Page last updated: 2024-08-18

4-butyrolactone and butyrolactone i

4-butyrolactone has been researched along with butyrolactone i in 106 studies

Research

Studies (106)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	24 (22.64)	18.2507
2000's	56 (52.83)	29.6817
2010's	17 (16.04)	24.3611
2020's	9 (8.49)	2.80

Authors

Authors	Studies
Dahl, D; Hisanaga, S; Honma, N; Hosoi, T; Ishiguro, K; Kishimoto, T; Ohsumi, K; Uchida, T; Uchiyama, M; Yamada, K	1
Hisanaga, S; Hosoi, T; Ishiguro, K; Kishimoto, T; Okumura, E; Okuyama, A; Saito, T; Uchida, T; Uchiyama, M	1
Higashi, H; Hishimura, S; Kitagawa, M; Ogino, H; Okabe, T; Okuyama, A; Takahashi, IS; Taya, Y	1
Okuyama, A; Someya, A; Tanaka, N	1
Higashi, H; Kitagawa, M; Kokubo, T; Matsumoto, H; Ogino, H; Okabe, T; Saitoh, S; Suzuki-Takahashi, I; Taya, Y; Yasuda, H	1
Mabuchi, I; Mishima, M	1
Nakamura, T; Nishimura, S; Okuyama, A; Shibata, Y	1
Himi-Nakamura, E; Hosoya, H; Iwata, K; Komatsu, S; Sakai, H; Tezuka, A; Totsukawa, G; Yazaki, K	1
Akiyama, T; Chigira, M; Dobashi, Y; Kameya, T; Kitagawa, M; Shoji, M; Tamauchi, H; Wakata, Y	1
Akiyama, T; Nakajima, M; Okuyama, A	1
Hisanaga, S; Honma, N; Hosono, Y; Kishimoto, T	1
Bulinski, JC; Chari, S; Hisanaga, S; Kishimoto, T; Kitazawa, H; Murofushi, H; Okuyama, A; Ookata, K; Sugita, M	1
Eckhart, W; Jiang, W; Kanemitsu, MY	1
Lu, Y; Takebe, H; Yagi, T; Yamagishi, N	1
Meijer, L	1
Ikeda, K; Izawa, H; Miyoshi, H; Monden, M; Monden, T; Ohnishi, T; Sekimoto, M; Tomita, N; Tsujie, M; Yamamoto, H	1
Coffman, AD; Parsons, SJ; Schimmel, TG	1
Eskin, A; Sankrithi, N	1
Arima, S; Furumai, R; Hayashi, M; Horinouchi, S; Inokoshi, J; Katagiri, M; Kim, YB; Omura, S; Tanaka, H; Yoshida, M	1
Hayashi, K; Matsumoto, Y; Nishida, E	1
First, NL; Fulka, J; Fulka1, J; Moor, RM	1
Goto, T; Hosaka, Y; Kawabe, K; Kitamura, T; Matsushima, H; Suzuki, M	1
Kato, G; Maeda, S	1
Kubelka, M; Motlík, J; Pavlok, A; Schultz, RM	1
Anger, M; Carnwath, JW; Kues, WA; Motlik, J; Niemann, H; Paul, D	1
Arata, Y; Fujita, M; Kato, JY; Kijima, S; Ohtani, K	1
Kalab, P; Kalous, J; Kubelka, M; Motlik, J; Pavlok, A	1
Boland, M; Dinnyes, A; Fair, T; Lonergan, P; Yang, X	1
Nagyová, E; Procházka, R; Vanderhyden, BC	1
Kanka, J; Motlík, J; Pavlok, A; Vodicka, P	1
Bang, OS; Franke, TF; Kang, SS; Lee, SR; Park, EK; Yang, SI	1
Iwamatsu, A; Nishida, E; Shinya, N; Taniguchi, E; Toyoshima-Morimoto, F	1
Miyata, Y; Nagano, M; Piao, Z; Suzuki, H; Ui-Tei, K	1
Lu, Y; Takebe, H; Yagi, T	1
Faerge, I; Hyttel, P; Mayes, M; Sirard, MA	1
Imai, H; Minami, N; Ohashi, A	1
Crotti, G; Galli, C; Lagutina, I; Lazzari, G; Ponderato, N; Turini, P	1
Bonk, A; Cabot, R; Day, BN; Lai, L; Park, KW; Prather, RS; Schatten, H; Sun, QY; Wu, GM	1
Kusiak, JW; Wang, X; Wei, W	1
Choi, YH; Hinrichs, K; Love, CC; Reinoehl, C; Varner, DD; Wiggins, CN	1
Anger, M; Kalous, J; Kubelka, M; Motlík, J; Pavlok, A; Schultz, RM	1
Fischer, A; Radulovic, J; Sananbenesi, F; Schrick, C; Spiess, J	2
Hashimoto, S; Imai, H; Minami, N; Takakura, R	1
Day, BN; Didion, BA; Lai, L; Mao, J; McCauley, TC; Park, KW; Prather, RS; Sun, QY; Wu, GM	1
Crotti, G; Duchi, R; Galli, C; Lazzari, G; Ponderato, N; Turini, P	1
Boland, M; Fair, T; Hyttel, P; Lonergan, P; Motlik, J	1
Anger, M; Kalous, J; Kubelka, M; Motlík, J; Schultz, RM	1
Boland, M; Faerge, I; Fair, T; Hyttel, PM; Lonergan, P	1
Hirata, M; Ishizaka, Y; Minemoto, Y; Nakagama, H; Ohtsubo, M; Sasagawa, T; Shimura, M; Uchida, S; Yamashita, K	1
Goto, T; Hosaka, Y; Kasuya, Y; Kitamura, T; Matsushima, H; Okuyama, A	1
Le Beux, G; Richard, FJ; Sirard, MA	1
Beaujean, N; Brochard, V; Cherifi, Y; Cozzi, J; Fraichard, A; Le Friec, G; Renard, JP; Zhou, Q	1
Bjerregaard, B; Hozak, P; Laurincik, J; Maddox-Hyttel, P; Motlik, J; Niemann, H; Philimonenko, VV; Wrenzycki, C	1
Hirao, Y; Kure-bayashi, S; Masuda, H; Nagai, T; Nishimoto, N; Takenouchi, N; Yamauchi, N	1
Bing, Y; Che, L; Hirao, Y; Nagai, T; Rodríguez-Martínez, H; Takenouchi, N	1
Handel, MA; Inselman, A	1
Juang, JL; Lin, H; Wang, PS	1
Beaman-Hall, CM; Mathur, A; Monaco, EA; Vallano, ML	1
Braña, MF; de Pascual-Teresa, B; Domínguez, MT; García, ML; López, B; Pozuelo, JM; Ramos, A	1
Donnay, I; Faerge, I; Galli, C; Grøndahl, C; Lazzari, G; Ponderato, N; Sayoud, H; Verhaeghe, B	1
Abdel-Kader, O; Ghozlan, H; Hassan, M	1
Aubel, D; de Jesus, M; El-Baba, MD; Fussenegger, M; Keller, B; Malphettes, L; Schoenmakers, R; Spielmann, M; van de Wetering, P; Weber, CC; Weber, W; Wurm, FM	1
Adona, PR; Lima Verde Leal, C	1
Baran, V; Kalous, J; Kubelka, M; Motlik, J; Schultz, RM; Solc, P	1
Jelínková, L; Kubelka, M	1
Armstrong, DT; Fung, M; Grupen, CG	1
Assumpção, ME; Caetano, HV; de Oliveira, VP; Marques, MG; Mello, MR; Mendes, CM; Milazzotto, MP; Nascimento, AB; Nicacio, AC; Visintin, JA	1
Chiou, CM; Ju, JC; Sha, SW; Tang, PC; Weng, YC; Yang, JH	1
Bhojwani, M; Kanitz, W; Rudolph, E; Schneider, F; Tomek, W; Zuehlke, H	1
Jávor, A; Lee, K; Macháty, Z; Nánássy, L	2
Fischer, A; Neve, R; Radulovic, J; Sananbenesi, F; Schrick, C; Tsai, LH; Wang, X	1
Adona, PR; Leal, CL; Pires, PR; Quetglas, MD; Schwarz, KR	2
Phattanawasin, P; Piyapolrungroj, N; Pojchanakom, K; Sotanaphun, U; Zungsontiporn, S	1
Dahse, HM; Grabley, S; Lozach, O; Meijer, L; Menzel, KD; Niu, X; Sattler, I; Walther, G	1
Handel, MA; Sun, F	1
Hanna, C; Kraemer, D; Long, CR; Menges, S	1
Adona, PR; Ferreira, EM; Ferriani, RA; Navarro, PA; Vireque, AA	1
Adona, PR; de Bem, TH; Leal, CL; Pires, PR; Quetglas, MD	1
Abe, N; Hirota, A; Sugiyama, Y; Yoshida, K	1
Cameron, DJ; Shaver, MP	1
Adona, PR; Bressan, FF; Chiaratti, MR; De Bem, TH; Fantinato-Neto, P; Leal, CL; Meirelles, FV; Miranda, MS; Perecin, F; Pimentel, JR; Pires, PR; Rochetti, R; Sampaio, RV; Sangalli, JR; Schwartz, KR; Smith, LC	1
Fair, T; Leal, CL; Lonergan, P; Mamo, S	1
Akagi, S; Hirao, Y; Iga, K; Naruse, K; Shimizu, M; Somfai, T; Takenouchi, N	1
Jin, X; Kong, X; Li, G; Liu, T; Wang, L	1
Bizukojc, M; Boruta, T	1
Guaitolini, CR; Guastali, MD; Kievitsbosch, T; Landim-Alvarenga, FC; Maziero, RR; Moraes, CN; Paschoal, DM	1
Chen, F; Figliozzi, RW; Hsia, SV; Kharel, MK; Martin-Caraballo, M; Rochford, K; Waguespack, Y; Zhang, Q	1
An, X; Bai, J; Chen, G; Chen, SF; Feng, BM; Hua, HM; Pei, YH; Wang, HF	1
Brissow, E; da Silva, IP; Damasceno, JL; de Siqueira, KA; Januário, AH; Junior, PA; Kellner Filho, LC; Magalhães, LG; Mendes, SA; Senabio, J; Soares, MA; Tavares, DC; Vandresen Filho, S	1
El-Metwally, MM; Frese, M; Hamed, A; Ismail, M; Sewald, N; Shaaban, M; Stammler, HG	1
Cao, MJ; Gao, YY; Lin, WX; Liu, B; Liu, GM; Liu, H; Liu, QM; Su, WJ; Xie, CL; Yang, XW	1
Lei, XL; Qian, ZJ; Yao, YB; Zhang, Y; Zhang, YY	1
