Page last updated: 2024-08-18

4-butyrolactone and protolichesterinic acid

4-butyrolactone has been researched along with protolichesterinic acid in 20 studies

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (20.00)	18.2507
2000's	3 (15.00)	29.6817
2010's	10 (50.00)	24.3611
2020's	3 (15.00)	2.80

Authors

Authors	Studies
Cai, L; Constant, H; Cordell, GA; Fong, HH; Ingolfsdóttir, K; Kinghorn, AD; Lin, LZ; Pengsuparp, T; Pezzuto, JM; Wagner, H	1
Brynjolfsdottir, A; Gudjonsdottir, GA; Hjalmarsdottir, MA; Ingolfsdottir, K; Sigurdsson, A; Steingrimsson, O	1
Gissurarson, SR; Ingólfsdóttir, K; Ogmundsdóttir, HM; Zoëga, GM	1
Chung, GA; Gissurarson, SR; Ingólfsdóttir, K; Skúlason, VG; Vilhelmsdóttir, M	1
Müller, K	1
Bucar, F; Ingólfsdóttir, K; Ogmundsdóttir, H; Schneider, I	1
Hughes, MA; McFadden, JM; Townsend, CA	1
Caggia, S; Cardile, V; Garbarino, J; Piovano, M; Russo, A	1
Amicosante, G; Bozzi, A; Brisdelli, F; Celenza, G; Garbarino, JA; Nicoletti, M; Perilli, M; Piovano, M; Sellitri, D	1
Authier, H; Boustie, J; Coste, A; Gouault, N; Le Lamer, AC; Pipy, B; Rouaud, I	1
Nicewicz, DA; Riener, M; Zeller, MA	1
El-Naggar, AM; O'Neill, KL; Shrestha, G; St Clair, LL	1
Bessadóttir, M; Eccles, S; Gowan, S; Ogmundsdóttir, HM; Ögmundsdóttir, S; Skúladóttir, EÁ	1
Becker, S; Bessadóttir, M; Eiríksson, FF; Ögmundsdóttir, HM; Ögmundsdóttir, MH; Ómarsdóttir, S; Thorsteinsdóttir, M	1
Lambert, IH; Thorsteinsdottir, M; Thorsteinsdottir, UA	1
Amicosante, G; Bellio, P; Bozzi, A; Brisdelli, F; Celenza, G; Nicoletti, M; Perilli, M; Piovano, M; Sellitri, D	1
Fernandes, RA; Nallasivam, JL	1
Areche, C; Caballero, L; Cartagena, C; Cornejo, A; González, C; Melo, F	1
Cherek, P; Jóhannsson, F; Ögmundsdóttir, HM; Rolfsson, Ó; Xu, M	1
González, EV; Schwaiger, S; Stuppner, H	1

Reviews

1 review(s) available for 4-butyrolactone and protolichesterinic acid

Article	Year
Pharmaceutically relevant metabolites from lichens. Applied microbiology and biotechnology, 2001, Volume: 56, Issue:1-2 Topics: 4-Butyrolactone; Anthraquinones; Benzofurans; Depsides; Hydroxybenzoates; Lactones; Lichens; Naphthoquinones	2001

