4-butyrolactone has been researched along with ligustilide in 199 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (2.01) | 18.7374 |
| 1990's | 9 (4.52) | 18.2507 |
| 2000's | 48 (24.12) | 29.6817 |
| 2010's | 113 (56.78) | 24.3611 |
| 2020's | 25 (12.56) | 2.80 |
| Authors | Studies |
|---|---|
| Harada, M; Ozaki, Y; Sekita, S | 1 |
| Huang, YZ; Pu, FD | 1 |
| Chen, YZ; Duan, ZX; Liu, S; Mei, QB; Ruan, YP; Tao, JY; Tian, QL; Zhang, HD | 1 |
| Fang, HJ; He, LY; Lü, RM; Zhang, XQ | 1 |
| Beck, JJ; Stermitz, FR | 1 |
| Chen, H; Guo, P; Li, ZL; Lin, YK; Zhang, TM | 1 |
| Kimura, I; Kimura, M; Kobayashi, S; Mimura, Y; Naitoh, T | 1 |
| Fu, G; Hu, S; Ji, L; Yang, L; Zhong, F | 1 |
| Kadota, S; Kohno, S; Matsumoto, K; Ojima, K; Tezuka, Y; Watanabe, H | 1 |
| He, XF; Zhang, JL; Zhou, ZH | 1 |
| Chen, R; Wang, H; Xu, H | 1 |
| Hu, J; Li, L; Shi, L; Wu, G | 1 |
| Kong, L; Ni, J; Wang, H; Zhang, Y; Zou, H | 1 |
| Li, XH; Zhou, CX | 1 |
| Cai, C; Du, L; Wang, T; Wang, X | 1 |
| Baba, K; Li, L; Taniguchi, M; Xiao, YQ; You, XL | 1 |
| Liang, H; Lu, XH; Zhao, YY | 1 |
| Bi, KS; Lin, YZ; Tang, X | 1 |
| Bian, BL; Li, H; Meng, FY; Wang, YT | 1 |
| Deng, C; Ji, J; Wang, X; Zhang, X | 1 |
| Chen, BM; He, YK; Hu, QN; Li, BY; Liang, YZ; Wang, YL | 1 |
| He, LC; Liang, MJ; Yang, GD | 1 |
| Fu, CM; Kan, KK; Lao, SC; Li, P; Li, SP; Wang, YT | 1 |
| Cao, J; Ding, M; Kou, H; Wang, Z; Yang, X | 1 |
| Bai, B; Du, JR; Qian, ZM; Wang, CY; Yu, Y | 1 |
| Li, P; Li, RY; Li, SL; Qi, LW; Sheng, LH; Zhang, LY | 1 |
| Guo, FQ; Li, XR; Liang, YZ | 1 |
| He, L; Shi, Y; Wang, S | 1 |
| He, LC; Liang, MJ | 1 |
| Bai, B; Du, J; Ke, Y; Kuang, X; Qian, ZM; Tzang, AH; Wang, C; Xu, Y; Yu, Y | 1 |
| Du, JR; Kuang, X; Liu, YX; Qian, ZM; Wang, CY; Yao, Y | 1 |
| Lu, Q; Qiu, TQ; Yang, H | 1 |
| Cao, YX; He, JY; He, LC; Xu, CB; Zhang, W | 1 |
| Cui, F; Feng, L; Hu, J | 1 |
| Cheng, SQ; Liang, SX; Lv, GH; Wang, Y; Xu, YC; Zhao, ZZ | 1 |
| Chen, JT; Yang, CR | 1 |
| Chan, SS; Cheng, TY; Lin, G | 1 |
| Liang, XM; Xiao, YS; Xu, Q; Xue, XY; Yang, F; Zhang, FF | 1 |
| Du, JR; Kuang, X; Liu, YX; Peng, HY; Qian, ZM; Wang, CY; Zhang, GY | 1 |
| Du, J; Ke, Y; Qian, ZM; Wang, C; Yu, Y; Zhu, L | 1 |
| Malemud, CJ | 1 |
| Bai, B; Du, JR; Lei, Y; Qian, ZM; Wang, CY; Yao, Y; Yu, Y; Zong, X | 1 |
| Deng, C; Dong, L; Shen, X; Wang, B | 1 |
| Xie, J; Xue, D; Yi, T; Zhang, H | 1 |
| Du, JR; Qian, ZM; Wang, CY; Yu, Y | 1 |
| Du, JR; Kuang, X; Liu, YX; Peng, HY; Zhang, GY | 1 |
| Ko, NL; Li, SL; Lin, G; Tam, YK; Yan, R | 1 |
| Chen, DF; Chen, W; Shen, JG; Wang, CY; Wang, TT; Zeng, HP | 1 |
| Shin, S; Sim, Y | 1 |
| Chen, SN; Jaki, BU; Lankin, DC; Main, M; Pauli, GF; Pro, SM; Schinkovitz, A | 1 |
| Bolton, JL; Deng, S; Dietz, BM; Farnsworth, NR; Hagos, GK; Liu, D; Pauli, GF; Pro, SM; Schinkovitz, A; van Breemen, RB; Yao, P | 1 |
| Ding, C; Du, G; Sheng, Y; Zhang, J; Zhang, Y | 1 |
| Hong, CQ; Piao, XL | 1 |
| Baser, KH; Cantrell, CL; Demirci, B; Klun, JA; Liu, Z; Ozek, T; Tabanca, N; Wedge, DE; Zhang, J; Zhang, S | 1 |
| Duan, JA; Li, SP; Lu, J; Qian, ZM; Xie, JJ; Yu, Y | 1 |
| Chen, YS; Du, JR; Kuang, X; Wang, J; Wang, YN | 1 |
| Duan, JA; Guo, J; Qian, D; Shang, EX; Tang, Y | 2 |
| Hu, JH; Qian, M; Shi, LF | 1 |
| Cai, Q; Huang, YP; Li, Y | 1 |
| Chen, YS; Du, JR; He, Y; Wang, CY; Wang, J; Yu, DK; Zhang, L | 1 |
| Bi, CW; Chen, VP; Cheung, AW; Choi, RC; Dong, TT; Duan, R; Guo, AJ; Lau, BW; Lau, DD; Li, J; Tsim, KW; Xie, HQ; Zheng, YZ; Zhu, JT; Zhu, Y | 1 |
| Chen, C; Du, JR; Tang, J; Wang, CY; Yang, W; Yu, Y | 1 |
| Chao, WW; Chen, ML; Hong, YH; Lin, BF | 1 |
| Du, JR; Kuang, X; Wang, CY; Wang, J; Wang, Y | 1 |
| Chen, T; Lian, Z; Liu, J; Liu, K; Qu, K; Shao, M; Tang, Y; Wu, A; Zhang, L; Zhang, Y; Zhu, H | 1 |
| Lau, AS; Law, AH; Li, JC; Or, TC; Yang, CL | 1 |
| Chen, X; Du, S; Lu, Y; Xu, B; Yao, Z | 1 |
| He, Z; Huang, L; Song, B; Tang, L; Wang, Z; Wu, H | 1 |
| Chen, D; Jiang, R; Khatibi, NH; Li, Y; Tang, J; Tu, L; Wang, C; Wang, S; Zhu, M | 1 |
| Du, F; Gong, Q; Ke, Y; Qian, ZM; Wu, XM; Yung, WH; Zhu, L | 1 |
| Chao, SH; Chen, CC; Chiou, WF; Lee, MH; Su, YW; Tsai, YC | 1 |
| Chai, X; Chen, S; Yu, C; Yu, L; Zeng, S | 1 |
| Chen, XN; Cheng, LL; Du, JR; Kuang, X; Wang, LL; Wang, Y; Yang, W; Yu, L | 1 |
| Appendino, G; Nilius, B; Pollastro, F; Prenen, J; Zhong, J; Zhu, Z | 1 |
| Han, Y; Qi, H; Rong, J | 1 |
| Gao, X; Jia, G; Ma, Z; Qin, X; Ren, Y; Zhang, L; Zhou, Y | 1 |
| Han, Y; Lau, AS; Qi, H; Rong, J; Zhao, J | 1 |
| Du, JR; Yu, Y; Zhang, MX | 1 |
| Annie Bligh, SW; Cho, CW; Fan, TP; Fisher, D; Garrard, IJ; Lu, GH; Yeh, JC | 1 |
| Choi, RJ; Chung, JW; Dong, MS; Guo, LY; Kim, YS; Nam, JW; Seo, EK; Shin, EM | 1 |
| Bai, L; Ma, Z | 2 |
| Ding, W; Duan, J; Liu, P; Qian, D; Shang, E; Tang, Y; Wu, J | 1 |
| Bhakta, S; Evangelopoulos, D; Gibbons, S; Gupta, A; Guzman, JD; Prieto, JM | 1 |
| Bi, CW; Chen, JP; Dong, TT; Du, CY; Lau, DT; Tsim, KW; Zhan, JY; Zhang, WL; Zhao, KJ; Zheng, KY; Zhu, KY | 1 |
| Feng, Z; Li, J; Lu, Y; Peng, B; Qian, Z; Wu, X; Zhao, P; Zhu, L | 1 |
| Han, T; Jiang, YP; Peng, C; Qin, LP; Ran, X; Yu, CH; Zhang, H | 1 |
| Wang, L; Xiao, HB; Zuo, AH | 1 |
| Conney, AH; Huang, Y; Khor, TO; Kong, AN; Lee, JH; Saw, CL; Shu, L; Su, ZY; Suh, N; Wu, Q; Wu, TY; Yang, CS | 1 |
| Pan, XB; Sa, RN; Sun, YJ; Wang, YL; Yang, YW; Zhu, SQ | 1 |
| Li, SH; Ma, X; Shao, H; Xia, PF | 1 |
| Huang, Y; Khor, TO; Kong, AN; Saw, CL; Su, ZY; Wang, H; Wu, Q; Xu, X; Yang, Y | 1 |
| Duan, JA; Li, W; Li, Z; Liu, P; Qian, D; Shang, EX | 1 |
| Chen, MM; Lu, YP; Peng, B; Sun, H; Wu, XM; Zhao, P; Zhu, L | 1 |
| Bao, L; Hung, SH; Mody, A; Svoronos, SA; Tseng, Y; Wang, C; Yin, J | 1 |
| An, PK; Fan, Q; Guo, ZX; Wang, YQ; Xia, Q | 1 |
| Deng, M; Xie, X; Xin, J; Yang, Y; Zhang, J | 1 |
| Chen, C; Chen, YS; Du, JR; He, Q; Kuang, X; Li, LJ; Li, YJ; Liu, K; Wang, LF; Wang, Y; Zhang, MX | 1 |
| Huang, J; Li, GY; Lin, RC; Lu, J; Lu, XQ; Wang, JH; Zhang, C | 1 |
| Cheng, MC; Wang, L; Xiao, HB; Zhuo, RJ; Zuo, AH | 1 |
| De Petrocellis, L; Di Marzo, V; Morera, E; Nalli, M; Ortar, G; Schiano Moriello, A | 1 |
| Li, YB; Lou, JS; Su, LN; Wang, YM | 1 |
| Chen, WM; Shaw, LH; Tsai, TH | 1 |
| Qiao, H; Shi, YB; Zhang, XY | 1 |
| Ding, G; Jin, Y; Wang, Z; Xiao, W; Yan, R; Yang, Y; Zeng, M; Zhang, J | 1 |
| Liu, D; Qi, XR; Wang, ZZ; Wu, K | 1 |
| Jiang, WD; Jin, YQ; Li, X; Lv, GH; Wang, XX; Zhang, LH; Zhao, ZZ | 1 |
| Cao, DL; Gao, YJ; Jiang, BC; Wu, XB; Zhao, LX | 1 |
