4-chloro-3-hydroxyanthranilic acid has been researched along with 3-hydroxyanthranilic acid in 19 studies
*3-Hydroxyanthranilic Acid: An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen. [MeSH]
*3-Hydroxyanthranilic Acid: An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen. [MeSH]
| Studies (4-chloro-3-hydroxyanthranilic acid) | Trials (4-chloro-3-hydroxyanthranilic acid) | Recent Studies (post-2010) (4-chloro-3-hydroxyanthranilic acid) | Studies (3-hydroxyanthranilic acid) | Trials (3-hydroxyanthranilic acid) | Recent Studies (post-2010) (3-hydroxyanthranilic acid) |
|---|---|---|---|---|---|
| 20 | 0 | 2 | 352 | 2 | 67 |
| Protein | Taxonomy | 4-chloro-3-hydroxyanthranilic acid (IC50) | 3-hydroxyanthranilic acid (IC50) |
|---|---|---|---|
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | 21.17 | |
| large T antigen | Betapolyomavirus macacae | 20.09 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 11 (57.89) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heyes, MP; Ji, XD; Nishimura, M | 1 |
| Carpenter, BK; Schwarcz, R; Todd, WP; Walsh, JL | 1 |
| Baran, H; Schwarcz, R | 1 |
| Cook, JS; Pogson, CI | 1 |
| Krieter, P; Parli, CJ; Schmidt, B | 1 |
| Chen, CY; Heyes, MP; Markey, SP; Naritsin, DB; Saito, K | 1 |
| Blight, AR; Cohen, TI; Heyes, MP; Saito, K | 1 |
| Heyes, MP; Markey, SP; Saito, K | 1 |
| Schwarcz, R; Ungerstedt, U; Walsh, JL; Wu, HQ | 1 |
| Heyes, MP; Major, EO; Markey, SP; Milstien, S; Saito, K; Vickers, JH | 1 |
| Chen, CY; Crowley, JS; Heyes, MP; Markey, SP; Masana, M; Saito, K | 1 |
| Heyes, MP | 1 |
| Heyes, MP; Markey, SP; Noma, A; Saito, K; Seishima, M; Suyama, K | 1 |
| Guidetti, P; Schwarcz, R; Wu, HQ | 1 |
| Lehrmann, E; Molinari, A; Schwarcz, R; Speciale, C | 1 |
| Begley, TP; Colabroy, KL; Ealick, SE; Ge, Y; Li, T; Liu, A; McLafferty, FW; Zhai, H; Zhang, Y | 1 |
| Begley, TP; Colabroy, KL; Ealick, SE; Zhang, Y | 1 |
| Blight, AR; Heyes, MP; Yates, JR | 1 |
| Blight, AR; Gay, EA; Heyes, MP; Yates, JR | 1 |
1 review(s) available for 4-chloro-3-hydroxyanthranilic acid and 3-hydroxyanthranilic acid
| Article | Year |
|---|---|
The kynurenine pathway and neurologic disease. Therapeutic strategies.
Topics: 3-Hydroxyanthranilic Acid; Animals; Gerbillinae; Guinea Pigs; Humans; Kynurenine; Macrophage Activation; Mice; Nervous System Diseases; Neurotoxins; Primates; Quinolinic Acid; Rats; Spinal Cord; Spinal Cord Injuries | 1996 |
18 other study(ies) available for 4-chloro-3-hydroxyanthranilic acid and 3-hydroxyanthranilic acid
| Article | Year |
|---|---|
Non-competitive inhibition of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilic acid in whole brain of rat.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Brain; Dioxygenases; Kinetics; Oxygenases; Rats | 1991 |
4-halo-3-hydroxyanthranilic acids: potent competitive inhibitors of 3-hydroxy-anthranilic acid oxygenase in vitro.
Topics: 3-Hydroxyanthranilic Acid; Animals; Kinetics; Liver; Models, Chemical; Oxidoreductases; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
Presence of 3-hydroxyanthranilic acid in rat tissues and evidence for its production from anthranilic acid in the brain.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Kidney; Kinetics; Male; ortho-Aminobenzoates; Oxidoreductases; Rats; Rats, Inbred Strains; Spleen; Tissue Distribution | 1990 |
Tryptophan and glucose metabolism in rat liver cells. The effects of DL-6-chlorotryptophan, 4-chloro-3-hydroxyanthranilate and pyrazinamide.
