4-chloro-2-(2-imidazolin-2-ylamino)isoindoline and phentolamine

4-chloro-2-(2-imidazolin-2-ylamino)isoindoline has been researched along with phentolamine in 2 studies

Compound Research Comparison

Studies (4-chloro-2-(2-imidazolin-2-ylamino)isoindoline)	Trials (4-chloro-2-(2-imidazolin-2-ylamino)isoindoline)	Recent Studies (post-2010) (4-chloro-2-(2-imidazolin-2-ylamino)isoindoline)	Studies (phentolamine)	Trials (phentolamine)	Recent Studies (post-2010) (phentolamine)
12	0	1	9,141	270	265

Protein Interaction Comparison

Protein	Taxonomy	phentolamine (IC50)
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	0.396
Alpha-2A adrenergic receptor	Homo sapiens (human)	0.006
Cytochrome P450 2D6	Homo sapiens (human)	10
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	0.0316
Alpha-2B adrenergic receptor	Homo sapiens (human)	0.018
Alpha-2C adrenergic receptor	Homo sapiens (human)	0.11
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	0.0492
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	0.0492
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	0.0492
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	0.0316
Alpha-1D adrenergic receptor	Homo sapiens (human)	0.0173
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	0.359
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	0.396
Alpha-1A adrenergic receptor	Homo sapiens (human)	0.0011
Alpha-1B adrenergic receptor	Homo sapiens (human)	0.0108
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	3.807
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	0.0316
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	0.5495

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Agbaba, D; Filipic, S; Nikolic, K	1
Göthert, M; Molderings, GJ	1

Other Studies

2 other study(ies) available for 4-chloro-2-(2-imidazolin-2-ylamino)isoindoline and phentolamine

Article	Year
QSAR study of imidazoline antihypertensive drugs. Bioorganic & medicinal chemistry, 2008, Aug-01, Volume: 16, Issue:15 Topics: Antihypertensive Agents; Binding Sites; Imidazoline Receptors; Imidazolines; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship	2008
Involvement of presynaptic imidazoline receptors in the alpha 2-adrenoceptor-independent inhibition of noradrenaline release by imidazoline derivatives. Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 343, Issue:3 Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Drug Interactions; Electric Stimulation; Imidazoles; Imidazoline Receptors; Isoindoles; Male; Norepinephrine; Phenoxybenzamine; Phentolamine; Prazosin; Pulmonary Artery; Rabbits; Receptors, Drug; Receptors, Neurotransmitter; Tritium; Yohimbine	1991

Article

Year

QSAR study of imidazoline antihypertensive drugs.

Bioorganic & medicinal chemistry, 2008, Aug-01, Volume: 16, Issue:15

Topics: Antihypertensive Agents; Binding Sites; Imidazoline Receptors; Imidazolines; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship

2008

Involvement of presynaptic imidazoline receptors in the alpha 2-adrenoceptor-independent inhibition of noradrenaline release by imidazoline derivatives.

Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 343, Issue:3

Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Drug Interactions; Electric Stimulation; Imidazoles; Imidazoline Receptors; Isoindoles; Male; Norepinephrine; Phenoxybenzamine; Phentolamine; Prazosin; Pulmonary Artery; Rabbits; Receptors, Drug; Receptors, Neurotransmitter; Tritium; Yohimbine

1991