4-butyrolactone has been researched along with lignans in 416 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (6.73) | 18.7374 |
| 1990's | 33 (7.93) | 18.2507 |
| 2000's | 173 (41.59) | 29.6817 |
| 2010's | 157 (37.74) | 24.3611 |
| 2020's | 25 (6.01) | 2.80 |
| Authors | Studies |
|---|---|
| Kupchan, SM; Rebhum, LI; Wang, RW | 1 |
| Horwitz, SB; Kende, AS; Schiff, PB | 1 |
| Kende, AS; Liebeskind, LS | 1 |
| Fujimoto, T; Nishibe, S; Nose, M; Ogihara, Y; Takeda, T | 1 |
| Adlercreutz, H; Mousavi, Y | 1 |
| Cheung, F; Robb, P; Serraino, M; Thompson, LU | 1 |
| Adlercreutz, H; Bannwart, C; Brunow, G; Fotsis, T; Hase, T; Wähälä, K | 1 |
| Adlercreutz, H; Benassayag, C; Garreau, B; Mäkelä, T; Nunez, EA; Vallette, G; Wähälä, K | 1 |
| Ishiguro, T; Kishi, T; Koga, K; Komeshima, N; Mizuguchi, H; Tanida, S; Tashiro, T; Tomioka, K; Tsukagoshi, S; Tsuruo, T | 1 |
| Fukuoka, K; Hirano, T; Hosaka, K; Matsumoto, Y; Mitsuhashi, H; Naito, T; Oka, K | 1 |
| Braquet, P; Esanu, A; Garay, RP; Robin, JP; Senn, N | 1 |
| Axelson, M; Borriello, SP; Lawson, AM; Setchell, KD | 1 |
| Ishiguro, T; Koga, K; Mizuguchi, H; Tomioka, K | 1 |
| Braquet, P; Esanu, A; Fagoo, M; Godfraind, T; Robin, JP | 1 |
| Adlercreutz, H; Bannwart, C; Brunow, G; Fotsis, T; Hase, T; Mäkelä, T; Musey, PI; Wähälä, K | 1 |
| Braquet, P; Chainey, A; Plante, GE; Prévost, C; Sirois, P | 1 |
| Calaf, G; Jordan, VC; Koch, R; Murphy, CS; Welshons, WV | 1 |
| Iitaka, Y; Ishiguro, T; Koga, K; Tomioka, K | 1 |
| Gupta, RS | 1 |
| Britton, RW; Bryan, RF; Gilmore, CJ; Kupchan, SM; Restivo, RJ; Ziegler, MF | 1 |
| Horwitz, SB; Schiff, PB | 1 |
| Adlercreatz, H; Anderson, LC; Axelson, M; Borriello, SP; Gordon, H; Harkness, R; Kirk, DN; Lawson, AM; Morgan, DM; Setchell, KD | 1 |
| Adlercreutz, H; Dwyer, JT; Fotsis, T; Goldin, BR; Gorbach, SL; Heikkinen, R; Woods, M | 1 |
| Knowler, JT; Waters, AP | 1 |
| Axelson, M; Setchell, KD | 2 |
| Axelson, M; Gustafsson, BE; Setchell, KD; Sjövall, J | 1 |
| Adlercreutz, H; Axelson, M; Fotsis, T; Heikkinen, R; Setchell, KD | 1 |
| Coert, A; Groen, MB; van der Vies, J; Vonk Noordegraaf, CA | 1 |
| Adlercreutz, H | 3 |
| Tomioka, K | 1 |
| Axelson, M; Kirk, DN; Lawson, AM; McLaughlin, LM; Patel, S; Setchell, KD | 1 |
| Dehennin, L; Jondet, M; Reiffsteck, A; Thibier, M | 1 |
| Axelson, M; Conway, E; Cooley, G; Farrant, RD; Kirk, DN; Lawson, AM; Setchell, KD; Taylor, NF; Wynn, S | 1 |
| Funke, CW; Groen, MB; Leemhuis, J; Stitch, SR; Toumba, JK; Vink, J; Woods, GF | 1 |
| Campbell, DR; Kirkman, LM; Lampe, JW; Martini, MC; Slavin, JL | 1 |
| Bollag, DM; Chang, CJ; Song, YN; Zhang, HL | 1 |
| Hutchins, AM; Lampe, JW; Slavin, JL | 1 |
| Adlercreutz, H; Fotsis, T; Hase, T; Kurzer, MS; Mäkelä, T; Wähälä, K | 1 |
| Joannou, GE; Kelly, GE; Nelson, C; Reeder, AY; Waring, MA | 1 |
| Griffiths, K; Morton, MS; Wahlqvist, ML; Wilcox, G | 1 |
| Kurzer, MS; Lampe, JW; Martini, MC; Phipps, WR; Slavin, JL | 1 |
| Sackett, DL | 1 |
| Adlercreutz, H; Arosemena, PJ; Bannwart, C; Brunow, G; Hase, T; Kellis, JT; Mäkelä, T; Vickery, LE; Wähälä, K | 1 |
| Fujimoto, T; Nishibe, S; Nose, M; Ogihara, Y | 1 |
| Atkinson, DA; Hill, HH; Shultz, TD | 1 |
| Eich, E; Fesen, MR; Kaloga, M; Mazumder, A; Pertz, H; Pommier, Y; Schulz, J | 1 |
| Benassayag, C; Haourigui, M; Martin, ME; Nunez, EA; Pelissero, C | 1 |
| Fong, HH; Luyengi, L; Orcheson, LJ; Rickard, SE; Seidl, MM; Thompson, LU | 1 |
| Abranches-Monteiro, L; Blacklock, N; Chan, PS; Cheng, C; Correia, R; Griffiths, K; Lloyd, S; Matos-Ferreira, A; Morton, MS | 1 |
| Ingram, D; Kolybaba, M; Lopez, D; Sanders, K | 1 |
| Jacobs, E; Kulling, SE; Metzler, M; Pfeiffer, E | 1 |
| Kurzer, MS; Wang, C | 1 |
| Adlercreutz, H; Akhmedkhanov, A; Toniolo, P; Zeleniuch-Jacquotte, A | 1 |
| Brüggemann-Rotgans, IE; Kardinaal, AF; Morton, MS; van Beresteijn, EC | 1 |
| Adlercreutz, H; Hampl, R; Lapcík, O; Lusa, K; Mäkelä, T; Mikola, H; Talme, M; Wähälä, K; Wang, GJ | 1 |
| Lam, Y; Nesbitt, PD; Thompson, LU | 1 |
| Jacobs, E; Kulling, SE; Metzler, M | 1 |
| Jacobs, E; Metzler, M | 1 |
| Kitts, DD; Thompson, LU; Wijewickreme, AN; Yuan, YV | 1 |
| Bonnet, F; Gilbert, R | 1 |
| Adlercreutz, H; Al-Maharik, N; Hampl, R; Lapcík, O; Mäkelä, T; Mikola, H; Uehara, M; Wähälä, K | 1 |
| Ahotupa, M; Eckerman, C; Franke, AA; Kangas, L; Mäkelä, SI; Reunanen, M; Saarinen, NM; Salmi, SM; Santti, R; Wärri, A | 1 |
| Honig, D; Jacobs, E; Kulling, SE; Lange-Böhmer, A; Metzler, M; Niemeyer, HB | 1 |
| Adlercreutz, H; Nurmi, T; Stumpf, K; Uehara, M | 1 |
| Hase, TA; Mäkelä, TH; Wähälä, KT | 1 |
| Clark, WF; Muir, AD; Parbtani, A; Westcott, ND | 1 |
| Hattori, M; Li, Y; Meselhy, MR; Qin, GW; Wang, LQ | 1 |
| Kinoshita, Y; Yamamoto, N; Yamauchi, S | 1 |
| Adlercreutz, H; Pietinen, P; Puska, P; Stumpf, K | 1 |
| Adlercreutz, HC; Juntunen, KS; Liukkonen, KH; Mazur, WM; Mykkänen, HM; Poutanen, KS; Uehara, M | 1 |
| Adlercreutz, H; Arai, Y; Uehar, M; Watanabe, S | 1 |
| Adlercreut, H; Hallmans, G; Hultén, K; Kilkkinen, A; Mazur, W; Pietinen, P; Stumpf, K | 1 |
| Adlercreutz, H; Arts, CJ; den Tonkelaar, I; Keinan-Boker, L; Peeters, PH; Thijssen, JH; Veer, PV | 1 |
| Adlercreutz, H; Kataja, V; Männistö, S; Pietinen, P; Stumpf, K; Uusitupa, M | 1 |
| Adlercreutz, H; Kilkkinen, A; Pietinen, P; Stumpf, K; Tapanainen, H; Valsta, LM | 1 |
| Bacigalupo, MA; Ius, A; Piazza, F; Roda, A; Setchell, KD; Simoni, P | 1 |
| Adlercreutz, H; Deyama, T; Heinonen, S; Liukkonen, K; Nishibe, S; Nurmi, T; Poutanen, K; Wähälä, K | 1 |
| Boyd, MR; McKee, TC; Meragelman, KM | 1 |
| Bos, R; Koulman, A; Medarde, M; Pras, N; Quax, WJ | 1 |
| Horner, NK; Kristal, AR; Lampe, JW; Potter, JD; Prunty, J; Skor, HE | 1 |
| Adlercreutz, H; Kaikkonen, J; Morrow, JD; Nurmi, T; Roberts, LJ; Salonen, JT; Vanharanta, M; Voutilainen, S | 1 |
| Adlercreutz, H; Akkila, J; Aro, A; Kleemola, P; Salminen, I; Tarpila, A; Tarpila, S | 1 |
| Adlercreutz, H; Kilkkinen, A; Klaukka, T; Korhonen, P; Pietinen, P; Virtamo, J | 1 |
| Chen, JX; Hajra, S; Ji, J; Liu, P; Sibi, MP | 1 |
| Ayton, R; Dalais, FS; Grehan, M; Medley, G; Murkies, AL; Rice, GE; Strauss, BJ; Wahlqvist, ML | 1 |
| Chung, BC; Huh, KB; Kim, MK; Lee, HC; Lim, SK; Nam, JH; Yu, VY | 1 |
| Adlercreutz, H; Dillner, J; Hakama, M; Hallmans, G; Harvei, S; Jellum, E; Lehtinen, M; Lumme, S; Luostarinen, T; Stattin, P; Stumpf, K; Tenkanen, L; Teppo, L | 1 |
| Collan, YU; Eckerman, C; Huovinen, R; Mäkelä, SI; Needham, L; Saarinen, NM; Santti, R; Valentín-Blasini, L; Wärri, A | 1 |
| Adlercreutz, H; Jacobs, DR; Pereira, MA; Pins, JJ; Stumpf, K | 1 |
| Adlercreutz, H; Hallmans, G; Hultén, K; Johansson, R; Lenner, P; Winkvist, A | 1 |
| Wang, LQ | 1 |
| Ammälä, J; Hakala, K; Mäkelä, SI; Pihlava, JM; Ryhänen, EL; Saarinen, NM; Santti, R; Sjöholm, R; Smeds, A | 1 |
| Adlercreutz, H; Manach, C; Mazur, W; Morand, C; Nicolle, C; Rémésy, C; Scalbert, A | 1 |
| Ambrosone, CB; Freudenheim, JL; McCann, SE; Moysich, KB; Shields, PG | 1 |
| Arisaka, O; Evans, BA; Miyake, N; Morgan, LD; Morton, MS | 1 |
| Adlercreutz, H; Mursu, J; Nurmi, T; Rissanen, TH; Salonen, JT; Salonen, R; Vanharanta, M; Voutilainen, S | 1 |
| Ammälä, J; Collan, YU; Eckerman, C; Huovinen, R; Lehtilä, R; Mäkelä, SI; Saarinen, NM; Santti, RS; Sjöholm, R; Valentín-Blasini, L; Wärri, A | 1 |
| Adlercreutz, H; Stumpf, K | 1 |
| Eklund, P; Lehtilä, R; Lindholm, A; Mikkola, JP; Sjöholm, R; Smeds, A | 1 |
| Grobbee, DE; Keinan-Boker, L; Peeters, PH; van der Schouw, YT | 1 |
| Foster, PR; McIntosh, GH; Noakes, M; Royle, PJ | 1 |
| Bingham, SA; Botting, NP; Fryatt, T; Grace, PB; Oldfield, MF; Taylor, JI | 1 |
| Adlercreutz, H; Bach Knudsen, KE; Heinonen, SM; Kjaer, AK; Nurmi, T; Serena, A; Tetens, I | 1 |
| Adlercreutz, H; Rissanen, TH; Salonen, JT; Vanharanta, M; Voutilainen, S | 1 |
| Chang, C; Chen, CC; Hsu, FL; Huang, RL; Huang, YL; Ou, JC | 1 |
| Adlercreutz, H; Kilkkinen, A; Pietinen, P; Stumpf, K; Valsta, LM; Virtamo, J | 1 |
| Boccardo, F; Lunardi, GL; Petti, AR; Rubagotti, A | 1 |
| Yamaguchi, M; Yamauchi, S | 1 |
| Andre, F; Antignac, JP; Cariou, R; Cravedi, JP; Le Bizec, B | 1 |
| Adlercreutz, H; Heinonen, S; Karppinen, S; Mättö, J; Mutanen, M; Oikarinen, S; Poutanen, K | 1 |
| Chen, J; Thompson, LU | 1 |
| Sakakibara, N; Shimada, M; Suzuki, S; Umezawa, T | 1 |
| Hirose, M; Imazawa, T; Iwata, T; Kasai, M; Kitamura, Y; Nishikawa, A; Okazaki, K; Son, HY; Tsutsumi, K; Yamagishi, M; Yamauchi, Y | 1 |
| Adlercreutz, H; Kilkkinen, A; Pietinen, P; Sankila, R; Vartiainen, E; Virtamo, J; Virtanen, MJ | 1 |
| Ando, M; Li, N; Sakai, J; Wu, JL | 1 |
| Adlercreutz, H; Albanes, D; Kilkkinen, A; Pietinen, P; Virtamo, J; Virtanen, MJ | 1 |
| Boccardo, F; Guglielmini, P; Lunardi, G; Murialdo, R; Parodi, M; Rubagotti, A; Schettini, G | 1 |
| Adlercreutz, H; Begum, AN; Fukushima, K; Heinonen, SM; Lapierre, C; Mila, I; Nagano, K; Nicolle, C; Rémésy, C; Scalbert, A | 1 |
| Hallund, J; Hausner, H; Johnsen, NF; Tetens, I | 1 |
| Eklund, PC; Holmbom, BR; Sjöholm, RE; Smeds, AI; Sundell, FJ; Willför, SM | 1 |
| Adlercreutz, H; Arslan, AA; Kato, I; Koenig, KL; Shore, RE; Toniolo, P; Zeleniuch-Jacquotte, A | 1 |
| Chung, BC; Jung, BH; Kim, SY; Lee, SH | 1 |
| Ahn, KS; Bae, K; Kim, DY; Kim, TJ; Kwon, OK; Lee, HK; Min, BS; Oh, SR; Park, BY | 1 |
| Chang, S; Dean, B; Doss, GA; King, C; Thomas, PE | 1 |
| Inouye, K; Muta, Y; Oyama, S; Shimada, M; Umezawa, T | 1 |
| Christensen, J; Hausner, H; Johnsen, NF; Knudsen, KE; Olsen, A; Overvad, K; Tetens, I; Tjønneland, A | 1 |
| Adlercreutz, H; Auprich, M; Brössner, C; Fink, K; Madersbacher, S; Petritsch, K; Petritsch, P; Rehak, P | 1 |
| Knudsen, KE; Loft, S; Møller, S; Olsen, A; Overvad, K; Stripp, C; Thomsen, BL; Tjønneland, A | 1 |
| Albuquerque, S; Bastos, JK; da Silva Filho, AA; da Silva, R; de Souza, GH; de Souza, VA; Donate, PM; e Silva, ML; Grando, MD; Montanheiro, M; Pereira, AC; Royo, Vde A; Saraiva, J | 1 |
| Ahn, KS; Jeong, GS; Joung, H; Lee, HK; Lee, SK; Li, G; Min, BS; Na, MK; Oh, SR | 1 |
| Korte, H; Lina, B; Nyman, L; Unkila, M | 1 |
| Arts, IC; Hollman, PC; Jansen, GH; Keijer, J; Müller, M; Nielen, MW | 1 |
| Arts, IC; Hollman, PC; Kuijsten, A; Vree, TB | 1 |
| Liu, Z; Moline, J; Wolff, MS | 1 |
| Adlercreutz, H; Biessy, C; Bylund, A; Hallmans, G; Kaaks, R; Stattin, P | 1 |
| Hurmerinta, TT; Mäkelä, SI; Penttinen, PE; Saarinen, NM; Smeds, AI | 1 |
| Adlercreutz, HC; Aura, AM; Heinonen, SM; Mutanen, M; Oikarinen, S; Poutanen, KS; Virtanen, H | 1 |
| Adlercreutz, H; Aura, AM; Heinonen, SM; Peñalvo, JL | 1 |
| Brooks, JD; Thompson, LU | 1 |
| Arts, IC; Buijsman, MN; Hollman, PC; Kuijsten, A; Mulder, PP | 1 |
| Eklund, PC; Mutanen, M; Oikarinen, SI; Pajari, AM; Sjöholm, RE; Smeds, AI | 1 |
| Balme, G; Bouyssi, D; Ferrié, L | 1 |
| De Simone, F; Mahmood, N; Mora, G; Piccinelli, AL; Poveda, L; Rastrelli, L | 1 |
| Engel, SM; Kaplan, D; Levy, B; Liu, Z; Wolff, MS | 1 |
| Chen, JM; Power, KA; Saarinen, NM; Thompson, LU | 1 |
| Burnett, JC; Day, BW; Gussio, R; Hamel, E; Hermone, AR; McGrath, C; Nguyen, TL; Wipf, P; Zaharevitz, DW | 1 |
| Boccardo, F; Guglielmini, P; Puntoni, M; Rubagotti, A | 1 |
| Adlercreutz, H; Bremnes, Y; Gram, IT; Stuedal, A; Ursin, G; Veierød, MB | 1 |
| Coulman, KD; Hum, WQ; Liu, Z; Michaelides, J; Thompson, LU | 1 |
| Alpert, CA; Blaut, M; Clavel, T; Doré, J; Henderson, G; Philippe, C; Rigottier-Gois, L | 1 |
| Bingham, SA; Day, NE; Doody, D; Dowsett, M; Dunning, AM; Folkerd, E; Grace, PB; Khaw, KT; Low, YL; Luben, RN; Mulligan, AA; Scollen, S; Taylor, JI; Wareham, NJ; Welch, AA | 1 |
| Arts, IC; Hollman, PC; Kuijsten, A; van't Veer, P | 1 |
| Bastos, JK; da Silva, GV; da Silva, R; de Albuquerque, S; Donate, PM; Heleno, VC; Lopes, JL; Pedersoli, S; Silva, ML | 1 |
| Bügel, S; Hallund, J; Ravn-Haren, G; Tetens, I; Tholstrup, T | 1 |
| Adami, HO; Adlercreutz, H; Andersson, SO; Bälter, KA; Bellocco, R; Chang, ET; Grönberg, H; Hedelin, M; Heinonen, SM; Johansson, JE; Klint, A | 1 |
| Appukkuttan, P; Beryozkina, T; Mont, N; Van der Eycken, E | 1 |
| Blaut, M; Clavel, T; Doré, J; Engst, W; Henderson, G | 1 |
| Chen, JM; Power, KA; Saarinen, NM; Thompson, LU; Ward, WE | 1 |
| Karonen, M; Liimatainen, J; Pihlaja, K; Sinkkonen, J | 1 |
| de Pascoli, IC; Lopes, LM; Nascimento, IR | 1 |
| Alfthan, G; Ariniemi, K; Erlund, I; Kilkkinen, A; Virtamo, J; Virtanen, MJ | 1 |
| Fukuyama, T; Inouye, T; Morimoto, K; Nishitani, S; Ryu, I | 1 |
| Chang-Claude, J; Linseisen, J; Piller, R | 1 |
| Chang-Claude, J; Linseisen, J; Piller, R; Verla-Tebit, E; Wang-Gohrke, S | 1 |
| Arts, IC; Hollman, PC; Kampman, E; Kuijsten, A; van't Veer, P | 1 |
| Chang, JY; Chang, WL; Chen, SP; Chen, YL; Cheng, YL; Harn, HJ; Lin, SZ; Tsai, NM | 1 |
| Bertrais, S; Galan, P; Hercberg, S; Ito, H; Mennen, LI; Sapinho, D; Scalbert, A | 1 |
| Bügel, S; Ferrari, M; Hallund, J; Kjaer, A; Teerlink, T; Tetens, I; Tholstrup, T; Wiinberg, N | 1 |
| Adlercreutz, H; Afanasyeva, Y; Arslan, AA; Berrino, F; Hallmans, G; Johansson, I; Kaaks, R; Koenig, KL; Krogh, V; Lenner, P; Lukanova, A; Lundin, E; Micheli, A; Muti, P; Rinaldi, S; Shore, RE; Stattin, P; Toniolo, P; Zeleniuch-Jacquotte, A | 1 |
| Alfermann, AW; Bayindir, U; Fuss, E; Mehregan, I; Mohagheghzadeh, A; Schmidt, TJ | 1 |
| Kwon, SW; Park, JH; Yoo, HH | 1 |
| Aguilar-Guadarrama, AB; Gutiérrez, Mdel C; Rios, MY | 1 |
| Albuquerque, S; Andrade E Silva, ML; Bastos, JK; Cintra, VP; da Silva, R; de Andrade Royo, V; Medola, JF; Pesqueira E Silva, EP; Saraiva, J; Tavares, DC | 1 |
| Blaut, M; Clavel, T; Doré, J; Gavini, F; Lippman, R | 1 |
| Almeida, VA; Bastos, JK; Carvalho, TC; Coímbra, HS; Costa, ES; Cunha, WR; Filho, AA; Furtado, NA; Lima, TC; Martins, CH; Pereira, AC; Royo, VA; Silva, ML; Silva, R; Vinhólis, AH | 1 |
| Bergman Jungeström, M; Dabrosin, C; Thompson, LU | 1 |
| Biro, F; Britton, JA; Calafat, AM; Chelimo, C; Godbold, J; Kushi, LH; Pfeiffer, CM; Pinney, SM; Teitelbaum, SL; Windham, G; Wolff, MS | 1 |
| Alexander, FE; Bolton-Smith, C; Heald, CL; Morton, MS; Ritchie, MR | 1 |
| Bambagiotti-Alberti, M; Bartolucci, G; Frediani, M; Frediani, P; Rosi, L | 1 |
| Adlercreutz, H; Landberg, R; Linko-Parvinen, AM; Peñalvo, JL; Tikkanen, MJ | 1 |
| Arts, IC; Feskens, EJ; Hollman, PC; Kampman, E; Kuijsten, A; Milder, IE; Van 't Veer, P | 1 |
| Akao, T; Hattori, M; Jin, JS; Kakiuchi, N; Nakamura, N; Zhao, YF | 1 |
| Adlercreutz, H; Ericson, U; Gullberg, B; Peñalvo, JL; Sonestedt, E; Wirfält, E | 1 |
| Miura, D; Miura, Y; Saarinen, NM; Santti, R; Yagasaki, K | 1 |
| Bombelli, R; Cosentino, M; Crema, F; Delle Canne, MG; Ferrari, M; Lecchini, S; Legnaro, M; Luini, A; Luzzani, M; Marino, F; Paracchini, S; Rasini, E | 1 |
| Airio, M; Mäkelä, S; Saarinen, NM; Smeds, A; Wärri, A | 1 |
| Albuquerque, S; da Silva, R; Donate, PM; Ferreira, MM; Kiralj, R | 1 |
| Akiyama, K; Kishida, T; Koba, Y; Maruyama, M; Nakashima, Y; Nakato, T; Sugahara, T; Tago, R; Yamauchi, S | 1 |
| Hu, C; Kitts, DD; Yuan, YV | 1 |
| Damdimopoulos, AE; Gauglitz, G; Inzunza, J; Jaehrling, J; Lemmen, JG; Mäkelä, S; Penttinen, P; Pettersson, K; Pongratz, I; van der Saag, P | 1 |
| Daniel, H; Fuchs, D; Linseisen, J; Piller, R; Wenzel, U | 1 |
| Cafici, L; Canonico, PL; Galli, U; Genazzani, AA; Imperio, D; Pagliai, F; Pirali, T; Sorba, G; Tron, GC | 1 |
| Chen, LH; Demark-Wahnefried, W; Fang, J; Li, H; Lin, X | 1 |
| Benedettelli, S; Bosi, S; Carrasco-Pancorbo, A; Cortacero-Ramírez, S; Dinelli, G; Fernández-Gutiérrez, A; Ghiselli, L; Marotti, I; Segura-Carretero, A | 1 |
| Akao, T; Hattori, M; Jin, JS; Kakiuchi, N; Min, BS; Nakamura, N; Zhao, YF | 1 |
| Hattori, M; Jin, JS; Kakiuchi, N | 1 |
| Chen, IS; Day, YJ; Huang, YJ; Liao, CH; Lin, YC; Tseng, CP | 1 |
| Nersesyan, AK | 1 |
| Gao, HY; Ikeda, R; Kawahara, N; Kuroyanagi, M; Muto, N; Nakane, T; Otaki, K; Sano, T | 1 |
