Compounds > 4-chlorokynurenine
Page last updated: 2024-09-05

4-chlorokynurenine and glycine

4-chlorokynurenine has been researched along with glycine in 3 studies

Compound Research Comparison

Studies
(4-chlorokynurenine)		Trials
(4-chlorokynurenine)		Recent Studies (post-2010)
(4-chlorokynurenine)		Studies
(glycine)		Trials
(glycine)		Recent Studies (post-2010) (glycine)
131635,1637568,415

Protein Interaction Comparison

ProteinTaxonomy4-chlorokynurenine (IC50)glycine (IC50)
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)1.4852
Sodium- and chloride-dependent glycine transporter 1Homo sapiens (human)106
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)0.3253
Sodium- and chloride-dependent glycine transporter 2Homo sapiens (human)128

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Baron, BM; Guidetti, P; McDonald, IA; Palfreyman, MG; Salituro, FG; Schmidt, W; Schwarcz, R; Tomlinson, RC; Wu, HQ1
Can, A; Dell, MJ; Gould, TD; Piantadosi, SC; Pribut, HJ; Schwarcz, R; Snodgrass, HR; Wu, HQ; Zanos, P; Zarate, CA1
Adeojo, LW; Evans, JW; Farmer, CA; George, JM; Gould, TD; Greenstein, D; Henter, ID; Kadriu, B; Machado-Vieira, R; Mannes, AJ; Oppenheimer, M; Park, LT; Smith, MA; Snodgrass, HR; Yuan, P; Zanos, P; Zarate, CA1

Trials

1 trial(s) available for 4-chlorokynurenine and glycine

ArticleYear
A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression.
    The international journal of neuropsychopharmacology, 2020, 07-29, Volume: 23, Issue:7

    Topics: Adolescent; Adult; Aged; Animals; Antidepressive Agents; Brain; Brain Chemistry; Cross-Over Studies; Depressive Disorder, Treatment-Resistant; Double-Blind Method; Female; Glycine; Humans; Kynurenine; Magnetic Resonance Imaging; Male; Mice; Middle Aged; Prodrugs; Psychiatric Status Rating Scales; Receptors, N-Methyl-D-Aspartate; Treatment Outcome; Young Adult

2020

Other Studies

2 other study(ies) available for 4-chlorokynurenine and glycine

ArticleYear
Enzyme-activated antagonists of the strychnine-insensitive glycine/NMDA receptor.
    Journal of medicinal chemistry, 1994, Feb-04, Volume: 37, Issue:3

    Topics: Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Chromatography, High Pressure Liquid; Cyclization; Glycine; Kinetics; Kynurenine; Lyases; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine; Transaminases

1994
The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition.
    The Journal of pharmacology and experimental therapeutics, 2015, Volume: 355, Issue:1

    Topics: Animals; Behavior, Animal; Conditioning, Psychological; Depressive Disorder, Major; Glycine; Hindlimb Suspension; Ketamine; Kynurenine; Male; Mice; Microdialysis; Prodrugs; Receptors, N-Methyl-D-Aspartate; Swimming

2015