4-butyrolactone has been researched along with dinoprostone in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 16 (76.19) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iglewski, BH; Kelly, R; Phipps, RP; Smith, RS | 1 |
| Bermejo, J; Brouard, I; Estévez, F; García, CI; Miranda, PO; Padrón, JI; Pivel, JP; Quintana, J | 1 |
| Aziz, RM; Carlton, PS; Chen, T; Dixit, R; Qin, H; Rose, ME; Stoner, GD | 1 |
| Aquino, M; Bruno, I; Gomez-Paloma, L; Guerrero, MD; Paya, M; Riccio, R; Terencio, MC | 1 |
| Accioly, MT; Bozza, PT; Carrossini, N; Kaufmann, C; Maya-Monteiro, CM; Morgado-Diaz, JA; Oliveira, SS; Pacheco, P; Robbs, BK; Viola, JP | 1 |
| Andrés, RM; Aquino, M; Bruno, I; De Simone, R; Guerrero, MD; Paya, M; Riccio, R; Terencio, MC | 1 |
| Budsberg, SC; Goodman, LA; Reynolds, LR; Torres, BT | 1 |
| Chao, SH; Chen, CC; Chiou, WF; Lee, MH; Su, YW; Tsai, YC | 1 |
| Christman, JW; van Breemen, RB; Xiao, L; Yu, R; Zhao, G | 1 |
| Cao, H; Christman, JW; Deng, J; Li, Y; Ornatowska, M; Sadikot, RT; Xiao, L; Yu, R; Zhao, G; Zhao, Q | 1 |
| Barton, MH; Budsberg, S; Giguère, S; King, D; Norton, N; Paske, E | 1 |
| Chandler, KJ; Sutton, DG | 1 |
| Boonmars, T; Chusorn, P; Jongthawin, J; Khuntikeo, N; Loilome, W; Namwat, N; Puapairoj, A; Tassaneeyakul, W; Techasen, A; Thanan, R; Yongvanit, P | 1 |
| Blouin, R; Goff, AK; Hallé, C; Palin, MF; Petit, HV | 1 |
| Barlow, BM; Blikslager, AT; Curling, A; Davis, JL; Fogle, C; Holland, B; Schirmer, J | 1 |
| Boos, A; Domosławska, A; Fingerhut, J; Gram, A; Hoffmann, B; Ihle, S; Janowski, T; Jurczak, A; Kowalewski, MP; Schuler, G; Siemieniuch, MJ; Zduńczyk, S | 1 |
| Dikshit, A; Eilati, E; Gao, C; Gomes Filho, MA; Hales, DB; Klug, T; McGee, S; Small, C | 1 |
| Miyanowaki, T; Morinaga, O; Shoyama, Y; Taniyama, R; Tung, NH; Uto, T | 1 |
| Barton, MH; Clifton, S; Darden, JE; Vandenplas, M | 1 |
| Andriani, KF; Bastos, JK; Borges, A; Borges, CHG; Caramori, GF; Conforti, VA; Cunha, WR; da Silva Laurentiz, R; de Andrade, CQJ; E Silva, MLA; Januário, AH; Lima, TC; Lucarini, R; Parreira, RLT; Pauletti, PM; Símaro, GV; Souza, AMP; Volpe, AC | 1 |
| Beale, B; Jarudecha, T; Kashemsant, N; Kwananocha, I; Lascelles, BDX; Lekcharoensuk, C; Peirone, B; Vijarnsorn, M | 1 |
4 trial(s) available for 4-butyrolactone and dinoprostone
| Article | Year |
|---|---|
Efficacy of cyclo-oxygenase inhibition by two commercially available firocoxib products in horses.
Topics: 4-Butyrolactone; Administration, Oral; Animals; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dosage Forms; Horses; Sulfones | 2014 |
Pharmacokinetics and pharmacodynamics of three formulations of firocoxib in healthy horses.
Topics: 4-Butyrolactone; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Dinoprostone; Horses; Injections, Intravenous; Ointments; Sulfones; Tablets; Thromboxane B2 | 2015 |
Formation of the early canine CL and the role of prostaglandin E2 (PGE2) in regulation of its function: an in vivo approach.