| Antignac, JP; Dip, R; Gmuender, H; Le Bizec, B; Lenz, S; Naegeli, H | 1 |
| Berrar, D; Gill, CI; Linton, T; McCann, MJ; McGlynn, H; Rowland, IR | 1 |
| Grougnet, R; Lazarou, D; Magiatis, P; Papadakis, EN; Papadopoulos, AI; Papadopoulou-Mourkidou, E; Skaltsounis, AL | 1 |
| Bennetau-Pelissero, C; Carreau, C; Flouriot, G; Potier, M | 1 |
| Alfermann, AW; Bayindir, U; Fuss, E | 1 |
| Bruun, JM; Bügel, S; Hallund, J; Tetens, I; Tholstrup, T | 1 |
| Feng, J; Shi, Z; Ye, Z | 1 |
| Airio, M; Dings, RP; Mäkelä, S; Saarinen, NM; Smeds, AI; Wärri, A | 1 |
| Jyrkkänen, HK; Kansanen, E; Kivelä, AM; Levonen, AL; Nurmi, T; Ylä-Herttuala, S | 1 |
| Chen, CY; Lin, RJ; Lo, WL | 1 |
| Dominguez, OP; Higuchi, Y; Horie, S; Ishikawa, T; Kumamoto, T; Matsumoto, K; Mochizuki, M; Nakanishi, W; Shimokawa, S; Tashima, K; Watanabe, T; Zhang, G | 1 |
| Arts, IC; Boer, JM; Bueno-de-Mesquita, HB; Hollman, PC; Kok, FJ; Kuijsten, A; van't Veer, P | 1 |
| Appukkuttan, P; Beryozkina, T; DeMaeyer, M; Mehta, VP; Mont, N; Toppet, S; Van der Eycken, E; Van Hecke, K; Van Meervelt, L; Voet, A | 1 |
| Adlercreutz, H; Borgquist, S; Ericson, U; Gullberg, B; Landberg, G; Olsson, H; Sonestedt, E; Wirfält, E | 1 |
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| Brodie, PJ; Callmander, MW; Cassera, MB; Kingston, DG; Liu, Y; Rakotobe, E; Rakotondraibe, LH; Rakotondrajaona, R; Rasamison, VE; Shen, Y; TenDyke, K; Wiley, JD; Young, K | 1 |
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| Chang, SH; Kang, CH; Kang, D; Kim, CS; Ko, KP; Koriyama, C; Lim, YK; Ngoan, LT; Park, SK; Shin, HR; Tokudome, S; Yeo, Y; Yoo, KY; Yoon, JH | 1 |
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| Brito, DCC; Figueiredo, JR; Guedes, MIF; Rodrigues, APR; Santos, RR; Silva, IP; Silva, JYG; Silva, RF; Silva, TES | 1 |
| Borges, A; de Laurentiz, RDS; de Lima, RG; Dos Santos, FF; E Silva, MLA; Lisoni, FCR; Molina, EF; Orenha, RP; Parreira, RLT; Picão, TB; Santos, MFC | 1 |
| Kang, JY; Ko, KP; Lee, J; Park, SK | 1 |
| Anoop, A; Garai, S; Hajra, S; Roy, S; Sen, B | 1 |
| Choi, H; Choi, J; Han, J; Lee, K | 1 |
| Abe, T; Asano, K; Jiang, R; Sasai, H; Suzuki, T; Zhou, DY | 1 |
| Chan, AT; Clish, CB; Eliassen, HA; Hu, FB; Huttenhower, C; Ivey, KL; Li, J; Li, R; Li, Y; Liu, G; Rimm, EB; Sun, Q; Wang, DD; Wang, F; Wilkinson, JE | 1 |
| Chapkin, RS; Hullar, MAJ; Ivanov, I; Lampe, JW; Mullens, DA; Randolph, TW | 1 |
| Ishida, M; Nishiwaki, H; Sartiva, H; Yamauchi, S; Yoneyama, K | 1 |
| Luo, J; Sun, L; Wang, P; Xu, Q; Yu, L; Zhang, L; Zheng, Z; Zhou, J; Zuo, D | 1 |
| Bian, Y; Bobek, KB; Ezzat, NS; Jones, BS; Jurca, T; Li, H; Shaw, TE; Yuan, Y | 1 |
| Deng, Z; Jahangir, M; Korma, SA; Mueed, A; Shibli, S | 1 |
| Chiou, JC; Du, WC; Hu, J; Kong, TH; Kung, CF; Lam, CY; Li, YZ; Mok, KW; Shum, TF; Sun, ZK; Tang, HH; Wong, MS; Xiao, HH; Ye, JJ; Yu, WX; Zang, XY; Zhang, JP; Zhou, LP | 1 |
21 review(s) available for 4-butyrolactone and lignans
| Article | Year |
|---|---|
[Asymmetric total synthesis of some biologically active natural products].
Topics: 4-Butyrolactone; Alkaloids; Antineoplastic Agents, Phytogenic; Chemical Phenomena; Chemistry; Dioxoles; Furans; Galantamine; Lactones; Lignans; Methods; Molecular Conformation; Optical Rotation; Podophyllotoxin | 1984 |
Podophyllotoxin, steganacin and combretastatin: natural products that bind at the colchicine site of tubulin.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Phytogenic; Bibenzyls; Binding Sites; Cell Division; Lignans; Podophyllotoxin; Polymers; Stilbenes; Structure-Activity Relationship; Tubulin | 1993 |
Food containing phytoestrogens, and breast cancer.
Topics: 4-Butyrolactone; Animals; Breast Neoplasms; Edible Grain; Estrogens; Estrogens, Non-Steroidal; Female; Finland; Food; Humans; Isoflavones; Japan; Lignans; Phytoestrogens; Plant Preparations; Pregnancy; Prenatal Exposure Delayed Effects | 2000 |
Phyto-oestrogens and cancer.
Topics: 4-Butyrolactone; Animals; Breast Neoplasms; Diet; Estrogens, Non-Steroidal; Female; Glycine max; Humans; Isoflavones; Lignans; Male; Neoplasms; Phytoestrogens; Plant Preparations; Prostatic Neoplasms; Tumor Cells, Cultured | 2002 |
Mammalian phytoestrogens: enterodiol and enterolactone.
Topics: 4-Butyrolactone; Female; Humans; Lignans; Male; Tumor Cells, Cultured | 2002 |
Phytoestrogens and breast cancer risk. Review of the epidemiological evidence.
Topics: 4-Butyrolactone; Adolescent; Adult; Age Factors; Breast Neoplasms; Case-Control Studies; Climacteric; Diet; Estrogens; Estrogens, Non-Steroidal; Female; Glycine max; Humans; Isoflavones; Lignans; Male; Phytoestrogens; Plant Preparations; Plants; Prospective Studies; Risk | 2003 |
Enterolactone as a risk factor for breast cancer: a review of the published evidence.
Topics: 4-Butyrolactone; Breast Neoplasms; Diet; Humans; Lignans; Risk Factors | 2006 |
Role of dietary lignans in the reduction of breast cancer risk.
Topics: 4-Butyrolactone; Animals; Anticarcinogenic Agents; Bacteria; Breast Neoplasms; Cell Division; Diet; Female; Humans; Intestines; Lignans; Mammary Neoplasms, Animal; Plants, Edible; Risk Factors | 2007 |
Lignans and human health.
Topics: 4-Butyrolactone; Animals; Cardiovascular Diseases; Colorectal Neoplasms; Dietary Fiber; Edible Grain; Endometrial Neoplasms; Feeding Behavior; Female; Health Status; Humans; Isoflavones; Lignans; Male; Phytoestrogens; Plants, Edible; Prostatic Neoplasms; Seeds; Vegetables | 2007 |
Serum enterolactone and postmenopausal breast cancer risk by estrogen, progesterone and herceptin 2 receptor status.
Topics: 4-Butyrolactone; Breast Neoplasms; Case-Control Studies; Cohort Studies; Estrogens; Humans; Lignans; Logistic Models; Middle Aged; Postmenopause; Progesterone; Prospective Studies; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Risk Factors | 2012 |
[Phytoestrogenis properties of flaxseed lignans].
Topics: 4-Butyrolactone; Animals; Antioxidants; Flax; Humans; Lignans; Neoplasms, Experimental; Phytoestrogens | 2012 |
Enterolactone concentrations and prognosis after postmenopausal breast cancer: assessment of effect modification and meta-analysis.
Topics: 4-Butyrolactone; Aged; Biomarkers, Tumor; Body Mass Index; Breast Neoplasms; Diet; Disease Progression; Disease-Free Survival; Female; Germany; Humans; Life Style; Lignans; Middle Aged; Postmenopause; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Factors | 2014 |
Gene polymorphisms in the ornithine decarboxylase-polyamine pathway modify gastric cancer risk by interaction with isoflavone concentrations.
Topics: 4-Butyrolactone; Adenosylmethionine Decarboxylase; Asian People; Case-Control Studies; Equol; Gene-Environment Interaction; Genistein; Humans; Isoflavones; Lignans; Multicenter Studies as Topic; NAD(P)H Dehydrogenase (Quinone); Nitric Oxide Synthase Type II; Ornithine Decarboxylase; Phytoestrogens; Polyamines; Polymorphism, Single Nucleotide; Stomach Neoplasms | 2015 |
Hinokinin, an emerging bioactive lignan.
Topics: 4-Butyrolactone; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antiparasitic Agents; Benzodioxoles; Dioxoles; Humans; Lignans; Plant Extracts | 2014 |
Recent advances and new concepts for the synthesis of axially stereoenriched biaryls.
Topics: 4-Butyrolactone; Gossypol; Lignans; Models, Molecular; Organic Chemicals; Stereoisomerism; Vancomycin | 2015 |
Gastrointestinal microbiome and breast cancer: correlations, mechanisms and potential clinical implications.
Topics: 4-Butyrolactone; Animals; Breast Neoplasms; Diet; Estrogens; Female; Gastrointestinal Microbiome; Humans; Lignans; Obesity | 2017 |
A Review of Lignan Metabolism, Milk Enterolactone Concentration, and Antioxidant Status of Dairy Cows Fed Flaxseed.
Topics: 4-Butyrolactone; Animal Feed; Animals; Antioxidants; Cattle; Dairy Products; Flax; Gastrointestinal Tract; Humans; Lignans; Metabolic Networks and Pathways; Milk; Oxidative Stress | 2018 |
Anticancer and antimetastatic potential of enterolactone: Clinical, preclinical and mechanistic perspectives.
Topics: 4-Butyrolactone; Animals; Humans; Lignans; Neoplasm Metastasis; Neoplasms | 2019 |
Factors Explaining Interpersonal Variation in Plasma Enterolactone Concentrations in Humans.
Topics: 4-Butyrolactone; Anti-Infective Agents; Body Mass Index; Female; Gastrointestinal Microbiome; Health Status; Humans; Lignans; Male; Nutrients | 2019 |
Dietary phytoestrogens and biomarkers of their intake in relation to cancer survival and recurrence: a comprehensive systematic review with meta-analysis.
Topics: 4-Butyrolactone; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Diet; Eating; Female; Humans; Isoflavones; Lignans; Male; Middle Aged; Neoplasms; Phytoestrogens; Young Adult | 2021 |
Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Dietary Supplements; Flax; Lignans; Mammals; Seeds | 2023 |
33 trial(s) available for 4-butyrolactone and lignans
| Article | Year |
|---|---|
Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets.
Topics: 4-Butyrolactone; Adult; Chromans; Colon; Cross-Over Studies; Diet; Equol; Female; Gas Chromatography-Mass Spectrometry; Genistein; Glycine max; Humans; Isoflavones; Lignans; Male; Sex Characteristics; Vegetables | 1995 |
Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products.
Topics: 4-Butyrolactone; Adult; Chromans; Cross-Over Studies; Defecation; Diet; Equol; Estrogens; Estrogens, Non-Steroidal; Fermentation; Food Handling; Genistein; Glycine max; Humans; Isoflavones; Lignans; Male; Phytoestrogens; Plant Preparations; Taste | 1995 |
Effect of flax seed ingestion on the menstrual cycle.
Topics: 4-Butyrolactone; Adult; Diet; Estrogens; Female; Hormones; Humans; Lignans; Luteal Phase; Menstrual Cycle; Osmolar Concentration; Plants, Edible | 1993 |
Human metabolism of mammalian lignan precursors in raw and processed flaxseed.
Topics: 4-Butyrolactone; Administration, Oral; Adult; Body Mass Index; Cross-Over Studies; Dietary Fiber; Dose-Response Relationship, Drug; Double-Blind Method; Female; Flax; Follicular Phase; Gas Chromatography-Mass Spectrometry; Humans; Lignans; Seeds; Time Factors | 1999 |
Novel metabolites of the mammalian lignans enterolactone and enterodiol in human urine.
Topics: 4-Butyrolactone; Female; Flax; Gas Chromatography-Mass Spectrometry; Humans; Lignans; Male; Molecular Structure; Seeds | 1999 |
Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with consumption of white wheat bread in healthy Finnish men and women.
Topics: 4-Butyrolactone; Adult; Bread; Cross-Over Studies; Diet; Dietary Fiber; Energy Intake; Estrogens; Female; Humans; Lignans; Male; Middle Aged; Secale; Triticum | 2000 |
The effect of flaxseed supplementation in processed foods on serum fatty acids and enterolactone.
Topics: 4-Butyrolactone; Adult; alpha-Linolenic Acid; Cross-Over Studies; Dietary Fiber; Dietary Supplements; Double-Blind Method; Fatty Acids; Female; Flax; Humans; Lignans; Male; Middle Aged; Seeds | 2002 |
Effects of dietary phytoestrogens in postmenopausal women.
Topics: 4-Butyrolactone; Aged; Bone Density; Diet; Double-Blind Method; Estrogens, Non-Steroidal; Female; Genistein; Glycine max; Hot Flashes; Humans; Isoflavones; Lignans; Linseed Oil; Middle Aged; Phytoestrogens; Plant Preparations; Postmenopause; Triticum | 1998 |
Whole grain food intake elevates serum enterolactone.
Topics: 4-Butyrolactone; Adult; Avena; Cross-Over Studies; Diet; Dietary Fiber; Female; Humans; Lignans; Male; Middle Aged; Obesity; Oryza; Regression Analysis; Sex Distribution; Triticum | 2002 |
Phloem fortification in rye bread elevates serum enterolactone level.
Topics: 4-Butyrolactone; Adult; Aged; Bread; Colon; Dietary Fiber; Dose-Response Relationship, Drug; Double-Blind Method; Fermentation; Food, Fortified; Humans; Lignans; Male; Middle Aged; Secale; Solubility | 2002 |
Whole-grain rye and wheat foods and markers of bowel health in overweight middle-aged men.
Topics: 4-Butyrolactone; Ammonia; Biomarkers; Blood Glucose; Butyrates; Cresols; Cross-Over Studies; Defecation; Diet; Dietary Fiber; Feces; Food; Glucuronidase; Humans; Hydrogen-Ion Concentration; Insulin; Intestines; Lignans; Male; Middle Aged; Propionates; Secale; Triticum | 2003 |
Intake of lignans is associated with serum enterolactone concentration in Finnish men and women.
Topics: 4-Butyrolactone; Adult; Butylene Glycols; Diet; Female; Furans; Humans; Lignans; Male; Middle Aged; Osmolar Concentration | 2003 |
Enterolactone in breast cyst fluid: correlation with EGF and breast cancer risk.
Topics: 4-Butyrolactone; Adult; Aged; Breast Neoplasms; Epidermal Growth Factor; Exudates and Transudates; Female; Fibrocystic Breast Disease; Humans; Lignans; Middle Aged; Odds Ratio; Predictive Value of Tests; Risk Factors; Statistics as Topic | 2003 |
Whole sesame seed is as rich a source of mammalian lignan precursors as whole flaxseed.
Topics: 4-Butyrolactone; Administration, Oral; Aged; Cross-Over Studies; Female; Flax; Humans; Lignans; Phytoestrogens; Postmenopause; Seeds; Sesamum | 2005 |
The relative bioavailability of enterolignans in humans is enhanced by milling and crushing of flaxseed.
Topics: 4-Butyrolactone; Adolescent; Adult; Biological Availability; Cross-Over Studies; Diet; Dietary Supplements; Female; Flax; Food Handling; Humans; Lignans; Male; Middle Aged; Seeds | 2005 |
A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women.
Topics: 4-Butyrolactone; Butylene Glycols; Cross-Over Studies; Denmark; Double-Blind Method; Female; Flax; Glucosides; Humans; Lignans; Lipids; Middle Aged; Postmenopause | 2006 |
Serum enterolactone concentration and the risk of coronary heart disease in a case-cohort study of Finnish male smokers.
Topics: 4-Butyrolactone; Aged; alpha-Tocopherol; beta Carotene; Biomarkers; Case-Control Studies; Coronary Disease; Finland; Humans; Lignans; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Smoking | 2006 |
Daily consumption for six weeks of a lignan complex isolated from flaxseed does not affect endothelial function in healthy postmenopausal women.
Topics: 4-Butyrolactone; Aged; Arginine; Blood Pressure; Body Weight; Cross-Over Studies; Diet; Double-Blind Method; Endothelin-1; Endothelium, Vascular; Female; Flax; Humans; Lignans; Middle Aged; Nitrates; Nitrites; Nitroglycerin; Patient Compliance; Placebos; Postmenopause; Vasodilation | 2006 |
Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteins.
Topics: 4-Butyrolactone; Adult; Biological Transport; Biomarkers; Bread; Cross-Over Studies; Eating; Erythrocytes; Female; Humans; Lignans; Lipoproteins; Lipoproteins, HDL; Lipoproteins, VLDL; Male; Osmolar Concentration; Resorcinols; Secale; Triticum | 2007 |
The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women.
Topics: 4-Butyrolactone; Biomarkers; C-Reactive Protein; Cross-Over Studies; Double-Blind Method; Female; Flax; Humans; Inflammation; Lignans; Middle Aged; Phytoestrogens; Postmenopause; Time Factors | 2008 |
Dietary enterolactone affects androgen and estrogen levels in healthy postmenopausal women.
Topics: 4-Butyrolactone; Androgens; Chromatography, High Pressure Liquid; DEET; Estrogens; Female; Humans; Lignans; Postmenopause; Spectrophotometry, Ultraviolet | 2009 |
Weekly excretion of the mammalian lignan enterolactone in milk of dairy cows fed flaxseed meal.
Topics: 4-Butyrolactone; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cattle; Diet; Female; Flax; Lignans; Milk; Time Factors | 2009 |
Dietary intake and urinary excretion of lignans in Finnish men.
Topics: 4-Butyrolactone; Coffee; Diet; Dietary Fiber; Finland; Fruit; Humans; Lignans; Male; Plant Extracts; Plant Roots; Secale; Tea | 2010 |
The interaction of monensin and flaxseed hulls on ruminal and milk concentration of the mammalian lignan enterolactone in late-lactating dairy cows.