Jia, A; Liu, C; Liu, X; Qi, J; Xia, X; Zhang, L; Zhang, Y; Zhao, B; Zhao, P	1
Lin, Y; Liu, YH; Lu, YJ; Luo, XW; Zhou, XF	1
Crespilho, AM; Guaitolini, CRF; Landim-Alvarenga, FDC; Lima, JS; Maziero, RRD; Monteiro, BA; Paschoal, DM; Sestari, DAO	1
Ahn, S; An, S; Han, BW; Jang, DM; Noh, M; Park, SC; Shin, J	1
Gerwick, L; Gerwick, WH; Glukhov, E; Lei, XL; Liu, YY; Ma, XX; Nie, YY; Yang, JM; Yang, WC; Zhang, Y	1
Bai, K; Fan, C; He, J; Hong, B; Le, Q; Niu, S; Tang, C; Xiao, M	1
Coporo-Blancas, D; Morales-Jiménez, J; Rivera-Chávez, J	1
Devi, P; Parvatkar, R; Singh, KS; Tilvi, S	1
Chen, G; Wu, L; Xie, CL; Yang, XW	1
Tian-Qi, C; Yan-Fang, D; Yan-Yan, W; Yong-Hui, Z	1
Chen, W; Gu, T; Huang, J; She, J; Tang, L; Tao, H; Yang, B; Zhou, X	1

Reviews

4 review(s) available for 4-butyrolactone and butyrolactone i

Article	Year
[CDK and MMP inhibitors]. Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:11 Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Colonic Neoplasms; Cyclin-Dependent Kinases; Dipeptides; Doxorubicin; Enzyme Inhibitors; Fibrosarcoma; Humans; Metalloendopeptidases; Mice; Mice, Nude; Protease Inhibitors; Succinates	1997
Chemical inhibitors of cyclin-dependent kinases. Progress in cell cycle research, 1995, Volume: 1 Topics: 4-Butyrolactone; Animals; Cell Cycle; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Humans; Kinetin; Piperidines; Purines; Staurosporine; Suramin	1995
Interplay between CDC2 kinase and MAP kinase pathway during maturation of mammalian oocytes. Theriogenology, 1998, Jan-15, Volume: 49, Issue:2 Topics: 4-Butyrolactone; Animals; Cattle; CDC2 Protein Kinase; Enzyme Inhibitors; Female; Fertilization in Vitro; Mammals; Meiosis; Mitogen-Activated Protein Kinases; Oocytes; Oogenesis; Swine	1998
Aliphatic polyester polymer stars: synthesis, properties and applications in biomedicine and nanotechnology. Chemical Society reviews, 2011, Volume: 40, Issue:3 Topics: 4-Butyrolactone; Caproates; Dendrimers; Dioxanes; Lactones; Nanotechnology; Polyesters; Polyglycolic Acid	2011

Other Studies

102 other study(ies) available for 4-butyrolactone and butyrolactone i

Article	Year
Porcine brain neurofilament-H tail domain kinase: its identification as cdk5/p26 complex and comparison with cdc2/cyclin B kinase. Cell motility and the cytoskeleton, 1995, Volume: 31, Issue:4 Topics: 4-Butyrolactone; Amino Acid Sequence; Animals; Brain; CDC2 Protein Kinase; Cell Fractionation; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Maturation-Promoting Factor; Microtubules; Molecular Sequence Data; Nerve Tissue Proteins; Neurofilament Proteins; Paclitaxel; Phosphorylation; Protein Serine-Threonine Kinases; Substrate Specificity; Swine	1995
Evidence for cdk5 as a major activity phosphorylating tau protein in porcine brain extract. Journal of biochemistry, 1995, Volume: 117, Issue:4 Topics: 4-Butyrolactone; Adenosine Triphosphate; Animals; Blotting, Western; Brain; Brain Chemistry; CDC2 Protein Kinase; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Electrophoresis; Enzyme Inhibitors; Ethers, Cyclic; Guanosine Triphosphate; Microtubules; Okadaic Acid; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Serine; Swine; tau Proteins; Tissue Extracts	1995
A cyclin-dependent kinase inhibitor, butyrolactone I, inhibits phosphorylation of RB protein and cell cycle progression. Oncogene, 1994, Volume: 9, Issue:9 Topics: 4-Butyrolactone; Cell Cycle; Cell Line; Histones; Humans; Phosphorylation; Protein Kinase Inhibitors; Retinoblastoma Protein; Thymidine	1994
Inhibition of cell cycle oscillation of DNA replication by a selective inhibitor of the cdc2 kinase family, butyrolactone I, in Xenopus egg extracts. Biochemical and biophysical research communications, 1994, Jan-28, Volume: 198, Issue:2 Topics: 4-Butyrolactone; Animals; CDC2 Protein Kinase; Cell Cycle; Cell-Free System; DNA Replication; Dose-Response Relationship, Drug; Ovum; Periodicity; Xenopus	1994
Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase. Oncogene, 1993, Volume: 8, Issue:9 Topics: 4-Butyrolactone; Amino Acid Sequence; Aspergillus; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Histones; In Vitro Techniques; Kinetics; Molecular Sequence Data; Nuclear Proteins; Protamine Kinase; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Retinoblastoma Protein; Substrate Specificity	1993
Cell cycle-dependent phosphorylation of smooth muscle myosin light chain in sea urchin egg extracts. Journal of biochemistry, 1996, Volume: 119, Issue:5 Topics: 4-Butyrolactone; Animals; Calcium; CDC2 Protein Kinase; Cell Cycle; Cell Extracts; Chickens; Chromatography, Ion Exchange; Egtazic Acid; Maturation-Promoting Factor; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Kinase; Ovum; Phosphorylation; Protein Kinase C; Sea Urchins	1996
p53-independent induction of apoptosis by cyclin-dependent kinase inhibition. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1996, Volume: 7, Issue:7 Topics: 4-Butyrolactone; Apoptosis; Cell Line; Cyclin-Dependent Kinases; Enzyme Inhibitors; Gene Expression Regulation; Humans; Tumor Suppressor Protein p53	1996
Mitosis-specific phosphorylation of smooth muscle regulatory light chain of myosin II at Ser-1 and/or -2 and Thr-9 in sea urchin egg extract. Cell structure and function, 1996, Volume: 21, Issue:6 Topics: 4-Butyrolactone; Animals; Binding Sites; Cell Cycle; Chickens; Enzyme Inhibitors; Gizzard, Avian; Metaphase; Mitosis; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Kinase; Ovum; Phosphorylation; Protein Kinase C; Sea Urchins; Serine; Threonine	1996
Cell cycle control with minimal participation of Cdk2 in a murine fibrosarcoma clone cultured in protein-free medium. Biochemical and biophysical research communications, 1997, Mar-27, Volume: 232, Issue:3 Topics: 4-Butyrolactone; Animals; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cell Separation; Culture Media, Serum-Free; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Fibrosarcoma; Flow Cytometry; Mice; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Tumor Cells, Cultured	1997
Phosphorylation of retinoblastoma protein at apoptotic cell death in rat neuroblastoma B50 cells. Neuroscience letters, 1997, Oct-10, Volume: 235, Issue:1-2 Topics: 4-Butyrolactone; Animals; Apoptosis; Bucladesine; Cyclin-Dependent Kinases; Cycloheximide; Enzyme Inhibitors; Neuroblastoma; Phosphorylation; Protein Kinase Inhibitors; Rats; Retinoblastoma Protein; Time Factors; Tumor Cells, Cultured	1997