| Diao, J; Li, C; Lu, L; Shi, Y; Wang, D; Wang, M; Wang, Y; Wei, L; Yin, Y | 1 |
| Furue, M; Kita, K; Morino-Koga, S; Nakamura-Satomura, A; Shi, W; Uchi, H; Wu, Z | 1 |
| Chen, C; Du, JR; He, Q; Kuang, X; Li, YJ; Wang, LF; Wang, YN; Yu, L | 1 |
| Ma, SC; Ren, J; Su, YL; Wang, AG; Wei, Q; Yang, JB | 1 |
| Liu, S; Lu, Y; Yu, S; Zhao, Y; Zhu, L | 1 |
| Chen, LP; Fan, Q; Liu, FL; Liu, X; Xia, PF; Zhao, L | 1 |
| Ikegami, F; Namiki, T; Saito, Y; Sumino, M | 1 |
| Fan, QJ; Kong, FL; Liu, JL; Tan, J; Yang, SM; Yuan, JC; Zheng, SL; Zhou, J | 1 |
| Gao, YJ; Wang, XT; Zhang, ZJ; Zhao, LX; Zhu, MD | 1 |
| Feng, ZB; Li, JJ; Lu, YP; Qian, ZM; Zhao, P; Zhu, L; Zhu, Q | 1 |
| Jiang, GH; Lan, ZQ; Liu, XF; Lu, XM | 1 |
| Antoine, MH; Bunel, V; Duez, P; Nortier, J; Stévigny, C | 1 |
| Shi, Y; Wei, L; Xiao, L; Yin, Y | 1 |
| Gong, LM; Li, SX; Luo, K; Wang, YQ; Xie, Y; Yan, JY; Yang, YT | 1 |
| Du, JR; Li, LJ; Wang, LF; Wang, Y | 1 |
| Dind, JX; Gu, ZR; Sun, YJ; Wang, YL | 1 |
| Piao, XX; Wang, GY; Wang, N; Wang, Y; Wu, Q | 1 |
| Chen, Q; Chen, T; Ge, C; Ge, M; Jia, X; Wang, X; Zhu, X | 1 |
| Furue, M; Morino-Koga, S; Shi, W; Uchi, H; Wu, Z | 1 |
| Dong, YL; Gao, YJ; Li, F; Qian, B; Zhang, ZJ; Zhao, LX | 1 |
| Chen, L; Fu, Y; Jiang, Z; Li, L; Ma, H; Ning, L; Qi, H; Yang, N; Yu, J; Zhao, Z; Zhu, H | 1 |
| Chen, H; Gao, W; Huo, L; Li, Y; Qu, Z; Zhang, J | 1 |
| Du, H; Fan, F; Li, J; Zhou, N | 1 |
| Guo, Y; Liu, Y; Lu, L; Lv, B; Meng, Q; Qu, L; Sun, S; Wang, J; Xiang, L; Xiao, Y; Yang, Y | 1 |
| Miyanowaki, T; Morinaga, O; Shoyama, Y; Taniyama, R; Tung, NH; Uto, T | 1 |
| Jia, YW; Liao, X; Liu, YM; Peng, SL; Xiao, MW; Xu, PL; Zeng, Q | 1 |
| Cai, H; Pei, K; Qiao, FX; Song, XQ; Tu, PF | 1 |
| Hara, N; Kashima, Y; Marumoto, S; Miyazawa, M; Motooka, R; Nakagawa, H; Nakahashi, H; Usami, A; Yoshii, T | 1 |
| Liu, D; Shen, J; Xiao, W; Xu, Z; Yu, A | 1 |
| Chen, Y; Huang, ZF; Liu, YH; Yang, Y; Yi, JH | 1 |
| Chang, FK; Chen, SY; Chi, K; Fu, RH; Huang, PC; Huang, YC; Lin, PC; Lin, SZ; Liu, SP | 1 |
| Hu, PY; Liu, D; Tang, Y; Wu, Q; Yang, M; Zheng, Q | 1 |
| Alimoradi, H; Baery, N; Barzegar-Fallah, A; Barzegar-Fallah, N; Malekmohammadi, N; Parsa, A; Soleymankhani, M | 1 |
| Li, J; Xu, W; Yang, L | 1 |
| Du, JR; Gu, MX; Liu, DL; Long, FY; Zhao, LX; Zhou, HJ | 1 |
| Guo, YZ; Jiang, LR; Ke, Y; Li, FM; Ma, J; Qian, ZM; Zhang, YT | 1 |
| Cui, X; Ji, S; Li, M; Li, X; Liu, X | 1 |
| Jia, YW; Liao, X; Liu, YM; Wan, LH; Zeng, Q | 1 |
| Li, J; Li, L; Ma, H; Qi, HY; Wu, MX; Yang, N; Yu, J; Zhao, ZL; Zheng, DD | 1 |
| Dou, G; He, H; Li, J; Li, L; Ma, H; Qi, H; Wang, C; Wu, M | 1 |
| He, H; Jiang, Z; Li, L; Qi, H; Wang, C; Yang, Y; Yu, Z | 1 |
| Chen, XQ; Liu, JW; Liu, ZY; Lu, Y; Wang, WN; Zhang, XG | 1 |
| Guo, Y; Hu, PY; Liu, D; Tang, Y; Yang, M; Yue, P; Zhang, D; Zheng, Q | 1 |
| Du, JR; Liu, DL; Long, FY; Sang, N; Shi, MQ; Zhou, HJ | 1 |
| Choi, ES; Han, BH; Jeong, DH; Kang, DG; Lee, HS; Lee, YJ; Yoon, JJ | 1 |
| Hwang, BY; Kim, GH; Kim, HK; Lee, SJ; Yoon, JU | 1 |
| Chen, K; Chen, L; Chen, Y; Dong, J; Duan, F; Jia, Z; Liu, J; Ma, K; Wang, M; Xiao, H; Xu, W | 1 |
| Du, JR; Han, L; He, Q; Kuang, X; Liu, DL; Shi, MQ; Zeng, QK; Zhao, LX | 1 |
| Ding, X; Feng, Z; Hu, Z; Li, X; Ni, W; Wu, A; Wu, D; Xuan, J; Zheng, G | 1 |
| Fang, Z; Hao, E; Lang, F; Li, L; Liu, Y; Qu, J; Yin, H; Zhi, Y | 1 |
| Hu, M; Long, H; Ma, F; Ma, J; Qin, Z; Tao, N; Wang, Y; Xu, Y; Zheng, Q | 1 |
| Chen, Q; Chen, Z; Deng, M; Li, Y; Liu, S; Ma, Y; Ming, J; Zhang, Y; Zhou, Y | 1 |
| Chen, J; Chen, T; Chen, Y; Lin, J; Shao, Z; Sheng, S; Wang, K; Wang, X; Xu, T; Ying, X; Zhang, Z | 1 |
| Chang, D; Li, J; Liang, H; Seto, SW; Wang, G; Wang, N; Wu, S | 1 |
| Gu, N; Huang, X; Jiang, W; Long, H; Qu, Y; Xie, Y; Zhang, Y; Zhu, Y | 1 |
| Chen, TT; Cui, J; Hua, YQ; Huang, TY; Li, MY; Lin, ZW; Yang, F | 1 |
| Choi, JG; Choi, YJ; Choo, M; Chung, SJ; Jeong, YS; Jin, X; Koo, HR; Lee, BH; Lee, W; Oh, MS; Park, S | 1 |
| Bai, G; Deng, YF; Hu, XY; Jiang, M; Lei, W; Ni, JN | 1 |
| Amusant, N; Eparvier, V; Houël, E; Odonne, G; Rodrigues, AMS; Stien, D | 1 |
| Hu, N; Jiang, W; Liu, L; Shi, L; Wang, Q; Yan, T; Yang, P; Zhang, S; Zhang, W | 1 |
| Bai, DT; Cao, HH; Chen, J; Cheng, M; Gu, LY; Guo, S; Hu, W; Li, L; Lu, TL; Mao, CQ; Yan, WH | 1 |
| Banwell, MG; Gardiner, MG; Lan, P; Sheng, B; Sun, P; Vo, Y | 1 |
| Feng, W; Li, B; Li, J; Liao, S; Lin, C; Liu, Y; Ou, L; Wang, D; Yao, J; Zhao, G; Zhao, J | 1 |
| Chen, SN; Duric, K; Friesen, JB; Lankin, DC; Liu, Y; McAlpine, JB; Nikolic, D; Pauli, GF | 1 |
| Chen, Y; Deng, H; Fang, Z; Lu, Q; Luo, Z; Zeng, A; Zhang, W | 1 |
| Hu, M; Long, H; Lu, J; Ma, F; Ma, J; Mei, J; Qin, Z; Tao, N; Wang, Y | 1 |
| Cai, WW; Dai, Z; Li, BY; Liu, HF; Liu, XQ; Luo, Y; Pan, HF; Wang, H; Wang, Q; Wei, SF; Xu, TT; Zhang, SJ; Zheng, JY; Zhu, WL | 1 |
| Li, X; Liao, Y; Liu, K; Tang, H; Xie, L; Xie, Q; Zhang, L; Zheng, Y | 1 |
| An, C; Dong, Y; Li, M; Li, X; Wang, X; Xiang, F; Yao, Y | 1 |
| Ding, Y; Gao, C; Ji, X; Li, N; Li, S; Ren, C; Yang, Y; Zhang, W | 1 |
| Guo, S; Wang, G; Yang, Z | 1 |
| Liu, J; Mao, ZG; Wang, N; Wang, YX; Wu, Q | 1 |
| Chen, C; Du, JR; Duan, W; Gan, YM; Liu, DL; Yang, YX | 1 |
| Liu, Y; Ma, G; Yang, B | 1 |
| Li, H; Liu, J; Tao, S | 1 |
| Fang, J; Fang, S; Huang, Y; Li, M; Luo, Y; Mei, Y; Pan, H; Wan, T; Wang, Q; Wang, Z; Xue, J; Zhang, Y | 1 |
| Bai, J; Ding, X; Jiang, X; Qian, M; Wu, H; Zhang, X; Zhao, W; Zhu, F | 1 |
| Chen, J; Jin, L; Shi, T; Xu, X; Zhu, T | 1 |
| Chen, L; Dou, G; Jiang, M; Jiang, Z; Li, C; Li, L; Li, P; Liu, G; Lu, Q; Ma, H; Qi, H; Wang, C; Yang, Y | 1 |
| Cha, X; Hu, L; Li, B; Li, J; Liu, Y; Wu, D; Xie, B; Zhang, B; Zheng, L | 1 |
| Chen, Y; He, S; Jin, X; Li, C; Lu, Q; Luo, Z; Mei, W; Zeng, A | 1 |
| Chen, Y; Lang, H; Lu, Y; Sun, J; Wu, J; Xiao, R; Zhou, X | 1 |
| Cao, Y; Dong, Z; Ma, X; Wang, X; Yang, D | 1 |
| Liu, J; Mao, Z; Seto, S; Tian, L; Wang, G; Wang, N; Wang, Y; Wu, Q | 2 |
| Dong, H; Jin, L; Li, M; Wei, J; Xie, X | 1 |
| Fang, Z; Gao, J; Ji, Y; Luo, Z; Yang, R; Zhang, N | 1 |
| Cai, YF; Guan, L; Luo, D; Peng, D; Qiao, HZ; Qiao, LJ; Tan, HY; Wang, Q; Wang, YX; Zhang, SJ | 1 |
| Liu, J; Tian, LY; Wang, N; Wu, Q | 1 |
| Bai, G; Chu, S; Ji, J; Jiang, M; Lei, W; Lu, Y; Shen, F; Yang, W | 1 |
4 review(s) available for 4-butyrolactone and ligustilide
| Article | Year |
|---|---|
[The new progress of the study about volatile oil of the angelica].
