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4-butyrolactone and alpha-methylene gamma-butyrolactone

4-butyrolactone has been researched along with alpha-methylene gamma-butyrolactone in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (11.69)	18.7374
1990's	17 (22.08)	18.2507
2000's	18 (23.38)	29.6817
2010's	27 (35.06)	24.3611
2020's	6 (7.79)	2.80

Authors

Authors	Studies
Antonucci, JM; Stansbury, JW	1
Gette, MT; Marks, JE	1
Apted, J	1
Benezra, C	1
Chakraborti, SK; Choudhury, K; Panda, CK; Sanyal, U	1
Groenewegen, WA; Heptinstall, S; Knight, DW	1
Barbier, P; Benezra, C; Ducombs, G; Stampf, JL	1
Bruynzeel, DP	2
Barbier, P; Benezra, C	2
Cardellina, JH; Diamond, KB; Warren, GR	1
Benezra, C; Cheminat, A; Stampf, JL	1
Hausen, BM; Prater, E; Schubert, H	1
Christensen, LP; Kristiansen, K	2
Chen, CF; Huang, BR; Lee, KH; Tseng, TL; Tzeng, CC; Wang, HM	1
Ando, M; Arao, K; Kataoka, T; Magae, J; Nagai, K; Nishimura, T; Otake, N; Suzuki, H; Taniguchi, M; Uramoto, M	1
Enriz, RD; Giordano, OS; Jáuregui, EA; Pestchanker, MJ; Rodríguez, AM; Santagata, LN	1
Chang, NC; Chang, YL; Chen, YL; Teng, CM; Tzeng, CC; Wang, TC	1
Arimatsu, Y; Harada, K; Ohmori, S; Ueda, A; Wei, CN	1
Huang, BR; Lee, KH; Tzeng, CC	1
Bruynzeel, DP; de Boer, EM; van der Mei, IA	1
Barkley, TM; McGovern, TW	1
McGovern, TW	1
Christensen, LP	1
Frehywot, GL; Kuhajda, FP; Li, JN; Mani, NS; Pizer, ES; Townsend, CA	1
Donadel, S; Giordano, OS; Guerreiro, E; Guzman, JA; Maria, AO; Wendel, GH	1
Kawahara, Y; Matsuda, H; Morikawa, T; Shimoda, H; Uemura, T; Yoshikawa, M	1
Franks, H; Guin, JD	1
Fuchino, H; Koide, T; Satake, M; Sekita, S; Takahashi, M	1
Huang, BR; Lee, KH	2
He, M; Lei, A; Zhang, X	1
Chan, ST; Chen, CC; Huang, WC; Tzeng, CC; Yang, TL	1
Alaimo, C; Delany, I; Ieva, R; Rappuoli, R; Scarlato, V; Spohn, G	1
Jean, M; Le Roch, M; Renault, J; Uriac, P	1
Bonivento, P; Cateni, F; Frausin, F; Scarcia, V; Zacchigna, M; Zilic, J	1
Chung, HT; Jeong, GS; Jeong, SO; Kim, NS; Kim, YC; Kwon, TO; Lee, HS; Pae, HO; Park, SD	1
Arseniyadis, S; Cossy, J; Moïse, J	1
Chung, HT; Jeong, GS; Kim, HS; Kim, YC; Pae, HO; Rhew, HY; Sohn, DH; Woo, WH	1
Bermejo, J; Cabrera, J; Estévez, F; León, F; Loro, JF; Quintana, J; Torres, F	1
Berl, V; Giménez-Arnau, E; Lepoittevin, JP	1
Kitson, RR; Millemaggi, A; Taylor, RJ	1
Ali, SF; Binienda, ZK; Gough, B; Kim, CS; Riccio, T; Ross, IA	1
Clark, BP; Hodgson, DM; Talbot, EP	1
Beuermann, S; Cockburn, RA; Hutchinson, RA; McKenna, TF; Payne, KA; Siegmann, R	1
Bandey, AH; Chashoo, G; Mondhe, D; Qazi, GN; Qazi, NA; Reddy, DM; Sampath Kumar, HM; Sawant, SD; Saxena, A; Saxena, AK; Sethi, VK; Shankar, M; Singh, SK; Srinivas, J; Taneja, SC; Verma, M	1
Kato, Y; Nomura, T; Ogita, S	2
Gao, Y; Sun, L; Wang, X; Xie, L; Xu, X	1
Hassan, A; Krische, MJ; Montgomery, TP; Park, BY	1
Hillmyer, MA; Lee, Y; Shin, J; Tolman, WB	1
Dong, Y; Guo, X; Liu, G; Yu, Y	1
Xie, L; Xu, X; Yang, Y; Zhang, F	1
Drolet, MP; Nicponski, DR; Ramachandran, PV; Schmidt, CM; Yip-Schneider, MT	1
De-Long, W; He, Y; Jun-Tao, F; Xing, Z; Yong-Ling, W	1
Li, QH; Liu, TL; Tao, HY; Wang, CJ; Wei, L; Zhou, X	1
