Page last updated: 2024-08-18

4-butyrolactone and epiisopiloturine

4-butyrolactone has been researched along with epiisopiloturine in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's14 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Batista, MC; Campelo, YD; Guimaraes, MA; Kuckelhaus, SS; Leite, JR; Lima, DF; Moraes, J; Nakano, E; Nascimento, C; Vasconcelos, L; Veras, LM; Vieira, MM1
Aragão, KS; Barbosa, AL; Campos, SA; Carvalho, NS; Damasceno, SR; Godejohann, M; Guimarães, MA; Leite, JR; Medeiros, JV; Prudêncio, RS; Silva, RO; Silva, VG; Véras, LM1
Campelo, YD; Carvalho, PS; Constantino, VR; Cunha, VR; de Souza de Almeida Leite, JR; Ellena, JA; Godejohann, M; Guimarães, MA; Lima, DF; Lima, FC; Mascarenhas, YP; Petrilli, HM; Sakai, VY; Silva, PR; Vasconcelos, LC; Véras, LM; Vieira, MM1
Campelo, YD; Ciancaglini, P; Colhone, MC; de Leite, JR; de Moraes, J; Guimarães, MA; Kuckelhaus, SS; Lima, DF; Lima, FC; Véras, LM1
Allegretti, SM; Campelo, YD; Campos, SA; de Moraes, J; de Oliveira, RN; Eaton, P; Guimarães, MA; Kuckelhaus, SA; Leite, JR; Lima, DF; Lolić, A; Mafud, AC; Mascarenhas, YP; Pinto, PL; Véras, LM; Verbić, T1
Aragão, KS; Carvalho, NS; Leite, JRSA; Lucetti, LT; Medeiros, JVR; Nicolau, LAD; Pacífico, DM; Souza, MHLP; Véras, LMC1
Andrade, IM; Correia, M; de Moraes, J; Delerue-Matos, C; Eaton, P; Ivanova, G; Leite, JR; Lima, DF; Mafud, AC; Mascarenhas, YP; Mayo, SJ; Pinto, PL; Quelemes, PV; Rangel, M; Rocha, JA; Soares, MJ; Véras, LM1
Arcanjo, DDR; Campelo, YDM; de Moraes, J; de Souza de Almeida Leite, JR; Eaton, P; Guimarães, MA; Kato, MJ; Lima, DF; Mafud, AC; Mascarenhas, YP; Mendonça, RZ; Pinto, PLS; Silva, MPN; Véras, LMC; Yamaguchi, LF1
Azevedo, IF; Biase, AG; Costa, J; de Andrade, IM; de Lima, LI; Grazina, LG; Leite, JR; Lima, DF; Mafra, I; Meira, L; Oliveira, MB; Rocha, JA; Véras, LM; Villa, C1
Azevedo, RB; de Lima, LI; de Souza de Almeida Leite, JR; Figueiró Longo, JP; Guimarães, MA; Jiang, CS; Mafud, AC; Mascarenhas, YP; Moraes, J; Muehlmann, LA; Py-Daniel, KR1
Barbosa, ALDR; da Silva Martins, C; de Aguiar Magalhãres, D; de Brito, TV; de Sousa de Almeida Leite, JR; Fernando Pereira Vasconcelos, D; Guimarães Sousa, S; José Dias Júnior, G; Maria Costa Véras, L; Oliveira Silva, R; Rodolfo Pereira da Silva, F; Rodrigues de Carvalho, L; Santos Martins, D; Simião da C Júnior, J; Soares de Oliveira, J1
Carvalho, BTS; de Moraes, J; Leite, JRSA; Lima, FCA; Passos, ING; Ramos, RM; Rego, NCS; Rocha, JA; Silva, FI; Sousa, JA1
Araujo, EVO; de Sousa, JAC; Guimaraes, MA; Leal, LKAM; Leite, JRSA; Lima, DF; Machado, NJ; Rocha, TM1
da Silva, DA; de Almeida, MP; de Araújo, AR; de Paula, RCM; Delerue-Matos, C; do Amaral Rodrigues, J; Eaton, P; Feitosa, JPA; Leite, JRSA; Lima, FCDA; Neto, AB; Pitombeira, NA; Plácido, A; Veras, LMC1

Other Studies

14 other study(ies) available for 4-butyrolactone and epiisopiloturine

ArticleYear
Activity of epiisopiloturine against Schistosoma mansoni.
    Current medicinal chemistry, 2012, Volume: 19, Issue:13

    Topics: 4-Butyrolactone; Animals; Chlorocebus aethiops; Imidazoles; Mice; Pilocarpus; Reproduction; Schistosoma mansoni; Vero Cells

2012
Anti-inflammatory and antinociceptive activity of epiisopiloturine, an imidazole alkaloid isolated from Pilocarpus microphyllus.
    Journal of natural products, 2013, Jun-28, Volume: 76, Issue:6

    Topics: 4-Butyrolactone; Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents; Brazil; Imidazoles; Male; Mice; Molecular Structure; Neutrophils; Pain Measurement; Peroxidase; Pilocarpus

