; Chromatography, High Pressure Liquid; Cohort Studies; Female; Half-Life; Humans; Hydroxylation; Indonesia; Male; Mephenytoin; Middle Aged; Polymorphism, Genetic; Proguanil; Regression Analysis; Triazines

1995
The multiple dose pharmacokinetics of proguanil.
    British journal of clinical pharmacology, 1993, Volume: 35, Issue:6

    Topics: Adult; Biguanides; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Female; Humans; Male; Polymorphism, Genetic; Proguanil; Triazines

1993
Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark.
    British journal of clinical pharmacology, 1993, Volume: 36, Issue:2

    Topics: Administration, Oral; Adult; Biguanides; Denmark; Female; Humans; Male; Mephenytoin; Middle Aged; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Proguanil; Sparteine; Triazines; Vietnam

1993
Single dose pharmacokinetics of proguanil and its metabolites in pregnancy.
    European journal of clinical pharmacology, 1993, Volume: 44, Issue:3

    Topics: Biguanides; Female; Humans; Malaria; Male; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Trimester, Third; Proguanil; Triazines

1993
Simultaneous measurement of proguanil and its metabolites in human plasma and urine by reversed-phase high-performance liquid chromatography, and its preliminary application in relation to genetically determined S-mephenytoin 4'-hydroxylation status.
    The American journal of tropical medicine and hygiene, 1996, Volume: 54, Issue:2

    Topics: Adult; Antimalarials; Biguanides; Chromatography, High Pressure Liquid; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Phenotype; Proguanil; Triazines

1996
Determination of proguanil and metabolites in small sample volumes of whole blood stored on filter paper by high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical applications, 1995, Dec-01, Volume: 674, Issue:1

    Topics: Antimalarials; Biguanides; Blood Specimen Collection; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Humans; Proguanil; Triazines

1995
Improved validated assay for the determination of proguanil and its metabolites in plasma, whole blood, and urine using solid-phase extraction and high-performance liquid chromatography.
    Therapeutic drug monitoring, 1998, Volume: 20, Issue:3

    Topics: Antimalarials; Biguanides; Biological Assay; Chromatography, High Pressure Liquid; Drug Monitoring; Folic Acid Antagonists; Humans; Proguanil; Reproducibility of Results; Sensitivity and Specificity; Triazines

1998
Improved method for the simultaneous determination of proguanil and its metabolites by high-performance liquid chromatography and solid-phase extraction of 100-microl capillary blood samples dried on sampling paper.
    Journal of chromatography. B, Biomedical sciences and applications, 1998, Nov-20, Volume: 719, Issue:1-2

    Topics: Antimalarials; Biguanides; Capillaries; Chromatography, High Pressure Liquid; Humans; Paper; Proguanil; Reproducibility of Results; Sensitivity and Specificity; Triazines

1998
Analysis of proguanil and its metabolites by application of the sweeping technique in micellar electrokinetic chromatography.
    Journal of chromatography. A, 2001, May-04, Volume: 916, Issue:1-2

    Topics: Biguanides; Chromatography, Micellar Electrokinetic Capillary; Proguanil; Sensitivity and Specificity; Triazines

2001
Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography-mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Jan-18, Volume: 830, Issue:2

    Topics: Administration, Oral; Animals; Antimalarials; Biguanides; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Freezing; Injections, Intravenous; Proguanil; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Triazines

2006