MAP4 is the in vivo substrate for CDC2 kinase in HeLa cells: identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4. Biochemistry, 1997, Dec-16, Volume: 36, Issue:50 Topics: 4-Butyrolactone; Binding Sites; Blotting, Western; CDC2 Protein Kinase; Cell Cycle; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; HeLa Cells; Humans; Microtubule-Associated Proteins; Microtubules; Mitosis; Peptide Mapping; Phosphopeptides; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Serine Endopeptidases; Thymidine	1997
Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosis. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1998, Volume: 9, Issue:1 Topics: 4-Butyrolactone; Amino Acid Sequence; Animals; Binding Sites; CDC2 Protein Kinase; Cell Line; Connexin 43; Cyclin B; Enzyme Inhibitors; Mitosis; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Rats	1998
Mutated p21(WAF1/CIP1/SDI1) lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells. Oncogene, 1998, Feb-12, Volume: 16, Issue:6 Topics: 4-Butyrolactone; Apoptosis; CDC2-CDC28 Kinases; Cell Survival; Colorectal Neoplasms; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Doxorubicin; Enzyme Inhibitors; Humans; Isopropyl Thiogalactoside; Mimosine; Mutation; Proliferating Cell Nuclear Antigen; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Tumor Cells, Cultured; X-Rays	1998
Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells. International journal of oncology, 1998, Volume: 13, Issue:2 Topics: 4-Butyrolactone; Adenoma; Antineoplastic Agents; Apoptosis; Carcinoma; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Division; Colonic Neoplasms; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Protein Serine-Threonine Kinases; Tumor Cells, Cultured	1998
Effect of butyrolactone I on the producing fungus, Aspergillus terreus. Applied and environmental microbiology, 1998, Volume: 64, Issue:10 Topics: 4-Butyrolactone; Aspergillus; Kinetics; Lovastatin; Spores, Fungal; Time Factors	1998
Effects of cyclin-dependent kinase inhibitors on transcription and ocular circadian rhythm of Aplysia. Journal of neurochemistry, 1999, Volume: 72, Issue:2 Topics: 4-Butyrolactone; Action Potentials; Animals; Aplysia; Circadian Rhythm; Cyclin-Dependent Kinases; Electrophysiology; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kinetin; Macromolecular Substances; Neural Conduction; Ocular Physiological Phenomena; Purines; RNA, Messenger; Roscovitine; Transcription, Genetic	1999
Neuronal differentiation of neuro 2a cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I. Biochemical and biophysical research communications, 1999, Mar-16, Volume: 256, Issue:2 Topics: 4-Butyrolactone; Acetylcholinesterase; Animals; Blotting, Western; Cell Cycle; Cell Differentiation; Cell Size; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Immunohistochemistry; Mice; Neurites; Neurons; Tumor Cells, Cultured	1999
Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells. Current biology : CB, 1999, Apr-22, Volume: 9, Issue:8 Topics: 4-Butyrolactone; Animals; CDC2-CDC28 Kinases; Cell Cycle; Centrosome; CHO Cells; Cricetinae; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; G1 Phase; Gene Expression; Hydroxyurea; Mimosine; Protein Serine-Threonine Kinases; Purines; Roscovitine; S Phase	1999
Checkpoint control of the G2/M phase transition during the first mitotic cycle in mammalian eggs. Human reproduction (Oxford, England), 1999, Volume: 14, Issue:6 Topics: 4-Butyrolactone; Adenine; Animals; Cyclin-Dependent Kinases; DNA; Enzyme Inhibitors; Female; G1 Phase; G2 Phase; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mitosis; Oocytes; Zygote	1999
Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines. Cancer letters, 1999, Apr-26, Volume: 138, Issue:1-2 Topics: 4-Butyrolactone; Cell Survival; Cyclin B; Cyclin B1; Cyclin-Dependent Kinases; DNA, Neoplasm; Enzyme Inhibitors; G2 Phase; Humans; Male; Mitosis; Prostatic Neoplasms; Tumor Cells, Cultured	1999
Neuron-specific Cdk5 kinase is responsible for mitosis-independent phosphorylation of c-Src at Ser75 in human Y79 retinoblastoma cells. Journal of biochemistry, 1999, Volume: 126, Issue:5 Topics: 4-Butyrolactone; Binding Sites; CSK Tyrosine-Protein Kinase; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; DNA, Antisense; Enzyme Inhibitors; Humans; Mitosis; Neurons; Phosphorylation; Protein-Tyrosine Kinases; Retinoblastoma; Serine; src-Family Kinases; Transfection; Tumor Cells, Cultured	1999
Butyrolactone I reversibly inhibits meiotic maturation of bovine oocytes,Without influencing chromosome condensation activity. Biology of reproduction, 2000, Volume: 62, Issue:2 Topics: 4-Butyrolactone; Animals; Blotting, Western; Cattle; CDC2 Protein Kinase; Cells, Cultured; Chromatin; Chromosomes; Culture Media; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Fertilization; Follicular Fluid; Germinal Center; Male; Meiosis; Mitogen-Activated Protein Kinases; Myelin Basic Protein; Oocytes; Protein Kinases; Spermatozoa; Tissue Fixation	2000
Cell cycle synchronization of porcine fetal fibroblasts: effects of serum deprivation and reversible cell cycle inhibitors. Biology of reproduction, 2000, Volume: 62, Issue:2 Topics: 4-Butyrolactone; Animals; Aphidicolin; Bromodeoxyuridine; Cell Cycle; Cell Cycle Proteins; Cell Survival; Cells, Cultured; Culture Media, Serum-Free; DNA Fragmentation; Enzyme Inhibitors; Fetus; Fibroblasts; Flow Cytometry; In Situ Nick-End Labeling; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine; Transcription, Genetic	2000
Cdk2-dependent and -independent pathways in E2F-mediated S phase induction. The Journal of biological chemistry, 2000, Mar-03, Volume: 275, Issue:9 Topics: 3T3 Cells; 4-Butyrolactone; Animals; Base Sequence; Carrier Proteins; CDC2-CDC28 Kinases; Cell Cycle Proteins; Chromatin; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cyclins; DNA Replication; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Humans; Interphase; Mice; Minichromosome Maintenance Complex Component 4; Minichromosome Maintenance Complex Component 7; Molecular Sequence Data; Nuclear Proteins; Protein Binding; Protein Serine-Threonine Kinases; Retinoblastoma-Binding Protein 1; RNA, Messenger; S Phase; Transcription Factor DP1; Transcription Factors; Transcriptional Activation; Transfection	2000
Bovine oocyte and embryo development following meiotic inhibition with butyrolactone I. Molecular reproduction and development, 2000, Volume: 57, Issue:2 Topics: 4-Butyrolactone; Animals; Cattle; Cyclin-Dependent Kinases; Embryonic and Fetal Development; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Meiosis; Oocytes	2000