Topics: 4-Butyrolactone; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Antiprotozoal Agents; Cattle; Diet; Female; Flax; Lactation; Lignans; Milk; Monensin; Rumen | 2009 |
Whole and fractionated yellow pea flours reduce fasting insulin and insulin resistance in hypercholesterolaemic and overweight human subjects.
Topics: 4-Butyrolactone; Adiposity; Adult; Body Composition; Cardiovascular Diseases; Cross-Over Studies; Diabetes Mellitus; Fasting; Female; Flour; Humans; Hypercholesterolemia; Insulin; Insulin Resistance; Lignans; Male; Middle Aged; Overweight; Phytotherapy; Pisum sativum; Plant Preparations; Risk Factors; Seeds | 2011 |
A probiotic mixture including galactooligosaccharides decreases fecal β-glucosidase activity but does not affect serum enterolactone concentration in men during a two-week intervention.
Topics: 4-Butyrolactone; Adult; Bacterial Load; beta-Glucosidase; Bifidobacterium; Bread; Cardiovascular Diseases; Fatty Acids, Volatile; Feces; Galactose; Humans; Lacticaseibacillus rhamnosus; Lactobacillaceae; Lignans; Male; Middle Aged; Oligosaccharides; Probiotics; Propionibacterium; Surveys and Questionnaires; Water | 2011 |
UPLC-QTOF/MS metabolic profiling unveils urinary changes in humans after a whole grain rye versus refined wheat bread intervention.
Topics: 4-Butyrolactone; Adult; Aminophenols; Benzoxazines; Biomarkers; Bread; Cross-Over Studies; Diet; Female; Humans; Lignans; Male; Mass Spectrometry; Metabolome; Middle Aged; Phenylpropionates; Secale; Triticum | 2013 |
Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.
Topics: 4-Butyrolactone; Aged; Antineoplastic Agents, Phytogenic; Biomarkers; Cell Proliferation; Dietary Supplements; Flax; Humans; Ki-67 Antigen; Lignans; Male; Middle Aged; Phytotherapy; Plant Extracts; Prostatic Neoplasms; Vascular Endothelial Growth Factor A | 2013 |
Low serum enterolactone concentration is associated with low colonic Lactobacillus-Enterococcus counts in men but is not affected by a synbiotic mixture in a randomised, placebo-controlled, double-blind, cross-over intervention study.
Topics: 4-Butyrolactone; Adult; Colon; Cross-Over Studies; Data Collection; Double-Blind Method; Enterococcus; Feces; Feeding Behavior; Humans; Lactobacillus; Lignans; Male; Middle Aged; Synbiotics; Young Adult | 2014 |
Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans.
Topics: 4-Butyrolactone; Aged; Butylene Glycols; Dietary Supplements; Female; Flax; Glycosides; Humans; Intestinal Mucosa; Lignans; Middle Aged; Postmenopause | 2014 |
Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets.
Topics: 4-Butyrolactone; Adult; Cross-Over Studies; Cross-Sectional Studies; Dietary Fiber; Female; Healthy Volunteers; Humans; Lignans; Male; Middle Aged; Phytoestrogens; Plant Extracts | 2017 |
Technical note: Quantification of lignans in the urine, milk, and plasma of flaxseed cake-fed dairy sheep.
Topics: 4-Butyrolactone; Animal Feed; Animals; Butylene Glycols; Flax; Glucosides; Lignans; Milk; Seeds; Sheep | 2021 |
Personalized Nutrition Using Microbial Metabolite Phenotype to Stratify Participants and Non-Invasive Host Exfoliomics Reveal the Effects of Flaxseed Lignan Supplementation in a Placebo-Controlled Crossover Trial.
Topics: 4-Butyrolactone; Cross-Over Studies; Dietary Supplements; Female; Flax; Humans; Lignans; Male; Phenotype | 2022 |
362 other study(ies) available for 4-butyrolactone and lignans
| Article | Year |
|---|---|
Antimitotic and antitubulin activity of the tumor inhibitor steganacin.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Binding, Competitive; Cell Division; Colchicine; Cycloparaffins; Female; Glycoproteins; Lactones; Lignans; Microtubules; Mitosis; Ovum; Podophyllotoxin; Sea Urchins; Tubulin; Tubulin Modulators; Ultracentrifugation | 1977 |
Steganacin: an inhibitor of HeLa cell growth and microtubule assembly in vitro.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Cell Division; Colchicine; Cycloparaffins; HeLa Cells; Lactones; Lignans; Microtubules; Mitotic Index; Protein Binding; Structure-Activity Relationship; Tubulin | 1978 |
Letter: Total synthesis of (+/-)-steganacin.
Topics: 4-Butyrolactone; Antineoplastic Agents; Cycloparaffins; Lactones; Lignans; Methods | 1976 |
Structural transformation of lignan compounds in rat gastrointestinal tract.
Topics: 4-Butyrolactone; Animals; Biotransformation; Furans; Glucosides; Lignans; Lignin; Male; Plants, Medicinal; Rats; Rats, Wistar | 1992 |
Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture.
Topics: 4-Butyrolactone; Breast Neoplasms; Cell Division; Cell Line; DNA Replication; Estradiol; Estrogen Antagonists; Estrogens; Female; Humans; Kinetics; Lignans; Tumor Cells, Cultured | 1992 |
Mammalian lignan production from various foods.
Topics: 4-Butyrolactone; Animals; Bacteria; Butylene Glycols; Chromatography, Gas; Edible Grain; Fabaceae; Feces; Fermentation; Food; Fruit; Humans; Lignans; Lignin; Mammals; Plants, Edible; Plants, Medicinal; Seaweed; Vegetables | 1991 |
Isotope dilution gas chromatographic-mass spectrometric method for the determination of lignans and isoflavonoids in human urine, including identification of genistein.
Topics: 4-Butyrolactone; Butylene Glycols; Chromans; Equol; Female; Furans; Gas Chromatography-Mass Spectrometry; Genistein; Humans; Indicator Dilution Techniques; Isoflavones; Lignans; Lignin; Magnetic Resonance Spectroscopy; Male | 1991 |
Phytoestrogens: new ligands for rat and human alpha-fetoprotein.
Topics: 4-Butyrolactone; Adult; alpha-Fetoproteins; Animals; Arachidonic Acid; Binding, Competitive; Butylene Glycols; Chromans; Equol; Estrogens; Estrogens, Non-Steroidal; Humans; Immunoelectrophoresis; Isoflavones; Ligands; Lignans; Masoprocol; Phytoestrogens; Plant Preparations; Rats; Rats, Inbred Strains | 1991 |
Absolute structure-cytotoxic activity relationships of steganacin congeners and analogues.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Cell Division; Humans; Indicators and Reagents; KB Cells; Lignans; Models, Molecular; Molecular Conformation; Molecular Structure; Structure-Activity Relationship | 1991 |
Antiproliferative activity of mammalian lignan derivatives against the human breast carcinoma cell line, ZR-75-1.
Topics: 4-Butyrolactone; Adenosine Triphosphatases; Animals; Benzyl Compounds; Breast Neoplasms; Butylene Glycols; Cell Division; Cell Line; Dogs; Dose-Response Relationship, Drug; Fluorouracil; Humans; Kidney Cortex; Lethal Dose 50; Lignans; Ouabain | 1990 |
Endogenous lignans--a potential endogenous digitalis.
Topics: 4-Butyrolactone; Erythrocytes; Furans; Humans; In Vitro Techniques; Ion Channels; Lignans | 1986 |
Production and metabolism of lignans by the human faecal flora.
Topics: 4-Butyrolactone; Bacteria; Butylene Glycols; Clostridium; Feces; Humans; Lignans; Linseed Oil; Metronidazole; Plant Extracts | 1985 |
Stereoselective reactions. VIII. Stereochemical requirement for the benzylic oxidation of lignan lactone. A highly selective synthesis of the antitumor lignan lactone steganacin by the oxidation of stegane.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Furans; Lactones; Lignans; Oxidation-Reduction; Plant Extracts; Stereoisomerism | 1985 |
Evidence that mammalian lignans show endogenous digitalis-like activities.
Topics: 4-Butyrolactone; Animals; Binding, Competitive; Cross Reactions; Digoxin; Furans; Guinea Pigs; Humans; In Vitro Techniques; Lignans; Myocardium; Ouabain; Radioimmunoassay; Receptors, Drug; Sodium-Potassium-Exchanging ATPase | 1986 |
Identification of lignans and phytoestrogens in urine of chimpanzees.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Chromans; Diet; Equol; Estrogens; Estrogens, Non-Steroidal; Isoflavones; Lignans; Male; Pan troglodytes; Phytoestrogens; Plant Extracts; Plant Preparations | 1986 |
Diuretic and natriuretic properties of prestegane B, a mammalian lignan.
Topics: 4-Butyrolactone; Animals; Chemical Phenomena; Chemistry; Diuretics; Dose-Response Relationship, Drug; Furans; Lignans; Natriuresis; Phosphates; Plant Extracts; Rats; Rats, Inbred Strains | 1987 |
Stimulation of breast cancer cells in vitro by the environmental estrogen enterolactone and the phytoestrogen equol.
Topics: 4-Butyrolactone; Benzopyrans; Breast Neoplasms; Butylene Glycols; Cell Division; Chromans; Equol; Estrogens; Female; Furans; Humans; Isoflavones; Lignans; Receptors, Progesterone; Tumor Cells, Cultured | 1987 |
Stereoselective reactions. XII. Synthesis of antitumor-active steganacin analogs, picrosteganol and epipicrosteganol, by selective isomerization.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Furans; Lactones; Lignans; Molecular Conformation; Stereoisomerism; X-Ray Diffraction | 1986 |
Species-specific differences in toxicity of antimitotic agents toward cultured mammalian cells.
Topics: 4-Butyrolactone; Animals; Benzimidazoles; Biological Transport; Cells, Cultured; Colchicine; Cricetinae; Cricetulus; Griseofulvin; HeLa Cells; Humans; Lignans; Maytansine; Mice; Mitosis; Nocodazole; Podophyllotoxin; Species Specificity; Vinblastine | 1985 |
Steganacin and steganangin, novel antileukemic lignan lactones from Steganotaenia araliacea.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Diterpenes; Lactones; Leukemia, Experimental; Lignans; Mice; Plant Extracts | 1973 |
Taxol stabilizes microtubules in mouse fibroblast cells.
Topics: 4-Butyrolactone; Animals; Cell Movement; DNA Replication; Fibroblasts; Fluorescent Antibody Technique; HeLa Cells; Humans; Lactones; Lignans; Mice; Microtubules; Paclitaxel; Terpenes; Tubulin | 1980 |
Lignan formation in man--microbial involvement and possible roles in relation to cancer.
Topics: 4-Butyrolactone; Bacteria; Butylene Glycols; Clostridium; Depression, Chemical; Female; Humans; Intestines; Lignans; Male; Menstruation; Metronidazole; Neoplasms; Oxytetracycline; Plant Extracts; Pregnancy | 1981 |
Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer.
Topics: 4-Butyrolactone; Aged; Benzopyrans; Breast Neoplasms; Butylene Glycols; Chromans; Diet; Diet, Vegetarian; Dietary Fiber; Energy Intake; Equol; Female; Furans; Humans; Isoflavones; Lignans; Menopause; Menstruation; Middle Aged; Plant Extracts | 1982 |
Effect of a lignan (HPMF) on RNA synthesis in the rat uterus.
Topics: 4-Butyrolactone; Animals; Cresols; Female; Lignans; Rats; RNA; Uterus | 1982 |
Conjugation of lignans in human urine.
Topics: 4-Butyrolactone; Adult; Age Factors; Butylene Glycols; Chromatography, Gas; Female; Furans; Glucuronates; Humans; Lignans; Male; Mass Spectrometry; Middle Aged; Plant Extracts; Pregnancy; Sex Factors | 1980 |
The excretion of lignans in rats -- evidence for an intestinal bacterial source for this new group of compounds.
Topics: 4-Butyrolactone; Animals; Bile; Butylene Glycols; Enterobacteriaceae; Enterohepatic Circulation; Female; Gas Chromatography-Mass Spectrometry; Germ-Free Life; Humans; Lignans; Male; Plant Extracts; Rats | 1981 |
Origin of lignans in mammals and identification of a precursor from plants.
Topics: 4-Butyrolactone; Animals; Biotransformation; Butylene Glycols; Diet; Enterobacteriaceae; Furans; Lignans; Plant Extracts; Rats; Seeds | 1982 |
Capillary gas chromatographic method for the analysis of lignans in human urine.
Topics: 4-Butyrolactone; Adult; Butylene Glycols; Chromatography, Gas; Chromatography, Ion Exchange; Female; Gas Chromatography-Mass Spectrometry; Glucuronates; Humans; Lignans; Male; Middle Aged; Plant Extracts | 1982 |
The dietary origin of the urinary lignan HPMF.
Topics: 4-Butyrolactone; Animals; Castration; Cresols; Diet; Female; Food, Formulated; Lignans; Lignin; Male; Plant Extracts; Rats; Rats, Inbred Strains | 1982 |
Does fiber-rich food containing animal lignan precursors protect against both colon and breast cancer? An extension of the "fiber hypothesis".
Topics: 4-Butyrolactone; Breast Neoplasms; Chemical Phenomena; Chemistry; Colonic Neoplasms; Dietary Fiber; Estrogens; Female; Humans; Lignans; Male; Plant Extracts | 1984 |
Measurement of enterolactone and enterodiol, the first mammalian lignans, using stable isotope dilution and gas chromatography mass spectrometry.
Topics: 4-Butyrolactone; Adult; Animals; Butylene Glycols; Diet; Female; Furans; Gas Chromatography-Mass Spectrometry; Haplorhini; Humans; Hydrolysis; Lignans; Middle Aged | 1983 |
Identification and quantitative estimation of a lignan in human and bovine semen.
Topics: 4-Butyrolactone; Animals; Cattle; Furans; Humans; Lignans; Male; Semen | 1982 |
The definitive identification of the lignans trans-2,3-bis(3-hydroxybenzyl)-gamma-butyrolactone and 2,3-bis(3-hydroxybenzyl)butane-1,4-diol in human and animal urine.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Chemical Phenomena; Chemistry; Chlorocebus aethiops; Chromatography, Gas; Chromatography, Thin Layer; Female; Furans; Gas Chromatography-Mass Spectrometry; Humans; Lignans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pregnancy | 1981 |
Excretion, isolation and structure of a new phenolic constituent of female urine.
Topics: 4-Butyrolactone; Adult; Cresols; Female; Humans; Lignans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Menstruation; Ovulation; Pregnancy; Spectrophotometry, Infrared | 1980 |
Cytotoxic cyclolignans from Koelreuteria henryi.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Phytogenic; Cattle; Dioxoles; Drug Screening Assays, Antitumor; Humans; Korea; Lignans; Magnetic Resonance Spectroscopy; Plants, Medicinal; Tubulin; Tumor Cells, Cultured | 1994 |
Isotope dilution gas chromatographic-mass spectrometric method for the determination of unconjugated lignans and isoflavonoids in human feces, with preliminary results in omnivorous and vegetarian women.
Topics: 4-Butyrolactone; Adult; Animals; Chromatography, Gel; Chromatography, Ion Exchange; Deuterium; Diet; Diet, Vegetarian; Estrogens; Feces; Female; Flavonoids; Furans; Gas Chromatography-Mass Spectrometry; Humans; Lignans; Radioisotope Dilution Technique | 1995 |
The variable metabolic response to dietary isoflavones in humans.
Topics: 4-Butyrolactone; Adult; Chromans; Diet; Equol; Estrogens, Non-Steroidal; Female; Glycine max; Humans; Isoflavones; Lignans; Male; Middle Aged; Phytoestrogens; Plant Preparations | 1995 |
Determination of lignans and isoflavonoids in human female plasma following dietary supplementation.
Topics: 4-Butyrolactone; Australia; Chromans; Diet; Equol; Estrogens; Female; Food, Fortified; Gas Chromatography-Mass Spectrometry; Genistein; Glycine max; Humans; Isoflavones; Lignans; Linseed Oil; Middle Aged; Monoamine Oxidase Inhibitors; Neoplasms; Plants, Edible; Postmenopause | 1994 |
Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens.
Topics: 4-Butyrolactone; Androstenedione; Animals; Antineoplastic Agents, Phytogenic; Aromatase; Aromatase Inhibitors; Estrogens; Humans; Lignans; Lignin; Spectrum Analysis; Substrate Specificity; Tumor Cells, Cultured | 1993 |
Structural transformation of lignan compounds in rat gastrointestinal tract; II. Serum concentration of lignans and their metabolites.
Topics: 4-Butyrolactone; Animals; Digestive System; Drugs, Chinese Herbal; Furans; Glucosides; Lignans; Lignin; Male; Molecular Structure; Rats; Rats, Wistar | 1993 |
Quantification of mammalian lignans in biological fluids using gas chromatography with ion mobility detection.
Topics: 4-Butyrolactone; Adult; Animals; Body Fluids; Chromatography, Gas; Diet; Humans; Ions; Lignans; Male; Mammals; Spectrum Analysis | 1993 |
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.
Topics: 4-Butyrolactone; Antiviral Agents; Base Sequence; Binding Sites; DNA Nucleotidyltransferases; Enzyme Inhibitors; Furans; HIV-1; Humans; Integrases; Lactones; Lignans; Molecular Sequence Data; Molecular Structure; Structure-Activity Relationship | 1996 |
Interactions between phytoestrogens and human sex steroid binding protein.
Topics: 4-Butyrolactone; Electrophoresis, Polyacrylamide Gel; Estradiol; Estrogens, Non-Steroidal; Genistein; Humans; Immunoelectrophoresis, Two-Dimensional; Isoflavones; Kinetics; Lignans; Masoprocol; Phytoestrogens; Plant Preparations; Plants; Sex Hormone-Binding Globulin; Structure-Activity Relationship; Testosterone | 1996 |
Dose-dependent production of mammalian lignans in rats and in vitro from the purified precursor secoisolariciresinol diglycoside in flaxseed.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Colon; Dietary Fiber; Female; Glycosides; In Vitro Techniques; Lignans; Lignin; Rats; Rats, Sprague-Dawley; Regression Analysis; Seeds | 1996 |
Lignans and isoflavonoids in plasma and prostatic fluid in men: samples from Portugal, Hong Kong, and the United Kingdom.
Topics: 4-Butyrolactone; Adult; Aged; Chromans; Equol; Gas Chromatography-Mass Spectrometry; Hong Kong; Humans; Isoflavones; Lignans; Male; Middle Aged; Portugal; Prostate; Semen; United Kingdom | 1997 |
Case-control study of phyto-oestrogens and breast cancer.
Topics: 4-Butyrolactone; Breast Neoplasms; Case-Control Studies; Chromans; Diet; Equol; Estrogens, Non-Steroidal; Female; Humans; Isoflavones; Lignans; Middle Aged; Phytoestrogens; Plant Preparations; Plants; Risk Factors | 1997 |
Studies on the genotoxicity of the mammalian lignans enterolactone and enterodiol and their metabolic precursors at various endpoints in vitro.
Topics: 4-Butyrolactone; Aneuploidy; Animals; Bacteria; Butylene Glycols; Cattle; Cell Line; Cell-Free System; Cricetinae; Estrogens; Furans; Hypoxanthine Phosphoribosyltransferase; Intestinal Mucosa; Intestines; Lignans; Male; Micronucleus Tests; Microtubules; Mitosis; Mutagenicity Tests; Mutagens | 1998 |
Effects of phytoestrogens on DNA synthesis in MCF-7 cells in the presence of estradiol or growth factors.
Topics: 4-Butyrolactone; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chamomile; Coumestrol; DNA, Neoplasm; Epidermal Growth Factor; Estradiol; Estrogens, Non-Steroidal; Female; Flavonoids; Genistein; Humans; Insulin; Isoflavones; Lignans; Luteolin; Oils, Volatile; Phytoestrogens; Plant Preparations; Plants, Medicinal; Tamoxifen; Tumor Cells, Cultured | 1998 |
Reliability of serum measurements of lignans and isoflavonoid phytoestrogens over a two-year period.
Topics: 4-Butyrolactone; Adult; Age Factors; Aged; Bias; Breast Neoplasms; Chromans; Equol; Feasibility Studies; Female; Genistein; Humans; Isoflavones; Lignans; Middle Aged; New York City; Pilot Projects; Postmenopause; Premenopause; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Time Factors | 1998 |
Phyto-oestrogen excretion and rate of bone loss in postmenopausal women.
Topics: 4-Butyrolactone; Aging; Bone Density; Chromans; Equol; Estrogens, Non-Steroidal; Female; Gas Chromatography-Mass Spectrometry; Genistein; Humans; Isoflavones; Lignans; Linear Models; Middle Aged; Osteoporosis, Postmenopausal; Phytoestrogens; Plant Preparations; Postmenopause; Prospective Studies; Time Factors | 1998 |
Time-resolved fluoroimmunoassay for plasma enterolactone.
Topics: 4-Butyrolactone; Fluoroimmunoassay; Gas Chromatography-Mass Spectrometry; Humans; Lignans; Sensitivity and Specificity | 1998 |
Oxidative metabolism of the mammalian lignans enterolactone and enterodiol by rat, pig, and human liver microsomes.
Topics: 4-Butyrolactone; Animals; Biotransformation; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Estrogens; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Lignans; Male; Mass Spectrometry; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Wistar; Swine | 1999 |
Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone.
Topics: 4-Butyrolactone; Animals; Antioxidants; Butylene Glycols; Emulsions; Estrogens; Flax; Free Radical Scavengers; Glucosides; Hydroxides; Lignans; Linoleic Acid; Lipid Peroxidation; Mammals; Oxidation-Reduction; Seeds | 1999 |
Enterolactone and coronary events.
Topics: 4-Butyrolactone; Coronary Disease; Diabetes Mellitus; Estrogens; Humans; Lignans; Risk Assessment | 2000 |
Rapid analysis of phytoestrogens in human urine by time-resolved fluoroimmunoassay.