Gagare, PD; Helppi, MA; Nair, HN; Nicponski, DR; Ramachandran, PV; Schmidt, CM; Yip-Schneider, MT	1
Krische, MJ; McInturff, EL; Mowat, J; Waldeck, AR	1
Murata, Y; Sakamoto, M; Sengoku, T; Takahashi, M; Yagishita, F; Yoda, H	2
Caboni, P; Diana, A; Liori, B; Sasanelli, N; Tocco, G; Tronci, L	1
Ishida, M; Murata, Y; Sakamoto, M; Sengoku, T; Takahashi, M; Yagishita, F; Yoda, H	1
Chen, W; Tian, Q; Yang, Q; Zhang, G; Zhou, T	1
Berl, V; Debeuckelaere, C; Elbayed, K; Lepoittevin, JP; Moussallieh, FM; Namer, IJ	1
D'Acunto, M; Lloyd, MG; Taylor, RJ; Unsworth, WP	1
Feng, J; Gao, Y; Wang, D; Wu, Y; Zhang, X	1
Albrecht, D; Bernhardt, J; Haertel, B; Lalk, M; Lindequist, U; Methling, K; Niehs, S; Schultze, N; Wachlin, G; Wurster, M; Zwicker, P	1
Akhtar, S; Bashir, S; Bhat, Y; Hassan, I; Kamili, A; Kanth, R; Mubashir, S; Rasool, F; Rather, P; Rather, S; Yaseen, A	1
He, J; Hu, L; Zhang, Y; Zhao, W	1
An, T; Cai, B; Chen, L; Duan, A; Ju, X; Kong, L; Li, X; Li, Y; Yang, Q	1
Contreras, JI; Karpf, AR; Kizhake, S; Kour, S; Natarajan, A; Rana, S; Robb, CM; Sonawane, YA; Zahid, M	1
Abutaleb, NS; Hamann, HJ; Pal, R; Ramachandran, PV; Seleem, MN	1
Bai, Y; Chen, EY; He, J; Wang, H; Zhang, Y	1
Case, AJ; Huxford, T; King, HM; Kizhake, S; Kour, S; Mallareddy, JR; Natarajan, A; Rana, S	1
Elston, DM; Lee, KP	1

Reviews

3 review(s) available for 4-butyrolactone and alpha-methylene gamma-butyrolactone

Article	Year
Bulb dermatitis. Dermatological problems in the flower bulb industries. Contact dermatitis, 1997, Volume: 37, Issue:2 Topics: 4-Butyrolactone; Dermatitis, Irritant; Dermatitis, Occupational; Hand Dermatoses; Humans; Patch Tests; Plants	1997
Alpha-methylene-gamma-butyrolactones: versatile skin bioactive natural products. Chemical record (New York, N.Y.), 2009, Volume: 9, Issue:5 Topics: 4-Butyrolactone; Biological Products; Dermatitis, Allergic Contact; Plant Extracts; Stereoisomerism	2009
The renaissance of alpha-methylene-gamma-butyrolactones: new synthetic approaches. Angewandte Chemie (International ed. in English), 2009, Volume: 48, Issue:50 Topics: 4-Butyrolactone; Drug Evaluation, Preclinical; Molecular Structure; Structure-Activity Relationship	2009

Other Studies

74 other study(ies) available for 4-butyrolactone and alpha-methylene gamma-butyrolactone

Article	Year
Evaluation of methylene lactone monomers in dental resins. Dental materials : official publication of the Academy of Dental Materials, 1992, Volume: 8, Issue:4 Topics: 4-Butyrolactone; Bisphenol A-Glycidyl Methacrylate; Composite Resins; Materials Testing; Methacrylates; Viscosity	1992
Tulip fingers. Archives of dermatology, 1990, Volume: 126, Issue:2 Topics: 4-Butyrolactone; Adult; Aged; Dermatitis, Contact; Dermatitis, Occupational; Female; Fingers; Glycosides; Hand Dermatoses; Humans; Male; Middle Aged; Patch Tests; Plants; Sodium Oxybate	1990
Hand dermatitis caused by Peruvian lily. The Medical journal of Australia, 1990, Nov-05, Volume: 153, Issue:9 Topics: 4-Butyrolactone; Adult; Female; Hand Dermatoses; Humans; Plants; Skin Tests	1990