Secretion of paracrine factors enabling expansion of cumulus cells is developmentally regulated in pig oocytes. Biology of reproduction, 2000, Volume: 63, Issue:4 Topics: 4-Butyrolactone; Animals; Cells, Cultured; Culture Media, Conditioned; Cyclin B; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; Follicle Stimulating Hormone; Histones; Hyaluronic Acid; Meiosis; Mice; Mice, Inbred ICR; Oocytes; Ovarian Follicle; Paracrine Communication; Swine	2000
Culture of bovine oocytes from small antral follicles in meiosis-inhibiting medium with butyrolactone I: RNA synthesis, nucleolar morphology and meiotic competence. Animal reproduction science, 2000, Dec-01, Volume: 64, Issue:1-2 Topics: 4-Butyrolactone; Animals; Cattle; Cell Nucleolus; Enzyme Inhibitors; Female; Image Processing, Computer-Assisted; Meiosis; Methylene Blue; Microscopy, Electron; Oocytes; Ovarian Follicle; Protein Kinase Inhibitors; RNA	2000
Overexpression of Akt inhibits NGF-induced growth arrest and neuronal differentiation of PC12 cells. Journal of cell science, 2001, Volume: 114, Issue:Pt 1 Topics: 4-Butyrolactone; Animals; CDC2 Protein Kinase; Cell Differentiation; Cell Division; Colforsin; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Gene Expression; Nerve Growth Factor; Neurites; Neurons; Nitroprusside; PC12 Cells; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats	2001
Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase. Nature, 2001, Mar-08, Volume: 410, Issue:6825 Topics: 4-Butyrolactone; Animals; Butadienes; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Nucleus; Cyclin B; Cyclin B1; Enzyme Inhibitors; HeLa Cells; Humans; MAP Kinase Kinase Kinase 1; Mitosis; Mutation; Nitriles; Phosphorylation; Polo-Like Kinase 1; Precipitin Tests; Prophase; Protein Kinases; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Xenopus; Xenopus Proteins	2001
CDK inhibitors suppress apoptosis induced by chemicals and by excessive expression of a cell death gene, reaper, in Drosophila cells. Apoptosis : an international journal on programmed cell death, 2000, Volume: 5, Issue:6 Topics: 4-Butyrolactone; Animals; Apoptosis; Cells, Cultured; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Drosophila melanogaster; Drosophila Proteins; Enzyme Inhibitors; Gene Expression Regulation; Kinetin; Peptides; Purines; Time Factors	2000
Inhibition of X-ray and doxorubicin-induced apoptosis by butyrolactone I, a CDK-specific inhibitor, in human tumor cells. Journal of radiation research, 2000, Volume: 41, Issue:4 Topics: 4-Butyrolactone; Antibiotics, Antineoplastic; Apoptosis; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Doxorubicin; Enzyme Inhibitors; Humans; Signal Transduction; Tumor Cells, Cultured; X-Rays	2000
Nuclear ultrastructure in bovine oocytes after inhibition of meiosis by chemical and biological inhibitors. Molecular reproduction and development, 2001, Volume: 59, Issue:4 Topics: 4-Butyrolactone; Adenine; Animals; Antineoplastic Agents; Cattle; Cell Nucleolus; Cell Nucleus; Cells, Cultured; Cycloheximide; Enzyme Inhibitors; Female; Meiosis; Microscopy, Electron; Nuclear Envelope; Oocytes; Protein Synthesis Inhibitors; Purines; Roscovitine	2001
Nuclear accumulation of cyclin B1 in mouse two-cell embryos is controlled by the activation of Cdc2. Biology of reproduction, 2001, Volume: 65, Issue:4 Topics: 4-Butyrolactone; Animals; CDC2 Protein Kinase; Cell Cycle; Cell Nucleus; Cyclin B; Cyclin B1; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; G2 Phase; Immunoblotting; Male; Mice; Mice, Inbred ICR; Mitosis; Okadaic Acid; S Phase	2001
Bovine oocytes treated prior to in vitro maturation with a combination of butyrolactone I and roscovitine at low doses maintain a normal developmental capacity. Molecular reproduction and development, 2001, Volume: 60, Issue:4 Topics: 4-Butyrolactone; Animals; Cattle; Cell Nucleus; Drug Synergism; Embryo, Mammalian; Embryonic and Fetal Development; Female; Freezing; In Vitro Techniques; Meiosis; Oocytes; Purines; Roscovitine; Survival Rate; Time Factors	2001
Regulation of mitogen-activated protein kinase phosphorylation, microtubule organization, chromatin behavior, and cell cycle progression by protein phosphatases during pig oocyte maturation and fertilization in vitro. Biology of reproduction, 2002, Volume: 66, Issue:3 Topics: 4-Butyrolactone; Animals; Cell Cycle; Chromatin; Cleavage Stage, Ovum; Enzyme Activation; Enzyme Inhibitors; Female; Fertilization in Vitro; Maturation-Promoting Factor; Meiosis; Metaphase; Microtubules; Mitogen-Activated Protein Kinases; Nuclear Envelope; Okadaic Acid; Oocytes; Phosphoprotein Phosphatases; Phosphorylation; Spindle Apparatus; Swine	2002
Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection. The Journal of biological chemistry, 2002, May-17, Volume: 277, Issue:20 Topics: 4-Butyrolactone; Amyloid beta-Peptides; Cell Death; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Enzyme Activation; Humans; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroblastoma; Neurons; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Signal Transduction; Tumor Cells, Cultured; Virulence Factors, Bordetella	2002
Suppression of meiosis by inhibitors of m-phase proteins in horse oocytes with low meiotic competence. Zygote (Cambridge, England), 2002, Volume: 10, Issue:1 Topics: 4-Butyrolactone; Adenine; Animals; Chromatin; Dimethyl Sulfoxide; Horses; Meiosis; Oocytes; Oogenesis; Purines; Roscovitine	2002
Activation of pig and cattle oocytes by butyrolactone I: morphological and biochemical study. Zygote (Cambridge, England), 2002, Volume: 10, Issue:1 Topics: 4-Butyrolactone; Animals; Blotting, Western; Cattle; CDC2 Protein Kinase; Cells, Cultured; Cyclin-Dependent Kinases; Histones; Mitogen-Activated Protein Kinases; Myelin Basic Protein; Oocytes; Swine	2002
Cyclin-dependent kinase 5 is required for associative learning. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, May-01, Volume: 22, Issue:9 Topics: 4-Butyrolactone; Animals; Association Learning; Cholinergic Fibers; Conditioning, Psychological; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Enzyme Inhibitors; Exercise Test; Fear; Gene Expression Profiling; Hippocampus; Immunohistochemistry; In Situ Hybridization; Male; Mice; Mice, Inbred BALB C; Microinjections; Neurons; Restraint, Physical; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Septum of Brain; Stress, Physiological; Up-Regulation	2002