2013
Industrial Scale Isolation, Structural and Spectroscopic Characterization of Epiisopiloturine from Pilocarpus microphyllus Stapf Leaves: A Promising Alkaloid against Schistosomiasis.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: 4-Butyrolactone; Crystallography, X-Ray; Imidazoles; Pilocarpus; Plant Extracts; Plant Leaves; Schistosomicides

2013
Nanopharmaceutical approach of epiisopiloturine alkaloid carried in liposome system: preparation and in vitro schistosomicidal activity.
    Journal of nanoscience and nanotechnology, 2014, Volume: 14, Issue:6

    Topics: 4-Butyrolactone; Animals; Anthelmintics; Imidazoles; Liposomes; Materials Testing; Nanocapsules; Schistosoma mansoni; Treatment Outcome

2014
Anthelmintic activity in vivo of epiisopiloturine against juvenile and adult worms of Schistosoma mansoni.
    PLoS neglected tropical diseases, 2015, Volume: 9, Issue:3

    Topics: 4-Butyrolactone; Animals; Dose-Response Relationship, Drug; Feces; Granuloma; Imidazoles; Liver; Mice; Microscopy, Electron, Scanning; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides

2015
Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus microphyllus leaves, protects against naproxen-induced gastrointestinal damage in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 87

    Topics: 4-Butyrolactone; Alkaloids; Animals; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Diseases; Imidazoles; Intestinal Mucosa; Male; Naproxen; Pilocarpus; Plant Extracts; Plant Leaves; Protective Agents; Rats; Rats, Wistar

2017
Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids from Pilocarpus microphyllus Leaves.
    Phytotherapy research : PTR, 2017, Volume: 31, Issue:4

    Topics: 4-Butyrolactone; Alkaloids; Animals; Anthelmintics; Anti-Bacterial Agents; Imidazoles; Pilocarpus; Plant Extracts; Plant Leaves; Vero Cells

2017
Synergistic effects of in vitro combinations of piplartine, epiisopiloturine and praziquantel against Schistosoma mansoni.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 88

    Topics: 4-Butyrolactone; Animals; Antiprotozoal Agents; Cell Shape; Chlorocebus aethiops; Cricetinae; Dogs; Drug Synergism; Drug Therapy, Combination; Imidazoles; Madin Darby Canine Kidney Cells; Male; Mice; Microscopy, Confocal; Piperidones; Praziquantel; Schistosoma mansoni; Vero Cells

2017
Seasonal change in main alkaloids of jaborandi (Pilocarpus microphyllus Stapf ex Wardleworth), an economically important species from the Brazilian flora.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: 4-Butyrolactone; Alkaloids; Brazil; DNA, Plant; Genetics, Population; Imidazoles; Microsatellite Repeats; Pilocarpine; Pilocarpus; Plant Leaves; Plants, Medicinal; Seasons

2017
Self-nanoemulsifying drug-delivery systems improve oral absorption and antischistosomal activity of epiisopiloturine.
    Nanomedicine (London, England), 2018, 04-01, Volume: 13, Issue:7

    Topics: 4-Butyrolactone; Administration, Oral; Animals; Biological Availability; Disease Models, Animal; Drug Delivery Systems; Emulsions; Humans; Imidazoles; Mice; Nanoparticles; Particle Size; Schistosoma mansoni; Schistosomiasis mansoni; Solubility

2018
Epiisopiloturine, an imidazole alkaloid, reverses inflammation and lipid peroxidation parameters in the Crohn disease model induced by trinitrobenzenosulfonic acid in Wistar rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 102

    Topics: 4-Butyrolactone; Alkaloids; Animals; Anti-Inflammatory Agents; Crohn Disease; Disease Models, Animal; Female; Imidazoles; Inflammation; Intestinal Mucosa; Lipid Peroxidation; Rats, Wistar; Trinitrobenzenesulfonic Acid

2018
Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties.
    PloS one, 2018, Volume: 13, Issue:6

    Topics: 4-Butyrolactone; Alkaloids; Animals; Anthelmintics; Imidazoles; Models, Molecular; Molecular Docking Simulation; Pilocarpus; Plant Extracts; Quantum Theory; Schistosoma mansoni; Thermodynamics

2018
Imidazole alkaloids inhibit the pro-inflammatory mechanisms of human neutrophil and exhibit anti-inflammatory properties in vivo.
    The Journal of pharmacy and pharmacology, 2019, Volume: 71, Issue:5

    Topics: 4-Butyrolactone; Alkaloids; Animals; Anti-Inflammatory Agents; Calcium; Humans; Hyperalgesia; Imidazoles; Interleukin-6; Male; Mice; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; NF-kappa B; Peroxidase; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2019
Acetylated cashew gum-based nanoparticles for the incorporation of alkaloid epiisopiloturine.
    International journal of biological macromolecules, 2019, May-01, Volume: 128

    Topics: 4-Butyrolactone; Acetylation; Alkaloids; Anacardium; Carbohydrate Conformation; Drug Carriers; Drug Liberation; Imidazoles; Models, Molecular; Nanoparticles; Plant Gums; Solubility

2019