Molecular recognition in allergic contact dermatitis. The concept of double-headed haptens. Dermatologic clinics, 1990, Volume: 8, Issue:1 Topics: 4-Butyrolactone; Animals; Catechols; Chemical Phenomena; Chemistry; Cross Reactions; Dermatitis, Contact; Guinea Pigs; Haptens; Immune Tolerance	1990
Mechanism of action of alpha-methylene-gamma-lactone derivatives of substituted nucleic acid bases in tumour cells. Chemotherapy, 1989, Volume: 35, Issue:3 Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Male; Mice; Neoplasms, Experimental; Nucleic Acids; Protein Biosynthesis; Transcription, Genetic	1989
Compounds extracted from feverfew that have anti-secretory activity contain an alpha-methylene butyrolactone unit. The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:9 Topics: 4-Butyrolactone; Blood Platelets; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Epinephrine; Furans; Humans; In Vitro Techniques; Neutrophils; Plant Extracts; Plants, Medicinal; Spectrophotometry, Infrared	1986
Enantiospecificity in allergic contact dermatitis. A review and new results in Frullania-sensitive patients. Contact dermatitis, 1985, Volume: 13, Issue:2 Topics: 4-Butyrolactone; Animals; Benzofurans; Benzoquinones; Dermatitis, Contact; Guinea Pigs; Humans; Plants; Quinones; Sesquiterpenes; Skin Tests; Stereoisomerism; Structure-Activity Relationship	1985
Allergic contact dermatitis to hydrangea. Contact dermatitis, 1986, Volume: 14, Issue:2 Topics: 4-Butyrolactone; Dermatitis, Contact; Dermatitis, Occupational; Hand Dermatoses; Humans; Male; Middle Aged; Plants	1986
Allergenic alpha-methylene-gamma-butyrolactones. Study of the capacity of beta-acetoxy- and beta-hydroxy-alpha-methylene-gamma-butyrolactones to induce allergic contact dermatitis in guinea pigs. Journal of medicinal chemistry, 1986, Volume: 29, Issue:5 Topics: 4-Butyrolactone; Animals; Dermatitis, Contact; Female; Furans; Guinea Pigs	1986
Native American food and medicinal plants. 3. alpha-Methylene butyrolactone from Erythronium grandiflorum Pursh. Journal of ethnopharmacology, 1985, Volume: 14, Issue:1 Topics: 4-Butyrolactone; Canada; Furans; Humans; Indians, North American; Mutation; Plant Extracts; Plants, Edible; Plants, Medicinal	1985
Allergic contact dermatitis to laurel (Laurus nobilis L.): isolation and identification of haptens. Archives of dermatological research, 1984, Volume: 276, Issue:3 Topics: 4-Butyrolactone; Animals; Dermatitis, Contact; Female; Furans; Guinea Pigs; Haptens; Plant Extracts; Skin Tests; Trees	1984
The sensitizing capacity of Alstroemeria cultivars in man and guinea pig. Remarks on the occurrence, quantity and irritant and sensitizing potency of their constituents tuliposide A and tulipalin A (alpha-methylene-gamma-butyrolactone). Contact dermatitis, 1983, Volume: 9, Issue:1 Topics: 4-Butyrolactone; Adult; Animals; Dermatitis, Contact; Female; Furans; Guinea Pigs; Hand Dermatoses; Humans; Middle Aged; Plant Extracts; Plants; Skin Tests	1983
Allergenic alpha-methylene-gamma-butyrolactones. Stereospecific syntheses of (+)- and (-)-gamma-methyl-alpha-methylene-gamma-butyrolactones. A study of the specificity of (+) and (-) enantiomers in inducing allergic contact dermatitis. Journal of medicinal chemistry, 1982, Volume: 25, Issue:8 Topics: 4-Butyrolactone; Allergens; Animals; Chemical Phenomena; Chemistry; Dermatitis, Contact; Freund's Adjuvant; Furans; Guinea Pigs; Molecular Conformation; Stereoisomerism	1982