Topics: 4-Butyrolactone; Animals; Cross Reactions; Estrogens, Non-Steroidal; Evaluation Studies as Topic; Female; Fluoroimmunoassay; Gas Chromatography-Mass Spectrometry; Genistein; Humans; Isoflavones; Lignans; Phytoestrogens; Plant Preparations; Rabbits; Sensitivity and Specificity; Serum Albumin, Bovine | 2000 |
Hydroxymatairesinol, a novel enterolactone precursor with antitumor properties from coniferous tree (Picea abies).
Topics: 4-Butyrolactone; Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Female; Furans; Genitalia, Male; Lignans; Male; Mammary Neoplasms, Experimental; Phytotherapy; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Trees; Uterus | 2000 |
Oxidative metabolites of the mammalian lignans enterodiol and enterolactone in rat bile and urine.
Topics: 4-Butyrolactone; Animals; Bile; Female; Gas Chromatography-Mass Spectrometry; Lignans; Male; Oxidation-Reduction; Rats; Rats, Wistar | 2000 |
Changes in the time-resolved fluoroimmunoassay of plasma enterolactone.
Topics: 4-Butyrolactone; Animals; Dose-Response Relationship, Drug; Europium; Fluoroimmunoassay; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Lignans; Reproducibility of Results; Sensitivity and Specificity; Snails; Sulfatases; Time Factors | 2000 |
Synthesis of enterolactone and enterodiol precursors as potential inhibitors of human estrogen synthetase (aromatase).
Topics: 4-Butyrolactone; Aromatase Inhibitors; Catechols; Enzyme Inhibitors; Humans; Lignans; Phenols | 2000 |
A novel treatment for lupus nephritis: lignan precursor derived from flax.
Topics: 4-Butyrolactone; Animals; Blood Coagulation Factors; Flax; Humans; Lignans; Lupus Nephritis; Mice; Phytotherapy; Platelet Activating Factor; Seeds | 2000 |
Human intestinal bacteria capable of transforming secoisolariciresinol diglucoside to mammalian lignans, enterodiol and enterolactone.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Culture Media; Estrogens; Eubacterium; Feces; Glucosides; Humans; Intestines; Lignans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Peptostreptococcus; Rats; Rats, Wistar | 2000 |
Improved stereoselective synthesis of optically active methylene lactone, key intermediate for the synthesis of 1,2-oxidized furofuran lignan, by direct alpha-methylenation to butanolide.
Topics: 4-Butyrolactone; Dioxoles; Furans; Hydrocarbons; Lignans; Magnetic Resonance Spectroscopy; Methane; Oxidation-Reduction; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2000 |
Changes in serum enterolactone, genistein, and daidzein in a dietary intervention study in Finland.
Topics: 4-Butyrolactone; Adult; Biomarkers; Dietary Fats; Dietary Fats, Unsaturated; Estrogens; Finland; Fruit; Genistein; Humans; Isoflavones; Lignans; Middle Aged; Vegetables | 2000 |
Comparison of plasma and urinary phytoestrogens in Japanese and Finnish women by time-resolved fluoroimmunoassay.
Topics: 4-Butyrolactone; Adult; Aged; Diet; Estrogens, Non-Steroidal; Europium; Female; Finland; Fluoroimmunoassay; Gas Chromatography-Mass Spectrometry; Genistein; Humans; Isoflavones; Japan; Lignans; Middle Aged; Phytoestrogens; Plant Preparations; Reference Values; Sensitivity and Specificity | 2000 |
Urinary phytoestrogens and postmenopausal breast cancer risk.
Topics: 4-Butyrolactone; Aged; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Cohort Studies; Confidence Intervals; Estrogens, Non-Steroidal; Female; Fluoroimmunoassay; Genetic Predisposition to Disease; Genistein; Humans; Isoflavones; Lignans; Logistic Models; Mass Screening; Middle Aged; Netherlands; Odds Ratio; Phytoestrogens; Plant Preparations; Postmenopause; Predictive Value of Tests; Reference Values; Risk Assessment; Risk Factors; Sensitivity and Specificity | 2001 |
Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland.
Topics: 4-Butyrolactone; Adult; Aged; Breast Neoplasms; Case-Control Studies; Diet; Dietary Fiber; Female; Finland; Humans; Lignans; Middle Aged; Odds Ratio; Plant Growth Regulators; Postmenopause; Premenopause; Preventive Medicine; Risk Factors; Vitamin E | 2001 |
Determinants of serum enterolactone concentration.
Topics: 4-Butyrolactone; Adult; Anthropometry; Body Mass Index; Cross-Sectional Studies; Diet; Educational Status; Female; Finland; Fluoroimmunoassay; Health Status; Humans; Lignans; Male; Middle Aged; Regression Analysis; Smoking | 2001 |
Analytical performance of luminescent immunoassays of different format for serum daidzein analysis.
Topics: 4-Butyrolactone; Cross Reactions; Dose-Response Relationship, Immunologic; Equilin; Female; Fluorescent Dyes; Genistein; Haptens; Horseradish Peroxidase; Humans; Immunoenzyme Techniques; Immunoglobulin Fc Fragments; Isoflavones; Lignans; Luminescent Measurements; Molecular Structure; Phenanthrolines; Polystyrenes; Radioimmunoassay; Serum Albumin, Bovine; Steroids | 2001 |
In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol.
Topics: 4-Butyrolactone; Chromatography, High Pressure Liquid; Feces; Gas Chromatography-Mass Spectrometry; Lignans; Plant Extracts | 2001 |
10-Demethoxystegane, a new lignan from Steganotaenia araliacea.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Apiaceae; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Humans; Inhibitory Concentration 50; Lignans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Ovarian Neoplasms; Plants, Medicinal; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured | 2001 |
A fast and simple GC MS method for lignan profiling in Anthriscus sylvestris and biosynthetically related Plant species.
Topics: 4-Butyrolactone; Apiaceae; Dioxoles; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Lignans; Plant Extracts; Podophyllotoxin | 2001 |
Dietary determinants of plasma enterolactone.
Topics: 4-Butyrolactone; Adult; Biomarkers; Cross-Sectional Studies; Diet; Female; Fruit; Gastrointestinal Neoplasms; Humans; Lignans; Male; Probability; Prospective Studies; Reference Values; Sensitivity and Specificity; Vegetables | 2002 |
Association between low serum enterolactone and increased plasma F2-isoprostanes, a measure of lipid peroxidation.
Topics: 4-Butyrolactone; Coronary Disease; Estrogens; F2-Isoprostanes; Homocysteine; Humans; Lignans; Lipid Peroxidation; Male; Middle Aged; Multivariate Analysis; Risk Factors | 2002 |
Use of oral antimicrobials decreases serum enterolactone concentration.
Topics: 4-Butyrolactone; Administration, Oral; Adult; Anti-Bacterial Agents; Biomarkers; Chronic Disease; Cross-Sectional Studies; Digestive System; Female; Humans; Lignans; Middle Aged; Risk Factors | 2002 |
Free-radical-mediated conjugate additions. Enantioselective synthesis of butyrolactone natural products: (-)-enterolactone, (-)-arctigenin, (-)-isoarctigenin, (-)-nephrosteranic acid, and (-)-roccellaric acid.
Topics: 4-Butyrolactone; Alkylation; Biological Products; Catalysis; Chemistry, Organic; Free Radicals; Fumarates; Furans; Lactones; Lignans; Magnetic Resonance Spectroscopy; Molecular Structure; Stereoisomerism; Succinates | 2002 |
Relationships of urinary phyto-oestrogen excretion to BMD in postmenopausal women.
Topics: 4-Butyrolactone; Aged; Aging; Apigenin; Body Mass Index; Bone Density; Estrogens, Non-Steroidal; Female; Femur Neck; Flavonoids; Gas Chromatography-Mass Spectrometry; Humans; Isoflavones; Lignans; Lumbar Vertebrae; Middle Aged; Phytoestrogens; Plant Preparations; Postmenopause; Regression Analysis | 2002 |
Circulating enterolactone and prostate cancer risk: a Nordic nested case-control study.
Topics: 4-Butyrolactone; Case-Control Studies; Cohort Studies; Estrogens; Finland; Fluoroimmunoassay; Humans; Lignans; Male; Middle Aged; Norway; Prospective Studies; Prostatic Neoplasms; Risk Factors; Sweden | 2002 |
Uptake and metabolism of hydroxymatairesinol in relation to its anticarcinogenicity in DMBA-induced rat mammary carcinoma model.
Topics: 4-Butyrolactone; 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Anticarcinogenic Agents; Diet; Estrogens, Non-Steroidal; Female; Isoflavones; Lignans; Mammary Neoplasms, Experimental; Organ Size; Phytoestrogens; Plant Preparations; Rats; Rats, Sprague-Dawley; Uterus | 2001 |
An incident case-referent study on plasma enterolactone and breast cancer risk.
Topics: 4-Butyrolactone; Aging; Breast Neoplasms; Cohort Studies; Dietary Fiber; Female; Humans; Lignans; Reference Values; Risk Factors; Surveys and Questionnaires | 2002 |
Structural determinants of plant lignans for the formation of enterolactone in vivo.
Topics: 4-Butyrolactone; Animals; Chromatography, High Pressure Liquid; Lignans; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship | 2002 |
Mammalian lignan formation in rats fed a wheat bran diet.
Topics: 4-Butyrolactone; Adaptation, Physiological; Animals; Coumaric Acids; Diet; Dietary Fiber; Fluoroimmunoassay; Gas Chromatography-Mass Spectrometry; Lignans; Male; Rats; Rats, Wistar; Solanum tuberosum; Starch | 2002 |
The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in women.
Topics: 4-Butyrolactone; Adult; Aged; Breast Neoplasms; Case-Control Studies; Dose-Response Relationship, Drug; Female; Food Analysis; Genotype; Humans; Interviews as Topic; Lignans; Middle Aged; Odds Ratio; Premenopause; Risk Factors; Steroid 17-alpha-Hydroxylase | 2002 |
Phytoestrogen concentrations in serum from Japanese men and women over forty years of age.
Topics: 4-Butyrolactone; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Chromans; Diet; Equol; Estrogens, Non-Steroidal; Female; Gas Chromatography-Mass Spectrometry; Genistein; Humans; Isoflavones; Japan; Lignans; Male; Middle Aged; Phytoestrogens; Plant Preparations; Prostatic Neoplasms; United Kingdom | 2002 |
Enterolactone inhibits the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in the rat.
Topics: 4-Butyrolactone; 9,10-Dimethyl-1,2-benzanthracene; Animals; Aromatase Inhibitors; Carcinogens; Cell Division; Enzyme Inhibitors; Estrogens; Estrogens, Non-Steroidal; Female; Isoflavones; Lignans; Mammary Neoplasms, Animal; Models, Chemical; Organ Size; Phytoestrogens; Plant Preparations; Rats; Rats, Sprague-Dawley; Time Factors; Uterus | 2002 |
Short-term variations in enterolactone in serum, 24-hour urine, and spot urine and relationship with enterolactone concentrations.
Topics: 4-Butyrolactone; Biomarkers; Female; Fluoroimmunoassay; Humans; Lignans; Male; Time Factors | 2003 |
Synthesis of (-)-matairesinol, (-)-enterolactone, and (-)-enterodiol from the natural lignan hydroxymatairesinol.
Topics: 4-Butyrolactone; Furans; Hydrogenation; Lignans; Picea; Stereoisomerism | 2003 |
Quantification of isoflavones and lignans in urine using gas chromatography/mass spectrometry.
Topics: 4-Butyrolactone; Equol; Female; Gas Chromatography-Mass Spectrometry; Genistein; Humans; Isoflavones; Lignans; Molecular Structure; Phytoestrogens; Plant Preparations; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Rye bread in the diet of pigs enhances the formation of enterolactone and increases its levels in plasma, urine and feces.
Topics: 4-Butyrolactone; Animal Feed; Animals; Biotransformation; Bread; Estrogens; Feces; Lignans; Metabolic Clearance Rate; Secale; Swine | 2003 |
Risk of cardiovascular disease-related and all-cause death according to serum concentrations of enterolactone: Kuopio Ischaemic Heart Disease Risk Factor Study.
Topics: 4-Butyrolactone; Adult; Cause of Death; Finland; Follow-Up Studies; Humans; Lignans; Male; Middle Aged; Myocardial Ischemia; Prospective Studies; Risk Assessment; Risk Factors | 2003 |
Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro.
Topics: 4-Butyrolactone; Anisoles; Benzodioxoles; Culture Techniques; Dioxoles; Enzyme-Linked Immunosorbent Assay; Glucosides; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Hydrolyzable Tannins; Lignans; Molecular Structure; Phyllanthus; Phytotherapy; Plant Extracts; Tannins | 2003 |
Synthesis of (+)-aptosimon, a 4-oxofurofuran lignan, by erythro selective aldol condensation and stereoconvergent cyclization as the key reactions.
Topics: 4-Butyrolactone; Biological Factors; Cyclization; Dioxoles; Furans; Lignans; Stereoisomerism | 2003 |
Identification of phytoestrogens in bovine milk using liquid chromatography/electrospray tandem mass spectrometry.
Topics: 4-Butyrolactone; Animals; Cattle; Chromans; Chromatography, Liquid; Coumestrol; Equol; Estrogens, Non-Steroidal; Genistein; Ions; Isoflavones; Lignans; Milk; Molecular Structure; Phytoestrogens; Plant Preparations; Spectrometry, Mass, Electrospray Ionization | 2003 |
Plasma enterolactone or intestinal Bifidobacterium levels do not explain adenoma formation in multiple intestinal neoplasia (Min) mice fed with two different types of rye-bran fractions.
Topics: 4-Butyrolactone; Animals; Bifidobacterium; Dietary Fiber; Genes, APC; Intestinal Neoplasms; Intestine, Large; Lignans; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Models, Animal; Plant Extracts; Random Allocation; Secale | 2003 |
Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro.
Topics: 4-Butyrolactone; Antineoplastic Agents; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Female; Humans; Lignans; Neoplasm Invasiveness; Neoplasm Metastasis; Phytotherapy; Receptors, Estrogen; Tamoxifen | 2003 |
Biosynthesis of yatein in Anthriscus sylvestris.
Topics: 4-Butyrolactone; Apiaceae; Benzyl Compounds; Carbon Isotopes; Deuterium; Dioxoles; Furans; Lactones; Lignans; Mass Spectrometry; Phenylalanine; Podophyllin | 2003 |
Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats.
Topics: 4-Butyrolactone; Animals; Anticarcinogenic Agents; Carcinogens; Female; Glucosides; Imidazoles; Lignans; Mammary Neoplasms, Experimental; Rats; Rats, Sprague-Dawley | 2003 |
Serum enterolactone concentration is not associated with breast cancer risk in a nested case-control study.
Topics: 4-Butyrolactone; Adult; Aged; Breast Neoplasms; Case-Control Studies; Cross-Sectional Studies; Estrogens; Female; Finland; Fluoroimmunoassay; Humans; Lignans; Middle Aged; Odds Ratio; Postmenopause; Premenopause; Prospective Studies; Risk Factors | 2004 |
Dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii.
Topics: 4-Butyrolactone; Butylene Glycols; Drugs, Chinese Herbal; Lignans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peperomia; Plants, Medicinal; Stereoisomerism | 2003 |
Serum enterolactone concentration is not associated with prostate cancer risk in a nested case-control study.
Topics: 4-Butyrolactone; Aged; Case-Control Studies; Fluoroimmunoassay; Humans; Lignans; Male; Middle Aged; Odds Ratio; Prostatic Neoplasms; Risk Factors | 2003 |
Serum enterolactone levels and the risk of breast cancer in women with palpable cysts.
Topics: 4-Butyrolactone; Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Female; Fibrocystic Breast Disease; Follow-Up Studies; Humans; Lignans; Middle Aged; Regression Analysis; Retrospective Studies; Risk Factors; Serum | 2004 |
Dietary lignins are precursors of mammalian lignans in rats.
Topics: 4-Butyrolactone; Animals; Biological Availability; Cell Wall; Cellulases; Chromatography, Liquid; Deuterium; Diet; Gas Chromatography-Mass Spectrometry; Glycoside Hydrolases; Isoflavones; Lignans; Lignin; Male; Phytoestrogens; Plant Preparations; Rats; Rats, Wistar; Secale; Spectrometry, Mass, Electrospray Ionization; Triticum | 2004 |
A single measurement is inadequate to estimate enterolactone levels in danish postmenopausal women due to large intraindividual variation.
Topics: 4-Butyrolactone; Aged; Circadian Rhythm; Denmark; Female; Fluoroimmunoassay; Humans; Lignans; Middle Aged; Models, Biological; Postmenopause; Random Allocation | 2004 |
A new lariciresinol-type butyrolactone lignan derived from hydroxymatairesinol and its identification in spruce wood.
Topics: 4-Butyrolactone; Animals; Lignans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Picea; Plants, Medicinal; Rats; Stereoisomerism; Urine; Wood | 2004 |
Circulating enterolactone and risk of breast cancer: a prospective study in New York.
Topics: 4-Butyrolactone; Adult; Breast Neoplasms; Case-Control Studies; Estrogens; Female; Humans; Lignans; Middle Aged; New York; Odds Ratio; Postmenopause; Premenopause; Prospective Studies; Risk Factors | 2004 |
Determination of phytoestrogens in traditional medicinal herbs using gas chromatography--mass spectrometry.
Topics: 4-Butyrolactone; Chemistry Techniques, Analytical; Fabaceae; Flavonoids; Gas Chromatography-Mass Spectrometry; Lignans; Phytoestrogens; Plants, Medicinal; Reproducibility of Results; Sensitivity and Specificity | 2004 |
Increase of caspase-3 activity by lignans from Machilus thunbergii in HL-60 cells.
Topics: 4-Butyrolactone; Caspase 3; Caspases; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Activation; HL-60 Cells; Humans; Lignans; Persea | 2004 |
Glucuronidation, oxidative metabolism, and bioactivation of enterolactone in rhesus monkeys.
Topics: 4-Butyrolactone; Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Female; Lignans; Liver; Macaca mulatta; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxidation-Reduction | 2004 |
Inhibitory effects of lignans on the activity of human matrix metalloproteinase 7 (matrilysin).
Topics: 4-Butyrolactone; Enzyme Inhibitors; Furans; Humans; Lignans; Matrix Metalloproteinase Inhibitors; Recombinant Proteins; Structure-Activity Relationship | 2004 |
Intake of whole grains and vegetables determines the plasma enterolactone concentration of Danish women.
Topics: 4-Butyrolactone; Body Mass Index; Case-Control Studies; Denmark; Diet; Edible Grain; Female; Humans; Life Style; Lignans; Middle Aged; Postmenopause; Vegetables | 2004 |
Phytoestrogen tissue levels in benign prostatic hyperplasia and prostate cancer and their association with prostatic diseases.
Topics: 4-Butyrolactone; Adenocarcinoma; Aged; Aged, 80 and over; Diet; Genistein; Humans; Lignans; Male; Middle Aged; Organ Size; Phytoestrogens; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms | 2004 |
Plasma enterolactone and breast cancer incidence by estrogen receptor status.
Topics: 4-Butyrolactone; Breast Neoplasms; Case-Control Studies; Cohort Studies; Diet; Female; Humans; Life Style; Lignans; Middle Aged; Postmenopause; Receptors, Estrogen; Risk Factors | 2004 |
Trypanocidal activity of (-)-cubebin derivatives against free amastigote forms of Trypanosoma cruzi.
Topics: 4-Butyrolactone; Animals; Benzodioxoles; Chagas Disease; Inhibitory Concentration 50; Lignans; Membrane Glycoproteins; Parasitic Sensitivity Tests; Protozoan Proteins; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
New furofuran and butyrolactone lignans with antioxidant activity from the stem bark of Styrax japonica.
Topics: 4-Butyrolactone; Antioxidants; Biphenyl Compounds; Furans; Glucosides; Glycosides; Korea; Lignans; Molecular Structure; Oleanolic Acid; Phenylpropionates; Picrates; Plant Bark; Plants, Medicinal; Stereoisomerism; Styrax | 2004 |
A thirteen week dietary toxicity study with 7-hydroxymatairesinol potassium acetate (HMRlignan) in rats.
Topics: 4-Butyrolactone; Animals; Body Weight; Diet; Female; Lignans; Male; Motor Activity; No-Observed-Adverse-Effect Level; Organ Size; Potassium Acetate; Rats; Rats, Wistar | 2005 |
Uptake and metabolism of enterolactone and enterodiol by human colon epithelial cells.
Topics: 4-Butyrolactone; Caco-2 Cells; Cell Line; Colon; HT29 Cells; Humans; Intestinal Mucosa; Lignans; Metabolic Clearance Rate | 2005 |
Pharmacokinetics of enterolignans in healthy men and women consuming a single dose of secoisolariciresinol diglucoside.
Topics: 4-Butyrolactone; Adult; Blood Specimen Collection; Butylene Glycols; Dietary Supplements; Female; Glucosides; Humans; Lignans; Male; Reference Values | 2005 |
Analysis of environmental biomarkers in urine using an electrochemical detector.
Topics: 4-Butyrolactone; Benzhydryl Compounds; Biomarkers; Child; Chromatography, High Pressure Liquid; Electrochemistry; Environmental Exposure; Female; Genistein; Humans; Isoflavones; Lignans; Middle Aged; Phenols; Phytoestrogens | 2005 |
Prospective study of plasma enterolactone and prostate cancer risk (Sweden).
Topics: 4-Butyrolactone; Cohort Studies; Humans; Life Style; Lignans; Male; Middle Aged; Obesity; Phytoestrogens; Prospective Studies; Prostatic Neoplasms; Risk; Smoking; Sweden | 2004 |
Structural determinants of plant lignans for growth of mammary tumors and hormonal responses in vivo.
Topics: 4-Butyrolactone; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Furans; Lignans; Male; Mammary Neoplasms, Experimental; Molecular Structure; Organ Size; Phytotherapy; Plants; Prostate; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Uterus | 2005 |
Suitability of a batch in vitro fermentation model using human faecal microbiota for prediction of conversion of flaxseed lignans to enterolactone with reference to an in vivo rat model.
Topics: 4-Butyrolactone; Animals; Area Under Curve; Dietary Fiber; Fatty Acids, Volatile; Feces; Fermentation; Flax; Humans; Lignans; Male; Models, Animal; Models, Biological; Predictive Value of Tests; Rats; Rats, Wistar; Secale | 2006 |
Dietary sesamin is converted to enterolactone in humans.