Bovine immature oocytes acquire developmental competence during meiotic arrest in vitro. Biology of reproduction, 2002, Volume: 66, Issue:6 Topics: 4-Butyrolactone; Animals; Blastocyst; Cattle; Cell Nucleus; Cells, Cultured; Culture Media; Female; Fertilization in Vitro; Fetal Blood; Kinetics; Meiosis; Oocytes; Oxygen; Serum Albumin, Bovine; Tissue and Organ Harvesting	2002
High developmental competence of pig oocytes after meiotic inhibition with a specific M-phase promoting factor kinase inhibitor, butyrolactone I. Biology of reproduction, 2002, Volume: 67, Issue:1 Topics: 4-Butyrolactone; Actin Cytoskeleton; Animals; Cell Nucleus; Chromatin; Cytoplasm; Embryonic and Fetal Development; Enzyme Activation; Enzyme Inhibitors; Female; Fertilization in Vitro; Maturation-Promoting Factor; Meiosis; Microscopy, Confocal; Mitochondria; Mitogen-Activated Protein Kinases; Oocytes; Phosphorylation; Swine	2002
Embryonic and foetal development of bovine oocytes treated with a combination of butyrolactone I and roscovitine in an enriched medium prior to IVM and IVF. Molecular reproduction and development, 2002, Volume: 62, Issue:4 Topics: 4-Butyrolactone; Animals; Cattle; Drug Interactions; Embryonic and Fetal Development; Fertilization in Vitro; Freezing; Oocytes; Purines; Roscovitine	2002
Maintenance of meiotic arrest in bovine oocytes in vitro using butyrolactone I: effects on oocyte ultrastructure and nucleolus function. Molecular reproduction and development, 2002, Volume: 62, Issue:3 Topics: 4-Butyrolactone; Animals; Cattle; Cell Nucleolus; Cell Size; Female; In Vitro Techniques; Meiosis; Nuclear Proteins; Oocytes; Ovarian Follicle; Protein Kinase Inhibitors	2002
Chromosome condensation in pig oocytes: lack of a requirement for either cdc2 kinase or MAP kinase activity. Molecular reproduction and development, 2002, Volume: 63, Issue:1 Topics: 4-Butyrolactone; Animals; CDC2 Protein Kinase; Chromosomes; Cyclin-Dependent Kinases; Egg Proteins; Enzyme Activation; Enzyme Inhibitors; Female; Histones; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Okadaic Acid; Oocytes; Phosphoprotein Phosphatases; Swine	2002
Ultrastructural modifications in bovine oocytes maintained in meiotic arrest in vitro using roscovitine or butyrolactone. Molecular reproduction and development, 2003, Volume: 64, Issue:3 Topics: 4-Butyrolactone; Animals; Cattle; Cell Nucleus; Enzyme Inhibitors; Growth Inhibitors; Meiosis; Oocytes; Purines; Roscovitine; Zona Pellucida	2003
Loss of p53 induces M-phase retardation following G2 DNA damage checkpoint abrogation. Archives of biochemistry and biophysics, 2003, Apr-01, Volume: 412, Issue:1 Topics: 4-Butyrolactone; Antineoplastic Agents; Aphidicolin; Blotting, Western; Caffeine; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Humans; Mitosis; Oncogene Proteins, Viral; Phenotype; Protein Kinases; Protein Serine-Threonine Kinases; Repressor Proteins; S Phase; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2003
Prominent induction of cyclin B1 in G2/M renal cancer cells with butyrolactone 1. International journal of urology : official journal of the Japanese Urological Association, 2003, Volume: 10, Issue:6 Topics: 4-Butyrolactone; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Cyclin B; Cyclin B1; Cyclin-Dependent Kinases; Cyclins; DNA, Neoplasm; Enzyme Inhibitors; Humans; Kidney Neoplasms	2003
Regulation of contextual fear conditioning by baseline and inducible septo-hippocampal cyclin-dependent kinase 5. Neuropharmacology, 2003, Volume: 44, Issue:8 Topics: 4-Butyrolactone; Animals; Conditioning, Psychological; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Enzyme Inhibitors; Fear; Hippocampus; Immunoblotting; Immunohistochemistry; Male; Memory; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microinjections; Nerve Tissue Proteins; Precipitin Tests; Septum of Brain; Species Specificity; Transcription Factors	2003
Effect of cycloheximide, 6-DMAP, roscovitine and butyrolactone I on resumption of meiosis in porcine oocytes. Theriogenology, 2003, Oct-01, Volume: 60, Issue:6 Topics: 4-Butyrolactone; Adenine; Animals; Cells, Cultured; Cyclin-Dependent Kinases; Cycloheximide; Enzyme Inhibitors; Female; Meiosis; Oocytes; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Purines; Roscovitine; Swine	2003
Generation of fertile cloned rats by regulating oocyte activation. Science (New York, N.Y.), 2003, Nov-14, Volume: 302, Issue:5648 Topics: 4-Butyrolactone; Animals; Cells, Cultured; Cloning, Organism; Embryo Transfer; Enzyme Inhibitors; Female; Fertility; Leupeptins; Male; Meiosis; Microsatellite Repeats; Mitosis; Nuclear Transfer Techniques; Oocytes; Rats; Rats, Sprague-Dawley	2003
Regulation of ribosomal RNA synthesis during the final phases of porcine oocyte growth. Biology of reproduction, 2004, Volume: 70, Issue:4 Topics: 4-Butyrolactone; Animals; Autoradiography; Carrier Proteins; Cell Nucleolus; Enzyme Inhibitors; Meiosis; Microscopy, Electron; Nuclear Proteins; Oocytes; Pol1 Transcription Initiation Complex Proteins; RNA, Messenger; RNA, Ribosomal; Swine; Tissue Distribution	2004
Influence of meiotic inhibition by butyrolactone-I during germinal vesicle stage on the ability of porcine oocytes to be activated by electric stimulation after nuclear maturation. Zygote (Cambridge, England), 2003, Volume: 11, Issue:3 Topics: 4-Butyrolactone; Animals; Cell Nucleus; Cells, Cultured; Cytoplasm; Electric Stimulation; Enzyme Inhibitors; Female; Meiosis; Oocytes; Swine; Time Factors	2003
Parthenogenetic activation and subsequent development of porcine oocytes activated by a combined electric pulse and butyrolactone I treatment. The Journal of reproduction and development, 2003, Volume: 49, Issue:2 Topics: 4-Butyrolactone; Animals; Blastomeres; Cells, Cultured; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Oocytes; Oxygen; Parthenogenesis; Sus scrofa	2003
Mitogen-activated protein kinase dynamics during the meiotic G2/MI transition of mouse spermatocytes. Biology of reproduction, 2004, Volume: 71, Issue:2 Topics: 4-Butyrolactone; Animals; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Cells, Cultured; Enzyme Inhibitors; G2 Phase; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Meiosis; Mesothelin; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Okadaic Acid; Oncogene Proteins v-mos; Phosphorylation; Protein Kinase Inhibitors; Spermatocytes; Spermatogenesis	2004
Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis. The Journal of biological chemistry, 2004, Jul-09, Volume: 279, Issue:28 Topics: 4-Butyrolactone; Apoptosis; Calcium; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Digoxin; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Humans; Male; Nerve Tissue Proteins; Prostatic Neoplasms; Purines; RNA, Small Interfering; Roscovitine	2004
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons. Biochemical pharmacology, 2004, May-15, Volume: 67, Issue:10 Topics: 4-Butyrolactone; Animals; Apoptosis; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cerebellum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinases; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Kinetin; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Proto-Oncogene Proteins; Purines; Pyrimidines; Rats; Rats, Sprague-Dawley; Roscovitine; Signal Transduction; Sulfonamides	2004
Synthesis and biological evaluation of analogues of butyrolactone I and molecular model of its interaction with CDK2. Organic & biomolecular chemistry, 2004, Jul-07, Volume: 2, Issue:13 Topics: 4-Butyrolactone; Binding Sites; Cell Line, Tumor; Cell Proliferation; Esters; Humans; Models, Molecular; Protein Kinase Inhibitors; Protein Structure, Tertiary	2004
Effect of prematuration, meiosis activating sterol and enriched maturation medium on the nuclear maturation and competence to development of calf oocytes. Theriogenology, 2004, Sep-15, Volume: 62, Issue:6 Topics: 4-Butyrolactone; Animals; Cattle; Cell Nucleus; Culture Media; Cytoplasm; Embryonic and Fetal Development; Female; Fertilization in Vitro; Follicular Fluid; Glutathione; Growth Inhibitors; Meiosis; Oocytes; Ovarian Follicle; Purines; Roscovitine; Sterols	2004
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells. Cellular signalling, 2004, Volume: 16, Issue:12 Topics: 4-Butyrolactone; Blotting, Northern; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; DNA-Binding Proteins; DNA, Complementary; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; HeLa Cells; Hepacivirus; Humans; Liver; Luciferases; Phosphorylation; Plasmids; Protein Kinase Inhibitors; Retinoblastoma Protein; RNA; Signal Transduction; Tetrazolium Salts; Thiazoles; Thymidine; Transcription Factors; Tumor Suppressor Protein p53	2004
Engineered Streptomyces quorum-sensing components enable inducible siRNA-mediated translation control in mammalian cells and adjustable transcription control in mice. The journal of gene medicine, 2005, Volume: 7, Issue:4 Topics: 4-Butyrolactone; Animals; Base Sequence; Cell Line; Gene Expression Regulation; Genetic Engineering; Humans; Mice; Molecular Sequence Data; Oligonucleotides; Protein Biosynthesis; RNA, Small Interfering; Streptomyces; Transcription, Genetic; Transgenes	2005
Meiotic inhibition with different cyclin-dependent kinase inhibitors in bovine oocytes and its effects on maturation and embryo development. Zygote (Cambridge, England), 2004, Volume: 12, Issue:3 Topics: 4-Butyrolactone; Animals; Cattle; Cyclin-Dependent Kinases; Embryo, Mammalian; Meiosis; Oocytes; Purines; Roscovitine	2004
PKB/AKT is involved in resumption of meiosis in mouse oocytes. Biology of the cell, 2006, Volume: 98, Issue:2 Topics: 4-Butyrolactone; Animals; CDC2 Protein Kinase; Centrosome; Chromones; Enzyme Activation; Female; In Vitro Techniques; Meiosis; Mice; Morpholines; Nuclear Envelope; Okadaic Acid; Oocytes; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Serine; Threonine	2006
Neither Aurora B activity nor histone H3 phosphorylation is essential for chromosome condensation during meiotic maturation of porcine oocytes. Biology of reproduction, 2006, Volume: 74, Issue:5 Topics: 4-Butyrolactone; Animals; Aurora Kinases; Benzamides; Chromosomes; Cycloheximide; Female; Histones; In Vitro Techniques; Meiosis; Oocytes; Phosphorylation; Protein Serine-Threonine Kinases; Quinazolines; Swine	2006
Effects of milrinone and butyrolactone-I on porcine oocyte meiotic progression and developmental competence. Reproduction, fertility, and development, 2006, Volume: 18, Issue:3 Topics: 4-Butyrolactone; Animals; Cell Nucleus; Culture Media; Drug Interactions; Female; Follicle Stimulating Hormone; In Vitro Techniques; Meiosis; Milrinone; Oocytes; Oogenesis; Sus scrofa	2006
In vitro maturation of pig oocytes with different media, hormone and meiosis inhibitors. Animal reproduction science, 2007, Volume: 97, Issue:3-4 Topics: 4-Butyrolactone; Animals; Chorionic Gonadotropin; Culture Media; Cycloheximide; Dose-Response Relationship, Drug; Embryo Culture Techniques; Epidermal Growth Factor; Female; Fertilization in Vitro; Follicular Fluid; Gonadotropins, Equine; Meiosis; Microscopy, Fluorescence; Oocytes; Polyvinyl Alcohol; Protein Synthesis Inhibitors; Swine; Time Factors	2007
Butyrolactone I reversibly alters nuclear configuration, periooplasmic microtubules and development of porcine oocytes. Theriogenology, 2007, Volume: 67, Issue:3 Topics: 4-Butyrolactone; Animals; Cell Nucleus; Cells, Cultured; Chromatin; Dose-Response Relationship, Drug; Meiosis; Microtubules; Oocytes; Parthenogenesis; Protein Kinase Inhibitors; Swine; Time Factors	2007
Molecular analysis of maturation processes by protein and phosphoprotein profiling during in vitro maturation of bovine oocytes: a proteomic approach. Cloning and stem cells, 2006,Winter, Volume: 8, Issue:4 Topics: 4-Butyrolactone; Animals; Blotting, Western; Cattle; CDC2 Protein Kinase; Electrophoresis, Gel, Two-Dimensional; Female; Meiosis; Oocytes; Oogenesis; Phosphoproteins; Phosphorylation; Protein Array Analysis; Proteomics; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2006
Effects of activation methods and culture conditions on development of parthenogenetic porcine embryos. Animal reproduction science, 2008, Mar-03, Volume: 104, Issue:2-4 Topics: 4-Butyrolactone; Animals; Cell Culture Techniques; Culture Media; Cycloheximide; Electroporation; Embryonic Development; Female; Oocytes; Oxygen; Parthenogenesis; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Swine	2008
Changes in MPF and MAPK activities in porcine oocytes activated by different methods. Theriogenology, 2007, Jul-15, Volume: 68, Issue:2 Topics: 4-Butyrolactone; Animals; Cycloheximide; Electroporation; Female; Maturation-Promoting Factor; Mitogen-Activated Protein Kinases; Oocytes; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Swine	2007
A hippocampal Cdk5 pathway regulates extinction of contextual fear. Nature neuroscience, 2007, Volume: 10, Issue:8 Topics: 4-Butyrolactone; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Classical; Cyclin-Dependent Kinase 5; Dose-Response Relationship, Drug; Enzyme Activation; Extinction, Psychological; Fear; Gene Expression Regulation; Hippocampus; Mice; Mice, Inbred BALB C; Protein Kinase Inhibitors; Signal Transduction	2007