A simple HPLC method for the isolation and quantification of the allergens tuliposide A and tulipalin A in Alstroemeria. Contact dermatitis, 1995, Volume: 32, Issue:4 Topics: 4-Butyrolactone; Allergens; Chromatography, High Pressure Liquid; Dermatitis, Contact; Glycosides; Humans; Plants; Sodium Oxybate	1995
Synthetic and cytotoxic studies of alpha-methylene-gamma-butyrolactone bearing pyrimidines. Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences, 1993, Volume: 9, Issue:12 Topics: 4-Butyrolactone; Antineoplastic Agents; Humans; Pyrimidines; Tumor Cells, Cultured	1993
Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes. Bioscience, biotechnology, and biochemistry, 1995, Volume: 59, Issue:11 Topics: 4-Butyrolactone; Cytotoxicity, Immunologic; Lactones; Phosphorylation; Sesquiterpenes; T-Lymphocytes, Cytotoxic; Tyrosine	1995
Structure-cytoprotective activity relationship of simple molecules containing an alpha,beta-unsaturated carbonyl system. Journal of medicinal chemistry, 1997, Jun-06, Volume: 40, Issue:12 Topics: 4-Butyrolactone; Animals; Anti-Ulcer Agents; Chemical Phenomena; Chemistry, Physical; Cyclization; Cyclopentanes; Electrochemistry; Male; Models, Molecular; Molecular Conformation; Molecular Structure; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship	1997
alpha-Methylene-gamma-butyrolactones: synthesis and vasorelaxing activity assay of coumarin, naphthalene, and quinoline derivatives. Chemical & pharmaceutical bulletin, 1998, Volume: 46, Issue:6 Topics: 4-Butyrolactone; Animals; Aorta, Thoracic; Coumarins; Female; Male; Naphthalenes; Platelet Aggregation Inhibitors; Quinolines; Rats; Rats, Wistar; Structure-Activity Relationship; Vasodilation; Vasodilator Agents	1998
Experimental study of contact dermatitis due to alstroemeria in guinea pigs. Contact dermatitis, 1998, Volume: 39, Issue:2 Topics: 4-Butyrolactone; Allergens; Animals; Dermatitis, Allergic Contact; Female; Guinea Pigs; Patch Tests; Plants	1998
Synthesis and anticancer evaluation of certain alpha-methylene-gamma-(4-substituted phenyl)-gamma-butyrolactone bearing thymine, uracil, and 5-bromouracil. Bioorganic & medicinal chemistry letters, 1999, Jan-18, Volume: 9, Issue:2 Topics: 4-Butyrolactone; Alkylating Agents; Antineoplastic Agents; Bromouracil; Thymine; Tumor Cells, Cultured; Uracil	1999
Contact dermatitis in Alstroemeria workers. Occupational medicine (Oxford, England), 1998, Volume: 48, Issue:6 Topics: 4-Butyrolactone; Adolescent; Adult; Agricultural Workers' Diseases; Dermatitis, Contact; Female; Hand Dermatoses; Humans; Male; Middle Aged; Occupational Exposure; Patch Tests; Physical Examination; Plants; Risk Assessment; Risk Factors; Seasons; Surveys and Questionnaires	1998
Botanical briefs: Peruvian lily--Alstroemeria (L.) spp. Cutis, 1999, Volume: 63, Issue:3 Topics: 4-Butyrolactone; Allergens; Dermatitis, Allergic Contact; Dermatitis, Occupational; Glycosides; Hand Dermatoses; Humans; Hydrolysis; Magnoliopsida; Occupational Exposure; Sodium Oxybate	1999