Other Studies

19 other study(ies) available for 4-butyrolactone and protolichesterinic acid

Article	Year
Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase. Journal of natural products, 1995, Volume: 58, Issue:7 Topics: 4-Butyrolactone; Chromatography, High Pressure Liquid; DNA; DNA-Directed RNA Polymerases; Flavonoids; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Plants, Medicinal; Reverse Transcriptase Inhibitors; Serum Albumin, Bovine; Templates, Genetic; Triterpenes; Xanthenes; Xanthones; Zidovudine	1995
In vitro susceptibility of Helicobacter pylori to protolichesterinic acid from the lichen Cetraria islandica. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:1 Topics: 4-Butyrolactone; Helicobacter pylori; Lichens; Microbial Sensitivity Tests; Plant Extracts	1997
Anti-proliferative effects of lichen-derived inhibitors of 5-lipoxygenase on malignant cell-lines and mitogen-stimulated lymphocytes. The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:1 Topics: 4-Butyrolactone; Depsides; Ethanol; Fibroblasts; Humans; Lactones; Lichens; Lipoxygenase Inhibitors; Lymphocyte Activation; Lymphocytes; Salicylates; Tumor Cells, Cultured	1998
Antimycobacterial activity of lichen metabolites in vitro. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 1998, Volume: 6, Issue:2 Topics: 4-Butyrolactone; Anti-Bacterial Agents; Benzofurans; Depsides; Hydroxybenzoates; Lactones; Lichens; Microbial Sensitivity Tests; Mycobacterium; Salicylates	1998
Anti-proliferative lichen compounds with inhibitory activity on 12(S)-HETE production in human platelets. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2004, Volume: 11, Issue:7-8 Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4-Butyrolactone; Benzoates; Benzofurans; Blood Platelets; Depsides; Emodin; Humans; In Vitro Techniques; Lactones; Lichens; Lipoxygenase; Lipoxygenase Inhibitors; Molecular Structure; Resorcinols; Salicylates	2004
New alpha-methylene-gamma-butyrolactones with antimycobacterial properties. Bioorganic & medicinal chemistry letters, 2005, Sep-01, Volume: 15, Issue:17 Topics: 4-Butyrolactone; Anti-Bacterial Agents; Microbial Sensitivity Tests; Mycobacterium bovis; Structure-Activity Relationship	2005
Effect of vicanicin and protolichesterinic acid on human prostate cancer cells: role of Hsp70 protein. Chemico-biological interactions, 2012, Jan-05, Volume: 195, Issue:1 Topics: 4-Butyrolactone; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Comet Assay; Depsides; DNA Fragmentation; Gene Expression Regulation, Neoplastic; HSP70 Heat-Shock Proteins; Humans; Hydroxybenzoates; L-Lactate Dehydrogenase; Lactones; Male; Prostatic Neoplasms; Reactive Oxygen Species	2012
Cytotoxic activity and antioxidant capacity of purified lichen metabolites: an in vitro study. Phytotherapy research : PTR, 2013, Volume: 27, Issue:3 Topics: 4-Butyrolactone; Anisoles; Antioxidants; Apoptosis; Benzofurans; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Depsides; Free Radical Scavengers; Humans; Hydroxybenzoates; Lactones; Lichens; Oxidative Stress; Reactive Oxygen Species; Salicylates	2013
Protolichesterinic acid derivatives: α-methylene-γ-lactones as potent dual activators of PPARγ and Nrf2 transcriptional factors. Bioorganic & medicinal chemistry letters, 2014, Aug-15, Volume: 24, Issue:16 Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lactones; Macrophages; Mice; Molecular Structure; NF-E2-Related Factor 2; PPAR gamma; Structure-Activity Relationship	2014
Butyrolactone synthesis via polar radical crossover cycloaddition reactions: diastereoselective syntheses of methylenolactocin and protolichesterinic acid. Organic letters, 2014, Sep-19, Volume: 16, Issue:18 Topics: 4-Butyrolactone; Alkenes; Catalysis; Cyclization; Cycloaddition Reaction; Lactones; Molecular Structure; Oxidation-Reduction; Stereoisomerism	2014
Anticancer activities of selected species of North American lichen extracts. Phytotherapy research : PTR, 2015, Volume: 29, Issue:1 Topics: 4-Butyrolactone; Antineoplastic Agents; Apoptosis; Benzofurans; Cell Line, Tumor; Cell Survival; Humans; Inhibitory Concentration 50; Lactones; Lichens; Lymphocytes; Molecular Structure; Salicylates; Thymidine Kinase; Tumor Suppressor Protein p53; United States	2015
Effects of anti-proliferative lichen metabolite, protolichesterinic acid on fatty acid synthase, cell signalling and drug response in breast cancer cells. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014, Oct-15, Volume: 21, Issue:12 Topics: 4-Butyrolactone; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Fatty Acid Synthases; Female; Humans; Lapatinib; Lichens; Molecular Structure; Quinazolines; Receptor, ErbB-2; Signal Transduction	2014
Anti-proliferative and pro-apoptotic effects of lichen-derived compound protolichesterinic acid are not mediated by its lipoxygenase-inhibitory activity. Prostaglandins, leukotrienes, and essential fatty acids, 2015, Volume: 98 Topics: 4-Butyrolactone; Apoptosis; Arachidonate 12-Lipoxygenase; Arachidonate 5-Lipoxygenase; Cell Line, Tumor; Cell Proliferation; Cytoplasm; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lichens; Multiple Myeloma; Pancreatic Neoplasms	2015
Protolichesterinic Acid, Isolated from the Lichen Cetraria islandica, Reduces LRRC8A Expression and Volume-Sensitive Release of Organic Osmolytes in Human Lung Epithelial Cancer Cells. Phytotherapy research : PTR, 2016, Volume: 30, Issue:1 Topics: 4-Butyrolactone; Apoptosis; Arachidonate 5-Lipoxygenase; bcl-2-Associated X Protein; Cell Cycle; Cell Line, Tumor; Cell Survival; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Humans; Hydroxyeicosatetraenoic Acids; Lichens; Lung Neoplasms; Membrane Proteins; Parmeliaceae; Taurine	2016
Protolichesterinic acid enhances doxorubicin-induced apoptosis in HeLa cells in vitro. Life sciences, 2016, Aug-01, Volume: 158 Topics: 4-Butyrolactone; Antibiotics, Antineoplastic; Apoptosis; Doxorubicin; Drug Synergism; HeLa Cells; Humans; Molecular Docking Simulation	2016
A protecting-group-free synthesis of (+)-nephrosteranic, (+)-protolichesterinic, (+)-nephrosterinic, (+)-phaseolinic, (+)-rocellaric acids and (+)-methylenolactocin. Organic & biomolecular chemistry, 2017, Jan-18, Volume: 15, Issue:3 Topics: 4-Butyrolactone; Furans; Lactones; Molecular Conformation; Stereoisomerism	2017
The Fumarprotocetraric Acid Inhibits Tau Covalently, Avoiding Cytotoxicity of Aggregates in Cells. Molecules (Basel, Switzerland), 2021, Jun-21, Volume: 26, Issue:12 Topics: 4-Butyrolactone; Antarctic Regions; Ascomycota; Cell Line, Tumor; Fumarates; Humans; Lichens; Neurodegenerative Diseases; Parmeliaceae; Protein Aggregates; tau Proteins; Tauopathies	2021
The Anti-Proliferative Lichen-Compound Protolichesterinic Acid Inhibits Oxidative Phosphorylation and Is Processed via the Mercapturic Pathway in Cancer Cells. Planta medica, 2022, Volume: 88, Issue:11 Topics: 4-Butyrolactone; Cell Proliferation; Glutathione; Lichens; Neoplasms; Oxidation-Reduction; Oxidative Phosphorylation; Reactive Oxygen Species	2022
Two-step isolation of the two major paraconic acids of Cetraria islandica. Journal of separation science, 2023, Volume: 46, Issue:6 Topics: 4-Butyrolactone; Chromatography, Liquid; Lichens; Parmeliaceae	2023