4-butyrolactone has been researched along with gamma-aminobutyric acid in 43 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (41.86) | 18.7374 |
| 1990's | 11 (25.58) | 18.2507 |
| 2000's | 7 (16.28) | 29.6817 |
| 2010's | 6 (13.95) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bourguignon, JJ; Charlier, B; Hechler, V; Maitre, M; Schmitt, M; Schoenfelder, A; Wermuth, CG | 1 |
| Cott, J; Engel, J | 1 |
| Engel, J; Liljequist, S | 1 |
| Biswas, B; Carlsson, A | 1 |
| Eng, N; Pericić, D; Walters, JR | 1 |
| Agnati, L; Fuxe, K; Hökfelt, T; Johansson, O; Ljungdahl, A; Perez de la Mora, M | 1 |
| Ohya, K; Sano, M | 1 |
| Covey, DF; Ferrendelli, JA; Holland, KD; Rothman, SM; Yoon, KW | 1 |
| Covey, DF; Ferrendelli, JA; Holland, KD; Rothman, SM | 1 |
| Baker, K; Clifford, DB; Covey, DF; Yang, J; Zorumski, CF | 2 |
| Depaulis, A; Marescaux, C; Snead, OC; Vergnes, M | 1 |
| Covey, DF; Ferrendelli, JA; Levine, JA; Naritoku, DK | 1 |
| Amit, Z; Smith, BR | 1 |
| Burke, TR; Rice, KC; Skolnick, P; Weissman, BA | 1 |
| Goto, Y; Maeda-Hagiwara, M; Shimizu, M; Watanabe, H; Watanabe, K | 1 |
| Dougherty, GG; Ellinwood, EH; Gonzalez, AE | 1 |
| Debeljuk, L; Díaz, MD; Maines, VM; Seilicovich, A | 1 |
| Abe, K; Abe, T; Klatzo, I; Spatz, M | 1 |
| Bolos-Sy, AM; Covey, DF; Ferrendelli, JA; Holland, KD; Mathews, GC; Reddy, PA; Rothman, SM; Tucker, JB | 1 |
| Snead, OC | 1 |
| Bolos-Sy, AM; Covey, DF; Ferrendelli, JA; Holland, KD; Isenberg, KE; Mathews, GC; Rothman, SM | 1 |
| Covey, DF; Rothman, SM; Yoon, KW | 1 |
| Hauhart, RE; Thurston, JH | 1 |
| Bolos-Sy, AM; Covey, DF; Ferrendelli, JA; Mathews, GC; Rothman, SM | 1 |
| Feigenbaum, JJ; Howard, SG | 1 |
| Covey, DF; Ferrendelli, JA; Krause, JE; Rothman, SM; Tucker, JB; Weiss, DS; White, G; Williams, KL | 1 |
| Covey, DF; de la Cruz, MA; Hill, MW; Rothman, SM | 1 |
| Banerjee, PK; Hu, RQ; Snead, OC | 1 |
| GIARMAN, NJ; SCHMIDT, KF | 1 |
| Bettler, B; Bräuner-Osborne, H; Cryan, JF; Froestl, W; Kaupmann, K; Klebs, K; Mombereau, C; Mosbacher, J; Sansig, G; Schmutz, M; van der Putten, H; Waldmeier, P; Wellendorph, P | 1 |
| Authier, N; Coudoré, F; Eschalier, A; Faict, TW; Ling, B; Richard, D | 1 |
| Chevrot, R; Cirou, A; Faure, D; Haudecoeur, E; Ron, E; Rosen, R; Shelp, BJ | 1 |
| Aguilar-Guadarrama, AB; Gutiérrez, Mdel C; Rios, MY | 1 |
| Hong, CS; Jeon, A; Lee, HS; Lee, J; Lim, JH; Ok, T | 1 |
| Cirou, A; Dessaux, Y; Faure, D; Haudecoeur, E; Raffoux, A; Tannières, M | 1 |
| Burke, LM; Castell, LM; Manore, M; Meeusen, R; Moran, S; Naylor, MJ; Popple, AD; Roelands, B; Stear, SJ | 1 |
| Dahl, SR; Olsen, KM; Strand, DH | 1 |
| Barbey, C; Beury-Cirou, A; Burini, JF; Crépin, A; Dufour, A; Faure, D; Feuilloley, M; Hélias, V; Heurlier, K; Latour, X; Nasser, W; Orange, N; Reverchon, S; Taupin, L | 1 |
| Sałat, K; Sałat, R | 1 |
| Cios, A; Filipek, B; Malawska, B; Mogilski, S; Sałat, K; Sałat, R; Więckowski, K; Wyska, E | 1 |
| Busardò, FP; Kyriakou, C; Marchei, E; Pacifici, R; Pedersen, DS; Pichini, S | 1 |
| Bargel, S; Bonnet, A; Boukerma, AK; Chevallier, C; Dufayet, L; Evrard, M; Guillotin, S; Loeuillet, E; Paradis, C; Pouget, AM; Reynoard, J; Vaucel, JA | 1 |
4 review(s) available for 4-butyrolactone and gamma-aminobutyric acid
| Article | Year |
|---|---|
The effect of chronic ethanol administration on central neurotransmitter mechanisms.