Isolation and quantification of tuliposides and tulipalins in tulips (Tulipa) by high-performance liquid chromatography. Contact dermatitis, 1999, Volume: 40, Issue:6 Topics: 4-Butyrolactone; Allergens; Chromatography, High Pressure Liquid; Glucosides; Glycosides; Plants; Sodium Oxybate	1999
Alstroemeria L. (Peruvian lily). American journal of contact dermatitis : official journal of the American Contact Dermatitis Society, 1999, Volume: 10, Issue:3 Topics: 4-Butyrolactone; Adult; Allergens; Dermatitis, Allergic Contact; Glucosides; Glycosides; Hand Dermatoses; Humans; Male; Occupational Diseases; Occupational Exposure; Patch Tests; Plant Extracts; Plants; Sodium Oxybate	1999
Direct release of the allergen tulipalin A from Alstroemeria cut flowers: a possible source of airborne contact dermatitis? Contact dermatitis, 1999, Volume: 41, Issue:6 Topics: 4-Butyrolactone; Air Pollution, Indoor; Allergens; Chromatography, Gas; Chromatography, High Pressure Liquid; Dermatitis, Allergic Contact; Gas Chromatography-Mass Spectrometry; Glycosides; Humans; Plants; Sodium Oxybate	1999
Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proceedings of the National Academy of Sciences of the United States of America, 2000, Mar-28, Volume: 97, Issue:7 Topics: 4-Butyrolactone; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fatty Acid Synthases; Humans; Protein Binding; Tumor Cells, Cultured	2000
Gastric anti-ulcer activity of several alpha,beta-unsaturated carbonyl compounds in rats. Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:5 Topics: 4-Butyrolactone; Animals; Anti-Ulcer Agents; Cyclopentanes; Gastric Mucosa; Protective Agents; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship	2000
Alcohol absorption inhibitors from bay leaf (Laurus nobilis): structure-requirements of sesquiterpenes for the activity. Bioorganic & medicinal chemistry, 2000, Volume: 8, Issue:8 Topics: 4-Butyrolactone; Absorption; Animals; Blood Glucose; Drugs, Chinese Herbal; Ethanol; Furans; Humans; Lactones; Lauraceae; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Structure; Plant Leaves; Rats; Rats, Wistar; Sesquiterpenes; Structure-Activity Relationship	2000
Fingertip dermatitis in a retail florist. Cutis, 2001, Volume: 67, Issue:4 Topics: 4-Butyrolactone; Dermatitis, Allergic Contact; Dermatitis, Occupational; Hand Dermatoses; Humans; Male; Middle Aged; Plants	2001
New sesquiterpene lactones from Elephantopus mollis and their leishmanicidal activities. Planta medica, 2001, Volume: 67, Issue:7 Topics: 4-Butyrolactone; Animals; Antiprotozoal Agents; Asteraceae; Brazil; Inhibitory Concentration 50; Leishmania major; Magnetic Resonance Spectroscopy; Molecular Structure; Peru; Plant Extracts; Plants, Medicinal; Sesquiterpenes; Sesquiterpenes, Germacrane; Sesquiterpenes, Guaiane	2001
Synthesis and cytotoxic evaluation of alpha-methylene-gamma-butyrolactone bearing naphthalene and naphtho[2,1-b]furan derivatives. European journal of medicinal chemistry, 2002, Volume: 37, Issue:4 Topics: 4-Butyrolactone; Antineoplastic Agents; Drug Screening Assays, Antitumor; Furans; Humans; Naphthalenes; Structure-Activity Relationship; Tumor Cells, Cultured	2002