Topics: 4-Butyrolactone; Angelica; Animals; Anti-Arrhythmia Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Drugs, Chinese Herbal; Dysmenorrhea; Female; Humans; Male; Muscle Contraction; Muscle, Smooth; Oils, Volatile; Plants, Medicinal; Uterus | 2005 |
Inhibitors of stress-activated protein/mitogen-activated protein kinase pathways.
Topics: 4-Butyrolactone; Animals; Flavones; Humans; Mitogen-Activated Protein Kinases; Resveratrol; Stilbenes | 2007 |
[Research progress studies on pharmacology and pharmacokinetics of ligustilide].
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Drugs, Chinese Herbal; Humans; Ligusticum | 2012 |
Z-ligustilide: A review of its pharmacokinetics and pharmacology.
Topics: 4-Butyrolactone; Animals; Drugs, Chinese Herbal; Humans; Molecular Structure; Rats | 2020 |
195 other study(ies) available for 4-butyrolactone and ligustilide
| Article | Year |
|---|---|
[Centrally acting muscle relaxant effect of phthalides (ligustilide, cnidilide and senkyunolide) obtained from Cnidium officinale Makino].
Topics: 4-Butyrolactone; Animals; Benzofurans; Drugs, Chinese Herbal; Furans; Male; Mephenesin; Muscle Relaxants, Central; Rats; Rats, Inbred Strains | 1989 |
[Studies on the chemical components of the essential oil from the rhizome of Ligusticum sinense Oliv. cv. Chuanxiong hort].
Topics: 4-Butyrolactone; Bicyclic Monoterpenes; Drugs, Chinese Herbal; Monoterpenes; Oils, Volatile; Phthalic Anhydrides; Terpenes | 1988 |
[Studies on the antiasthmatic action of ligustilide of dang-gui, Angelica sinensis (Oliv.) Diels].
Topics: 4-Butyrolactone; Animals; Asthma; China; Female; Furans; Guinea Pigs; In Vitro Techniques; Male; Nucleotides, Cyclic; Parasympatholytics; Plants, Medicinal; Trachea | 1984 |
[Thin layer chromatography and densitometry of ligustilide in umbelliferous plants].
Topics: 4-Butyrolactone; Chromatography, Thin Layer; Densitometry; Furans; Plants, Medicinal | 1980 |
Addition of methyl thioglycolate and benzylamine to (Z)-ligustilide, a bioactive unsaturated lactone constituent of several herbal medicines. An improved synthesis of (Z)-ligustilide.
Topics: 4-Butyrolactone; Anti-Infective Agents; Antiviral Agents; Benzylamines; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Plant Roots; Plants, Medicinal; Spectrometry, Mass, Fast Atom Bombardment; Thioglycolates | 1995 |
[Studies on the chemical components of essential oil from the aerial parts of Ligusticum chuanxiong Hort].
Topics: 4-Butyrolactone; Benzofurans; Drugs, Chinese Herbal; Oils, Volatile; Sesquiterpenes, Eudesmane; Tetrahydronaphthalenes | 1993 |
Chemical structure-activity of cnidium rhizome-derived phthalides for the competence inhibition of proliferation in primary cultures of mouse aorta smooth muscle cells.
Topics: 4-Butyrolactone; Analysis of Variance; Animals; Aorta, Thoracic; Benzofurans; Cell Division; Cells, Cultured; Drugs, Chinese Herbal; Male; Mice; Muscle, Smooth, Vascular; Phthalic Anhydrides; Structure-Activity Relationship | 1993 |
[Studies on the essential oils in Ligusticum chuanxiong Hort. of different habitats and species].
Topics: 4-Butyrolactone; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Oils, Volatile; Plant Oils | 1996 |
Effects of methylenechloride-soluble fraction of Japanese angelica root extract, ligustilide and butylidenephthalide, on pentobarbital sleep in group-housed and socially isolated mice.
Topics: 4-Butyrolactone; Animals; Brain; Carbolines; Diazepam; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Methoxamine; Methylene Chloride; Mice; Parasympatholytics; Pentobarbital; Phthalic Anhydrides; Plant Extracts; Plant Roots; Plants, Medicinal; Sleep; Social Isolation; Yohimbine | 1998 |
[HPLC determination of five constituents in plants of genus Ligusticum].
Topics: 4-Butyrolactone; Apiaceae; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Quality Control; Scopoletin; Species Specificity | 1996 |
[Chemical constituents of radix Angelicae Sinensis].
Topics: 4-Butyrolactone; Angelica sinensis; Apiaceae; Drugs, Chinese Herbal; Palmitic Acid; Phthalic Anhydrides; Plants, Medicinal | 1998 |
[The determination of ligustilide in Ligusticum chuanxiong Hort. by supercritical fluid extraction].
Topics: 4-Butyrolactone; Chromatography, Supercritical Fluid; Drugs, Chinese Herbal; Ligusticum | 1998 |
[Screening and analysis of biologically active components in traditional Chinese medicine by molecular biochromatography].
Topics: 4-Butyrolactone; Chromatography; Coumaric Acids; Drug Combinations; Drugs, Chinese Herbal | 1999 |
[Studies on the stability of ligustilide with solvent effect].
Topics: 4-Butyrolactone; Chloroform; Cyclohexanes; Drug Stability; Gas Chromatography-Mass Spectrometry | 2001 |
[Constituent analysis of essential oils from radix of Angelica acutiloba].
Topics: 4-Butyrolactone; Angelica; China; Gas Chromatography-Mass Spectrometry; Oils, Volatile; Plant Roots; Plants, Medicinal | 2002 |
[Studies on chemical constituents of the rhizomae of Ligusticum chuanxiong].
Topics: 4-Butyrolactone; Coumaric Acids; Ligusticum; Molecular Structure; Plants, Medicinal; Rhizome; Terpenes | 2002 |
[Isolation and identification of the ligustilide compounds from the root of Angelica sinensis].
Topics: 4-Butyrolactone; Angelica sinensis; Benzofurans; Molecular Structure; Plant Roots; Plants, Medicinal | 2003 |
[Determination of ligustilide in volatile oil from rhizome of ligusticum chuanxiong by RP-HPLC].
Topics: 4-Butyrolactone; Chromatography, High Pressure Liquid; Ligusticum; Oils, Volatile; Plants, Medicinal; Rhizome | 2004 |
[Study on preparation of refined Xiong-gui sustained release pills].
Topics: 4-Butyrolactone; Angelica sinensis; Delayed-Action Preparations; Drug Combinations; Drugs, Chinese Herbal; Ligusticum; Plants, Medicinal; Technology, Pharmaceutical | 2005 |
Development of pressurized hot water extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry for determination of ligustilides in Ligusticum chuanxiong and Angelica sinensis.
Topics: 4-Butyrolactone; Angelica sinensis; Chromatography; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Hot Temperature; Ligusticum; Plant Extracts; Time Factors | 2005 |
LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui.
Topics: 4-Butyrolactone; Absorption; Administration, Oral; Aldehydes; alpha-Linolenic Acid; Angelica sinensis; Animals; Benzofurans; Diynes; Drugs, Chinese Herbal; Fatty Alcohols; Linoleic Acid; Mass Spectrometry; Phthalic Anhydrides; Plant Extracts; Rabbits | 2005 |
Screening, analysis and in vitro vasodilatation of effective components from Ligusticum Chuanxiong.
Topics: 4-Butyrolactone; Animals; Aorta, Abdominal; Calcium Chloride; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Ligusticum; Muscle, Smooth, Vascular; Norepinephrine; Parasympatholytics; Phthalic Anhydrides; Plant Extracts; Plant Oils; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation | 2005 |
Optimization of pressurized liquid extraction for Z-ligustilide, Z-butylidenephthalide and ferulic acid in Angelica sinensis.
Topics: 4-Butyrolactone; Algorithms; Angelica sinensis; Chromatography, High Pressure Liquid; Coumaric Acids; Particle Size; Phthalic Anhydrides; Pressure; Solvents; Temperature; Ultrasonics | 2006 |
[Determination of lactone components in chuanxiong by reversed-phase high performance liquid chromatography].
Topics: 4-Butyrolactone; Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Lactones; Ligusticum; Reproducibility of Results | 2005 |
Live cell extraction and HPLC-MS analysis for predicting bioactive components of traditional Chinese medicines.
Topics: 4-Butyrolactone; Benzofurans; Cell Extracts; Cells, Cultured; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Endothelial Cells; Humans; Isoflavones; Mass Spectrometry | 2006 |
Analysis of volatile oil in Rhizoma ligustici chuanxiong-Radix paeoniae rubra by gas chromatography-mass spectrometry and chemometric resolution.
Topics: 4-Butyrolactone; Gas Chromatography-Mass Spectrometry; Ligusticum; Oils, Volatile; Paeonia; Palmitic Acid; Plant Roots; Plants, Medicinal; Rhizome | 2006 |
Determination of ligustilide in rat blood and tissues by capillary gas chromatography/mass spectrometry.
Topics: 4-Butyrolactone; Animals; Female; Gas Chromatography-Mass Spectrometry; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 2006 |
Inhibitory effects of ligustilide and butylidenephthalide on bFGF-stimulated proliferation of rat smooth muscle cells.
Topics: 4-Butyrolactone; Animals; Aorta, Thoracic; Cell Proliferation; Cells, Cultured; Female; Fibroblast Growth Factor 2; Ligusticum; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phthalic Anhydrides; Plants, Medicinal; Rats; Rats, Sprague-Dawley | 2006 |
Ligustilide inhibits spontaneous and agonists- or K+ depolarization-induced contraction of rat uterus.
Topics: 4-Butyrolactone; Acetylcholine; Angelica; Animals; Calcium; Dinoprost; Dose-Response Relationship, Drug; Dysmenorrhea; Female; Oxytocics; Oxytocin; Phytotherapy; Potassium; Rats; Uterine Contraction; Uterus | 2006 |
Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice.
Topics: 4-Butyrolactone; Analysis of Variance; Animals; bcl-2-Associated X Protein; Brain Infarction; Caspase 3; Caspases; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione Peroxidase; Immunohistochemistry; Ischemic Attack, Transient; Malondialdehyde; Mice; Mice, Inbred ICR; Neuroprotective Agents; Prosencephalon; Proto-Oncogene Proteins c-bcl-2; Reperfusion; Superoxide Dismutase; Tetrazolium Salts | 2006 |
Ligustilide inhibits vascular smooth muscle cells proliferation.
Topics: 4-Butyrolactone; Animals; Anthracenes; Blotting, Western; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Imidazoles; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylation; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; Retinoblastoma Protein | 2006 |
Ligustilide induces vasodilatation via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release.