Topics: 4-Butyrolactone; Animals; Aromatic-L-Amino-Acid Decarboxylases; Behavior, Animal; Brain; Catecholamines; Dihydroxyphenylalanine; Dopamine; Ethanol; gamma-Aminobutyric Acid; Humans; Male; Mice; Neurons; Neurotransmitter Agents; Norepinephrine; Propranolol; Rats; Receptors, Cholinergic; Receptors, Dopamine; Substance Withdrawal Syndrome; Synaptic Transmission; Time Factors | 1979 |
Gamma hydroxybutyrate is not a GABA agonist.
Topics: 4-Butyrolactone; Animals; Central Nervous System; Convulsants; Electroencephalography; GABA Agonists; gamma-Aminobutyric Acid; Humans; Mammals; Muscle Contraction; Picrotoxin; Rabbits; Rats; Receptors, GABA; Respiration; Seizures; Sodium Oxybate | 1996 |
BJSM reviews: A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--Part 16.
Topics: 4-Butyrolactone; Animals; Athletic Performance; Coumaric Acids; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; gamma-Aminobutyric Acid; Humans; Hydroxybutyrates; Hypolipidemic Agents; Muscle, Skeletal; Phenylpropionates; Rats | 2011 |
Gamma-hydroxybutyrate (GHB), 1,4-butanediol (1,4BD), and gamma-butyrolactone (GBL) intoxication: A state-of-the-art review.
Topics: 4-Butyrolactone; gamma-Aminobutyric Acid; Humans; Sodium Oxybate; Substance Withdrawal Syndrome | 2023 |
39 other study(ies) available for 4-butyrolactone and gamma-aminobutyric acid
| Article | Year |
|---|---|
Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies.
Topics: Animals; Binding Sites; Brain; Hydroxybutyrates; In Vitro Techniques; Rats; Structure-Activity Relationship | 1988 |
Suppression by GABAergic drugs of the locomotor stimulation induced by morphine, amphetamine, and apomorphine: evidence for both pre- and post-synaptic inhibition of catecholamine systems.
Topics: 4-Butyrolactone; Aminobutyrates; Aminooxyacetic Acid; Animals; Apomorphine; Brain; Clonidine; Corpus Striatum; Dextroamphetamine; Diencephalon; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Limbic System; Methyltyrosines; Mice; Morphine; Motor Activity; Naloxone; Norepinephrine; Reserpine; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase | 1977 |
On the mode of action of diazepam on brain catecholamine metabolism.
Topics: 4-Butyrolactone; 5-Hydroxytryptophan; Anesthesia; Animals; Brain; Catecholamines; Diazepam; Dihydroxyphenylalanine; Dopamine; gamma-Aminobutyric Acid; Male; Rats | 1978 |
Post-mortem and aminooxyacetic acid-induced accumulation of GABA: effect of gamma-butyrolactone and picrotoxin.
Topics: 4-Butyrolactone; Acetates; Aminobutyrates; Aminooxyacetic Acid; Animals; Brain; Chloral Hydrate; Furans; gamma-Aminobutyric Acid; Male; Organ Specificity; Picrotoxin; Postmortem Changes; Rats | 1978 |
Regulation of the mesocortical dopamine neurons.