Topics: 4-Butyrolactone; Adult; Biotransformation; Diet; Dioxoles; Female; Humans; Intestinal Absorption; Kinetics; Lignans; Male; Middle Aged | 2005 |
Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells.
Topics: 17-Hydroxysteroid Dehydrogenases; 4-Butyrolactone; Animals; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Estradiol; Female; Genistein; Humans; Lignans; Mammals; Phytoestrogens | 2005 |
A validated method for the quantification of enterodiol and enterolactone in plasma using isotope dilution liquid chromatography with tandem mass spectrometry.
Topics: 4-Butyrolactone; Adult; Carbon Isotopes; Chromatography, Liquid; Drug Stability; Female; Humans; Lignans; Male; Mass Spectrometry; Middle Aged; Reproducibility of Results | 2005 |
The plant lignans matairesinol and secoisolariciresinol administered to Min mice do not protect against intestinal tumor formation.
Topics: 4-Butyrolactone; Adenomatous Polyposis Coli Protein; Animals; Butylene Glycols; Diet; Disease Models, Animal; Female; Furans; Intestinal Neoplasms; Lignans; Male; Mice; Mice, Inbred C57BL; Plants | 2006 |
Selective Lewis acid catalyzed transformation (gamma-butyrolactone versus cyclopropane) of 2-methoxy-4-benzyltetrahydrofuran derivatives. Efficient synthesis of lignan lactones.
Topics: 4-Butyrolactone; Catalysis; Cyclization; Cyclopropanes; Furans; Lactones; Lignans; Molecular Structure; Stereoisomerism | 2005 |
Anti-HIV activity of dibenzylbutyrolactone-type lignans from Phenax species endemic in Costa Rica.
Topics: 4-Butyrolactone; Anti-HIV Agents; Apigenin; Chemistry, Pharmaceutical; Costa Rica; Ethanol; Geography; Lactones; Lignans; Plant Extracts; Plant Leaves; Structure-Activity Relationship; Technology, Pharmaceutical; Urticaceae | 2005 |
Xenobiotic phenols in early pregnancy amniotic fluid.
Topics: 4-Butyrolactone; Amniotic Fluid; Benzhydryl Compounds; Estrogens, Non-Steroidal; Female; Genistein; Humans; Isoflavones; Lignans; Maternal Exposure; Maternal-Fetal Exchange; Phenols; Phytoestrogens; Pregnancy; Xenobiotics | 2006 |
Mammalian lignans enterolactone and enterodiol, alone and in combination with the isoflavone genistein, do not promote the growth of MCF-7 xenografts in ovariectomized athymic nude mice.
Topics: 4-Butyrolactone; Animals; Apoptosis; Body Weight; Cell Line, Tumor; Cell Proliferation; Drug Therapy, Combination; Feeding Behavior; Genistein; Humans; Lignans; Mice; Mice, Nude; Neoplasms; Ovariectomy; Xenograft Model Antitumor Assays | 2006 |
A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.
Topics: 2-Methoxyestradiol; 4-Butyrolactone; Aminophenols; Binding Sites; Chalcone; Colchicine; Cyclopropanes; Estradiol; Indans; Lignans; Models, Molecular; Molecular Structure; Nocodazole; Podophyllotoxin; Protein Binding; Stilbenes; Structure-Activity Relationship; Sulfonamides; Thiazoles; Tubulin; Tubulin Modulators | 2005 |
Plasma levels of enterolactone and percentage mammographic density among postmenopausal women.
Topics: 4-Butyrolactone; Aged; Biomarkers; Body Mass Index; Breast Neoplasms; Cohort Studies; Female; Humans; Lignans; Mammography; Middle Aged; Postmenopause | 2005 |
Intestinal bacterial communities that produce active estrogen-like compounds enterodiol and enterolactone in humans.
Topics: 4-Butyrolactone; Actinobacteria; Adult; Bacteria, Anaerobic; Butylene Glycols; Colony Count, Microbial; Culture Media; Female; Flow Cytometry; Glucosides; Humans; In Situ Hybridization, Fluorescence; Intestines; Lignans; Male; Middle Aged; Peptostreptococcus; Phytoestrogens | 2005 |
Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men.
Topics: 4-Butyrolactone; Aged; Androgens; Androstane-3,17-diol; Aromatase; Diet; Equol; Genistein; Genotype; Humans; Isoflavones; Lignans; Male; Middle Aged; Phytoestrogens; Polymorphism, Genetic; Sex Hormone-Binding Globulin; Testosterone | 2005 |
Detailed 1H and 13C NMR structural assignment of three biologically active lignan lactones.
Topics: 4-Butyrolactone; Benzodioxoles; Carbon Isotopes; Dioxoles; Lactones; Lignans; Magnetic Resonance Spectroscopy; Molecular Structure; Protons | 2006 |
Dietary phytoestrogen, serum enterolactone and risk of prostate cancer: the cancer prostate Sweden study (Sweden).
Topics: 4-Butyrolactone; Diet; Health Behavior; Humans; Life Style; Lignans; Male; Phytoestrogens; Prostatic Neoplasms; Risk Factors; Sweden | 2006 |
Microwave-enhanced synthesis of new (-)-steganacin and (-)-steganone aza analogues.
Topics: 4-Butyrolactone; Aza Compounds; Cyclization; Lignans; Microwaves; Molecular Structure; Stereoisomerism; Triazoles | 2006 |
Phylogeny of human intestinal bacteria that activate the dietary lignan secoisolariciresinol diglucoside.
Topics: 4-Butyrolactone; Bacteria, Anaerobic; Butylene Glycols; Culture Media; Glucosides; Humans; Intestines; Lignans; Phylogeny | 2006 |
Genistein alone and in combination with the mammalian lignans enterolactone and enterodiol induce estrogenic effects on bone and uterus in a postmenopausal breast cancer mouse model.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Bone and Bones; Bone Density; Drug Combinations; Estrogens; Female; Genistein; Humans; Lignans; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Mice, Nude; Organ Size; Ovariectomy; Phytoestrogens; Postmenopause; Uterus; Xenograft Model Antitumor Assays | 2006 |
Lignans from the bark extract of Pinus sylvestris L.
Topics: 4-Butyrolactone; Acetone; Benzofurans; Guaiacol; Lignans; Magnetic Resonance Spectroscopy; Molecular Structure; Pinus sylvestris; Plant Extracts; Propylene Glycols; Spectrometry, Mass, Electrospray Ionization; Water | 2006 |
Configurational analysis of cubebins and bicubebin from Aristolochia lagesiana and Aristolochia pubescens.
Topics: 4-Butyrolactone; Aristolochia; Circular Dichroism; Lignans; Magnetic Resonance Spectroscopy; Molecular Conformation; Plant Extracts; Plants, Medicinal | 2006 |
Effective acceleration of atom transfer carbonylation of alkyl iodides by metal complexes. Application to the synthesis of the hinokinin precursor and dihydrocapsaicin.
Topics: 4-Butyrolactone; Alkynes; Benzodioxoles; Capsaicin; Dioxoles; Iodides; Lignans; Manganese Compounds; Molecular Structure; Palladium | 2006 |
Plasma enterolactone and genistein and the risk of premenopausal breast cancer.
Topics: 4-Butyrolactone; Adult; Breast Neoplasms; Case-Control Studies; Diet; Female; Genistein; Humans; Lignans; Middle Aged; Phytoestrogens; Plant Preparations; Premenopause; Risk Factors | 2006 |
CYP17 genotype modifies the association between lignan supply and premenopausal breast cancer risk in humans.
Topics: 4-Butyrolactone; Adult; Anticarcinogenic Agents; Breast Neoplasms; Case-Control Studies; Female; Genistein; Genotype; Germany; Humans; Lignans; Logistic Models; Middle Aged; Premenopause; Risk Factors; Steroid 17-alpha-Hydroxylase | 2006 |
Plasma enterolignans are associated with lower colorectal adenoma risk.
Topics: 4-Butyrolactone; Adenoma; Case-Control Studies; Chromatography, Liquid; Colorectal Neoplasms; Diet; Female; Humans; Incidence; Lignans; Middle Aged; Netherlands; Odds Ratio; Retrospective Studies; Spectrometry, Mass, Electrospray Ionization; Surveys and Questionnaires | 2006 |
In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzodioxoles; Bupleurum; Cell Line, Tumor; Cell Proliferation; Cell Shape; Dose-Response Relationship, Drug; G2 Phase; Humans; Inhibitory Concentration 50; Lignans; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Microtubules; Phosphorylation; Plant Extracts; Plant Roots; Tubulin; Weight Gain; Xenograft Model Antitumor Assays | 2006 |
Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods.
Topics: 4-Butyrolactone; Adult; Antioxidants; Biomarkers; Caffeic Acids; Chlorogenic Acid; Coffee; Cohort Studies; Diet; Female; Flavonoids; Food; Fruit; Gallic Acid; Humans; Hydroxybenzoates; Kaempferols; Lignans; Male; Middle Aged; Phenols; Polyphenols; Vegetables; Wine | 2006 |
Circulating enterolactone and risk of endometrial cancer.
Topics: 4-Butyrolactone; Adult; Aged; Biomarkers, Tumor; Case-Control Studies; Endometrial Neoplasms; Female; Humans; Italy; Lignans; Middle Aged; New York; Odds Ratio; Prospective Studies; Risk Assessment; Risk Factors; Sweden | 2006 |
Diarylbutyrolactone lignans from Linum corymbulosum in vitro cultures.
Topics: 4-Butyrolactone; Benzodioxoles; Culture Techniques; Dioxoles; Flax; Lignans; Molecular Structure | 2006 |
An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius.
Topics: 4-Butyrolactone; Carthamus tinctorius; Cell Line; Enzyme Activation; Estrogens; Glucosides; Glycosides; Lignans; Molecular Structure; Plant Extracts; Seeds; Solubility | 2006 |
Analgesic activity of affinin, an alkamide from Heliopsis longipes (Compositae).
Topics: 4-Butyrolactone; Alkenes; Amides; Analgesics; Animals; Asteraceae; Benzodioxoles; Brain; Dioxoles; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Lignans; Medicine, Traditional; Methylene Chloride; Mexico; Mice; Pain; Plant Extracts; Plants, Medicinal; Polyunsaturated Alkamides | 2007 |
(-)-Hinokinin causes antigenotoxicity but not genotoxicity in peripheral blood of Wistar rats.
Topics: 4-Butyrolactone; Animals; Antimutagenic Agents; Benzodioxoles; Chromosome Aberrations; Dioxoles; Doxorubicin; Female; Lignans; Male; Micronucleus Tests; Rats; Rats, Wistar | 2007 |
Clostridium saccharogumia sp. nov. and Lactonifactor longoviformis gen. nov., sp. nov., two novel human faecal bacteria involved in the conversion of the dietary phytoestrogen secoisolariciresinol diglucoside.
Topics: 4-Butyrolactone; Adult; Base Composition; Butylene Glycols; Clostridium; Colon; Culture Media; Dietary Carbohydrates; DNA; DNA, Ribosomal; Feces; Genotype; Glucosides; Gram-Positive Rods; Humans; Lignans; Male; Molecular Sequence Data; Nucleic Acid Hybridization; Phenotype; Phylogeny; Phytoestrogens; RNA, Ribosomal, 16S | 2007 |
Evaluation of piper cubeba extract, (-)-cubebin and its semi-synthetic derivatives against oral pathogens.
Topics: 4-Butyrolactone; Anti-Infective Agents; Benzodioxoles; Candida albicans; Dioxoles; Enterococcus faecalis; Lignans; Microbial Sensitivity Tests; Piper; Plant Extracts; Streptococcus | 2007 |
Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Endothelium, Vascular; Estradiol; Female; Flax; Humans; Lignans; Mice; Neoplasm Transplantation; Neovascularization, Pathologic; Phytoestrogens; Umbilical Veins; Vascular Endothelial Growth Factor A | 2007 |
Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls.
Topics: 4-Butyrolactone; Biomarkers; California; Child; Cities; Creatinine; Environmental Monitoring; Female; Humans; Isoflavones; Lignans; New York; Ohio; Phenols; Phthalic Acids; Phytoestrogens; Pilot Projects | 2007 |
Phyto-oestrogens and risk of prostate cancer in Scottish men.
Topics: 4-Butyrolactone; Aged; Case-Control Studies; Diet; Diet Surveys; Energy Intake; Equol; Genistein; Humans; Isoflavones; Lignans; Male; Middle Aged; Phytoestrogens; Prostatic Neoplasms; Risk Assessment; Scotland | 2007 |
A convenient route to the synthesis of isotopomeric dihydro-2(3H)furanones.
Topics: 4-Butyrolactone; Deuterium; Fumarates; Furans; Isotope Labeling; Lignans; Maleates; Ruthenium; Succinic Acid | 2007 |
Relation between plasma enterodiol and enterolactone and dietary intake of lignans in a Dutch endoscopy-based population.
Topics: 4-Butyrolactone; Adenomatous Polyps; Adult; Aged; Case-Control Studies; Colonoscopy; Colorectal Neoplasms; Diet; Female; Humans; Lignans; Male; Middle Aged; Phytoestrogens | 2007 |
Isolation and characterization of a human intestinal bacterium, Eubacterium sp. ARC-2, capable of demethylating arctigenin, in the essential metabolic process to enterolactone.
Topics: 4-Butyrolactone; Adenosine Triphosphate; Biotransformation; Eubacterium; Feces; Furans; Humans; Intestines; Lignans; Molecular Structure; Phylogeny; RNA, Bacterial; RNA, Ribosomal, 16S; Tetrahydrofolates; Time Factors | 2007 |
Variation in fasting and non-fasting serum enterolactone concentrations in women of the Malmö Diet and Cancer cohort.
Topics: 4-Butyrolactone; Biomarkers; Cohort Studies; Diet; Fasting; Female; Fluoroimmunoassay; Humans; Lignans; Middle Aged; Phytoestrogens; Postprandial Period; Prospective Studies; Risk Assessment; Risk Factors | 2008 |
Hydroxymatairesinol and its mammalian metabolite enterolactone reduce the growth and metastasis of subcutaneous AH109A hepatomas in rats.
Topics: 4-Butyrolactone; Animals; Apoptosis; Cell Cycle; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Lignans; Liver Neoplasms, Experimental; Male; Neoplasm Invasiveness; Neoplasm Metastasis; Rats; Tumor Cells, Cultured | 2007 |
Estrogenic activity of 7-hydroxymatairesinol potassium acetate (HMR/lignan) from Norway spruce (Picea abies) knots and of its active metabolite enterolactone in MCF-7 cells.
Topics: 4-Butyrolactone; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Female; Gene Expression Regulation, Neoplastic; Humans; Lignans; Phytoestrogens; Picea; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Tamoxifen | 2007 |
Conformational study of (8alpha,8'beta)-bis(substituted phenyl)-lignano-9,9'-lactones by means of combined computational, database mining, NMR, and chemometric approaches.
Topics: 4-Butyrolactone; Benzodioxoles; Databases, Factual; Dioxoles; Lignans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Quantum Theory | 2007 |
Antimicrobiological activity of lignan: effect of benzylic oxygen and stereochemistry of 2,3-dibenzyl-4-butanolide and 3,4-dibenzyltetrahydrofuran lignans on activity.
Topics: 4-Butyrolactone; Anti-Infective Agents; Bacillus subtilis; Furans; Lignans; Molecular Conformation; Oxygen; Pseudomonas fluorescens; Staphylococcus aureus; Structure-Activity Relationship | 2007 |
Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro.
Topics: 4-Butyrolactone; Animals; Biphenyl Compounds; Butylene Glycols; Flax; Free Radical Scavengers; Glucosides; Hydrazines; Lignans; Liposomes; Mammals; Molecular Structure; Picrates; Seeds | 2007 |
Diet-derived polyphenol metabolite enterolactone is a tissue-specific estrogen receptor activator.
Topics: 4-Butyrolactone; Animals; Biological Transport; Cell Line; Cell Nucleus; Diet; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Gene Expression; Genes, Reporter; Humans; Ligands; Lignans; Mice; Mice, Transgenic; Protein Structure, Tertiary; Receptors, Estrogen; Tissue Distribution; Transcriptional Activation | 2007 |
The human peripheral blood mononuclear cell proteome responds to a dietary flaxseed-intervention and proteins identified suggest a protective effect in atherosclerosis.
Topics: 4-Butyrolactone; Adult; Atherosclerosis; Blood Proteins; Diet; Electrophoresis, Gel, Two-Dimensional; Flax; Humans; Lignans; Male; Peptide Mapping; Proteome; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2007 |
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry.
Topics: 4-Butyrolactone; Antineoplastic Agents; Catalysis; Cell Line, Tumor; Humans; Lactones; Lignans; Molecular Conformation; Podophyllotoxin; Ruthenium; Triazoles; Tubulin | 2007 |
Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway.
Topics: 4-Butyrolactone; Apoptosis; Caspases; Cell Survival; Cytochromes c; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunoblotting; In Situ Nick-End Labeling; Lignans; Male; Membrane Potential, Mitochondrial; Mitochondria; Phytoestrogens; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2007 |
Lignan profile in seeds of modern and old Italian soft wheat (Triticum aestivum L.) cultivars as revealed by CE-MS analyses.
Topics: 4-Butyrolactone; Benzodioxoles; Butylene Glycols; Dioxoles; Electrophoresis, Capillary; Furans; Italy; Lignans; Seeds; Tandem Mass Spectrometry; Triticum | 2007 |
Enantioselective dehydroxylation of enterodiol and enterolactone precursors by human intestinal bacteria.
Topics: 4-Butyrolactone; Bacteria, Anaerobic; Biotransformation; Butylene Glycols; Eubacterium; Feces; Glucosides; Humans; Hydroxylation; Intestines; Lignans; Molecular Structure; Phylogeny; RNA, Bacterial; RNA, Ribosomal, 16S; Stereoisomerism | 2007 |
Enantioselective oxidation of enterodiol to enterolactone by human intestinal bacteria.
Topics: 4-Butyrolactone; Chromatography, High Pressure Liquid; Chromatography, Liquid; Genes, Bacterial; Humans; Intestines; Lignans; Mass Spectrometry; Molecular Structure; Oxidation-Reduction; Phylogeny; RNA, Bacterial; RNA, Ribosomal, 16S; Ruminococcus; Sequence Analysis, RNA; Spectrophotometry, Ultraviolet; Stereoisomerism; Substrate Specificity | 2007 |
(2R,3R)-2-(3',4'-dihydroxybenzyl)-3-(3'',4''-dimethoxybenzyl)butyrolactone suppresses fMLP-induced superoxide production by inhibiting fMLP-receptor binding in human neutrophils.
Topics: 4-Butyrolactone; Adult; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Lignans; Macrophage-1 Antigen; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Piper; Receptors, Formyl Peptide; Superoxides | 2008 |
Re: (-)-Hinokinin causes antigenotoxicity but not genotoxicity in peripheral blood of Wistar rats.
Topics: 4-Butyrolactone; Animals; Antimutagenic Agents; Benzodioxoles; Chromosome Aberrations; Dioxoles; Lignans; Mutagens; Rats; Rats, Wistar | 2008 |
Neurite outgrowth-promoting active constituents of the Japanese cypress (Chamaecyparis obtusa).
Topics: 4-Butyrolactone; Animals; Benzodioxoles; Chamaecyparis; Dioxoles; Lignans; Molecular Structure; Nerve Growth Factor; Neurites; PC12 Cells; Plant Leaves; Plants, Medicinal; Rats | 2008 |
Global gene expression profiles induced by phytoestrogens in human breast cancer cells.
Topics: 4-Butyrolactone; Animals; Biomarkers, Tumor; Breast Neoplasms; Cattle; Estradiol; Estrogen Receptor beta; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genistein; Humans; Isoflavones; Lignans; Milk; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Phytoestrogens; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Soy Milk; Tumor Cells, Cultured | 2008 |
Enterolactone restricts the proliferation of the LNCaP human prostate cancer cell line in vitro.
Topics: 4-Butyrolactone; Cell Division; Cell Line, Tumor; Cell Survival; Humans; Lignans; Male; Mitochondria; Phytoestrogens; Polymerase Chain Reaction; Prostate-Specific Antigen; Prostatic Neoplasms | 2008 |
Effect of the form of the sesame-based diet on the absorption of lignans.
Topics: 4-Butyrolactone; Animal Nutritional Physiological Phenomena; Animals; Diet; Dioxoles; Food Analysis; Lignans; Male; Rats; Rats, Wistar; Seeds; Sesamum | 2008 |
Enterodiol and enterolactone, two major diet-derived polyphenol metabolites have different impact on ERalpha transcriptional activation in human breast cancer cells.
Topics: 4-Butyrolactone; Animals; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Estrogen Receptor alpha; Flavonoids; HeLa Cells; Humans; Lignans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phenols; Phytoestrogens; Polyphenols; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation | 2008 |
Hinokinin biosynthesis in Linum corymbulosum Reichenb.
Topics: 4-Butyrolactone; Amino Acid Sequence; Benzodioxoles; Butylene Glycols; Cells, Cultured; Cloning, Molecular; Dioxoles; DNA, Complementary; Flax; Furans; Gene Expression; Gene Library; Genes, Plant; Lignans; Molecular Sequence Data; Oxidoreductases; Phylogeny; Plant Proteins; RNA, Plant; Sequence Alignment; Sequence Homology, Amino Acid | 2008 |
Effects of metabolites of the lignans enterolactone and enterodiol on osteoblastic differentiation of MG-63 cells.
Topics: 4-Butyrolactone; Alkaline Phosphatase; Cell Differentiation; Cell Line; Cell Survival; Collagen Type I; Dose-Response Relationship, Drug; Humans; Lignans; Osteoblasts; Osteonectin; Reverse Transcriptase Polymerase Chain Reaction; RNA; Transcription, Genetic | 2008 |
Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats.
Topics: 4-Butyrolactone; 9,10-Dimethyl-1,2-benzanthracene; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Butylene Glycols; Carcinogens; Cell Proliferation; Dietary Supplements; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Furans; Gene Expression Regulation, Neoplastic; Humans; Lignans; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Ovariectomy; Phytoestrogens; Rats; Receptors, Progesterone; Transplantation, Heterologous | 2008 |
Enterolactone induces heme oxygenase-1 expression through nuclear factor-E2-related factor 2 activation in endothelial cells.