Nuclear maturation kinetics and in vitro embryo development of cattle oocytes prematured with butyrolactone I combined or not combined with roscovitine. Animal reproduction science, 2008, Mar-03, Volume: 104, Issue:2-4 Topics: 4-Butyrolactone; Animals; Cattle; Cell Culture Techniques; Culture Media; Embryonic Development; Female; Fertilization in Vitro; Male; Oocytes; Pregnancy; Protein Kinase Inhibitors; Purines; Roscovitine	2008
Prematuration of bovine oocytes with butyrolactone I: effects on meiosis progression, cytoskeleton, organelle distribution and embryo development. Animal reproduction science, 2008, Volume: 108, Issue:1-2 Topics: 4-Butyrolactone; Animals; Cattle; Cytoskeleton; Embryo, Mammalian; Embryonic Development; Fertilization in Vitro; Meiosis; Oocytes; Organelles	2008
Weed growth inhibitors from Aspergillus fischeri TISTR 3272. Natural product research, 2007, Volume: 21, Issue:14 Topics: 4-Butyrolactone; Aspergillus; Cyclopentanes; Diketopiperazines; Echinochloa; Herbicides; Isocoumarins; Mimosa; Molecular Structure; Ochratoxins; Peptides, Cyclic	2007
Butyrolactone I derivatives from Aspergillus terreus carrying an unusual sulfate moiety. Journal of natural products, 2008, Volume: 71, Issue:4 Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Aspergillus; Brain; CDC2 Protein Kinase; Cyclin-Dependent Kinase 5; Drug Screening Assays, Antitumor; Dyrk Kinases; Glycogen Synthase Kinase 3; Humans; Oocytes; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Starfish; Sulfates; Swine	2008
Regulation of the meiotic prophase I to metaphase I transition in mouse spermatocytes. Chromosoma, 2008, Volume: 117, Issue:5 Topics: 4-Butyrolactone; Animals; Aurora Kinases; Benzamides; Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; Cohesins; Cyclin-Dependent Kinases; Enzyme Inhibitors; Histones; Male; Meiotic Prophase I; Metaphase; Mice; Okadaic Acid; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; Spermatocytes	2008
Synchronisation of canine germinal vesicle stage oocytes prior to in vitro maturation alters the kinetics of nuclear progression during subsequent resumption of meiosis. Reproduction, fertility, and development, 2008, Volume: 20, Issue:5 Topics: 4-Butyrolactone; Animals; Antimitotic Agents; Cell Culture Techniques; Cell Nucleus; Cells, Cultured; Dogs; Drug Combinations; Estradiol; Female; Gonadotropins, Equine; Meiosis; Oocyte Retrieval; Oocytes; Oogenesis; Purines; Roscovitine	2008
Prematuration of bovine oocytes with butyrolactone I reversibly arrests meiosis without increasing meiotic abnormalities after in vitro maturation. European journal of obstetrics, gynecology, and reproductive biology, 2009, Volume: 145, Issue:1 Topics: 4-Butyrolactone; Animals; Cattle; Chromosomes; Dose-Response Relationship, Drug; Female; Meiosis; Microtubules; Models, Animal; Oocytes; Protein Kinase Inhibitors; Reproductive Techniques, Assisted; Spindle Apparatus	2009
Effect of cyclin-dependent kinase (CDK) inhibition on expression, localization and activity of maturation promoting factor (MPF) and mitogen activated protein kinase (MAPK) in bovine oocytes. Reproduction in domestic animals = Zuchthygiene, 2010, Volume: 45, Issue:6 Topics: 4-Butyrolactone; Animals; Cattle; Cyclin B1; Cyclin-Dependent Kinases; Gene Expression Regulation; Maturation-Promoting Factor; Mitogen-Activated Protein Kinase Kinases; Oocytes; RNA, Messenger	2010
Soybean lipoxygenase inhibitory and DPPH radical-scavenging activities of aspernolide A and butyrolactones I and II. Bioscience, biotechnology, and biochemistry, 2010, Volume: 74, Issue:4 Topics: 4-Butyrolactone; Biphenyl Compounds; Diet; Glycine max; Inorganic Chemicals; Lipoxygenase; Organic Chemicals; Picrates	2010
Viable calves produced by somatic cell nuclear transfer using meiotic-blocked oocytes. Cellular reprogramming, 2011, Volume: 13, Issue:5 Topics: 4-Butyrolactone; Animals; Blastocyst; Brain-Derived Neurotrophic Factor; Cattle; Cloning, Organism; Female; Gene Expression Regulation, Developmental; Interferon Type I; Meiosis; Nuclear Transfer Techniques; Octamer Transcription Factor-3; Oocytes; Pregnancy; Pregnancy Proteins; Protein Kinase Inhibitors	2011
Gene expression in bovine oocytes and cumulus cells after meiotic inhibition with the cyclin-dependent kinase inhibitor butyrolactone I. Reproduction in domestic animals = Zuchthygiene, 2012, Volume: 47, Issue:4 Topics: 4-Butyrolactone; Animals; Cattle; Cumulus Cells; Cyclin-Dependent Kinases; Female; Gene Expression; Gene Expression Profiling; In Vitro Oocyte Maturation Techniques; Meiosis; Oocytes; Protein Kinase Inhibitors; Real-Time Polymerase Chain Reaction; RNA, Messenger	2012
Milrinone treatment of bovine oocytes during in vitro maturation benefits production of nuclear transfer embryos by improving enucleation rate and developmental competence. The Journal of reproduction and development, 2012, Volume: 58, Issue:4 Topics: 4-Butyrolactone; Animals; Blastocyst; Cattle; Cellular Reprogramming; Cumulus Cells; Cyclin-Dependent Kinases; Cytoskeleton; Ectogenesis; Embryo Transfer; Female; In Vitro Oocyte Maturation Techniques; Metaphase; Milrinone; Nuclear Transfer Techniques; Oocytes; Osmolar Concentration; Phosphodiesterase 3 Inhibitors; Polar Bodies; Protein Kinase Inhibitors	2012
Hippocampal glycogen synthase kinase 3β is critical for the antidepressant effect of cyclin-dependent kinase 5 inhibitor in rats. Journal of molecular neuroscience : MN, 2014, Volume: 54, Issue:1 Topics: 4-Butyrolactone; Animals; Antidepressive Agents; Chromones; Cyclin-Dependent Kinase 5; Depression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Helplessness, Learned; Hippocampus; Indoles; Male; Maleimides; Morpholines; Purines; Rats; Rats, Sprague-Dawley; Roscovitine	2014
Induction of secondary metabolism of Aspergillus terreus ATCC 20542 in the batch bioreactor cultures. Applied microbiology and biotechnology, 2016, Volume: 100, Issue:7 Topics: 4-Butyrolactone; Anthraquinones; Aspergillus; Batch Cell Culture Techniques; Benzofurans; Biomass; Bioreactors; Chromatography, High Pressure Liquid; Cyclopentanes; Fatty Acids, Monounsaturated; Fermentation; Inulin; Lovastatin; Phenyl Ethers; Pyridones; Rapeseed Oil; Secondary Metabolism	2016