Topics: 4-Butyrolactone; Acetylcholine; Aminooxyacetic Acid; Baclofen; Cerebral Cortex; Dopamine; gamma-Aminobutyric Acid; Isoxazoles; Neurons; Pimozide; Pyrrolidinones; Sulpiride | 1977 |
Analysis of drugs by pyrolysis. I. Selected ion monitoring combined with a pyrolysis method for the determination of carpronium chloride in biological samples.
Topics: 4-Butyrolactone; Aminobutyrates; gamma-Aminobutyric Acid; Hot Temperature; Humans; Ions; Mass Spectrometry; Parasympathomimetics; Quaternary Ammonium Compounds | 1977 |
Gamma-butyrolactone antagonism of the picrotoxin receptor: comparison of a pure antagonist and a mixed antagonist/inverse agonist.
Topics: 4-Butyrolactone; Animals; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Membrane Potentials; Rats; Receptors, GABA-A | 1991 |
Physiological regulation of the picrotoxin receptor by gamma-butyrolactones and gamma-thiobutyrolactones in cultured hippocampal neurons.
Topics: 4-Butyrolactone; Animals; Cells, Cultured; Electrophysiology; Furans; gamma-Aminobutyric Acid; Hippocampus; Lactones; Neurons; Picrotoxin; Receptors, Drug; Succinimides | 1990 |
Alpha-substituted thiobutyrolactones potentiate GABA currents in voltage-clamped chick spinal cord neurons.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Cells, Cultured; Chick Embryo; Diazepam; Furans; gamma-Aminobutyric Acid; Ion Channels; Membrane Potentials; Phenobarbital; Picrotoxin; Spinal Cord | 1988 |
Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents.
Topics: 4-Butyrolactone; Animals; Convulsants; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1989 |
Convulsant gamma-butyrolactones block GABA currents in cultured chick spinal cord neurons.
Topics: 4-Butyrolactone; Animals; Cells, Cultured; Chick Embryo; Furans; gamma-Aminobutyric Acid; Membrane Potentials; Picrotoxin; Spinal Cord | 1989 |
Effects of anticonvulsant and convulsant gamma-butyrolactones and thiobutyrolactones on GABA-mediated chloride uptake.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Cerebral Cortex; Chlorides; Convulsants; Female; Furans; gamma-Aminobutyric Acid; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Sesterterpenes; Structure-Activity Relationship | 1987 |
The role of gamma-aminobutyric acid (GABA) in the regulation of ethanol and acetaldehyde self-administration.
Topics: 4-Butyrolactone; Acetaldehyde; Animals; Ethanol; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Postural Balance; Rats; Self Administration | 1985 |
Alkyl-substituted gamma-butyrolactones inhibit [35S]TBPS binding to a GABA linked chloride ionophore.
Topics: 4-Butyrolactone; Animals; Barbiturates; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chlorides; Furans; gamma-Aminobutyric Acid; In Vitro Techniques; Ionophores; Male; Membranes; Picrotoxin; Rats; Rats, Inbred Strains | 1984 |
gamma-butyrolactone enhances the activity of GABA in the gastric acid secretion of anesthetized rats.
Topics: 4-Butyrolactone; Anesthesia; Animals; Diazepam; Drug Synergism; Furans; gamma-Aminobutyric Acid; Gastric Acid; Male; Rats; Rats, Inbred Strains; Sodium Oxybate | 1983 |
gamma-Butyrolactone effects on behavior induced by dopamine agonists.
Topics: 4-Butyrolactone; Amphetamine; Animals; Apomorphine; Bicuculline; Furans; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Male; Methylphenidate; Rats; Receptors, Dopamine; Stereotyped Behavior | 1983 |
Prolonged treatment with gamma-aminobutyric acid (GABA)-mimetic substances in prepubertal male rats.
Topics: 4-Butyrolactone; Alkynes; Aminocaproates; Animals; Body Weight; gamma-Aminobutyric Acid; Male; Organ Size; Prolactin; Rats; Rats, Inbred Strains; Seminal Vesicles; Sexual Maturation; Testis; Time Factors | 1983 |
Effect of endogenous central nervous system depressants in ischemic cerebral edema of gerbils.
Topics: 4-Butyrolactone; Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Furans; gamma-Aminobutyric Acid; Gerbillinae; Norepinephrine; Serotonin; Specific Gravity; Sucrose | 1980 |
Dual modulation of the gamma-aminobutyric acid type A receptor/ionophore by alkyl-substituted gamma-butyrolactones.