Topics: 4-Butyrolactone; Animals; Corpus Luteum; Dinoprost; Dinoprostone; Dogs; Female; Gene Expression Regulation; Intramolecular Oxidoreductases; Male; Prostaglandin-E Synthases; Receptors, Prostaglandin; Sulfones | 2015 |
The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Dog Diseases; Dogs; Double-Blind Method; Drug Therapy, Combination; Fatty Acids, Unsaturated; Female; Gait; Male; Osteoarthritis; Pain; Pain Measurement; Prospective Studies; Sulfones | 2019 |
17 other study(ies) available for 4-butyrolactone and dinoprostone
| Article | Year |
|---|---|
The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclooxygenase-2 and prostaglandin E2 production in human lung fibroblasts: implications for inflammation.
Topics: 4-Butyrolactone; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Fibroblasts; Homoserine; Humans; Inflammation; Isoenzymes; Lung; Membrane Proteins; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Pseudomonas aeruginosa; RNA, Messenger; Up-Regulation; Virulence | 2002 |
Enantioselective synthesis and biological activity of (3S,4R)- and (3S,4S)-3-hydroxy-4-hydroxymethyl- 4-butanolides in relation to PGE2.
Topics: 4-Butyrolactone; Binding, Competitive; Cell Differentiation; Cell Survival; Dinoprostone; HL-60 Cells; Humans; Proto-Oncogene Proteins c-fos; Radioligand Assay; RNA, Messenger; Stereoisomerism; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 2004 |
The effects of L-748706, a selective cyclooxygenase-2 inhibitor, on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinogens; Carcinoma, Squamous Cell; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dimethylnitrosamine; Dinoprostone; Esophageal Neoplasms; Gene Expression Regulation, Enzymologic; Male; Piroxicam; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; RNA, Messenger; Sulfones | 2005 |
Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prosta
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Combinatorial Chemistry Techniques; Cyclooxygenase 2; Dinoprostone; Female; Furans; Humans; Intramolecular Oxidoreductases; Mice; Microsomes; NF-kappa B; Phospholipases A; Phospholipases A2; Prostaglandin Antagonists; Prostaglandin-E Synthases; Structure-Activity Relationship; Thiophenes | 2007 |
Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells.
Topics: 4-Butyrolactone; Adenocarcinoma; Aspirin; Caco-2 Cells; Cell Growth Processes; Colonic Neoplasms; Cyclooxygenase 2; Dinoprostone; HCT116 Cells; HT29 Cells; Humans; Lipid Metabolism; Organelles; Subcellular Fractions | 2008 |
Toward the discovery of new agents able to inhibit the expression of microsomal prostaglandin E synthase-1 enzyme as promising tools in drug development.
Topics: 4-Butyrolactone; Animals; Cell Line; Cyclooxygenase 2; Dinoprostone; Drug Discovery; Gene Expression; Intramolecular Oxidoreductases; Macrophages; Mice; Microsomes; Oleanolic Acid; Prostaglandin-E Synthases; Thiophenes | 2010 |
Effects of firocoxib, meloxicam, and tepoxalin administration on eicosanoid production in target tissues of healthy cats.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Cross-Over Studies; Cyclooxygenase Inhibitors; Dinoprostone; Duodenum; Eicosanoids; Gastric Mucosa; Intestinal Mucosa; Kinetics; Leukotriene B4; Male; Meloxicam; Orchiectomy; Pyrazoles; Reference Values; Sulfones; Thiazines; Thiazoles | 2010 |
Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-κB and AP-1 signaling pathways.
Topics: 4-Butyrolactone; Animals; Cell Line; Dinoprostone; Down-Regulation; I-kappa B Kinase; Lipopolysaccharides; Macrophages; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Transcription Factor AP-1; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2011 |
Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2.