Effect of Temporary Meiotic Attenuation of Oocytes with Butyrolactone I and Roscovitine in Resistance to Bovine Embryos on Vitrification. Reproduction in domestic animals = Zuchthygiene, 2016, Volume: 51, Issue:2 Topics: 4-Butyrolactone; Animals; Apoptosis; Cattle; Cell Cycle Checkpoints; Drug Therapy, Combination; Embryo Culture Techniques; Meiosis; Protein Kinase Inhibitors; Purines; Roscovitine	2016
Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells. PloS one, 2016, Volume: 11, Issue:8 Topics: 4-Butyrolactone; Animals; Chlorocebus aethiops; Gas Chromatography-Mass Spectrometry; Herpes Simplex; Herpesvirus 1, Human; Humans; Membrane Potentials; Microscopy, Fluorescence; Neurons; Reverse Transcriptase Polymerase Chain Reaction; Vero Cells; Virus Replication	2016
Isolation and identification of phase I metabolites of butyrolactone I in rats. Xenobiotica; the fate of foreign compounds in biological systems, 2017, Volume: 47, Issue:3 Topics: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Rats; Rats, Wistar; Staphylococcus aureus	2017
Bioactive compounds of Aspergillus terreus-F7, an endophytic fungus from Hyptis suaveolens (L.) Poit. World journal of microbiology & biotechnology, 2017, Volume: 33, Issue:3 Topics: 4-Butyrolactone; Animals; Anthelmintics; Antineoplastic Agents; Antiprotozoal Agents; Aspergillus; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclopentanes; Endophytes; Furans; Humans; Hyptis; Lactones; Leishmania; MCF-7 Cells; Schistosoma	2017
X-ray, structural assignment and molecular docking study of dihydrogeodin from Aspergillus Terreus TM8. Natural product research, 2019, Volume: 33, Issue:1 Topics: 4-Butyrolactone; Antiviral Agents; Aspergillus; Benzofurans; Benzophenones; Crystallography, X-Ray; Cyclophilin A; Immunosuppressive Agents; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure	2019
Deep-Sea-Derived Butyrolactone I Suppresses Ovalbumin-Induced Anaphylaxis by Regulating Mast Cell Function in a Murine Model. Journal of agricultural and food chemistry, 2018, Jun-06, Volume: 66, Issue:22 Topics: 4-Butyrolactone; Anaphylaxis; Animals; Aspergillus; Cells, Cultured; Disease Models, Animal; Female; Food Hypersensitivity; Histamine; Humans; Immunoglobulin E; Mast Cells; Mice; Mice, Inbred BALB C; Ovalbumin; Proto-Oncogene Proteins c-kit; Seawater	2018
Butyrolactone-I from Coral-Derived Fungus Marine drugs, 2018, Jun-07, Volume: 16, Issue:6 Topics: 4-Butyrolactone; Animals; Anthozoa; Anti-Inflammatory Agents; Aspergillus; Cell Line; Cyclooxygenase 2; I-kappa B Proteins; Inflammation; Interleukin-1beta; Lipopolysaccharides; Mice; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphorylation; Signal Transduction	2018
Isolation and Characterization of Antiangiogenesis Compounds from the Fungus Aspergillus terreus Associated with Apostichopus japonicus Using Zebrafish Assay. Natural product communications, 2017, Volume: 12, Issue:2 Topics: 4-Butyrolactone; Angiogenesis Inhibitors; Animals; Aspergillus; Stichopus; Zebrafish	2017
Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. Chinese journal of natural medicines, 2019, Volume: 17, Issue:2 Topics: 4-Butyrolactone; Animals; Aspergillus; Chemistry Techniques, Analytical; Dipeptides; Enzyme Inhibitors; Indoles; Molecular Structure; Mycobacterium tuberculosis; Peptides; Polyketides; Porifera; Protein Tyrosine Phosphatases	2019
Treatment with roscovitine and butyrolactone I prior to Zygote (Cambridge, England), 2020, Volume: 28, Issue:1 Topics: 4-Butyrolactone; Animals; Blastocyst; Cattle; Embryo, Mammalian; Female; Fertilization in Vitro; In Vitro Oocyte Maturation Techniques; Meiosis; Oocytes; Protein Kinase Inhibitors; Roscovitine	2020
Cyclin-Dependent Kinase 5 Inhibitor Butyrolactone I Elicits a Partial Agonist Activity of Peroxisome Proliferator-Activated Receptor γ. Biomolecules, 2020, 02-11, Volume: 10, Issue:2 Topics: 4-Butyrolactone; Adipogenesis; Adiponectin; Binding Sites; Bone Marrow Cells; Cells, Cultured; Crystallography, X-Ray; Cyclin-Dependent Kinase 5; Humans; Mesenchymal Stem Cells; Phosphorylation; PPAR gamma; Protein Kinase Inhibitors; Protein Structure, Tertiary	2020
An anti-inflammatory isoflavone from soybean inoculated with a marine fungus Bioscience, biotechnology, and biochemistry, 2020, Volume: 84, Issue:8 Topics: 4-Butyrolactone; Acetylcholinesterase; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Aspergillus; Cholinesterase Inhibitors; Cyclohexanones; Free Radical Scavengers; Furocoumarins; Genistein; Glycine max; Inflammation; Isoflavones; Lipopolysaccharides; Mice; RAW 264.7 Cells	2020
Synthesis and Biological Evaluation of Analogues of Butyrolactone I as PTP1B Inhibitors. Marine drugs, 2020, Oct-23, Volume: 18, Issue:11 Topics: 4-Butyrolactone; Cell Line; Cell Proliferation; Glucose; Humans; Hypoglycemic Agents; Insulin; Molecular Structure; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rosiglitazone	2020
One-step partial synthesis of (±)-asperteretone B and related hPTP1B Bioorganic & medicinal chemistry, 2020, 12-15, Volume: 28, Issue:24 Topics: 4-Butyrolactone; Aspergillus; Binding Sites; Drug Design; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Principal Component Analysis; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Stereoisomerism; Structure-Activity Relationship	2020
Chemical Investigation of Marine-Derived Fungus Aspergillus flavipes for Potential Anti-Inflammatory Agents. Chemistry & biodiversity, 2021, Volume: 18, Issue:2 Topics: 4-Butyrolactone; Anti-Inflammatory Agents; Aspergillus; Biological Products; Cyclopentanes; Humans; Interleukin-6; Lipopolysaccharides; THP-1 Cells; Tumor Necrosis Factor-alpha	2021
Pharmacokinetics and Metabolism Study of Deep-Sea-Derived Butyrolactone I in Rats by UHPLC-MS/MS and UHPLC-Q-TOF-MS. Marine drugs, 2021, Dec-22, Volume: 20, Issue:1 Topics: 4-Butyrolactone; Administration, Oral; Animals; Anti-Allergic Agents; Aspergillus; Biological Availability; Chromatography, High Pressure Liquid; Disease Models, Animal; Food Hypersensitivity; Infusions, Intravenous; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry	2021
Butyrolactone I attenuates inflammation in murine NASH by inhibiting the NF-κB signaling pathway. Biochemical and biophysical research communications, 2022, 10-20, Volume: 626 Topics: 4-Butyrolactone; Animals; Disease Models, Animal; Inflammation; Lipopolysaccharides; Liver; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Signal Transduction	2022
Lipid metabolism regulatory activity and adverse effects of fungi-derived butyrolactone I. Natural product research, 2023, Volume: 37, Issue:11 Topics: 4-Butyrolactone; Fungi; Lipid Metabolism; Molecular Docking Simulation	2023