Topics: 4-Butyrolactone; Antioxidants; Base Sequence; Binding Sites; Cells, Cultured; Chromatin Immunoprecipitation; DNA Primers; Endothelial Cells; Enzyme Induction; Gene Expression; Gene Silencing; Heme Oxygenase-1; Humans; Lignans; NF-E2-Related Factor 2; Promoter Regions, Genetic; RNA, Messenger; RNA, Small Interfering | 2008 |
Cytotoxic activity of Ipomoea cairica.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Benzoates; Cell Line, Tumor; Fatty Acids; Furans; Humans; Ipomoea; Lignans; Oleanolic Acid; Phytosterols; Plant Extracts | 2008 |
Chemical constituents of Aristolochia constricta: antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid.
Topics: 4-Butyrolactone; Animals; Aristolochia; Benzodioxoles; Dioxoles; Diterpenes; Ecuador; Guinea Pigs; Ileum; Lignans; Medicine, Traditional; Parasympatholytics; Plants, Medicinal; Stereoisomerism | 2008 |
Plasma enterolignans are not associated with nonfatal myocardial infarction risk.
Topics: 4-Butyrolactone; Adult; Antioxidants; Cardiovascular Diseases; Case-Control Studies; Female; Humans; Lignans; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Risk; Treatment Outcome | 2009 |
Diversity oriented microwave-assisted synthesis of (-)-steganacin aza-analogues.
Topics: 4-Butyrolactone; Antineoplastic Agents; Aza Compounds; Lactones; Lignans; Microwaves; Tubulin Modulators | 2008 |
Enterolactone is differently associated with estrogen receptor beta-negative and -positive breast cancer in a Swedish nested case-control study.
Topics: 4-Butyrolactone; Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Diet; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Humans; Lignans; Linear Models; Microarray Analysis; Middle Aged; Obesity; Prospective Studies; Reproducibility of Results; Risk Assessment; Smoking; Surveys and Questionnaires; Sweden | 2008 |
The binding of lignans, flavonoids and coumestrol to CYP450 aromatase: a molecular modelling study.
Topics: 4-Butyrolactone; Androgens; Aromatase; Benzoflavones; Catalytic Domain; Computer Simulation; Coumestrol; Estrone; Heme; Lignans; Models, Molecular; Phytoestrogens | 2009 |
Amides and benzenoids from Zanthoxylum ailanthoides with inhibitory activity on superoxide generation and elastase release by neutrophils.
Topics: 4-Butyrolactone; Amides; Benzamides; Benzene Derivatives; Benzodioxoles; Coumarins; Dioxoles; Humans; Inhibitory Concentration 50; Lignans; Molecular Structure; Neutrophils; Pancreatic Elastase; Plant Bark; Plants, Medicinal; Superoxides; Taiwan; Zanthoxylum | 2009 |
Secondary metabolites of Aspergillus sp. F1, a commensal fungal strain of Trewia nudiflora.
Topics: 4-Butyrolactone; Aspergillus; China; Lignans; Molecular Structure; Seeds | 2009 |
In vitro metabolism of flax lignans by ruminal and faecal microbiota of dairy cows.
Topics: 4-Butyrolactone; Animals; Cattle; Chromatography, High Pressure Liquid; Feces; Flax; Lignans; Plant Components, Aerial; Plant Extracts; Rumen; Seeds | 2008 |
Enterolactone inhibits insulin-like growth factor-1 receptor signaling in human prostatic carcinoma PC-3 cells.
Topics: 4-Butyrolactone; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; Lignans; Male; Phosphotyrosine; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Signal Transduction | 2009 |
Milk concentration of the mammalian lignan enterolactone, milk production, milk fatty acid profile, and digestibility in dairy cows fed diets containing whole flaxseed or flaxseed meal.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Cattle; Diet; Digestion; Fatty Acids; Flax; Glucosides; Lactation; Lignans; Male; Milk; Seeds | 2009 |
The protective association of high plasma enterolactone with breast cancer is reasonably robust in women with polymorphisms in the estrogen receptor alpha and beta genes.
Topics: 4-Butyrolactone; Aged; Breast Neoplasms; Cohort Studies; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Genetic Predisposition to Disease; Humans; Lignans; Middle Aged; Phytoestrogens; Polymorphism, Single Nucleotide; Prospective Studies | 2009 |
Ruminal metabolism of flaxseed ( Linum usitatissimum) lignans to the mammalian lignan enterolactone and its concentration in ruminal fluid, plasma, urine and milk of dairy cows.
Topics: 4-Butyrolactone; Animal Nutritional Physiological Phenomena; Animals; Cattle; Diet; Dietary Supplements; Feces; Female; Fermentation; Flax; Glucuronidase; Hydrogen-Ion Concentration; Lignans; Linseed Oil; Milk; Rumen | 2009 |
Impact of a lignan-rich diet on adiposity and insulin sensitivity in post-menopausal women.
Topics: 4-Butyrolactone; Adiposity; Aged; Analysis of Variance; Biomarkers; Body Composition; Body Mass Index; Diet; Diet Records; Female; Fluoroimmunoassay; Humans; Insulin Resistance; Lignans; Middle Aged; Phytoestrogens; Postmenopause; Statistics, Nonparametric | 2009 |
[Studies on chemical constituents of rhizome of Buddleia davidii].
Topics: 4-Butyrolactone; Benzodioxoles; Buddleja; Chromatography, High Pressure Liquid; Dioxoles; Lignans; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Roots; Plants, Medicinal; Sesquiterpenes; Steroids | 2009 |
Occurrence of phytoestrogens in municipal wastewater and surface waters.
Topics: 4-Butyrolactone; Chromatography, Liquid; Coumestrol; Dairying; Environmental Monitoring; Fresh Water; Isoflavones; Lignans; Phytoestrogens; Spectrometry, Mass, Electrospray Ionization; Waste Disposal, Fluid; Water Pollutants, Chemical | 2009 |
Asymmetric syntheses of (-)-enterolactone and (7'R)-7'-hydroxyenterolactone via organocatalyzed aldol reaction.
Topics: 4-Butyrolactone; Aldehydes; Catalysis; Lignans; Molecular Structure; Organic Chemicals | 2009 |
Plasma enterolactone and risk of colon and rectal cancer in a case-cohort study of Danish men and women.
Topics: 4-Butyrolactone; Case-Control Studies; Cohort Studies; Colonic Neoplasms; Denmark; Feeding Behavior; Female; Humans; Life Style; Lignans; Male; Middle Aged; Phytoestrogens; Rectal Neoplasms; Risk Factors | 2010 |
Chemopreventive actions by enterolactone and 13 VIOXX-related lactone derivatives in H295R human adrenocortical carcinoma cells.
Topics: 4-Butyrolactone; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Cell Cycle; Cell Line, Tumor; Enzyme Induction; Flavonoids; Gene Expression; Humans; Lactones; Lignans; Mitogen-Activated Protein Kinase Kinases; Neoplasms, Hormone-Dependent; Phytoestrogens; Protein Processing, Post-Translational; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship; Sulfones | 2010 |
Chemical constituents of the bark of Machilus wangchiana and their biological activities.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Phytogenic; Drugs, Chinese Herbal; Female; Flavonoids; Ginkgolides; Glucuronidase; Humans; Lactones; Lauraceae; Lignans; Molecular Structure; Neutrophils; Plant Bark; Rats; Sesquiterpenes; Stereoisomerism | 2009 |
Estrogen-induced angiogenic factors derived from stromal and cancer cells are differently regulated by enterolactone and genistein in human breast cancer in vivo.
Topics: 4-Butyrolactone; Angiogenesis Inducing Agents; Animals; Breast Neoplasms; Cell Proliferation; Estrogens; Female; Genistein; Humans; Lignans; Mice; Mice, Nude; Stromal Cells; Vascular Endothelial Growth Factor A | 2010 |
Influence of lignans depletion on murine mammary gland morphology.
Topics: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Apoptosis; Bacteria; Cell Division; Ciprofloxacin; Female; Gentamicins; Intestines; Lignans; Mammary Glands, Animal; Metronidazole; Mice; Morphogenesis; Phytoestrogens | 2010 |
(-)-Hinokinin-loaded poly(D,-lactide-co-glycolide) microparticles for Chagas disease.
Topics: 4-Butyrolactone; Animals; Antiprotozoal Agents; Benzodioxoles; Chagas Disease; Delayed-Action Preparations; Dioxanes; Dioxoles; Disease Models, Animal; Humans; Lactic Acid; Lignans; Mice; Microspheres; Parasitemia; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Treatment Outcome; Trypanosoma cruzi | 2010 |
Two new lignans from Phyllanthus amarus.
Topics: 4-Butyrolactone; India; Lignans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phyllanthus; Plant Leaves | 2009 |
Two new compounds from the dried tender stems of Cinnamomum cassia.
Topics: 4-Butyrolactone; Anisoles; Cinnamates; Cinnamomum aromaticum; Drugs, Chinese Herbal; Endothelial Cells; Furans; Galactitol; Humans; Hydrogen Peroxide; Lignans; Molecular Structure; Naphthalenes; Oxidation-Reduction; Plant Stems; Umbilical Cord; Wounds and Injuries | 2009 |
Bacterial transformation of dietary lignans in gnotobiotic rats.
Topics: 4-Butyrolactone; Animals; Biotransformation; Butylene Glycols; Cecum; Diet; Feces; Flax; Germ-Free Life; Gram-Positive Bacteria; Lignans; Rats; Rats, Sprague-Dawley | 2010 |
Reduction of parasitism tissue by treatment of mice chronically infected with Trypanosoma cruzi with lignano lactones.
Topics: 4-Butyrolactone; Animals; Benzodioxoles; beta-Galactosidase; Chagas Disease; Chronic Disease; Dioxoles; Heart; Karyometry; Lactones; Lignans; Liver; Mice; Mice, Inbred BALB C; Spleen; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Enterodiol and enterolactone modulate the immune response by acting on nuclear factor-kappaB (NF-kappaB) signaling.
Topics: 4-Butyrolactone; Cell Line; Cell Proliferation; Cells, Cultured; Humans; Immunologic Factors; Lignans; Lymphocytes; NF-kappa B; Signal Transduction; Tumor Necrosis Factor-alpha | 2010 |
Effect of the dibenzylbutyrolactone lignan (-)-hinokinin on doxorubicin and methyl methanesulfonate clastogenicity in V79 Chinese hamster lung fibroblasts.
Topics: 4-Butyrolactone; Animals; Benzodioxoles; Cell Line; Cricetinae; Cricetulus; Dioxoles; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Fibroblasts; Lignans; Lung; Methyl Methanesulfonate; Micronucleus Tests; Mutagens | 2010 |
A short semi-synthesis and complete NMR-spectroscopic characterization of the naturally occurring lignan glycoside matairesinol 4,4'-di-O-beta-D-diglucoside.
Topics: 4-Butyrolactone; Apocynaceae; Biological Products; Glucosides; Lignans; Magnetic Resonance Spectroscopy; Plant Stems; Stereoisomerism | 2010 |
Human intestinal bacterium, strain END-2 is responsible for demethylation as well as lactonization during plant lignan metabolism.
Topics: 4-Butyrolactone; Bacteria, Anaerobic; Biotransformation; Butylene Glycols; Chromatography, High Pressure Liquid; Feces; Humans; Intestines; Lignans; Mass Spectrometry; Methylation; Molecular Structure; Stereoisomerism; Substrate Specificity | 2010 |
Antiasthmatic action of dibenzylbutyrolactone lignans from fruits of Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea-pigs.
Topics: 4-Butyrolactone; Airway Resistance; Albuterol; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cromolyn Sodium; Dexamethasone; Disease Models, Animal; Eosinophil Peroxidase; Forsythia; Fruit; Guinea Pigs; Lignans; Male; Molecular Structure; Ovalbumin; Phospholipases A2; Plant Extracts | 2011 |
Reference profile correlation reveals estrogen-like trancriptional activity of Curcumin.
Topics: 4-Butyrolactone; Cell Line, Tumor; Curcumin; Estradiol; Gene Expression Profiling; Humans; Inhibitor of Apoptosis Proteins; Lignans; Microtubule-Associated Proteins; Phytoestrogens; Proto-Oncogene Proteins; Quercetin; Reference Values; Survivin; Trans-Activators; Transcription, Genetic | 2010 |
Complementary fragmentation pattern analysis by gas chromatography-mass spectrometry and liquid chromatography tandem mass spectrometry confirmed the precious lignan content of Cirsium weeds.
Topics: 4-Butyrolactone; Chromatography, Liquid; Cirsium; Fruit; Gas Chromatography-Mass Spectrometry; Glucosides; Lignans; Nuclear Magnetic Resonance, Biomolecular; Oximes; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trimethylsilyl Compounds | 2010 |
Tamoxifen, flaxseed, and the lignan enterolactone increase stroma- and cancer cell-derived IL-1Ra and decrease tumor angiogenesis in estrogen-dependent breast cancer.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Cell Line, Tumor; Estrogen Receptor alpha; Estrogens; Female; Flax; Humans; Immunohistochemistry; Interleukin 1 Receptor Antagonist Protein; Lignans; Macrophages; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Neovascularization, Pathologic; Stromal Cells; Tamoxifen | 2011 |
Cytostatic inhibition of cancer cell growth by lignan secoisolariciresinol diglucoside.
Topics: 4-Butyrolactone; Adenocarcinoma; Anticarcinogenic Agents; Butylene Glycols; Cell Cycle; Cell Line, Tumor; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cyclin A; Cytostatic Agents; Dietary Carbohydrates; Dose-Response Relationship, Drug; Glucosides; Glycosides; Humans; Lignans; Mass Spectrometry | 2010 |
Effect of flaxseed lignans added to milk or fed to cows on oxidative degradation of dairy beverages enriched with polyunsaturated fatty acids.
Topics: 4-Butyrolactone; Animals; Antioxidants; Butylene Glycols; Cattle; Diet; Fatty Acids, Unsaturated; Female; Flax; Food, Fortified; Glucosides; Hot Temperature; Lignans; Milk; Oxidation-Reduction; Oxidative Stress; Photochemical Processes | 2011 |
Prediagnostic plasma enterolactone levels and mortality among women with breast cancer.
Topics: 4-Butyrolactone; Aged; Breast Neoplasms; Cohort Studies; Female; Humans; Lignans; Middle Aged; Neoplasm Staging; Prognosis; Receptors, Estrogen; Survival Analysis | 2011 |
Stereoselective synthesis of β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones.
Topics: 4-Butyrolactone; Catalysis; Chromium; Furans; Lactones; Lignans; Stereoisomerism; Zinc | 2011 |
Identification of novel pregnane X receptor activators from traditional Chinese medicines.
Topics: 4-Butyrolactone; Berberine; Cyclooctanes; Cytochrome P-450 CYP3A; Dioxoles; Drugs, Chinese Herbal; Genes, Reporter; Hep G2 Cells; Herb-Drug Interactions; Humans; Lignans; Magnoliopsida; Medicine, Chinese Traditional; Plants, Medicinal; Pregnane X Receptor; Receptors, Steroid; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stilbenes | 2011 |
Effect of combined lignan phytoestrogen and melatonin treatment on secretion of steroid hormones by adrenal carcinoma cells.
Topics: 4-Butyrolactone; Adrenal Glands; Animals; Aromatase; Cell Line; Cyclic AMP; Dogs; Humans; Lignans; Melatonin; Phytoestrogens; Steroids | 2011 |
Role of bifidobacteria in the activation of the lignan secoisolariciresinol diglucoside.
Topics: 4-Butyrolactone; Bifidobacterium; Biotransformation; Butylene Glycols; Glucosides; Lignans | 2011 |
A single dose of enterolactone activates estrogen signaling and regulates expression of circadian clock genes in mice.
Topics: 4-Butyrolactone; Animals; Circadian Clocks; CLOCK Proteins; Estradiol; Estrogens; Female; Gene Expression Regulation; Lignans; Liver; Luciferases; Male; Mice; Mice, Inbred C57BL; Orchiectomy; Ovariectomy; Phytoestrogens; Protein Array Analysis; Random Allocation; Signal Transduction; Uterus | 2011 |
Flaxseed and breast cancer: what should we tell our patients?
Topics: 4-Butyrolactone; Breast Neoplasms; Female; Humans; Lignans | 2011 |
Serum enterolactone and prognosis of postmenopausal breast cancer.
Topics: 4-Butyrolactone; Aged; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Female; Humans; Lignans; Middle Aged; Postmenopause; Prognosis | 2011 |
Dibenzylbutane- and butyrolactone-type lignans as apoptosis inducers in human hepatoma HuH-7 cells.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Inducing Factor; Benzodioxoles; Caspase 3; Cell Line, Tumor; Cell Survival; Dioxoles; Humans; L-Lactate Dehydrogenase; Lactones; Lignans; Myristicaceae; Plant Extracts; Plants, Medicinal | 2012 |
Antiproliferative activity of lignans against the breast carcinoma cell lines MCF 7 and BT 20.
Topics: 4-Butyrolactone; Anticarcinogenic Agents; Breast Neoplasms; Butylene Glycols; Cell Line, Tumor; Cell Proliferation; Estradiol; Estrogens; Female; Furans; Humans; Lignans; Phytoestrogens; Selective Estrogen Receptor Modulators; Tamoxifen | 2012 |
Serum enterolactone levels and mortality outcome in women with early breast cancer: a retrospective cohort study.
Topics: 4-Butyrolactone; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Fluoroimmunoassay; Humans; Italy; Kaplan-Meier Estimate; Lignans; Mastectomy; Middle Aged; Proportional Hazards Models; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Up-Regulation | 2012 |
Mammary gene expression and activity of antioxidant enzymes and concentration of the mammalian lignan enterolactone in milk and plasma of dairy cows fed flax lignans and infused with flax oil in the abomasum.
Topics: 4-Butyrolactone; Abomasum; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Cattle; Dietary Supplements; Enzymes; Female; Flax; Gene Expression; Lactation; Lignans; Linseed Oil; Milk; Plant Preparations; RNA, Messenger; Seeds | 2012 |
Urinary enterolignan concentrations are positively associated with serum HDL cholesterol and negatively associated with serum triglycerides in U.S. adults.
Topics: 4-Butyrolactone; Adult; Aged; Aged, 80 and over; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Cross-Sectional Studies; Dietary Fiber; Female; Humans; Lignans; Male; Middle Aged; Nutrition Surveys; Regression Analysis; Risk Factors; Triglycerides; United States; Young Adult | 2012 |
Evaluation of flavonoids and enterolactone in overnight urine as intake biomarkers of fruits, vegetables and beverages in the Inter99 cohort study using the method of triads.
Topics: 4-Butyrolactone; Adult; Cohort Studies; Diet; Feeding Behavior; Female; Flavonoids; Fruit; Humans; Lignans; Male; Middle Aged; Models, Biological; Vegetables | 2012 |
The association between dietary lignans, phytoestrogen-rich foods, and fiber intake and postmenopausal breast cancer risk: a German case-control study.
Topics: 4-Butyrolactone; Aged; Breast Neoplasms; Carcinoma; Case-Control Studies; Cucurbita; Diet; Dietary Fiber; Female; Germany; Glycine max; Helianthus; Humans; Lignans; Middle Aged; Phytoestrogens; Postmenopause; Risk; Seeds | 2012 |
Effects of abomasal infusion of flaxseed (Linum usitatissimum) oil on microbial β-glucuronidase activity and concentration of the mammalian lignan enterolactone in ruminal fluid, plasma, urine and milk of dairy cows.
Topics: 4-Butyrolactone; Abomasum; Animals; Animals, Inbred Strains; Bacterial Proteins; Catheters, Indwelling; Cattle; Dairying; Fatty Acids, Omega-3; Feces; Female; Flax; Gastrointestinal Contents; Glucuronidase; Intestinal Absorption; Lignans; Linseed Oil; Milk; Plant Epidermis; Quebec; Rumen; Seeds | 2013 |
Analysis of prostate cancer association with four single-nucleotide polymorphisms from genome-wide studies and serum phyto-estrogen concentrations.
Topics: 4-Butyrolactone; Aged; Alleles; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Lignans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prostatic Neoplasms; Risk Factors; Scotland | 2012 |
In vivo infection by Trypanosoma cruzi: a morphometric study of tissue changes in mice.
Topics: 4-Butyrolactone; Animals; Antiprotozoal Agents; Benzodioxoles; Biometry; Cell Line; Chagas Disease; Dioxoles; Disease Models, Animal; Fibroblasts; Karyotyping; Lignans; Liver; Macaca mulatta; Male; Mice; Mice, Inbred BALB C; Spleen; Trypanosoma cruzi | 2013 |
Plant polyphenols in prevention of heart disease.
Topics: 4-Butyrolactone; Anti-Inflammatory Agents; Antioxidants; Cardiovascular Diseases; Curcumin; Diet, Mediterranean; Humans; Lignans; Plants; Polyphenols; Resveratrol; Stilbenes | 2012 |
Among plant lignans, pinoresinol has the strongest antiinflammatory properties in human intestinal Caco-2 cells.
Topics: 4-Butyrolactone; Anti-Inflammatory Agents; Butylene Glycols; Caco-2 Cells; Cell Differentiation; Chemokine CCL2; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Furans; Glucosides; Humans; Interleukin-1beta; Interleukin-6; Interleukin-8; Intestines; Lignans; NF-kappa B; Plant Extracts; Signal Transduction | 2012 |
Validation of FFQ-based assessment of dietary lignans compared with serum enterolactone in Swedish women.
Topics: 4-Butyrolactone; Aged; Biomarkers; Diet; Female; Humans; Lignans; Middle Aged; Obesity; Phytoestrogens; Reproducibility of Results; Surveys and Questionnaires; Sweden | 2013 |
Interaction effects between genes involved in the AKT signaling pathway and phytoestrogens in gastric carcinogenesis: a nested case-control study from the Korean Multi-Center Cancer Cohort.