Topics: 4-Butyrolactone; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Chloride; Calcium Signaling; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mesenteric Artery, Superior; Myography; Norepinephrine; Potassium Chloride; Rats; Ryanodine Receptor Calcium Release Channel; Serotonin; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2006 |
Factors affecting stability of z-ligustilide in the volatile oil of radix angelicae sinensis and ligusticum chuanxiong and its stability prediction.
Topics: 4-Butyrolactone; Angelica sinensis; Antioxidants; Ascorbic Acid; Drug Stability; Drugs, Chinese Herbal; Glycerol; Hydrogen-Ion Concentration; Light; Ligusticum; Models, Chemical; Oils, Volatile; Photolysis; Propylene Glycol; Solvents; Temperature | 2006 |
[Determination of ligustilide for quality assessment of Ligusticum chuanxiong].
Topics: 4-Butyrolactone; China; Chromatography, High Pressure Liquid; Ecosystem; Ligusticum; Plants, Medicinal; Quality Control; Reproducibility of Results; Rhizome | 2006 |
[Studies on chemical constituents from Ligusticum glaucescens Franch].
Topics: 4-Butyrolactone; Benzofurans; Coumaric Acids; Ligusticum; Methanol; Molecular Structure; Plants, Medicinal; Rhizome | 2006 |
Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta.
Topics: 4-Butyrolactone; Animals; Aorta, Thoracic; Benzofurans; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Ligusticum; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents | 2007 |
[High performance liquid chromatography-mass spectrometry analysis of radix Angelica sciensis].
Topics: 4-Butyrolactone; Angelica sinensis; Benzofurans; Chromatography, High Pressure Liquid; Coumaric Acids; Molecular Structure; Phthalic Anhydrides; Plant Roots; Plants, Medicinal; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2006 |
Neuroprotective effect of Z-ligustilide against permanent focal ischemic damage in rats.
Topics: 4-Butyrolactone; Animals; Body Temperature; Brain Edema; Brain Ischemia; Infarction, Middle Cerebral Artery; Male; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2007 |
Ligustilide attenuates pain behavior induced by acetic acid or formalin.
Topics: 4-Butyrolactone; Acetic Acid; Analgesics; Animals; Drugs, Chinese Herbal; Female; Formaldehyde; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; Pain; Pain Measurement | 2007 |
Ligustilide reduces phenylephrine induced-aortic tension in vitro but has no effect on systolic pressure in spontaneously hypertensive rats.
Topics: 4-Butyrolactone; Administration, Oral; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Biological Transport; Caco-2 Cells; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Hypertension; In Vitro Techniques; Intestinal Absorption; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Rats; Rats, Sprague-Dawley; Systole | 2007 |
Fast determination of Z-ligustilide in plasma by gas chromatography/mass spectrometry following headspace single-drop microextraction.
Topics: 4-Butyrolactone; Administration, Oral; Angelica sinensis; Animals; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Humans; Isomerism; Medicine, Chinese Traditional; Plant Extracts; Plant Oils; Rabbits | 2007 |
A new procedure for the preparative separation and isolation of Z-ligustilide from the roots of Angelica sinensis.
Topics: 4-Butyrolactone; Angelica sinensis; Aorta; Argon; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Dimerization; Drugs, Chinese Herbal; Models, Chemical; Oxygen; Plant Extracts; Plant Roots; Plants, Medicinal; Powders; Water | 2007 |
Protection against hydrogen peroxide-induced injury by Z-ligustilide in PC12 cells.
Topics: 4-Butyrolactone; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cytoprotection; Cytotoxins; Dose-Response Relationship, Drug; Free Radical Scavengers; Hydrogen Peroxide; Mitochondria; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; Up-Regulation | 2008 |
Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats.
Topics: 4-Butyrolactone; Acetylcholinesterase; Angelica sinensis; Animals; Antioxidants; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Choline O-Acetyltransferase; Cognition Disorders; Male; Maze Learning; Parasympathetic Nervous System; Prosencephalon; Rats; Rats, Wistar; Reversal Learning | 2008 |
Pharmacokinetics and metabolism of ligustilide, a major bioactive component in Rhizoma Chuanxiong, in the rat.
Topics: 4-Butyrolactone; Animals; Drug Administration Routes; Drugs, Chinese Herbal; Gastric Juice; Intestinal Secretions; Ligusticum; Male; Microsomes; Plant Extracts; Rats; Rats, Sprague-Dawley | 2008 |
Characterization of chemical components in extracts from Si-wu decoction with proliferation-promoting effects on rat mesenchymal stem cells.
Topics: 4-Butyrolactone; Animals; Benzofurans; Cell Proliferation; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flow Cytometry; Gas Chromatography-Mass Spectrometry; Mesenchymal Stem Cells; Molecular Structure; Palmitates; Rats; Rats, Sprague-Dawley; Stearates; Structure-Activity Relationship | 2008 |
Combinatorial anti-Trichophyton effects of Ligusticum chuanxiong essential oil components with antibiotics.
Topics: 4-Butyrolactone; Anti-Bacterial Agents; Antifungal Agents; Drug Synergism; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Itraconazole; Ketoconazole; Ligusticum; Microbial Sensitivity Tests; Oils, Volatile; Phthalic Anhydrides; Plant Oils; Plant Roots; Trichophyton | 2008 |
Dynamic nature of the ligustilide complex.
Topics: 4-Butyrolactone; Angelica sinensis; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phthalic Anhydrides; Plant Roots; Plants, Medicinal; Stereoisomerism | 2008 |
Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.
Topics: 4-Butyrolactone; Alkylation; Angelica sinensis; Animals; Antioxidants; Cell Line, Tumor; Gene Expression Regulation, Enzymologic; Genes, Reporter; Glutathione; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Mice; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); Plant Extracts; Tandem Mass Spectrometry | 2008 |
Identification and comparison of metabolites after oral administration of essential oil of Ligusticum chuanxiong or its major constituent ligustilide in rats.
Topics: 4-Butyrolactone; Administration, Oral; Animals; Drugs, Chinese Herbal; Ligusticum; Male; Molecular Structure; Oils, Volatile; Plant Oils; Rats; Rats, Wistar | 2008 |
[Development of gas chromatographic-mass spectrometry-pattern recognition method for the quality control of Chinese Angelica].
Topics: 4-Butyrolactone; Angelica sinensis; Cluster Analysis; Discriminant Analysis; Gas Chromatography-Mass Spectrometry; Principal Component Analysis | 2008 |
Bioactivity-guided fractionation and GC/MS fingerprinting of Angelica sinensis and Angelica archangelica root components for antifungal and mosquito deterrent activity.
Topics: 4-Butyrolactone; Angelica; Animals; Antifungal Agents; Chemical Fractionation; Colletotrichum; Culicidae; Drugs, Chinese Herbal; Feeding Behavior; Female; Gas Chromatography-Mass Spectrometry; Insect Bites and Stings; Insect Repellents; Male; Plant Roots | 2009 |
Optimization and comparison of five methods for extraction of coniferyl ferulate from Angelica sinensis.
Topics: 4-Butyrolactone; Angelica sinensis; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Coumaric Acids; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Molecular Structure; Plant Extracts; Sonication | 2009 |
Protective effect of Z-ligustilide against amyloid beta-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brains.
Topics: 4-Butyrolactone; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Humans; Inflammation Mediators; Injections, Intraventricular; Male; Maze Learning; Neuroprotective Agents; NF-kappa B; Rats; Rats, Wistar; Signal Transduction; Tumor Necrosis Factor-alpha | 2009 |
Determination of ligustilide in rat brain after nasal administration of essential oil from Rhizoma Chuanxiong.
Topics: 4-Butyrolactone; Administration, Inhalation; Animals; Brain; Drugs, Chinese Herbal; Female; Ligusticum; Male; Oils, Volatile; Rats; Rats, Sprague-Dawley; Rhizome | 2009 |
[Enzyme kinetics of ligustilide metabolism in rat liver microsomes].
Topics: 4-Butyrolactone; Animals; Benzoflavones; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; Ketoconazole; Kinetics; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Trimethoprim | 2009 |
[In situ absorption of self-microemulsifying soft capsule of volatile oil from rhizome of ligusticum chuanxiong in rats' intestine].
Topics: 4-Butyrolactone; Animals; beta-Cyclodextrins; Capsules; Duodenum; Emulsions; Female; Intestinal Absorption; Ligusticum; Oils, Volatile; Plants, Medicinal; Rats; Rats, Wistar; Rhizome | 2009 |
Z-ligustilide extracted from Radix Angelica Sinensis decreased platelet aggregation induced by ADP ex vivo and arterio-venous shunt thrombosis in vivo in rats.
Topics: 4-Butyrolactone; Adenosine Diphosphate; Angelica sinensis; Animals; Blood Coagulation; Depression, Chemical; Disease Models, Animal; Drugs, Chinese Herbal; Male; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Thrombosis | 2009 |
Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis.
Topics: 4-Butyrolactone; Angelica sinensis; Astragalus propinquus; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Drug Antagonism; Drugs, Chinese Herbal; Humans; Isoflavones; Medicine, Chinese Traditional; Polysaccharides; Saponins; Triterpenes | 2010 |
[Pharmacological activities of Z-ligustilide and metabolites in rats].
Topics: 4-Butyrolactone; Animals; Benzofurans; Biotransformation; Hydrogen Peroxide; Male; Microsomes, Liver; Oxidative Stress; PC12 Cells; Protective Agents; Rats; Rats, Sprague-Dawley | 2009 |
Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation.
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Anti-Inflammatory Agents; Cell Line; Coumaric Acids; Female; Inflammation; Inflammation Mediators; Lipopolysaccharides; Luciferases; Macrophages; Mice; Mice, Inbred BALB C; NF-kappa B; Phytotherapy; Plant Extracts | 2010 |
Z-ligustilide attenuates lipopolysaccharide-induced proinflammatory response via inhibiting NF-kappaB pathway in primary rat microglia.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Dose-Response Relationship, Drug; Inflammation; Lipopolysaccharides; Microglia; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2010 |
Effects of ligustilide on lipopolysaccharide-induced endotoxic shock in rabbits.
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Bilirubin; Blood Pressure; Blood Proteins; Blood Urea Nitrogen; Creatine; Dexamethasone; Dose-Response Relationship, Drug; Female; Interleukin-1beta; Lipopolysaccharides; Male; Nitric Oxide; Rabbits; Shock, Septic; Tumor Necrosis Factor-alpha | 2011 |
Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Biological Assay; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Humans; Ligusticum; Lipopolysaccharides; Mice; Microglia; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Tumor Necrosis Factor-alpha | 2011 |
Determination of ligustilide in the brains of freely moving rats using microdialysis coupled with ultra performance liquid chromatography/mass spectrometry.
Topics: 4-Butyrolactone; Administration, Mucosal; Animals; Brain; Chromatography, High Pressure Liquid; Ligusticum; Male; Mass Spectrometry; Microdialysis; Nasal Mucosa; Plant Extracts; Rats; Rats, Sprague-Dawley | 2011 |
[Simultaneous determination of five effective components in Rhizoma Chuanxiong by RP-HPLC].
Topics: 4-Butyrolactone; Benzofurans; Calibration; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Pyrazines | 2010 |
[Study on feasibility of cutting process of fresh Angelica sinensis Radix].