Topics: 4-Butyrolactone; Alkylation; Animals; Cell Line; Female; gamma-Aminobutyric Acid; Hippocampus; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1995 |
The ontogeny of [3H]gamma-hydroxybutyrate and [3H]GABAB binding sites: relation to the development of experimental absence seizures.
Topics: 4-Butyrolactone; Animals; Animals, Newborn; Binding Sites; Electrophysiology; Epilepsy, Absence; gamma-Aminobutyric Acid; Rats; Rats, Sprague-Dawley; Sodium Oxybate; Tritium | 1994 |
Developmental alteration in GABAA receptor structure and physiological properties in cultured cerebellar granule neurons.
Topics: 4-Butyrolactone; Animals; Base Sequence; Benzodiazepines; Cells, Cultured; Cerebellum; Chlordiazepoxide; Chloride Channels; Drug Synergism; Female; gamma-Aminobutyric Acid; Gene Expression; Molecular Sequence Data; Neurons; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, GABA; RNA, Messenger; Time Factors | 1994 |
Multiple mechanisms of picrotoxin block of GABA-induced currents in rat hippocampal neurons.
Topics: 4-Butyrolactone; Animals; Chlorides; Electric Conductivity; gamma-Aminobutyric Acid; Hippocampus; Neurons; Picrotoxin; Rats; Reaction Time | 1993 |
Comparative effects of valproate and the new experimental anticonvulsant drug alpha-ethyl-alpha-methyl-thiobutyrolactone on selected metabolite levels in the plasma, livers, and brains of infant mice.
Topics: 3-Hydroxybutyric Acid; 4-Butyrolactone; Amino Acids; Animals; Animals, Suckling; Anticonvulsants; Blood Glucose; Brain Chemistry; Carnitine; Coenzyme A; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Hydroxybutyrates; Liver; Mice; Valproic Acid | 1996 |
Physiological comparison of alpha-ethyl-alpha-methyl-gamma-thiobutyrolactone with benzodiazepine and barbiturate modulators of GABAA receptors.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Binding Sites; Cells, Cultured; Chlordiazepoxide; Chlorine; Dose-Response Relationship, Drug; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Patch-Clamp Techniques; Phenobarbital; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Transfection | 1996 |
Lactone modulation of the gamma-aminobutyric acid A receptor: evidence for a positive modulatory site.
Topics: 4-Butyrolactone; Animals; Chlordiazepoxide; Female; Flumazenil; gamma-Aminobutyric Acid; Lactones; Phenobarbital; Picrotoxin; Receptors, GABA-A; Xenopus laevis | 1997 |
Effects of anticonvulsant lactams on in vitro seizures in the hippocampal slice preparation.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Calcium Channel Blockers; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Lactams; Mice; Phenytoin; Piperidines; Potassium Channel Blockers; Receptors, GABA-A; Seizures; Sodium Channel Blockers; Synaptic Transmission | 1999 |
Regulation of gamma-aminobutyric acid (GABA) release in cerebral cortex in the gamma-hydroxybutyric acid (GHB) model of absence seizures in rat.
Topics: 4-Butyrolactone; Animals; Cerebral Cortex; Electroencephalography; Epilepsy, Absence; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hydroxybutyrates; Male; Microdialysis; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Solvents; Thalamus | 2000 |
Some neurochemical aspects of the depressant action of gamma-butyrolactone on the central nervous system.
Topics: 4-Butyrolactone; Acetylcholine; Amino Acids; Animals; Brain; Central Nervous System; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Lactones; Mice; Rats; Serotonin | 1963 |
Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice.
Topics: 4-Butyrolactone; Adjuvants, Anesthesia; Animals; Anticonvulsants; Autoradiography; Baclofen; Behavior, Animal; Benzocycloheptenes; Binding, Competitive; Body Weight; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Electroencephalography; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Inbred BALB C; Mice, Knockout; Motor Activity; Organophosphorus Compounds; Phenols; Radioligand Assay; Receptors, GABA-B; Sodium Oxybate; Time Factors | 2003 |
GC/MS profiling of gamma-hydroxybutyrate and precursors in various animal tissues using automatic solid-phase extraction. Preliminary investigations of its potential interest in postmortem interval determination.