Topics: 4-Butyrolactone; Animals; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Dibenzocycloheptenes; Dinoprostone; Enzyme Assays; Enzyme Inhibitors; Humans; Intramolecular Oxidoreductases; Isomerases; Lipocalins; Macrophages; Mice; Mice, Inbred C57BL; Piperidines; Prostaglandin D2; Prostaglandin H2; Prostaglandin-E Synthases; Sheep; Thiophenes | 2011 |
Lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 mediates late-phase PGE2 production in bone marrow derived macrophages.
Topics: 4-Butyrolactone; Animals; Cyclooxygenase 1; Dinoprostone; Enzyme Inhibitors; Gene Expression Regulation; Intramolecular Oxidoreductases; Lipocalins; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Mice, Inbred C57BL; Microsomes; Nitric Oxide Synthase Type II; Primary Cell Culture; Prostaglandin D2; Prostaglandin-E Synthases; Proto-Oncogene Proteins; RNA, Small Interfering; Thiophenes; Trans-Activators | 2012 |
The dilemmas of medicine selection for equine veterinarians.
Topics: 4-Butyrolactone; Animals; Cyclooxygenase 2 Inhibitors; Dinoprostone; Horses; Sulfones | 2014 |
PGE2 signaling and its biosynthesis-related enzymes in cholangiocarcinoma progression.
Topics: 4-Butyrolactone; Adult; Aged; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholangiocarcinoma; Cyclooxygenase 2; Dinoprostone; Female; Humans; Intramolecular Oxidoreductases; Male; Middle Aged; Prostaglandin-E Synthases; Signal Transduction; Thiophenes | 2014 |
Effects of different n-6:n-3 fatty acid ratios and of enterolactone on gene expression and PG secretion in bovine endometrial cells.
Topics: 4-Butyrolactone; Aldehyde Reductase; Animals; Cattle; Cells, Cultured; Diet; Dinoprost; Dinoprostone; Endometrium; Epithelial Cells; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Gene Expression; Intramolecular Oxidoreductases; Lignans; Prostaglandin-E Synthases; Reproducibility of Results; RNA, Messenger | 2015 |
Flaxseed reduces the pro-carcinogenic micro-environment in the ovaries of normal hens by altering the PG and oestrogen pathways in a dose-dependent manner.
Topics: 4-Butyrolactone; Animals; Anticarcinogenic Agents; Chickens; Cyclooxygenase 1; Cyclooxygenase 2; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP3A; Diet; Dietary Supplements; Dinoprostone; Estrogen Receptor alpha; Estrogens; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Flax; Hydroxyestrones; Lignans; Liver; Ovarian Neoplasms; Ovary; RNA, Messenger | 2015 |
Anti-inflammatory Activity of Constituents Isolated from Aerial Part of Angelica acutiloba Kitagawa.
Topics: 4-Butyrolactone; Angelica; Animals; Anti-Inflammatory Agents; Benzofurans; Dinoprostone; Diynes; Fatty Alcohols; Furocoumarins; Heme Oxygenase-1; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Nitric Oxide; Phytochemicals; Plant Components, Aerial; Plant Extracts; Plant Roots; Plants, Medicinal; RAW 264.7 Cells; Tumor Necrosis Factor-alpha | 2015 |
Effect of firocoxib on cyclooxygenase 2, microsomal prostaglandin E2 synthase 1, and cytosolic phospholipase A2 gene expression in equine mononuclear cells.
Topics: 4-Butyrolactone; Animals; Centrifugation, Density Gradient; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytosol; Dinoprostone; Gene Expression Regulation; Horses; Intramolecular Oxidoreductases; Leukocytes, Mononuclear; Lipopolysaccharides; Membrane Proteins; Microsomes; Phospholipases A2; Polymerase Chain Reaction; Prostaglandin-E Synthases; Sulfones | 2015 |
In vivo and in silico anti-inflammatory mechanism of action of the semisynthetic (-)-cubebin derivatives (-)-hinokinin and (-)-O-benzylcubebin.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodioxoles; Catalytic Domain; Computer Simulation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyproheptadine; Dextrans; Dinoprostone; Dioxoles; Edema; Furans; Indomethacin; Ligands; Lignans; Male; Mice; Molecular Docking Simulation; Polysorbates; Rats, Wistar; Rutaceae | 2017 |