Topics: 4-Butyrolactone; Angelica sinensis; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Plant Roots; Technology, Pharmaceutical | 2010 |
Treatment with Z-ligustilide, a component of Angelica sinensis, reduces brain injury after a subarachnoid hemorrhage in rats.
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Blood-Brain Barrier; Brain Edema; Disease Models, Animal; Dose-Response Relationship, Drug; In Situ Nick-End Labeling; Male; Neuroprotective Agents; Phytotherapy; Plant Oils; Random Allocation; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2011 |
Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801.
Topics: 4-Butyrolactone; Animals; Cell Line; Chromones; Erythropoietin; Flavonoids; Gene Expression Regulation; Glucose; Imidazoles; L-Lactate Dehydrogenase; Male; Morpholines; Neurons; Oxygen; Plasmids; Pyridines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Repressor Proteins; Transcription Factors | 2011 |
Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-κB and AP-1 signaling pathways.
Topics: 4-Butyrolactone; Animals; Cell Line; Dinoprostone; Down-Regulation; I-kappa B Kinase; Lipopolysaccharides; Macrophages; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Transcription Factor AP-1; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2011 |
Identification of novel pregnane X receptor activators from traditional Chinese medicines.
Topics: 4-Butyrolactone; Berberine; Cyclooctanes; Cytochrome P-450 CYP3A; Dioxoles; Drugs, Chinese Herbal; Genes, Reporter; Hep G2 Cells; Herb-Drug Interactions; Humans; Lignans; Magnoliopsida; Medicine, Chinese Traditional; Plants, Medicinal; Pregnane X Receptor; Receptors, Steroid; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stilbenes | 2011 |
Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice.
Topics: 4-Butyrolactone; Acetylcholinesterase; Angelica; Animals; Choline O-Acetyltransferase; Cholinergic Agents; Male; Maze Learning; Memory; Memory Disorders; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Plant Roots; Scopolamine; Tacrine | 2011 |
Ligustilide: a novel TRPA1 modulator.
Topics: 4-Butyrolactone; Animals; CHO Cells; Cricetinae; Cricetulus; Medicine, Traditional; Mice; Molecular Structure; Mustard Plant; Patch-Clamp Techniques; Plant Oils; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2011 |
Potential roles of PI3K/Akt and Nrf2-Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation.
Topics: 4-Butyrolactone; Animals; Glucose; Heme Oxygenase-1; Hormesis; Hypoxia; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Oxidative Stress; PC12 Cells; Phosphatidylinositol 3-Kinases; Proteins; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Signal Transduction | 2012 |
Identification and quantification of the major volatile constituents in antidepressant active fraction of xiaoyaosan by gas chromatography-mass spectrometry.
Topics: 4-Butyrolactone; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Lactones; Male; Mice; Mice, Inbred ICR; Molecular Structure; Motor Activity; Palmitic Acid; Phytotherapy; Plants, Medicinal; Sesquiterpenes; Volatilization | 2012 |
Z-ligustilide potentiates the cytotoxicity of dopamine in rat dopaminergic PC12 cells.
Topics: 4-Butyrolactone; Acetylcysteine; Animals; Apoptosis; Bisbenzimidazole; Cell Count; DNA Fragmentation; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Glutathione; Levodopa; Neuroprotective Agents; PC12 Cells; Rats; Reactive Oxygen Species; Time Factors | 2012 |
[Protective effects of Z-ligustilide against cytotoxicity induced by Abeta25-35 in neuron cells].
Topics: 4-Butyrolactone; Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Cell Line, Tumor; Humans; Neuroblastoma; Neurons; Neuroprotective Agents; Peptide Fragments | 2012 |
Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles.
Topics: 4-Butyrolactone; Angelica sinensis; Cell Growth Processes; Cell Survival; Countercurrent Distribution; Drug Synergism; Human Umbilical Vein Endothelial Cells; Humans; Oils, Volatile; Phthalic Anhydrides; Plant Extracts; Plant Roots; Robotics | 2012 |
Anti-inflammatory effects of (Z)-ligustilide through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cell Culture Techniques; Cell Line; Cell Survival; Cyclooxygenase 2; Dose-Response Relationship, Drug; Down-Regulation; Edema; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; Molecular Structure; NF-kappa B; Nitric Oxide Synthase Type II; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2012 |
The anti-inflammatory effect of Z-Ligustilide in experimental ovariectomized osteopenic rats.
Topics: 4-Butyrolactone; Aldehydes; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Female; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-1beta; Neutrophils; NF-kappa B; Nitric Oxide Synthase Type II; Osteoporosis; Ovariectomy; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
[Influence of different solutions on extracting of active components in Danggui Chishao drug pair].
Topics: 4-Butyrolactone; Benzoates; Benzofurans; Bridged-Ring Compounds; Chromatography, Liquid; Drugs, Chinese Herbal; Gallic Acid; Glucosides; Hydroxybenzoates; Mass Spectrometry; Monoterpenes; Phthalic Acids; Solvents; Vanillic Acid | 2012 |
Antimycobacterials from lovage root (Ligusticum officinale Koch).
Topics: 4-Butyrolactone; Animals; Antibiotics, Antitubercular; Cytotoxins; Diynes; Fatty Alcohols; Furocoumarins; Ligusticum; Macrophages; Mice; Mycobacterium bovis; Mycobacterium smegmatis; Mycobacterium tuberculosis; Phytotherapy; Plant Extracts; Plant Roots; Sesquiterpenes | 2013 |
Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications.
Topics: 4-Butyrolactone; Angelica; Animals; Astragalus propinquus; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Coumaric Acids; Drugs, Chinese Herbal; Erythropoiesis; Female; Glucosides; Humans; Isoflavones; Medicine, Chinese Traditional; Osteogenesis; Plant Roots; Promoter Regions, Genetic; Receptors, Estrogen; Saponins; Triterpenes | 2012 |
Anti-inflammatory effects of Z-ligustilide nanoemulsion.
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Anti-Inflammatory Agents; Biological Availability; Emulsions; Inflammation; Inflammation Mediators; Interleukin-17; Interleukin-1beta; Lipopolysaccharides; Male; Nanoparticles; Plant Oils; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Uveitis; Vascular Endothelial Growth Factor A | 2013 |
Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion.
Topics: 4-Butyrolactone; Animals; Brain Ischemia; Cognition; Hippocampus; Male; Maze Learning; Memory; Neuroprotective Agents; Parietal Lobe; Phytotherapy; Rats; Rats, Sprague-Dawley | 2012 |
Analysis of the chemical composition, acute toxicity and skin sensitivity of essential oil from rhizomes of Ligusticum chuanxiong.
Topics: 4-Butyrolactone; Animals; Female; Guinea Pigs; Irritants; Ligusticum; Male; Mice; Mice, Inbred ICR; Oils, Volatile; Rabbits; Rhizome; Skin; Toxicity Tests, Acute | 2012 |
Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation.
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; CpG Islands; DNA Methylation; Drugs, Chinese Herbal; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Male; Mice; NF-E2-Related Factor 2; Promoter Regions, Genetic; Prostate; Prostatic Neoplasms | 2013 |
[Study on the dynamic variations of Z-ligustilide and n-butylidenephthalide content in essential oil of radix angelicae sinensis from different growth period].
Topics: 4-Butyrolactone; Angelica sinensis; Biomass; Gas Chromatography-Mass Spectrometry; Oils, Volatile; Phthalic Anhydrides; Plant Roots; Plants, Medicinal; Seasons | 2012 |
[Study on quality evaluation of Angelica sinensis by grey incidence degree method].
Topics: 4-Butyrolactone; Algorithms; Angelica sinensis; Coumaric Acids; Models, Statistical; Oils, Volatile; Plant Roots; Plants, Medicinal; Polysaccharides; Quality Control | 2012 |
Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation.
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Gene Expression; Hep G2 Cells; Humans; Interleukin-1beta; Mice; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Nitric Oxide; Phthalic Anhydrides; Phytochemicals; Plant Extracts; RNA, Messenger; Superoxide Dismutase; Superoxide Dismutase-1; Tumor Necrosis Factor-alpha | 2013 |
Simultaneous determination of bioactive components in essential oil of Xiang-Fu-Si-Wu Formula in Beagle dog plasma by UPLC-MS/MS and its application to pharmacokinetics.
Topics: 4-Butyrolactone; Animals; Chromatography, High Pressure Liquid; Dogs; Female; Lactones; Reproducibility of Results; Sesquiterpenes; Tandem Mass Spectrometry | 2013 |
Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia-reperfusion injury in vivo and in vitro.
Topics: 4-Butyrolactone; Animals; Blotting, Western; Brain Ischemia; Cell Line; Disease Models, Animal; Fluorescent Antibody Technique; Heme Oxygenase-1; Humans; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2013 |
The Effect of Z-Ligustilide on the Mobility of Human Glioblastoma T98G Cells.
Topics: 4-Butyrolactone; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Cytoskeleton; Glioblastoma; Humans; Neoplasm Proteins; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein | 2013 |
[Effects of conjunctive application of Chinese herbal medicine residue compost and chemical fertilizer on ferulic acid and ligustilide contents in Angelica sinensis].
Topics: 4-Butyrolactone; Agriculture; Angelica sinensis; Biomass; Chromatography, High Pressure Liquid; Coumaric Acids; Fertilizers; Industrial Waste; Nitrogen; Phosphorus; Plant Roots; Plant Stems; Potassium; Seasons | 2013 |
Radix Angelica Sinensis that contains the component Z-ligustilide promotes adult neurogenesis to mediate recovery from cognitive impairment.
Topics: 4-Butyrolactone; Adult Stem Cells; Angelica sinensis; Animals; Blotting, Western; Cell Differentiation; Cognition Disorders; Cranial Irradiation; Disease Models, Animal; Drugs, Chinese Herbal; Hippocampus; Immunohistochemistry; Male; Neural Stem Cells; Neurodegenerative Diseases; Neurogenesis; Rats; Rats, Wistar | 2013 |
Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model.
Topics: 4-Butyrolactone; Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cells, Cultured; Disease Models, Animal; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Glucuronidase; Insulin-Like Growth Factor I; Klotho Proteins; Male; Memory Disorders; Mice; Mice, Inbred Strains; Molecular Targeted Therapy; Neuroprotective Agents; Oxidative Stress; Peptide Fragments; Phosphorylation; Signal Transduction; tau Proteins; Up-Regulation | 2014 |
Anti-inflammatory ligustilides from Ligusticum chuanxiong Hort.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Benzofurans; Drugs, Chinese Herbal; Inflammation; Ligusticum; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Nitric Oxide; Phytotherapy; Plant Roots | 2013 |
Structure elucidation of degradation products of Z-ligustilide by UPLC-QTOF-MS and NMR spectroscopy.
Topics: 4-Butyrolactone; Benzofurans; Chromatography, High Pressure Liquid; Hydrolysis; Ligusticum; Magnetic Resonance Spectroscopy; Metabolic Networks and Pathways; Oxidation-Reduction; Plant Roots; Plants, Medicinal; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2013 |
3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.
Topics: 4-Butyrolactone; Animals; Benzofurans; HEK293 Cells; Humans; Oxidation-Reduction; Protein Binding; Rats; TRPA1 Cation Channel; TRPC Cation Channels; TRPM Cation Channels | 2013 |
[Study on the constituents of essential oil of Shunaoxin dropping pills by GC-MS].
