4-chlorophenylbiguanide has been researched along with biguanides in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 10 (58.82) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moody, RR; Ochekpe, NA; Taylor, RB | 1 |
| Bygbjerg, I; Flachs, H; Hvidberg, EF; Ravn, P; Rønn, A | 1 |
| Chulay, JD; Sixsmith, DG; Watkins, WM | 1 |
| Moody, RR; Selkirk, AB; Taylor, RB | 1 |
| Chiba, K; Darmansjah, I; Ishizaki, T; Kusaka, M; Setiabudy, R | 1 |
| Breckenridge, AM; Edwards, G; Helsby, NA; Ward, SA | 1 |
| Brøsen, K; Flachs, H; Skjelbo, E | 1 |
| Moody, RR; Nosten, F; Taylor, RB; ter Kuile, F; Wangboonskul, J; White, NJ | 1 |
| Chiba, K; Ishizaki, T; Kusaka, M; Setiabudy, R | 1 |
| Kolawole, JA; Moody, RR; Taylor, RB | 1 |
| Brøsen, K; Jeppesen, U; Rasmussen, BB | 1 |
| Bergqvist, Y; Funding, L; Krysèn, B; Leek, T; Yvell, K | 1 |
| Deckel, AW; Fuqua, L | 1 |
| Bergqvist, Y; Funding, L; Kaneko, A; Krysén, B; Leek, T | 1 |
| Low, AS; Reid, RG; Taylor, RB | 1 |
| Gross, AS; Hoskins, JM; Shenfield, GM | 1 |
| Charman, WN; Chiu, FC; Leveque, NL | 1 |
2 trial(s) available for 4-chlorophenylbiguanide and biguanides
| Article | Year |
|---|---|
Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide.
Topics: Administration, Oral; Adult; Antimetabolites; Aryl Hydrocarbon Hydroxylases; Biguanides; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Fluvoxamine; Folic Acid Antagonists; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Proguanil; Selective Serotonin Reuptake Inhibitors; Triazines | 1997 |
Concordance between proguanil phenotype and CYP2C19 genotype in Chinese.
Topics: Adult; Alleles; Antimetabolites; Aryl Hydrocarbon Hydroxylases; Asian People; Biguanides; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Mixed Function Oxygenases; Phenotype; Proguanil; Triazines | 2003 |
15 other study(ies) available for 4-chlorophenylbiguanide and biguanides
| Article | Year |
|---|---|
Determination of proguanil and its metabolites cycloguanil and 4-chlorophenylbiguanide in plasma, whole blood and urine by high-performance liquid chromatography.
Topics: Biguanides; Chromatography, High Pressure Liquid; Humans; Kinetics; Proguanil; Triazines | 1987 |
Human pharmacokinetics of proguanil and its metabolites.
Topics: Adult; Biguanides; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Erythrocytes; Female; Half-Life; Humans; Kinetics; Male; Proguanil; Triazines | 1987 |
The activity of proguanil and its metabolites, cycloguanil and p-chlorophenylbiguanide, against Plasmodium falciparum in vitro.
Topics: Animals; Biguanides; Chloroquine; Microbial Sensitivity Tests; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1984 |
High-performance liquid chromatography of proguanil, cycloguanil and 4-chlorophenylbiguanide using hydrophobic pairing ion and its application to serum assay.
Topics: Animals; Biguanides; Cattle; Chromatography, High Pressure Liquid; Humans; Proguanil; Surface-Active Agents; Triazines | 1980 |
Metabolic disposition of proguanil in extensive and poor metabolisers of S-mephenytoin 4'-hydroxylation recruited from an Indonesian population.
Topics: Adult; Biguanides; Chromatography, High Pressure Liquid; Cohort Studies; Female; Half-Life; Humans; Hydroxylation; Indonesia; Male; Mephenytoin; Middle Aged; Polymorphism, Genetic; Proguanil; Regression Analysis; Triazines | 1995 |
The multiple dose pharmacokinetics of proguanil.
Topics: Adult; Biguanides; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Female; Humans; Male; Polymorphism, Genetic; Proguanil; Triazines | 1993 |
Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark.
Topics: Administration, Oral; Adult; Biguanides; Denmark; Female; Humans; Male; Mephenytoin; Middle Aged; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Proguanil; Sparteine; Triazines; Vietnam | 1993 |
Single dose pharmacokinetics of proguanil and its metabolites in pregnancy.
Topics: Biguanides; Female; Humans; Malaria; Male; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Trimester, Third; Proguanil; Triazines | 1993 |
Simultaneous measurement of proguanil and its metabolites in human plasma and urine by reversed-phase high-performance liquid chromatography, and its preliminary application in relation to genetically determined S-mephenytoin 4'-hydroxylation status.
Topics: Adult; Antimalarials; Biguanides; Chromatography, High Pressure Liquid; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Phenotype; Proguanil; Triazines | 1996 |
Determination of proguanil and metabolites in small sample volumes of whole blood stored on filter paper by high-performance liquid chromatography.
Topics: Antimalarials; Biguanides; Blood Specimen Collection; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Humans; Proguanil; Triazines | 1995 |
Improved validated assay for the determination of proguanil and its metabolites in plasma, whole blood, and urine using solid-phase extraction and high-performance liquid chromatography.
Topics: Antimalarials; Biguanides; Biological Assay; Chromatography, High Pressure Liquid; Drug Monitoring; Folic Acid Antagonists; Humans; Proguanil; Reproducibility of Results; Sensitivity and Specificity; Triazines | 1998 |
Effects of serotonergic drugs on lateralized aggression and aggressive displays in Anolis carolinensis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Biguanides; Functional Laterality; Lizards; Male; Posture; Quipazine; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Receptor Agonists | 1998 |
Improved method for the simultaneous determination of proguanil and its metabolites by high-performance liquid chromatography and solid-phase extraction of 100-microl capillary blood samples dried on sampling paper.
Topics: Antimalarials; Biguanides; Capillaries; Chromatography, High Pressure Liquid; Humans; Paper; Proguanil; Reproducibility of Results; Sensitivity and Specificity; Triazines | 1998 |
Analysis of proguanil and its metabolites by application of the sweeping technique in micellar electrokinetic chromatography.
Topics: Biguanides; Chromatography, Micellar Electrokinetic Capillary; Proguanil; Sensitivity and Specificity; Triazines | 2001 |
Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography-mass spectrometry.
Topics: Administration, Oral; Animals; Antimalarials; Biguanides; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Freezing; Injections, Intravenous; Proguanil; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Triazines | 2006 |