Compounds > 4-chlorokynurenine
Page last updated: 2024-09-05

4-chlorokynurenine and 7-chlorokynurenic acid

4-chlorokynurenine has been researched along with 7-chlorokynurenic acid in 5 studies

Compound Research Comparison

Studies
(4-chlorokynurenine)		Trials
(4-chlorokynurenine)		Recent Studies (post-2010)
(4-chlorokynurenine)		Studies
(7-chlorokynurenic acid)		Trials
(7-chlorokynurenic acid)		Recent Studies (post-2010) (7-chlorokynurenic acid)
1316246017

Protein Interaction Comparison

ProteinTaxonomy4-chlorokynurenine (IC50)7-chlorokynurenic acid (IC50)
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)0.48
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)0.48
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)0.48
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)0.48
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)0.48
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)0.48
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)0.48

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hokari, M; Schwarcz, R; Smith, QR; Wu, HQ1
Lee, SC; Schwarcz, R; Wu, HQ1
Guidetti, P; Schwarcz, R; Wu, HQ1
Lee, SC; Schwarcz, R1
Schwarcz, R; Snodgrass, HR; Yaksh, TL1

Other Studies

5 other study(ies) available for 4-chlorokynurenine and 7-chlorokynurenic acid

ArticleYear
Facilitated brain uptake of 4-chlorokynurenine and conversion to 7-chlorokynurenic acid.
    Neuroreport, 1996, Dec-20, Volume: 8, Issue:1

    Topics: Amino Acids; Animals; Biotransformation; Brain; Excitatory Amino Acid Antagonists; Kynurenic Acid; Kynurenine; Male; Perfusion; Prodrugs; Rats; Rats, Sprague-Dawley

1996
Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus.
    European journal of pharmacology, 2000, Mar-03, Volume: 390, Issue:3

    Topics: Animals; Brain Diseases; Dialysis Solutions; Hippocampus; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Microdialysis; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley

2000
In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum.
    Experimental neurology, 2000, Volume: 163, Issue:1

    Topics: 3-Hydroxyanthranilic Acid; Animals; Biotransformation; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Infusions, Parenteral; Kynurenic Acid; Kynurenine; Male; Malonates; Neurons; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glycine

2000
Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo.
    Neuroscience letters, 2001, May-25, Volume: 304, Issue:3

    Topics: Animals; Corpus Striatum; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Osmolar Concentration; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley

2001
Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.
    The journal of pain, 2017, Volume: 18, Issue:10

    Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Kynurenic Acid; Kynurenine; Male; Prodrugs; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord

2017