Topics: 4-Butyrolactone; Angelica; Apiaceae; Benzofurans; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Lactones; Oils, Volatile; Phthalic Anhydrides | 2013 |
Identification of multiple ingredients for a Traditional Chinese Medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry.
Topics: 4-Butyrolactone; Benzoates; Bridged-Ring Compounds; Chromatography, High Pressure Liquid; Digoxin; Drugs, Chinese Herbal; Glucosides; Humans; Isoflavones; Limit of Detection; Medicine, Chinese Traditional; Monoterpenes; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Triterpenes | 2013 |
HPLC method with fluorescence detection for the determination of ligustilide in rat plasma and its pharmacokinetics.
Topics: 4-Butyrolactone; Administration, Oral; Angelica sinensis; Animals; Biological Availability; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Injections, Intravenous; Limit of Detection; Male; Plant Roots; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Spectrometry, Fluorescence; Time Factors | 2014 |
An automated dual-gradient liquid chromatography-MS/MS method for the simultaneous determination of ferulic acid, ligustrazine and ligustilide in rat plasma and its application to a pharmacokinetic study.
Topics: 4-Butyrolactone; Absorption; Administration, Oral; Animals; Automation; Calibration; Chromatography, High Pressure Liquid; Chromatography, Liquid; Coumaric Acids; Male; Medicine, Chinese Traditional; Plant Extracts; Pressure; Pyrazines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sulfamethoxazole; Tandem Mass Spectrometry | 2014 |
Pharmacokinetics, brain distribution, release and blood-brain barrier transport of Shunaoxin pills.
Topics: 4-Butyrolactone; Animals; Biological Transport; Blood-Brain Barrier; Brain; Cell Line; Cell Survival; Coumaric Acids; Dogs; Drugs, Chinese Herbal; Male; Rats; Rats, Sprague-Dawley; Tablets | 2014 |
[Comparison on content of ligustilides in different danggui samples].
Topics: 4-Butyrolactone; Angelica sinensis; China; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Geography; Quality Control | 2013 |
Ligustilide attenuates inflammatory pain via inhibition of NFκB-mediated chemokines production in spinal astrocytes.
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Astrocytes; Cells, Cultured; Chemokine CCL2; Chemokines; Hyperalgesia; Male; Mice; Mice, Inbred ICR; NF-kappa B; Nociception; Nociceptive Pain; RNA, Messenger; Spinal Cord | 2014 |
Ligustilide prevents the apoptosis effects of tumour necrosis factor-alpha during C2C12 cell differentiation.
Topics: 4-Butyrolactone; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 8; Cell Differentiation; Cell Line; Cell Survival; Mice; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Tumor Necrosis Factor-alpha | 2014 |
Z-Ligustilide inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via ROS-dependent Nrf2 activation.
Topics: 4-Butyrolactone; Angelica; Benzo(a)pyrene; Cell Survival; Cells, Cultured; Cnidium; Cytochrome P-450 CYP1A1; Dermatitis; Drug Evaluation, Preclinical; Environmental Pollutants; Humans; Keratinocytes; NF-E2-Related Factor 2; Phytotherapy; Plant Extracts; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Up-Regulation | 2014 |
Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia/reperfusion rats: involvement of inhibition of TLR4/peroxiredoxin 6 signaling.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Brain Ischemia; Cell Movement; Gene Expression Regulation; Inflammation; Injections, Intraperitoneal; Macrophage Activation; Male; Microglia; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; NF-kappa B; Oxidative Stress; Peroxiredoxin VI; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; STAT3 Transcription Factor; T-Lymphocytes; Toll-Like Receptor 4 | 2014 |
New dimeric phthalides from Ligusticum sinense Oliv cv. Chaxiong.
Topics: 4-Butyrolactone; Benzofurans; Crystallography, X-Ray; Drugs, Chinese Herbal; Ligusticum; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Rhizome | 2014 |
Complexation of Z-ligustilide with hydroxypropyl-β-cyclodextrin to improve stability and oral bioavailability.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; 4-Butyrolactone; Animals; beta-Cyclodextrins; Biological Availability; Drug Stability; Male; Rats; Rats, Sprague-Dawley; Spectroscopy, Fourier Transform Infrared; Temperature | 2014 |
[Optimation the extracting technology of Angelica sinensis by central composite design and response surface methodology].
Topics: 4-Butyrolactone; Angelica sinensis; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Methanol; Models, Statistical; Plant Roots; Reproducibility of Results; Solvents; Technology, Pharmaceutical | 2013 |
A simultaneous determination of principal compounds in tokishakuyakusan by high-performance liquid chromatography with diode array detector.
Topics: 4-Butyrolactone; Cholestenones; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Glucosides; Lactones; Limit of Detection; Linear Models; Monoterpenes; Reproducibility of Results; Sesquiterpenes | 2015 |
[Quantitative determination of 5 active ingredients in different harvest periods of Ligusticum chuanxiong by HPLC].
Topics: 4-Butyrolactone; Acetic Acid; Acetonitriles; Benzofurans; Chromatography, High Pressure Liquid; Coumaric Acids; Ligusticum; Methanol; Solvents; Time Factors | 2014 |
Ligustilide inhibits microglia-mediated proinflammatory cytokines production and inflammatory pain.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Calcium-Binding Proteins; Cell Line, Transformed; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Inflammation; Lipopolysaccharides; Male; Mice; Microfilament Proteins; Microglia; Pain; Pain Measurement; Pain Threshold; RNA, Messenger; Spinal Cord; Time Factors | 2014 |
Ligustilide prevents cognitive impairment and attenuates neurotoxicity in D-galactose induced aging mice brain.
Topics: 4-Butyrolactone; Aging; Animals; Brain; Cognition Disorders; Galactose; GAP-43 Protein; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Male; Malondialdehyde; Maze Learning; Mice; Mice, Inbred ICR; Neuroprotective Agents; Neurotoxicity Syndromes; Sodium-Potassium-Exchanging ATPase; Statistics, Nonparametric | 2015 |
[Effects of environmental factors on volatile constituent ligustilide of slices of Chuanxiong Rhizoma].
Topics: 4-Butyrolactone; Chromatography, High Pressure Liquid; Rhizome; Temperature; Volatilization | 2014 |
Nephroprotective effects of ferulic acid, Z-ligustilide and E-ligustilide isolated from Angelica sinensis against cisplatin toxicity in vitro.
Topics: 4-Butyrolactone; Acute Kidney Injury; Angelica sinensis; Antineoplastic Agents; Cell Line; Cisplatin; Collagen; Coumaric Acids; Humans; In Vitro Techniques; Kidney Diseases; Plant Extracts; Protective Agents; Reactive Oxygen Species; Wound Healing | 2015 |
Ligustilide inhibits tumour necrosis factor-alpha-induced autophagy during C2C12 cells differentiation.
Topics: 4-Butyrolactone; Animals; Autophagy; Cell Differentiation; Cell Line; Mice; Microtubule-Associated Proteins; Phagosomes; Tumor Necrosis Factor-alpha | 2015 |
[Study on material basis of essential oil from Yin Teng Gu Bi Kang prescription on activating blood circulation].
Topics: 4-Butyrolactone; Animals; Blood Circulation; Chromatography, Supercritical Fluid; Cyclohexenes; Gas Chromatography-Mass Spectrometry; Limonene; Oils, Volatile; Rats; Terpenes | 2014 |
[Protective effect of ligustilide against low potassium induced apoptosis in cultured rat cerebellar granule neurons].
Topics: 4-Butyrolactone; Animals; Animals, Newborn; Apoptosis; Caspase 3; Cells, Cultured; Cerebellum; Insulin-Like Growth Factor I; Neurons; Organophosphorus Compounds; Phosphorylation; Potassium; Rats; Receptor, IGF Type 1; Signal Transduction | 2015 |
[Application of entropy-weight TOPSIS model in synthetical quality evaluation of Angelica sinensis growing in Gansu Province].
Topics: 4-Butyrolactone; Angelica sinensis; Coumaric Acids; Drugs, Chinese Herbal; Entropy; Medicine, Chinese Traditional; Oils, Volatile; Phthalic Anhydrides | 2014 |
[Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells].
Topics: 4-Butyrolactone; Aniline Compounds; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Calcium; Caspase 3; Cell Survival; Cytochromes c; Glutamic Acid; Mitochondria; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Xanthenes | 2015 |
Interaction between Z-ligustilide from Radix Angelica sinensis and human serum albumin.
Topics: 4-Butyrolactone; Angelica sinensis; Fluorescence; Fluorescence Resonance Energy Transfer; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Protein Binding; Serum Albumin; Spectrometry, Fluorescence; Thermodynamics | 2015 |
Z-ligustilide ameliorated ultraviolet B-induced oxidative stress and inflammatory cytokine production in human keratinocytes through upregulation of Nrf2/HO-1 and suppression of NF-κB pathway.
Topics: 4-Butyrolactone; Cell Survival; Cells, Cultured; Chemokine CCL2; Gene Silencing; Heme Oxygenase-1; Humans; I-kappa B Proteins; Interleukin-6; Interleukin-8; Keratinocytes; NF-E2-Related Factor 2; Oxidative Stress; Plant Extracts; Protein Transport; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Transcription Factor RelA; Transfection; Ultraviolet Rays; Up-Regulation | 2015 |
Ligustilide Ameliorates Inflammatory Pain and Inhibits TLR4 Upregulation in Spinal Astrocytes Following Complete Freund's Adjuvant Peripheral Injection.
Topics: 4-Butyrolactone; Animals; Astrocytes; Cells, Cultured; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice, Inbred ICR; Pain; RNA, Messenger; Spinal Cord; Toll-Like Receptor 4; Up-Regulation | 2016 |
Protective HSP70 Induction by Z-Ligustilide against Oxygen-Glucose Deprivation Injury via Activation of the MAPK Pathway but Not of HSF1.
Topics: 4-Butyrolactone; Animals; Benzhydryl Compounds; Cell Survival; Glucose; HEK293 Cells; HSP70 Heat-Shock Proteins; Humans; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Neuroprotective Agents; Oxygen; PC12 Cells; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Small Interfering | 2015 |
Vasorelaxant effects of Shunaoxin pill are mediated by NO/cGMP pathway, HO/CO pathway and calcium channel blockade in isolated rat thoracic aorta.
Topics: 4-Butyrolactone; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Calcium Channels; Carbon Monoxide; Coumaric Acids; Cyclic GMP; Drugs, Chinese Herbal; Heme Oxygenase (Decyclizing); In Vitro Techniques; Male; Nitric Oxide; Norepinephrine; Potassium Chloride; Rats, Wistar; Tablets; Vasodilator Agents | 2015 |
[A cell membrane chromatography method for investigation of 5-hydroxytryptamine receptor-ligustilide interaction].
Topics: 4-Butyrolactone; Animals; Binding Sites; Cell Membrane; Chromatography; Rats; Receptors, Serotonin; Sumatriptan | 2015 |
Analysis of Chuanxiong Rhizoma and its active components by Fourier transform infrared spectroscopy combined with two-dimensional correlation infrared spectroscopy.
Topics: 4-Butyrolactone; Drugs, Chinese Herbal; Porosity; Resins, Synthetic; Spectroscopy, Fourier Transform Infrared; Sucrose | 2016 |
Anti-inflammatory Activity of Constituents Isolated from Aerial Part of Angelica acutiloba Kitagawa.