Topics: 4-Butyrolactone; Animal Structures; Animals; Butylene Glycols; Calibration; Central Nervous System; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Male; Postmortem Changes; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Sodium Oxybate; Solid Phase Extraction; Temperature; Time Factors | 2005 |
GABA controls the level of quorum-sensing signal in Agrobacterium tumefaciens.
Topics: 4-Butyrolactone; Acetophenones; Agrobacterium tumefaciens; Bacterial Proteins; gamma-Aminobutyric Acid; Gene Expression Regulation, Bacterial; Glutamate Decarboxylase; Molecular Structure; Nicotiana; Operon; Signal Transduction | 2006 |
Analgesic activity of affinin, an alkamide from Heliopsis longipes (Compositae).
Topics: 4-Butyrolactone; Alkenes; Amides; Analgesics; Animals; Asteraceae; Benzodioxoles; Brain; Dioxoles; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Lignans; Medicine, Traditional; Methylene Chloride; Mexico; Mice; Pain; Plant Extracts; Plants, Medicinal; Polyunsaturated Alkamides | 2007 |
Enantiomerically pure synthesis of beta-substituted gamma-butyrolactones: a key intermediate to concise synthesis of pregabalin.
Topics: 4-Butyrolactone; Anticonvulsants; Crystallography, X-Ray; gamma-Aminobutyric Acid; Pregabalin; Stereoisomerism | 2007 |
Different regulation and roles of lactonases AiiB and AttM in Agrobacterium tumefaciens C58.
Topics: 4-Butyrolactone; Agrobacterium tumefaciens; Bacterial Proteins; Carboxylic Ester Hydrolases; gamma-Aminobutyric Acid; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Host-Pathogen Interactions; Lac Operon; Models, Biological; Mutation; Nicotiana; Plant Tumors; Polymerase Chain Reaction; Quorum Sensing; Recombinant Fusion Proteins; Solanum lycopersicum; Sugar Phosphates | 2009 |
Determination of γ-hydroxybutyrate (GHB), β-hydroxybutyrate (BHB), pregabalin, 1,4-butane-diol (1,4BD) and γ-butyrolactone (GBL) in whole blood and urine samples by UPLC-MSMS.
Topics: 3-Hydroxybutyric Acid; 4-Butyrolactone; Butylene Glycols; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Humans; Illicit Drugs; Pregabalin; Reproducibility of Results; Sensitivity and Specificity; Sodium Oxybate; Tandem Mass Spectrometry | 2012 |
Quorum sensing signaling molecules produced by reference and emerging soft-rot bacteria (Dickeya and Pectobacterium spp.).
Topics: 4-Butyrolactone; Acyl-Butyrolactones; Bacterial Proteins; Enterobacteriaceae; gamma-Aminobutyric Acid; Homoserine; Indoleacetic Acids; Kinetics; Lactones; Multienzyme Complexes; Pectobacterium; Quinolones; Quorum Sensing; RNA, Messenger; Signal Transduction; Solanum tuberosum; Tryptophan | 2012 |
The application of support vector regression for prediction of the antiallodynic effect of drug combinations in the mouse model of streptozocin-induced diabetic neuropathy.
Topics: 4-Butyrolactone; Algorithms; Analgesics; Animals; Computer Simulation; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Administration Schedule; Drug Combinations; Furans; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mice; Pain; Pain Measurement; Pain Threshold; Piperazines; Pregabalin; Software; Streptozocin; Support Vector Machine; Time Factors | 2013 |
Antiallodynic and antihyperalgesic activity of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice.
Topics: 4-Butyrolactone; Analgesics; Animals; Antineoplastic Agents; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Male; Mice; Neuralgia; Pain Measurement; Piperazines; Pregabalin; Touch | 2014 |
Ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) for determination of GHB, precursors and metabolites in different specimens: Application to clinical and forensic cases.
Topics: 4-Butyrolactone; Cerebrospinal Fluid; Chromatography, High Pressure Liquid; Forensic Sciences; gamma-Aminobutyric Acid; Hair; Humans; Hydroxybutyrates; Illicit Drugs; Male; Methanol; Middle Aged; Plasma; Sodium Oxybate; Tandem Mass Spectrometry | 2017 |