Topics: 4-Butyrolactone; Aged; Anticarcinogenic Agents; Asian People; Case-Control Studies; CDC2 Protein Kinase; Equol; fas Receptor; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Genistein; Humans; Isoflavones; Lignans; Male; MAP Kinase Kinase Kinase 1; Middle Aged; Odds Ratio; Phytoestrogens; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-akt; Republic of Korea; Signal Transduction; Stomach Neoplasms | 2012 |
Plasma enterolactone and incidence of endometrial cancer in a case-cohort study of Danish women.
Topics: 4-Butyrolactone; Cohort Studies; Denmark; Diet Surveys; Endometrial Neoplasms; Female; Fluoroimmunoassay; Hormone Replacement Therapy; Humans; Incidence; Lignans; Middle Aged; Phytoestrogens; Proportional Hazards Models; Surveys and Questionnaires | 2013 |
Mutagenicity and antimutagenicity of (-)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays.
Topics: 4-Butyrolactone; Animals; Antimutagenic Agents; Benzodioxoles; Cell Line; Chagas Disease; Comet Assay; Cricetinae; Dioxoles; DNA Damage; Humans; Lignans; Mutagens; Piper; Plant Extracts; Salmonella; Seeds; Trypanocidal Agents | 2012 |
Anti-proliferative effects of physiological concentrations of enterolactone in models of prostate tumourigenesis.
Topics: 4-Butyrolactone; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; DNA Replication; Humans; Lignans; Male; Mitochondria; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction | 2013 |
Evaluation of the in vivo therapeutic properties of (-)-cubebin and (-)-hinokinin against Trypanosoma cruzi.
Topics: 4-Butyrolactone; Animals; Benzodioxoles; Chagas Disease; Dioxoles; Lignans; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Piper; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Chemical constituents of Spatholobus suberectus.
Topics: 4-Butyrolactone; Fabaceae; Lignans; Molecular Structure; Plant Extracts | 2012 |
Ligand binding affinities of arctigenin and its demethylated metabolites to estrogen receptor alpha.
Topics: 4-Butyrolactone; Binding, Competitive; Estradiol; Estrogen Receptor alpha; Furans; Humans; Immobilized Proteins; Ligands; Lignans; Methylation; Phytoestrogens | 2013 |
Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC.
Topics: 4-Butyrolactone; Animals; Arctium; Chromatography, High Pressure Liquid; Feces; Fruit; Furans; Glucosides; Lignans; Male; Plant Extracts; Rats, Sprague-Dawley | 2013 |
Sociodemographic and lifestyle variables are compound- and class-specific correlates of urine phytoestrogen concentrations in the U.S. population.
Topics: 4-Butyrolactone; Adult; Age Factors; Alcohol Drinking; Body Mass Index; Equol; Exercise; Female; Humans; Isoflavones; Life Style; Lignans; Male; Middle Aged; Nutrition Surveys; Phytoestrogens; Sex Factors; Smoking; Socioeconomic Factors; United States | 2013 |
Isolation of anti-tumor compounds from the stem bark of Zanthoxylum ailanthoides Sieb. & Zucc. by silica gel column and counter-current chromatography.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Benzodioxoles; Cell Line, Tumor; Cell Survival; Coumarins; Countercurrent Distribution; Dioxoles; Humans; Lignans; Plant Bark; Silica Gel; Zanthoxylum | 2013 |
Relationship of obesity and high urinary enterolignan concentrations in 6806 children and adults: analysis of National Health and Nutrition Examination Survey data.
Topics: 4-Butyrolactone; Adolescent; Adult; Bacteria; Biomarkers; Child; Female; Gastrointestinal Tract; Humans; Lignans; Logistic Models; Male; Microbiota; Obesity; Overweight; Risk Factors; Waist Circumference | 2013 |
Plasma enterolactone and breast cancer risk in the Nurses' Health Study II.
Topics: 4-Butyrolactone; Adult; Breast Neoplasms; Case-Control Studies; Cohort Studies; Diet; Estradiol; Female; Humans; Lignans; Multivariate Analysis; Nurses; Premenopause; Prospective Studies; Receptors, Estrogen; Receptors, Progesterone; United States; Vegetables | 2013 |
Dietary flavonol intake is associated with age of puberty in a longitudinal cohort of girls.
Topics: 4-Butyrolactone; Age Factors; Biomarkers; Breast; Child; Diet; Female; Flavonols; Hair; Humans; Lignans; Longitudinal Studies; Phytoestrogens; Plant Extracts; Puberty | 2013 |
Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase.
Topics: 4-Butyrolactone; Carthamus tinctorius; Cell Survival; Dose-Response Relationship, Drug; Furans; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Leukocytes, Mononuclear; Lignans; Molecular Structure; Neopterin; Plant Extracts; Plants, Medicinal; Seeds; Tryptophan | 2013 |
The lignan (-)-hinokinin displays modulatory effects on human monoamine and GABA transporter activities.
Topics: 4-Butyrolactone; Attention Deficit Disorder with Hyperactivity; Benzodioxoles; Dioxoles; Dopamine; Dose-Response Relationship, Drug; GABA Plasma Membrane Transport Proteins; Humans; Lignans; Molecular Structure; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism | 2013 |
Bioaccessibility of lignans from flaxseed (Linum usitatissimum L.) determined by single-batch in vitro simulation of the digestive process.
Topics: 4-Butyrolactone; Bacteria, Anaerobic; Biological Availability; Butylene Glycols; Colon; Fatty Acids, Volatile; Fermentation; Flax; Glucosides; Humans; In Vitro Techniques; Lignans; Seeds | 2014 |
Design and validation of a novel immunological test for enterolactone.
Topics: 4-Butyrolactone; Animals; Antibodies; Enzyme-Linked Immunosorbent Assay; Lignans; Limit of Detection; Magnetic Resonance Spectroscopy; Rabbits; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Higher urinary lignan concentrations in women but not men are positively associated with shorter time to pregnancy.
Topics: 4-Butyrolactone; Adolescent; Adult; Body Mass Index; Diet; Female; Humans; Isoflavones; Lignans; Male; Phytoestrogens; Pregnancy; Prospective Studies; Socioeconomic Factors; Time-to-Pregnancy; Young Adult | 2014 |
Permeability and conjugative metabolism of flaxseed lignans by Caco-2 human intestinal cells.
Topics: 4-Butyrolactone; Algorithms; Butylene Glycols; Caco-2 Cells; Chromatography, High Pressure Liquid; Flax; Glucosides; Humans; Intestinal Mucosa; Lignans; Molecular Structure; Permeability | 2014 |
Preventive effects of lignan extract from flax hulls on experimentally induced benign prostate hyperplasia.
Topics: 4-Butyrolactone; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Energy Intake; Flax; Hyperplasia; Lignans; Male; Phytotherapy; Plant Extracts; Prostate; Prostatic Hyperplasia; Rats, Wistar; Seeds; Testosterone Propionate; Weight Gain | 2014 |
Urinary lignans and inflammatory markers in the US National Health and Nutrition Examination Survey (NHANES) 1999-2004 and 2005-2008.
Topics: 4-Butyrolactone; Adult; Aged; Biomarkers; C-Reactive Protein; Chronic Disease; Cross-Sectional Studies; Female; Humans; Inflammation; Leukocyte Count; Lignans; Male; Middle Aged; Nutrition Surveys; United States | 2014 |
Specific hydrolysis and accumulation of antiproliferative lignans in the fruit of Leuzea carthamoides (Willd.) DC.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Fruit; Gas Chromatography-Mass Spectrometry; Glycosides; Humans; Hungary; Hydrolysis; Leuzea; Lignans; Molecular Structure | 2014 |
Gut microbiota metabolites of dietary lignans and risk of type 2 diabetes: a prospective investigation in two cohorts of U.S. women.
Topics: 4-Butyrolactone; Adult; Case-Control Studies; Diabetes Mellitus, Type 2; Diet; Female; Humans; Lignans; Microbiota; Middle Aged; Prospective Studies; Risk Factors | 2014 |
Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro.
Topics: 3T3-L1 Cells; 4-Butyrolactone; Adipocytes; Adipose Tissue; Adiposity; Animals; Cell Differentiation; Diet, High-Fat; Dietary Fats; Disease Models, Animal; Insulin Resistance; Lignans; Linseed Oil; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Sesame Oil | 2014 |
Role of ABCG2 in transport of the mammalian lignan enterolactone and its secretion into milk in Abcg2 knockout mice.
Topics: 4-Butyrolactone; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Diketopiperazines; Dogs; Female; Heterocyclic Compounds, 4 or More Rings; Lignans; Madin Darby Canine Kidney Cells; Mice; Mice, Knockout; Milk; Mitoxantrone; Neoplasm Proteins; Substrate Specificity | 2014 |
Pharmacokinetics and bioavailability of plant lignan 7-hydroxymatairesinol and effects on serum enterolactone and clinical symptoms in postmenopausal women: a single-blinded, parallel, dose-comparison study.
Topics: 4-Butyrolactone; Aged; Biological Availability; Dose-Response Relationship, Drug; Female; Hot Flashes; Humans; Lignans; Middle Aged; Norway; Postmenopause; Single-Blind Method; Treatment Outcome | 2013 |
Isolation, structural elucidation and anti-inflammatory activity of astragalin, (-)hinokinin, aristolactam I and aristolochic acids (I & II) from Aristolochia indica.
Topics: 4-Butyrolactone; Anti-Inflammatory Agents; Aristolochia; Aristolochic Acids; Benzodioxoles; Chromatography, High Pressure Liquid; Dioxoles; Interleukin-6; Kaempferols; Lignans | 2014 |
Cardiometabolic risk factors are associated with high urinary enterolactone concentration, independent of urinary enterodiol concentration and dietary fiber intake in adults.
Topics: 4-Butyrolactone; Adult; Aged; Aged, 80 and over; Blood Glucose; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, HDL; Dietary Fiber; Female; Humans; Lignans; Logistic Models; Male; Metabolic Syndrome; Middle Aged; Nutrition Surveys; Obesity; Odds Ratio; Phytoestrogens; Risk Factors; Triglycerides | 2014 |
Gene expression profiling of sesaminol triglucoside and its tetrahydrofuranoid metabolites in primary rat hepatocytes.
Topics: 4-Butyrolactone; Animals; ATP-Binding Cassette Transporters; Cytochrome P-450 Enzyme System; Dioxoles; Furans; Gene Expression; Gene Expression Profiling; Glucosides; Hepatocytes; Inactivation, Metabolic; Lignans; Liver; Mammals; Plant Extracts; Rats, Sprague-Dawley; Seeds; Sesamum | 2014 |
Chemopreventive effects of (-)-hinokinin against 1,2-dimethylhydrazine-induced genotoxicity and preneoplastic lesions in rat colon.
Topics: 1,2-Dimethylhydrazine; 4-Butyrolactone; Animals; Anticarcinogenic Agents; Benzodioxoles; Carcinogens; Colon; Comet Assay; Dimethylhydrazines; Dioxoles; DNA Damage; Lignans; Male; Molecular Structure; Piper; Rats; Rats, Wistar; Stereoisomerism | 2014 |
Effects of different n-6:n-3 fatty acid ratios and of enterolactone on gene expression and PG secretion in bovine endometrial cells.
Topics: 4-Butyrolactone; Aldehyde Reductase; Animals; Cattle; Cells, Cultured; Diet; Dinoprost; Dinoprostone; Endometrium; Epithelial Cells; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Gene Expression; Intramolecular Oxidoreductases; Lignans; Prostaglandin-E Synthases; Reproducibility of Results; RNA, Messenger | 2015 |
The anti-proliferative effects of enterolactone in prostate cancer cells: evidence for the role of DNA licencing genes, mi-R106b cluster expression, and PTEN dosage.
Topics: 4-Butyrolactone; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Lignans; Male; MicroRNAs; Mitochondria; Prostatic Neoplasms; PTEN Phosphohydrolase; RNA, Messenger | 2014 |
Endogenous enzyme-hydrolyzed fruit of Cirsium brachycephalum: optimal source of the antiproliferative lignan trachelogenin regulating the Wnt/β-catenin signaling pathway in the SW480 colon adenocarcinoma cell line.
Topics: 4-Butyrolactone; Adenocarcinoma; Antineoplastic Agents, Phytogenic; beta Catenin; Cell Line, Tumor; Cirsium; Colonic Neoplasms; Fruit; Glycogen Synthase Kinase 3; Humans; Lignans; Molecular Structure; Proto-Oncogene Proteins c-myc; Wnt Signaling Pathway | 2015 |
Concentration of hinokinin, phenolic acids and flavonols in leaves and stems of Hydrocotyle leucocephala is differently influenced by PAR and ecologically relevant UV-B level.
Topics: 4-Butyrolactone; Benzodioxoles; Centella; Chlorogenic Acid; Flavonols; Hydroxybenzoates; Kaempferols; Lignans; Oxidative Stress; Photosynthesis; Plant Leaves; Plant Stems; Propanols; Quercetin; Ultraviolet Rays | 2015 |
Sassarandainol: a new neolignan and anti-inflammatory constituents from the stem of Sassafras randaiense.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Cell Line; gamma-Tocopherol; Lignans; Mice; Molecular Structure; Nitric Oxide Synthase Type II; Nitrites; Plant Stems; Sassafras; Sitosterols | 2015 |
Enterolignan-producing phenotypes are associated with increased gut microbial diversity and altered composition in premenopausal women in the United States.
Topics: 4-Butyrolactone; Adult; Diet Records; Female; Gastrointestinal Tract; Humans; Lignans; Microbiota; Middle Aged; Phenotype; Premenopause; United States | 2015 |
Synthesis and cytotoxicity evaluation of 4-amino-4-dehydroxylarctigenin derivatives in glucose-starved A549 tumor cells.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Furans; Glucose; Humans; Lignans; Structure-Activity Relationship | 2015 |
Urinary enterolactone is associated with obesity and metabolic alteration in men in the US National Health and Nutrition Examination Survey 2001-10.
Topics: 4-Butyrolactone; Adolescent; Adult; Age Factors; Aged; Body Mass Index; Child; Cross-Sectional Studies; Down-Regulation; Female; Humans; Lignans; Logistic Models; Male; Metabolic Syndrome; Middle Aged; Nutrition Surveys; Obesity; Phytoestrogens; Sex Characteristics; United States; Waist Circumference; Young Adult | 2015 |
Comparative pharmacokinetics of purified flaxseed and associated mammalian lignans in male Wistar rats.
Topics: 4-Butyrolactone; Administration, Oral; Animals; Biological Availability; Butylene Glycols; Dietary Supplements; Dose-Response Relationship, Drug; Estrogens; Flax; Glucosides; Half-Life; Injections, Intravenous; Intestinal Absorption; Kinetics; Lignans; Male; Metabolic Clearance Rate; Phytoestrogens; Random Allocation; Rats, Wistar; Seeds | 2015 |
Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells.
Topics: 4-Butyrolactone; Antineoplastic Agents; Arctium; ATP Binding Cassette Transporter, Subfamily B; Benzofurans; Caco-2 Cells; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Furans; Glucosides; Humans; Lignans; Molecular Structure; Rhodamine 123; Seeds | 2015 |
Flaxseed reduces the pro-carcinogenic micro-environment in the ovaries of normal hens by altering the PG and oestrogen pathways in a dose-dependent manner.
Topics: 4-Butyrolactone; Animals; Anticarcinogenic Agents; Chickens; Cyclooxygenase 1; Cyclooxygenase 2; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP3A; Diet; Dietary Supplements; Dinoprostone; Estrogen Receptor alpha; Estrogens; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Flax; Hydroxyestrones; Lignans; Liver; Ovarian Neoplasms; Ovary; RNA, Messenger | 2015 |
Urinary phytoestrogens and cancer, cardiovascular, and all-cause mortality in the continuous National Health and Nutrition Examination Survey.
Topics: 4-Butyrolactone; Adult; Biomarkers; Body Mass Index; Cardiovascular Diseases; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Isoflavones; Lignans; Male; Middle Aged; Mortality; Neoplasms; Nutrition Surveys; Phytoestrogens; Proportional Hazards Models; Risk Factors; Treatment Outcome | 2016 |
Urinary enterolactone associated with liver enzyme levels in US adults: National Health and Nutrition Examination Survey (NHANES).
Topics: 4-Butyrolactone; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Cross-Sectional Studies; Female; gamma-Glutamyltransferase; Humans; Lignans; Liver; Logistic Models; Male; Middle Aged; Nutrition Surveys; Phytoestrogens; United States | 2015 |
In vitro and in vivo anthelmintic activity of (-)-6,6'-dinitrohinokinin against schistosomula and juvenile and adult worms of Schistosoma mansoni.
Topics: 4-Butyrolactone; Animals; Anthelmintics; Benzodioxoles; Cricetinae; Cricetulus; Female; Fibroblasts; In Vitro Techniques; Lignans; Liver; Lung; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Schistosoma mansoni; Schistosomiasis mansoni | 2015 |
Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Cell Proliferation; Dioxoles; Drug Screening Assays, Antitumor; Forests; HCT116 Cells; Humans; Inhibitory Concentration 50; Lignans; Madagascar; Malpighiaceae; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Leaves; Plasmodium falciparum; Stereoisomerism | 2015 |
Triclosan and prescription antibiotic exposures and enterolactone production in adults.
Topics: 4-Butyrolactone; Adult; Anti-Bacterial Agents; Female; Gastrointestinal Microbiome; Humans; Lignans; Male; Middle Aged; Prescription Drugs; Triclosan; Young Adult | 2015 |
A Prospective Investigation of the Association Between Urinary Excretion of Dietary Lignan Metabolites and Weight Change in US Women.
Topics: 4-Butyrolactone; Adult; Aged; Body Weight; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Incidence; Lignans; Middle Aged; Prospective Studies; United States; Urinalysis | 2015 |
A new γ-alkylated-γ-butyrolactone from the roots of Solanum melongena.
Topics: 4-Butyrolactone; Animals; Furans; Inflammation; Inhibitory Concentration 50; Kaempferols; Lignans; Macrophages; Mice; Nitric Oxide; Plant Extracts; Plant Roots; RAW 264.7 Cells; Solanum melongena; Triterpenes | 2015 |
Urinary Phytoestrogens Are Associated with Subtle Indicators of Semen Quality among Male Partners of Couples Desiring Pregnancy.
Topics: 4-Butyrolactone; Adult; Body Mass Index; Cholesterol; Cotinine; DNA Fragmentation; Endpoint Determination; Female; Fertility; Genistein; Humans; Isoflavones; Lignans; Linear Models; Male; Phytoestrogens; Pregnancy; Prospective Studies; Semen Analysis | 2015 |
Short communication: Concentrations of the mammalian lignan enterolactone in preovulatory follicles and the correlation with intrafollicular estradiol in dairy cows fed extruded flaxseed.
Topics: 4-Butyrolactone; Animals; Cattle; Diet; Dietary Supplements; Estradiol; Female; Flax; Follicular Fluid; Follicular Phase; Lactation; Lignans; Milk; Ovarian Follicle; Pregnancy; Progesterone | 2015 |
Effects of an equol-producing bacterium isolated from human faeces on isoflavone and lignan metabolism in mice.
Topics: 4-Butyrolactone; Actinobacteria; Animals; Equol; Feces; Female; Gastrointestinal Microbiome; Humans; Isoflavones; Lignans; Lipids; Mice; Mice, Inbred ICR; Phytoestrogens | 2016 |
Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer.
Topics: 4-Butyrolactone; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclins; Cytoskeleton; Focal Adhesion Kinase 1; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression; Humans; Ki-67 Antigen; Lignans; Neoplasm Invasiveness; Neoplasm Metastasis; Paxillin; Proliferating Cell Nuclear Antigen; RNA, Messenger; S Phase; Signal Transduction | 2015 |
Effect of bovine ABCG2 polymorphism Y581S SNP on secretion into milk of enterolactone, riboflavin and uric acid.
Topics: 4-Butyrolactone; Animals; ATP-Binding Cassette Transporters; Biological Transport; Butylene Glycols; Cattle; Dogs; Female; Lactation; Lignans; Madin Darby Canine Kidney Cells; Milk; Mitoxantrone; Polymorphism, Single Nucleotide; Riboflavin; Uric Acid | 2016 |
Occurrence and Profiles of the Artificial Endocrine Disruptor Bisphenol A and Natural Endocrine Disruptor Phytoestrogens in Urine from Children in China.
Topics: 4-Butyrolactone; Benzhydryl Compounds; Child; China; Chromatography, Liquid; Endocrine Disruptors; Environmental Monitoring; Female; Humans; Isoflavones; Lignans; Male; Phenols; Phytoestrogens; Risk Assessment; Tandem Mass Spectrometry; United States | 2015 |
Antileukemic activity of lignans and phenylpropanoids of Cinnamomum parthenoxylon.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Benzodioxoles; Cell Proliferation; Cinnamomum; HL-60 Cells; Humans; Lignans; Plant Extracts; U937 Cells | 2016 |
High-Throughput LC-MS/MS Method for Direct Quantification of Glucuronidated, Sulfated, and Free Enterolactone in Human Plasma.
Topics: 4-Butyrolactone; Calibration; Chromatography, Gel; Cohort Studies; Female; Glucuronides; Humans; Lignans; Male; Middle Aged; Sulfates; Tandem Mass Spectrometry | 2016 |
Binding of enterolactone and enterodiol to human serum albumin: increase of cysteine-34 thiol group reactivity.
Topics: 4-Butyrolactone; Antioxidants; Binding Sites; Cysteine; Humans; Lignans; Protein Binding; Serum Albumin; Spectrometry, Fluorescence; Sulfhydryl Compounds | 2016 |
Detection of novel metabolites of flaxseed lignans in vitro and in vivo.
Topics: 4-Butyrolactone; Adult; Bifidobacterium pseudocatenulatum; Butylene Glycols; Dietary Supplements; Feces; Female; Flax; Furans; Gastrointestinal Microbiome; Glucosides; Humans; Intestinal Mucosa; Intestines; Lignans; Male; Middle Aged; Prebiotics; Probiotics; Young Adult | 2016 |
Longitudinal biobanks-based study on the joint effects of infections, nutrition and hormones on risk of prostate cancer.