Topics: 4-Butyrolactone; Angelica; Animals; Anti-Inflammatory Agents; Benzofurans; Dinoprostone; Diynes; Fatty Alcohols; Furocoumarins; Heme Oxygenase-1; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Nitric Oxide; Phytochemicals; Plant Components, Aerial; Plant Extracts; Plant Roots; Plants, Medicinal; RAW 264.7 Cells; Tumor Necrosis Factor-alpha | 2015 |
Quick and selective extraction of Z-ligustilide from Angelica sinensis using magnetic multiwalled carbon nanotubes.
Topics: 4-Butyrolactone; Angelica sinensis; Chemistry Techniques, Analytical; Magnetics; Microscopy, Electron, Transmission; Nanotubes, Carbon; Plant Extracts; Plant Roots; Plants, Medicinal; Reproducibility of Results; Time Factors | 2015 |
[Establishment and application of HPLC-QAMS for quality evaluation of Chuanxiong Rhizoma].
Topics: 4-Butyrolactone; Acetonitriles; Benzofurans; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Hydroxybenzoates; Quality Control; Rhizome | 2015 |
Chemical Composition and Aroma Evaluation of Essential Oils from Skunk Cabbage (Symplocarpus foetidus).
Topics: 4-Butyrolactone; Araceae; Benzene Derivatives; Distillation; Disulfides; Ethylene Glycols; Furans; Gas Chromatography-Mass Spectrometry; Guaiacol; Indicator Dilution Techniques; Odorants; Oils, Volatile; Olfactometry; Plant Leaves; Plant Oils; Plant Stems; Valerates; Volatilization | 2015 |
Ligustilide treatment promotes functional recovery in a rat model of spinal cord injury via preventing ROS production.
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Disease Models, Animal; Drugs, Chinese Herbal; Male; Neuroprotective Agents; Phytotherapy; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recovery of Function; Spinal Cord Injuries | 2015 |
[Comparative Study on Volatile Oil Composition of Chuanxiong Rhizoma, Angelicae Sinensis Radix and Ligustici Rhizoma et Radix].
Topics: 4-Butyrolactone; Angelica sinensis; Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ligusticum; Oils, Volatile; Phthalic Anhydrides; Plant Oils; Plant Roots; Rhizome | 2015 |
Therapeutic Effect of Ligustilide-Stimulated Adipose-Derived Stem Cells in a Mouse Thromboembolic Stroke Model.
Topics: 4-Butyrolactone; Adipose Tissue; Animals; Apoptosis; Cell- and Tissue-Based Therapy; Cells, Cultured; Chemokine CXCL12; Disease Models, Animal; Mice; Mice, Inbred BALB C; Receptors, CXCR4; Stem Cell Transplantation; Stem Cells; Stroke; Thromboembolism | 2016 |
Elucidation of Transport Mechanism of Paeoniflorin and the Influence of Ligustilide, Senkyunolide I and Senkyunolide A on Paeoniflorin Transport through Mdck-Mdr1 Cells as Blood-Brain Barrier in Vitro Model.
Topics: 4-Butyrolactone; Animals; ATP Binding Cassette Transporter, Subfamily B; Benzofurans; Biological Transport; Blood-Brain Barrier; Dogs; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucosides; Humans; In Vitro Techniques; Madin Darby Canine Kidney Cells; Molecular Structure; Monoterpenes | 2016 |
Kelussia odoratissima Mozaff attenuates thromboembolic brain injury, possibly due to its Z-ligustilide content.
Topics: 4-Butyrolactone; Animals; Antioxidants; Apiaceae; Brain Edema; Catalase; Cerebral Cortex; Disease Models, Animal; Glutathione; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Stroke; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2016 |
Protection against β-amyloid-induced neurotoxicity by naturally occurring Z-ligustilide through the concurrent regulation of p38 and PI3-K/Akt pathways.
Topics: 4-Butyrolactone; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cell Survival; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphatidylinositol 3-Kinases; Rats; Reactive Oxygen Species; Signal Transduction | 2016 |
Differences in Proinflammatory Property of Six Subtypes of Peroxiredoxins and Anti-Inflammatory Effect of Ligustilide in Macrophages.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Cell Line; Inflammation; Interleukin-6; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxiredoxins; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2016 |
(Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells.
Topics: 4-Butyrolactone; Antigens, CD; Apoferritins; Brain Ischemia; Cation Transport Proteins; Cell Line, Tumor; Cell Survival; Down-Regulation; Gene Expression Regulation; Glucose; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neuroprotective Agents; Oxygen; Receptors, Transferrin | 2016 |
Screening of Bioactive Ingredients in Ligusticum Chuanxiong Hort for Protection against Myocardial Ischemia.
Topics: 4-Butyrolactone; Animals; Cardiotonic Agents; Chromatography, High Pressure Liquid; Coumaric Acids; Disease Models, Animal; Dogs; Ligusticum; Myocardial Infarction; Myocardial Ischemia; Plant Extracts; Reference Standards; Rhizome | 2016 |
PEGylation of magnetic multi-walled carbon nanotubes for enhanced selectivity of dispersive solid phase extraction.
Topics: 4-Butyrolactone; Magnetic Fields; Nanocomposites; Nanotubes, Carbon; Pinellia; Polyethylene Glycols | 2017 |
Intranasal Pretreatment with Z-Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways.
Topics: 4-Butyrolactone; Administration, Intranasal; Animals; Blood-Brain Barrier; Brain Ischemia; Drugs, Chinese Herbal; HSP70 Heat-Shock Proteins; Humans; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Rats, Sprague-Dawley; Rhizome; Signal Transduction | 2017 |
Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa.
Topics: 4-Butyrolactone; Breast Neoplasms; Cell Line, Tumor; Epigenesis, Genetic; Epigenetic Repression; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase 1; Humans; Tamoxifen | 2017 |
Sensitization of tamoxifen-resistant breast cancer cells by Z-ligustilide through inhibiting autophagy and accumulating DNA damages.
Topics: 4-Butyrolactone; Autophagy; Breast Neoplasms; Cell Line, Tumor; DNA Damage; Female; Humans; MCF-7 Cells | 2017 |
A novel enzyme-assisted approach for efficient extraction of Z-ligustilide from Angelica sinensis plants.
Topics: 4-Butyrolactone; Angelica sinensis; Cellulase; Endophytes; Enzymes; Plant Extracts; Plant Proteins | 2017 |
The influence and mechanism of ligustilide, senkyunolide I, and senkyunolide A on echinacoside transport through MDCK-MDR1 cells as blood-brain barrier in vitro model.
Topics: 4-Butyrolactone; Animals; Benzofurans; Biological Transport; Blood-Brain Barrier; Dogs; Drugs, Chinese Herbal; Glycosides; Humans; Madin Darby Canine Kidney Cells | 2018 |
Klotho upregulation contributes to the neuroprotection of ligustilide against cerebral ischemic injury in mice.
Topics: 4-Butyrolactone; Animals; Brain Ischemia; Glucuronidase; HEK293 Cells; Humans; Klotho Proteins; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Signal Transduction; Up-Regulation | 2018 |
Ligustilide attenuates vascular inflammation and activates Nrf2/HO-1 induction and, NO synthesis in HUVECs.
Topics: 4-Butyrolactone; Anti-Inflammatory Agents, Non-Steroidal; E-Selectin; Fluoresceins; Fluorescent Dyes; Heme Oxygenase-1; HL-60 Cells; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1; Vasculitis | 2018 |
Acaricidal and repellent effects of Cnidium officinale-derived material against Dermanyssus gallinae (Acari: Dermanyssidae).
Topics: 4-Butyrolactone; Acaricides; Animals; Cnidium; Female; Male; Mites; Phthalic Anhydrides; Plant Extracts; Rhizome | 2018 |
Preparing the key metabolite of Z-ligustilide in vivo by a specific electrochemical reaction.
Topics: 4-Butyrolactone; Animals; Benzofurans; Drugs, Chinese Herbal; Electrochemistry; Leuconostoc mesenteroides; Mass Spectrometry; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 2018 |
The neuroprotective effects and probable mechanisms of Ligustilide and its degradative products on intracerebral hemorrhage in mice.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Cerebral Hemorrhage; Homeodomain Proteins; Interleukin-6; Male; Mice; Neuroprotective Agents; NF-kappa B; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2018 |
The Protective Effect of Ligustilide in Osteoarthritis: An in Vitro and in Vivo Study.
Topics: 4-Butyrolactone; ADAMTS5 Protein; Aged; Animals; Cell Survival; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Humans; Interleukin-1beta; Male; Matrix Metalloproteinase 3; Mice; Mice, Inbred C57BL; Middle Aged; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Osteoarthritis | 2018 |
Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2.
Topics: 4-Butyrolactone; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Membrane Potential, Mitochondrial; NF-E2-Related Factor 2; Ovarian Neoplasms; Reactive Oxygen Species; Transcription, Genetic | 2018 |
Ligustilide inhibits the activation of cancer-associated fibroblasts.
Topics: 4-Butyrolactone; Apoptosis; Cancer-Associated Fibroblasts; Cell Proliferation; Humans; Male; Prostatic Neoplasms; Signal Transduction; Tumor Cells, Cultured | 2019 |
Ligustilide attenuates nitric oxide-induced apoptosis in rat chondrocytes and cartilage degradation via inhibiting JNK and p38 MAPK pathways.
Topics: 4-Butyrolactone; Animals; Apoptosis; Cartilage, Articular; Cell Nucleus Shape; Cell Survival; Chondrocytes; Disease Models, Animal; Enzyme Activation; Injections, Intra-Articular; JNK Mitogen-Activated Protein Kinases; Male; Membrane Potential, Mitochondrial; Nitric Oxide; Nitroprusside; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Rats, Sprague-Dawley | 2019 |
Ligustilide alleviated IL-1β induced apoptosis and extracellular matrix degradation of nucleus pulposus cells and attenuates intervertebral disc degeneration in vivo.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Apoptosis; Cells, Cultured; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Extracellular Matrix; Humans; Inflammation Mediators; Interleukin-1beta; Intervertebral Disc Degeneration; NF-kappa B; Nitric Oxide Synthase Type II; Nucleus Pulposus; Proteolysis; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Ligustilide Ameliorates the Permeability of the Blood-Brain Barrier Model In Vitro During Oxygen-Glucose Deprivation Injury Through HIF/VEGF Pathway.
Topics: 4-Butyrolactone; Animals; Aquaporin 4; Astrocytes; Blood-Brain Barrier; Capillary Permeability; Cell Hypoxia; Cells, Cultured; Coculture Techniques; Endothelial Cells; Glucose; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Rats, Sprague-Dawley; Signal Transduction; Tight Junctions; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein | 2019 |
Z-Ligustilide protects vascular endothelial cells from oxidative stress and rescues high fat diet-induced atherosclerosis by activating multiple NRF2 downstream genes.
Topics: 4-Butyrolactone; Animals; Atherosclerosis; Cells, Cultured; Diet, High-Fat; Endothelial Cells; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidative Stress | 2019 |
Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Apoptosis; Bone Density Conservation Agents; Cell Line; Disease Models, Animal; Embryo, Nonmammalian; Gene Expression Regulation; Green Fluorescent Proteins; Larva; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; Osteoporosis; Prednisolone; Primary Cell Culture; Proto-Oncogene Proteins c-bcl-2; Rats; Receptors, G-Protein-Coupled; Zebrafish; Zebrafish Proteins | 2019 |
Z-ligustilide and n-Butylidenephthalide Isolated from the Aerial Parts of Angelica tenuissima Inhibit Lipid Accumulation In Vitro and In Vivo.