Topics: 3-Hydroxyanthranilic Acid; Animals; Gluconeogenesis; In Vitro Techniques; Liver; Male; ortho-Aminobenzoates; Pyrazinamide; Rats; Rats, Inbred Strains; Tryptophan | 1983 |
Metabolism of 6-chlorotryptophan to 4-chloro-3-hydroxyanthranilic acid: a potent inhibitor of 3-hydroxyanthranilic acid oxidase.
Topics: 3-Hydroxyanthranilic Acid; Animals; Guinea Pigs; Kinetics; Liver; Male; ortho-Aminobenzoates; Oxidoreductases; Rats; Sweetening Agents; Tryptophan | 1980 |
Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Cell Line; Central Nervous System; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Lyases; Macaca mulatta; Quinolinic Acid; Transaminases; Tryptophan | 1995 |
Quinolinic acid accumulation and functional deficits following experimental spinal cord injury.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Dioxygenases; Evoked Potentials, Somatosensory; Female; Guinea Pigs; Macrophage Activation; Myelitis; Oxygenases; Quinolinic Acid; Reflex, Abnormal; Silicon Dioxide; Spinal Cord Compression; Spinal Cord Injuries | 1995 |
6-Chloro-D,L-tryptophan, 4-chloro-3-hydroxyanthranilate and dexamethasone attenuate quinolinic acid accumulation in brain and blood following systemic immune activation.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Dexamethasone; Immune System; Kynurenine; Lung; Male; Mice; Mice, Inbred C57BL; Pokeweed Mitogens; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1994 |
4-Chloro-3-hydroxyanthranilate inhibits quinolinate production in the rat hippocampus in vivo.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Dioxygenases; Dose-Response Relationship, Drug; Extracellular Space; Hippocampus; Male; Microdialysis; Oxygenases; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 1994 |
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biopterins; Brain; Encephalitis; Fetus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Macaca mulatta; Myelitis; Neopterin; Poliomyelitis; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1993 |
4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Carbolines; Cell Line; Harmine; Humans; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Macrophages; Quinolinic Acid; Rats; Tryptophan; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
4-chloro-3-hydroxyanthranilate attenuate quinolinic acid accumulation in brain following transient cerebral ischemia in the gerbil.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Dexamethasone; Female; Gerbillinae; Ischemic Attack, Transient; Kynurenine; Organ Specificity; Quinolinic Acid; Reference Values; Tryptophan Oxygenase | 1996 |
In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biotransformation; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Infusions, Parenteral; Kynurenic Acid; Kynurenine; Male; Malonates; Neurons; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glycine | 2000 |
Immunohistochemical visualization of newly formed quinolinate in the normal and excitotoxically lesioned rat striatum.
Topics: 3-Hydroxyanthranilic Acid; Animals; Corpus Striatum; Drug Combinations; Immunohistochemistry; Macrophages; Male; Microglia; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reference Values | 2001 |
The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Amino Acid Sequence; Dioxygenases; Disulfides; Dithionitrobenzoic Acid; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Mass Spectrometry; Molecular Sequence Data; Oxygen Consumption; Ralstonia; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Superoxides | 2005 |
Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Dioxygenases; Enzyme Inhibitors; Ferric Compounds; Ligands; Mutagenesis, Site-Directed; NAD; Oxidation-Reduction; Protein Conformation; Ralstonia; Substrate Specificity | 2005 |
4-chloro-3-hydroxyanthranilate reduces local quinolinic acid synthesis, improves functional recovery, and preserves white matter after spinal cord injury.
Topics: 3-Hydroxyanthranilic Acid; Algorithms; Animals; Behavior, Animal; Blood-Brain Barrier; Female; Guinea Pigs; Kynurenic Acid; Myelin Sheath; Permeability; Proprioception; Quinolinic Acid; Reference Standards; Reflex, Monosynaptic; Spinal Cord Compression; Spinal Cord Injuries | 2006 |
Effects of methylprednisolone and 4-chloro-3-hydroxyanthranilic acid in experimental spinal cord injury in the guinea pig appear to be mediated by different and potentially complementary mechanisms.
Topics: 3-Hydroxyanthranilic Acid; Animals; Behavior, Animal; Disease Models, Animal; Evoked Potentials, Somatosensory; Female; Guinea Pigs; Methylprednisolone; Quinolinic Acid; Spinal Cord Injuries | 2014 |