Topics: 4-Butyrolactone; Adult; Blood Banks; Case-Control Studies; Chlamydia Infections; Chlamydia trachomatis; Cohort Studies; Finland; Human papillomavirus 18; Humans; Lignans; Longitudinal Studies; Male; Middle Aged; Norway; Papillomavirus Infections; Prostatic Neoplasms; Risk Factors; Sweden; Testosterone; Vitamin D | 2016 |
(-)-Hinokinin Induces G2/M Arrest and Contributes to the Antiproliferative Effects of Doxorubicin in Breast Cancer Cells.
Topics: 4-Butyrolactone; Antineoplastic Combined Chemotherapy Protocols; Benzodioxoles; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Doxorubicin; Female; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Lignans; M Phase Cell Cycle Checkpoints | 2016 |
From pure compounds to complex exposure: Effects of dietary cadmium and lignans on estrogen, epidermal growth factor receptor, and mitogen activated protein kinase signaling in vivo.
Topics: 4-Butyrolactone; Animals; Bread; Cadmium; Diet; ErbB Receptors; Estrogens; Female; Flax; Genes, Reporter; Lignans; Liver; Luciferases; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinases; Ovariectomy; Response Elements; Risk Assessment; Seeds; Selective Estrogen Receptor Modulators; Signal Transduction; Time Factors; Triticum; Uterus | 2016 |
Nitric oxide inhibitory constituents from the barks of Cinnamomum cassia.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Cell Line; Cinnamomum aromaticum; Lignans; Lipopolysaccharides; Mice; Microglia; Molecular Structure; Nitric Oxide; Plant Bark | 2016 |
Use of antibiotics is associated with lower enterolactone plasma concentration.
Topics: 4-Butyrolactone; Anti-Bacterial Agents; Body Mass Index; Cohort Studies; Exercise; Female; Gastrointestinal Microbiome; Humans; Life Style; Lignans; Linear Models; Male; Middle Aged; Neoplasms; Nutrition Assessment; Risk Factors; Surveys and Questionnaires; Tandem Mass Spectrometry; Time Factors | 2016 |
Phosphorylated cyclopropanes in the synthesis of α-alkylidene-γ-butyrolactones: total synthesis of (±)-savinin, (±)-gadain and (±)-peperomin E.
Topics: 4-Butyrolactone; Benzodioxoles; Biological Products; Catalysis; Crystallography, X-Ray; Cyclopropanes; Lignans; Models, Molecular; Phosphorylation; Rhodium; Stereoisomerism | 2016 |
Effects of Phytoestrogen Extracts Isolated from Elder Flower on Hormone Production and Receptor Expression of Trophoblast Tumor Cells JEG-3 and BeWo, as well as MCF7 Breast Cancer Cells.
Topics: 4-Butyrolactone; Cell Line, Tumor; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; Humans; Immunohistochemistry; Lignans; MCF-7 Cells; Phytoestrogens; Plant Extracts; Pregnancy; Progesterone; Receptors, Estrogen; Sambucus; Trophoblastic Neoplasms; Uterine Neoplasms | 2016 |
Performance and egg quality of laying hens fed flaxseed: highlights on n-3 fatty acids, cholesterol, lignans and isoflavones.
Topics: 4-Butyrolactone; alpha-Linolenic Acid; Animal Feed; Animals; Butylene Glycols; Chickens; Cholesterol; Diet; Dietary Supplements; Eggs; Fatty Acids; Fatty Acids, Omega-3; Female; Flax; Isoflavones; Lignans; Phytoestrogens; Seeds | 2017 |
The treatment effects of flaxseed-derived secoisolariciresinol diglycoside and its metabolite enterolactone on benign prostatic hyperplasia involve the G protein-coupled estrogen receptor 1.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Phytogenic; Binding Sites; Butylene Glycols; Cell Line, Tumor; Cell Proliferation; Dietary Supplements; Flax; Gene Expression Regulation, Neoplastic; Glucosides; Glycosides; Humans; Lignans; Male; Models, Molecular; Molecular Docking Simulation; Neoplasm Proteins; Prostate; Prostatic Hyperplasia; Random Allocation; Rats; Rats, Wistar; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA Interference; Seeds | 2016 |
In vivo and in silico anti-inflammatory mechanism of action of the semisynthetic (-)-cubebin derivatives (-)-hinokinin and (-)-O-benzylcubebin.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodioxoles; Catalytic Domain; Computer Simulation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyproheptadine; Dextrans; Dinoprostone; Dioxoles; Edema; Furans; Indomethacin; Ligands; Lignans; Male; Mice; Molecular Docking Simulation; Polysorbates; Rats, Wistar; Rutaceae | 2017 |
Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis.
Topics: 4-Butyrolactone; Apoptosis; Breast Neoplasms; Cell Line, Tumor; DNA Repair; Female; Humans; Lignans; Radiation-Sensitizing Agents | 2016 |
Enterolactone alters FAK-Src signaling and suppresses migration and invasion of lung cancer cell lines.
Topics: 4-Butyrolactone; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cytoskeleton; Flax; Focal Adhesion Kinase 1; Humans; Lignans; Lung Neoplasms; Phosphorylation; Plant Extracts; Signal Transduction; src-Family Kinases | 2017 |
A novel benzimidazole and other constituents with antiproliferative and antioxidant properties from Thymelaea microphylla Coss. et Dur.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Benzimidazoles; Butylated Hydroxytoluene; Cell Line, Tumor; Chromatography, High Pressure Liquid; Coumarins; Dose-Response Relationship, Drug; Furans; HeLa Cells; Humans; Lignans; Molecular Structure; Rats; Secondary Metabolism; Thymelaeaceae | 2017 |
Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors.
Topics: 4-Butyrolactone; Cell Cycle; Dioxoles; Estrogens; Furans; Gene Expression Profiling; Humans; Lignans; MCF-7 Cells; Oligonucleotide Array Sequence Analysis; Signal Transduction | 2017 |
Effect of Antibiotics and Diet on Enterolactone Concentration and Metabolome Studied by Targeted and Nontargeted LC-MS Metabolomics.
Topics: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Cholesterol, LDL; Chromatography, Liquid; Diet; Gastrointestinal Microbiome; Lignans; Lipid Metabolism; Mass Spectrometry; Metabolome; Metabolomics; Phytoestrogens; Swine | 2017 |
Prediagnostic enterolactone concentrations and mortality among Danish men diagnosed with prostate cancer.
Topics: 4-Butyrolactone; Adult; Cohort Studies; Denmark; Diet; Early Detection of Cancer; Humans; Lignans; Male; Middle Aged; Proportional Hazards Models; Prostatic Neoplasms; Registries; Risk Factors; Survival Analysis; White People | 2017 |
Linoleic acid, α-linolenic acid and enterolactone affect lipid oxidation and expression of lipid metabolism and antioxidant-related genes in hepatic tissue of dairy cows.
Topics: 4-Butyrolactone; alpha-Linolenic Acid; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cattle; Diet; Fatty Acids; Female; Gene Expression Regulation; Lignans; Linoleic Acid; Lipid Peroxidation; Liver; Oxidative Stress; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2017 |
Incomplete metabolism of phytoestrogens by gut microbiota from children under the age of three.
Topics: 4-Butyrolactone; Adult; Butylene Glycols; Case-Control Studies; Child, Preschool; Coumarins; Equol; Feces; Female; Furans; Gastrointestinal Microbiome; Humans; Hydrolyzable Tannins; Infant; Isoflavones; Lignans; Male; Phytoestrogens; Polyphenols | 2018 |
Genistein and enterolactone in relation to Ki-67 expression and HER2 status in postmenopausal breast cancer patients.
Topics: 4-Butyrolactone; Aged; Breast Carcinoma In Situ; Breast Neoplasms; Case-Control Studies; Cell Proliferation; Female; Genistein; Germany; Humans; Isoflavones; Ki-67 Antigen; Lignans; Middle Aged; Neoplasm Grading; Neoplasm Invasiveness; Phytoestrogens; Postmenopause; Prognosis; Receptor, ErbB-2; Tumor Burden | 2017 |
Enterolactone has stronger effects than enterodiol on ovarian cancer.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Survival; Female; Humans; Lignans; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Phytoestrogens; Tumor Burden; Wound Healing | 2017 |
Plasma phytoestrogens concentration and risk of colorectal cancer in two different Asian populations.
Topics: 4-Butyrolactone; Adult; Aged; Asian People; Case-Control Studies; Colorectal Neoplasms; Female; Genistein; Humans; Isoflavones; Lignans; Male; Middle Aged; Phytoestrogens; Republic of Korea; Risk Factors; Vietnam | 2018 |
Short communication: The mammalian lignan enterolactone is absorbed by newborn dairy calves fed enterolactone-enriched milk.
Topics: 4-Butyrolactone; Animal Feed; Animals; Animals, Newborn; Cattle; Diet; Humans; Lignans; Milk | 2017 |
Plasma enterolactone and risk of prostate cancer in middle-aged Swedish men.
Topics: 4-Butyrolactone; Case-Control Studies; Humans; Life Style; Lignans; Male; Middle Aged; Prostatic Neoplasms; Risk Factors; Sweden | 2018 |
Pre-diagnostic plasma enterolactone concentrations and breast cancer prognosis among postmenopausal women - The Danish Diet, Cancer and Health cohort.
Topics: 4-Butyrolactone; Aged; Breast Neoplasms; Cohort Studies; Denmark; Female; Humans; Lignans; Middle Aged; Phytoestrogens; Postmenopause; Prognosis | 2018 |
In vitro schistosomicidal activity of the lignan (-)-6,6'-dinitrohinokinin (DNHK) loaded into poly(lactic-co-glycolic acid) nanoparticles against Schistosoma mansoni.
Topics: 4-Butyrolactone; Animals; Benzodioxoles; Drug Carriers; Female; Lactic Acid; Lignans; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Schistosoma mansoni; Schistosomicides; Snails; X-Ray Diffraction | 2017 |
Isolation of the (+)-Pinoresinol-Mineralizing Pseudomonas sp. Strain SG-MS2 and Elucidation of Its Catabolic Pathway.
Topics: 4-Butyrolactone; Benzaldehydes; Calcification, Physiologic; Furans; Gastrointestinal Microbiome; Humans; Lignans; Lignin; Metabolic Networks and Pathways; Minerals; Pseudomonas | 2018 |
Replacing ground corn with incremental amounts of liquid molasses does not change milk enterolactone but decreases production in dairy cows fed flaxseed meal.
Topics: 4-Butyrolactone; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Cattle; Diet; Digestion; Fatty Acids; Female; Lactation; Lignans; Milk; Molasses; Random Allocation; Zea mays | 2018 |
Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep.
Topics: 4-Butyrolactone; Animal Feed; Animals; Anti-Bacterial Agents; Diet; Female; Flax; Fluoroquinolones; Food-Drug Interactions; Lignans; Milk; Seeds; Sheep | 2018 |
Phenolic Constituents Isolated from the Twigs of Cinnamomum cassia and Their Potential Neuroprotective Effects.
Topics: 4-Butyrolactone; Cell Line, Tumor; Cinnamomum aromaticum; Cytotoxins; Humans; Lignans; Neuroprotective Agents; Phenols; Plant Bark | 2018 |
Circulating enterolactone concentrations and prognosis of postmenopausal breast cancer: assessment of mediation by inflammatory markers.
Topics: 4-Butyrolactone; Aged; Biomarkers; Breast Neoplasms; Case-Control Studies; Disease-Free Survival; Female; Humans; Inflammation; Lignans; Middle Aged; Postmenopause; Prognosis; Proportional Hazards Models; Prospective Studies | 2018 |
COX Inhibition Profiles and Molecular Docking Studies of the Lignan Hinokinin and Some Synthetic Derivatives.
Topics: 4-Butyrolactone; Benzodioxoles; Binding Sites; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Lactones; Lignans; Meloxicam; Molecular Docking Simulation; Protein Binding; Quantitative Structure-Activity Relationship; Substrate Specificity; Sulfones | 2018 |
7-Hydroxymatairesinol improves body weight, fat and sugar metabolism in C57BJ/6 mice on a high-fat diet.
Topics: 3T3-L1 Cells; 4-Butyrolactone; Adipogenesis; Adipose Tissue; Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; Diet, High-Fat; Dietary Supplements; Fatty Liver; Gene Expression; Insulin Resistance; Lignans; Lipid Metabolism; Lipids; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Obesity; Picea; Plant Extracts | 2018 |
Linoorbitides and enterolactone mitigate inflammation-induced oxidative stress and loss of intestinal epithelial barrier integrity.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Caco-2 Cells; Catalase; Electric Impedance; Flax; Humans; Intestinal Mucosa; Lignans; Lipopolysaccharides; Mice; Oxidative Stress; PPAR gamma; RAW 264.7 Cells; Zonula Occludens-1 Protein | 2018 |
Prediagnosis plasma concentrations of enterolactone and survival after colorectal cancer: the Danish Diet, Cancer and Health cohort.
Topics: 4-Butyrolactone; Aged; Cohort Studies; Colorectal Neoplasms; Denmark; Diet; Female; Humans; Incidence; Lignans; Male; Middle Aged; Survival Analysis | 2019 |
Influence of different lignan compounds on enterolignan production by Bifidobacterium and Lactobacillus strains.
Topics: 4-Butyrolactone; Bifidobacterium; Diet; Humans; Lactobacillus; Lignans | 2019 |
The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Biomarkers; Butylene Glycols; Cell Line, Tumor; Cell Survival; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Flax; Gene Expression Profiling; Glucosides; Immunohistochemistry; Lignans; Mammary Neoplasms, Animal; Mice; NF-kappa B; Signal Transduction | 2019 |
Modular Synthesis and Biological Investigation of 5-Hydroxymethyl Dibenzyl Butyrolactones and Related Lignans.
Topics: 4-Butyrolactone; Cell Survival; Furans; Humans; Jurkat Cells; Lactones; Lignans; Molecular Structure; Stereoisomerism | 2018 |
The effect of enterolactone on sphingolipid pathway and hepatic insulin resistance development in HepG2 cells.
Topics: 4-Butyrolactone; Ceramides; Hep G2 Cells; Humans; Insulin; Insulin Resistance; Lignans; Lipid Metabolism; Liver; Phytoestrogens; Signal Transduction; Sphingolipids | 2019 |
Dietary flaxseed and tamoxifen affect the inflammatory microenvironment in vivo in normal human breast tissue of postmenopausal women.
Topics: 4-Butyrolactone; Breast; Breast Neoplasms; Diet; Estrogen Antagonists; Female; Flax; Humans; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-18; Interleukin-1beta; Interleukin-8; Lignans; Matrix Metalloproteinase 9; Microdialysis; Middle Aged; Postmenopause; Seeds; Tamoxifen; Tumor Microenvironment | 2019 |
The effect of enterolactone on liver lipid precursors of inflammation.
Topics: 4-Butyrolactone; Eicosanoids; Fatty Acids; Fatty Acids, Nonesterified; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Hep G2 Cells; Hepatocytes; Humans; Inflammation; Lignans; Lipid Metabolism; Lipids; Liver; Palmitic Acid; Prostaglandins; Triglycerides | 2019 |
Pre-diagnostic plasma enterolactone concentrations are associated with lower mortality among individuals with type 2 diabetes: a case-cohort study in the Danish Diet, Cancer and Health cohort.
Topics: 4-Butyrolactone; Aged; Case-Control Studies; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Lignans; Male; Middle Aged; Neoplasms; Prognosis; Random Allocation | 2019 |
Serum enterolactone concentrations are low in colon but not in rectal cancer patients.
Topics: 4-Butyrolactone; Aged; Case-Control Studies; Colon; Colonic Neoplasms; Diet, Western; Dietary Fiber; Feeding Behavior; Female; Gastrointestinal Microbiome; Healthy Volunteers; Humans; Intestinal Mucosa; Lignans; Male; Middle Aged; Rectal Neoplasms; Rectum; Risk Factors | 2019 |
A rapid UHPLC-MS/MS method for quantitation of phytoestrogens and the distribution of enterolactone in an Alabama estuary.
Topics: 4-Butyrolactone; Alabama; Chromatography, High Pressure Liquid; Endocrine Disruptors; Environmental Monitoring; Estuaries; Humans; Lignans; Phytoestrogens; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical | 2019 |
Prognostic associations of circulating phytoestrogens and biomarker changes in long-term survivors of postmenopausal breast cancer.
Topics: 4-Butyrolactone; Aged; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Cohort Studies; Female; Genistein; Germany; Humans; Lignans; Middle Aged; Phytoestrogens; Postmenopause; Prognosis; Proportional Hazards Models; Prospective Studies; Survival Analysis; Survivors | 2020 |
Formation of Tetrahydrofurano-, Aryltetralin, and Butyrolactone Norlignans through the Epoxidation of 9-Norlignans.
Topics: 4-Butyrolactone; Catalysis; Epoxy Compounds; Kinetics; Lignans; Molecular Structure | 2020 |
Antinociceptive Effect of Hinokinin and Kaurenoic Acid Isolated from
Topics: 4-Butyrolactone; Analgesics; Animals; Aristolochia; Benzodioxoles; Chromatography, High Pressure Liquid; Diterpenes; Lignans; Magnetic Resonance Spectroscopy; Male; Mice; Pain; Pain Measurement; Plant Extracts | 2020 |
Associations of Urinary Phytoestrogen Concentrations with Sleep Disorders and Sleep Duration among Adults.
Topics: 4-Butyrolactone; Adult; Age Factors; Aged; Biomarkers; Cross-Sectional Studies; Female; Humans; Isoflavones; Lignans; Male; Middle Aged; Phytoestrogens; Racial Groups; Sex Factors; Sleep; Sleep Wake Disorders | 2020 |
The anti-cancer effect of flaxseed lignan derivatives on different acute myeloid leukemia cancer cells.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Apoptosis; Butylene Glycols; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Child; Female; Flax; Glucosides; Humans; Leukemia, Myeloid, Acute; Lignans; Plant Extracts; Reactive Oxygen Species; Seeds | 2020 |
Assembly of Plant Enzymes in
Topics: 4-Butyrolactone; Berberidaceae; Biotransformation; Cytochrome P-450 Enzyme System; Escherichia coli; Forsythia; Furans; Lignans; NADP; Oxidation-Reduction; Podophyllotoxin; Podophyllum peltatum | 2020 |
Hinokinin alleviates high fat diet/streptozotocin-induced cardiac injury in mice through modulation in oxidative stress, inflammation and apoptosis.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Benzodioxoles; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Diet, High-Fat; Dyslipidemias; Hyperglycemia; Lignans; Mice; Oxidative Stress; Signal Transduction; Streptozocin | 2021 |
Gut microbiota-derived metabolites and risk of coronary artery disease: a prospective study among US men and women.
Topics: 4-Butyrolactone; Adult; Case-Control Studies; Coronary Disease; Diet; Female; Gastrointestinal Microbiome; Humans; Lignans; Male; Methylamines; Prospective Studies; Risk Factors; United States | 2021 |
Oral Pharmacokinetics of Enriched Secoisolariciresinol Diglucoside and Its Polymer in Rats.
Topics: 4-Butyrolactone; Animals; Biological Availability; Butylene Glycols; Female; Flax; Glucosides; Lignans; Molecular Structure; Polymers; Rats; Rats, Wistar; Seeds | 2021 |
Optimization of (-)-cubebin biotransformation to (-)-hinokinin by the marine fungus Absidia coerulea 3A9.
Topics: 4-Butyrolactone; Absidia; Aquatic Organisms; Benzodioxoles; Biotransformation; Lignans; Seawater | 2021 |
In vitro exposure of sheep ovarian tissue to the xenoestrogens zearalenone and enterolactone: Effects on preantral follicles.
Topics: 4-Butyrolactone; Animals; Female; Lignans; Oocytes; Ovarian Follicle; Ovary; Sheep; Zearalenone | 2021 |
Topics: 4-Butyrolactone; Antineoplastic Agents; Benzodioxoles; Lactic Acid; Lignans; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2022 |
The Association between Plasma Concentration of Phytoestrogens and Hypertension within the Korean Multicenter Cancer Cohort.
Topics: 4-Butyrolactone; Asian People; Biomarkers; Case-Control Studies; Cohort Studies; Equol; Female; Humans; Hypertension; Lignans; Logistic Models; Male; Phytoestrogens; Republic of Korea; Risk | 2021 |
Stereochemistry of the Benzylidene γ-Butyrolactone Dictates the Reductive Heck Cyclization Mode in the Asymmetric Synthesis of Aryltetralin Lignans: A Detailed Experimental and Theoretical Study.
Topics: 4-Butyrolactone; Cyclization; Lignans; Models, Theoretical; Molecular Structure; Podophyllotoxin | 2022 |
Divergent Total Syntheses of Gymnothelignan N, Beilschmin A, and Eupomatilones 1, 3, 4, and 7.
Topics: 4-Butyrolactone; Lignans; Stereoisomerism | 2022 |
Using α- and β-Epimerizations of
Topics: 4-Butyrolactone; Kinetics; Lignans; Stereoisomerism | 2022 |
Dietary lignans, plasma enterolactone levels, and metabolic risk in men: exploring the role of the gut microbiome.
Topics: 4-Butyrolactone; Adult; Diet; Gastrointestinal Microbiome; Humans; Lignans; Male | 2022 |
Plant Growth Suppressive Activity of (
Topics: 4-Butyrolactone; Coumarins; Lactuca; Lignans; Plant Development | 2022 |
Secoisolariciresinol diglucoside-derived metabolite, enterolactone, attenuates atopic dermatitis by suppressing Th2 immune response.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Butylene Glycols; Child, Preschool; Dermatitis, Atopic; Dinitrochlorobenzene; Glucosides; Humans; Immunity; Lignans; Mice; Mice, Inbred BALB C; Skin | 2022 |
Total Synthesis of Polysubstituted γ-Butyrolactone Lignans (-)-Hinokinin, (-)-Bicubebin B, and (-)-Isodeoxypodophyllotoxin via Oxime Carbonate Formation.
Topics: 4-Butyrolactone; Biological Products; Lignans | 2023 |
Identification of the Microbial Transformation Products of Secoisolariciresinol Using an Untargeted Metabolomics Approach and Evaluation of the Osteogenic Activities of the Metabolites.
Topics: 4-Butyrolactone; Butylene Glycols; Diet; Humans; Lignans | 2023 |