Topics: 4-Butyrolactone; Angelica; Animals; Diet, High-Fat; Drug Evaluation, Preclinical; Gene Expression Regulation; Hep G2 Cells; Humans; Lipid Metabolism; Lipogenesis; Male; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phthalic Anhydrides; Plant Components, Aerial; Plant Extracts; Sterol Regulatory Element Binding Protein 1 | 2019 |
Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, through inhibiting AP-1 and NF-κB expression.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Apolipoproteins E; Atherosclerosis; Benzofurans; HEK293 Cells; Humans; Immunologic Factors; Inflammation Mediators; Lipids; Male; Mice, Inbred C57BL; NF-kappa B; Proto-Oncogene Proteins c-akt; Transcription Factor AP-1; Tumor Necrosis Factor Receptor Superfamily, Member 9 | 2019 |
The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach.
Topics: 4-Butyrolactone; Antifungal Agents; Candida albicans; Candida parapsilosis; Eugenol | 2019 |
Simultaneous quantification of ligustilide, dl-3-n-butylphthalide and senkyunolide A in rat plasma by GC-MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction.
Topics: 4-Butyrolactone; Administration, Oral; Animals; Benzofurans; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Limit of Detection; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 2019 |
[UPLC fingerprint and multi-components content determination of different processed products of Angelica sinensis].
Topics: 4-Butyrolactone; Angelica sinensis; Benzofurans; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Hydroxybenzoates; Medicine, Chinese Traditional; Principal Component Analysis | 2019 |
Direct and Metal-Catalyzed Photochemical Dimerization of the Phthalide (
Topics: 4-Butyrolactone; Benzofurans; Catalysis; Crystallography, X-Ray; Cycloaddition Reaction; Dimerization; Metals; Molecular Structure; Photochemistry | 2019 |
Ligustilide suppresses RANKL-induced osteoclastogenesis and bone resorption via inhibition of RANK expression.
Topics: 4-Butyrolactone; Angelica sinensis; Animals; Animals, Newborn; Bone Resorption; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression; Macrophages; Male; Mice, Inbred C57BL; Molecular Structure; Osteoblasts; Osteoclasts; Osteogenesis; RANK Ligand; Rats, Sprague-Dawley; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction | 2019 |
Studying Mass Balance and the Stability of (
Topics: 4-Butyrolactone; Angelica sinensis; Countercurrent Distribution; Plant Extracts | 2019 |
Ligustilide Inhibited Rat Vascular Smooth Muscle Cells Migration via c-Myc/MMP2 and ROCK/JNK Signaling Pathway.
Topics: 4-Butyrolactone; Animals; Atherosclerosis; Blood Pressure; Cell Movement; Cell Proliferation; Cells, Cultured; Humans; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Proto-Oncogene Proteins c-myc; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; rho-Associated Kinases | 2019 |
Ligustilide promotes apoptosis of cancer-associated fibroblasts via the TLR4 pathways.
Topics: 4-Butyrolactone; Animals; Apoptosis; Cancer-Associated Fibroblasts; Cell Cycle; Cell Proliferation; Heterografts; Humans; Male; Mice; Mice, Inbred C57BL; Prostatic Neoplasms; Toll-Like Receptor 4; Tumor Microenvironment | 2020 |
Ligustilide improves aging-induced memory deficit by regulating mitochondrial related inflammation in SAMP8 mice.
Topics: 4-Butyrolactone; Aging; Animals; Apoptosis; Brain; Inflammation; Male; Maze Learning; Memory Disorders; Mice; Mitochondria; Neuroprotective Agents; Oxidative Stress; Spatial Memory | 2020 |
Simultaneous determination of 20 bioactive components in Chuanxiong Rhizoma from different production origins in Sichuan province by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry combined with multivariate s
Topics: 4-Butyrolactone; Benzofurans; China; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Geography; Limit of Detection; Linear Models; Multivariate Analysis; Reproducibility of Results; Tandem Mass Spectrometry | 2020 |
Ligustilide provides neuroprotection by promoting angiogenesis after cerebral ischemia.
Topics: 4-Butyrolactone; Angiogenesis Inducing Agents; Animals; Behavior, Animal; Brain Ischemia; Cell Line; Male; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Neuroprotective Agents | 2020 |
Ligustilide alleviates the insulin resistance, lipid accumulation, and pathological injury with elevated phosphorylated AMPK level in rats with diabetes mellitus.
Topics: 4-Butyrolactone; AMP-Activated Protein Kinase Kinases; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diet, High-Fat; Humans; Insulin; Insulin Resistance; Lipid Metabolism; Liver; NF-E2-Related Factor 2; Obesity; Phosphorylation; Protein Kinases; Rats | 2021 |
[Effect of ligustilide on oxygen and glucose deprivation/reperfusion-induced mitochondria fission in PC12 cells].
Topics: 4-Butyrolactone; Animals; Apoptosis; Cell Survival; Glucose; Mitochondria; Oxygen; PC12 Cells; Rats; Reactive Oxygen Species; Reperfusion Injury | 2020 |
Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation.
Topics: 4-Butyrolactone; AMP-Activated Protein Kinases; Animals; Behavior, Animal; Benzofurans; Brain Ischemia; Cell Line; Cell Polarity; Cytokines; Dose-Response Relationship, Drug; Encephalitis; Enzyme Activation; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Phenotype; Psychomotor Performance | 2020 |
Z-Ligustilide Ameliorates Diabetic Rat Retinal Dysfunction Through Anti-Apoptosis and an Antioxidation Pathway.
Topics: 4-Butyrolactone; Animals; Antioxidants; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Male; Rats; Rats, Sprague-Dawley | 2020 |
Metabolic profiling of ligustilide and identification of the metabolite in rat and human hepatocytes by liquid chromatography combined with high-resolution mass spectrometry.
Topics: 4-Butyrolactone; Animals; Chromatography, High Pressure Liquid; Hepatocytes; Humans; Mass Spectrometry; Rats | 2020 |
Systems pharmacology approach uncovers Ligustilide attenuates experimental colitis in mice by inhibiting PPARγ-mediated inflammation pathways.
Topics: 4-Butyrolactone; Animals; Biological Products; Colitis; Colon; Cytokines; Dextran Sulfate; Female; Inflammation; Inflammation Mediators; Inflammatory Bowel Diseases; Mice, Inbred C57BL; Models, Biological; Network Pharmacology; NF-kappa B; PPAR gamma; Signal Transduction; Transcription Factor AP-1 | 2021 |
Ligustilide inhibits the proliferation of non-small cell lung cancer via glycolytic metabolism.
Topics: 4-Butyrolactone; A549 Cells; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Glycolysis; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Random Allocation | 2021 |
Quality suitability regionalization analysis of Angelica sinensis in Gansu, China.
Topics: 4-Butyrolactone; Angelica sinensis; Benzofurans; China; Chlorogenic Acid; Chromatography, High Pressure Liquid; Coumaric Acids; Plant Extracts | 2020 |
Z-Ligustilide Selectively Targets AML by Restoring Nuclear Receptors Nur77 and NOR-1-mediated Apoptosis and Differentiation.
Topics: 4-Butyrolactone; Animals; Apoptosis; Cell Differentiation; Humans; Leukemia, Myeloid, Acute; Membrane Transport Proteins; Mice; Mice, Inbred NOD; Mice, SCID; Nuclear Receptor Subfamily 4, Group A, Member 1 | 2021 |
Ligustilide inhibits the proliferation of human osteoblastoma MG63 cells through the TLR4-ERK pathway.
Topics: 4-Butyrolactone; Apoptosis; Bone Neoplasms; Caspases; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Osteoblastoma; Toll-Like Receptor 4; Tumor Cells, Cultured | 2022 |
Ligustilide inhibited Angiotensin II induced A7r5 cell autophagy via Akt/mTOR signaling pathway.
Topics: 4-Butyrolactone; Angiotensin II; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Calcium; Cell Line; Cell Survival; Down-Regulation; Microtubule-Associated Proteins; Nitric Oxide; Protein Interaction Maps; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation | 2021 |
Ligustilide enhances hippocampal neural stem cells activation to restore cognitive function in the context of postoperative cognitive dysfunction.
Topics: 4-Butyrolactone; Animals; Cell Proliferation; Cognition; Hippocampus; Mice; Neural Stem Cells; Neurogenesis; Postoperative Cognitive Complications | 2021 |
Alleviation of glucolipotoxicity-incurred cardiomyocyte dysfunction by Z-ligustilide involves in the suppression of oxidative insult, inflammation and fibrosis.
Topics: 4-Butyrolactone; Animals; Apoptosis; Cell Survival; Cells, Cultured; Fibrosis; Inflammation; Molecular Structure; Myocytes, Cardiac; Oxidation-Reduction; Rats | 2021 |
Ligustilide attenuates ischemic stroke injury by promoting Drp1-mediated mitochondrial fission via activation of AMPK.
Topics: 4-Butyrolactone; AMP-Activated Protein Kinases; Animals; Apoptosis; Brain Ischemia; Dynamins; Ischemic Stroke; Mitochondrial Dynamics; Rats | 2022 |
Cool Temperature Enhances Growth, Ferulic Acid and Flavonoid Biosynthesis While Inhibiting Polysaccharide Biosynthesis in
Topics: 4-Butyrolactone; Angelica sinensis; Carbohydrate Metabolism; Cold Temperature; Coumaric Acids; Flavonoids; Gene Expression Regulation, Plant; Oils, Volatile; Plant Oils; Plant Physiological Phenomena; Polysaccharides | 2022 |
A network pharmacology technique used to investigate the potential mechanism of Ligustilide's effect on atherosclerosis.
Topics: 4-Butyrolactone; Atherosclerosis; Humans; Medicine, Chinese Traditional; Molecular Docking Simulation; Network Pharmacology | 2022 |
Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat.
Topics: 4-Butyrolactone; AMP-Activated Protein Kinases; Animals; Cognitive Dysfunction; Dementia, Vascular; Disease Models, Animal; Maze Learning; Rats; Sirtuin 1 | 2022 |
Ligustilide ameliorates hippocampal neuronal injury after cerebral ischemia reperfusion through activating PINK1/Parkin-dependent mitophagy.
Topics: 4-Butyrolactone; Animals; Brain Ischemia; Hippocampus; Infarction, Middle Cerebral Artery; Ischemic Stroke; Mammals; Mitophagy; Protein Kinases; Rats; Reperfusion; Reperfusion Injury; Ubiquitin-Protein Ligases | 2022 |
[Mitophagy mediated by ligustilide relieves OGD/R-induced injury in HT22 cells].
Topics: 4-Butyrolactone; Apoptosis; Calcium; Glucose; Humans; Mitochondrial Proteins; Mitophagy; Reactive Oxygen Species; Reperfusion Injury | 2022 |
CaMKII, that binds with ligustilide, as a potential drug target of Suxiao jiuxin pill, a traditional Chinese medicine to dilate thoracic aorta.
Topics: 4-Butyrolactone; Aorta, Thoracic; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Drugs, Chinese Herbal; Medicine, Chinese Traditional | 2022 |