Highly enantioselective syntheses of functionalized alpha-methylene-gamma-butyrolactones via Rh(I)-catalyzed intramolecular Alder ene reaction: application to formal synthesis of (+)-pilocarpine. Journal of the American Chemical Society, 2002, Jul-17, Volume: 124, Issue:28 Topics: 4-Butyrolactone; Alkynes; Catalysis; Naphthalenes; Organometallic Compounds; Pilocarpine; Rhodium; Stereoisomerism	2002
Three-dimensional pharmacophore mapping of certain anticancer alpha-methylene-gamma-butyrolactones. Oncology research, 2003, Volume: 13, Issue:11 Topics: 4-Butyrolactone; Antineoplastic Agents; Models, Molecular; Molecular Conformation; Technology, Pharmaceutical	2003
Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel alpha-methylene-gamma-butyrolactone derivatives. Carcinogenesis, 2004, Volume: 25, Issue:10 Topics: 4-Butyrolactone; Anti-Ulcer Agents; Cell Adhesion; Cyclooxygenase 2; Electrophoretic Mobility Shift Assay; Epithelial Cells; Gene Expression Regulation; Humans; I-kappa B Kinase; Intercellular Adhesion Molecule-1; Isoenzymes; Luciferases; Matrix Metalloproteinase 9; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; Neoplasm Invasiveness; NF-kappa B; NF-kappaB-Inducing Kinase; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; U937 Cells	2004
CrgA is an inducible LysR-type regulator of Neisseria meningitidis, acting both as a repressor and as an activator of gene transcription. Journal of bacteriology, 2005, Volume: 187, Issue:10 Topics: 4-Butyrolactone; Bacterial Capsules; Bacterial Proteins; Base Sequence; Fimbriae, Bacterial; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Molecular Sequence Data; NAD(P)H Dehydrogenase (Quinone); Neisseria meningitidis; Promoter Regions, Genetic; Transcription Factors; Transcriptional Activation	2005
Synthesis of a laterally branched polyamine from alpha-methylene-gamma-butyrolactone. Organic letters, 2005, Jun-23, Volume: 7, Issue:13 Topics: 4-Butyrolactone; Alkynes; Catalysis; Furans; Molecular Structure; Polyamines; Stereoisomerism	2005
Synthesis and biological properties of new alpha-methylene-gamma-butyrolactones and alpha,beta-unsaturated delta-lactones. European journal of medicinal chemistry, 2006, Volume: 41, Issue:2 Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Humans; Inhibitory Concentration 50; Lactones; Structure-Activity Relationship; Tumor Cells, Cultured	2006
The alpha-methylene-gamma-butyrolactone moiety in dehydrocostus lactone is responsible for cytoprotective heme oxygenase-1 expression through activation of the nuclear factor E2-related factor 2 in HepG2 cells. European journal of pharmacology, 2007, Jun-22, Volume: 565, Issue:1-3 Topics: 4-Butyrolactone; Active Transport, Cell Nucleus; Antioxidants; Cell Line; Cytoprotection; Heme Oxygenase-1; Humans; Lactones; NF-E2-Related Factor 2; Response Elements; Sesquiterpenes	2007
Cross-metathesis between alpha-methylene-gamma-butyrolactone and olefins: a dramatic additive effect. Organic letters, 2007, Apr-26, Volume: 9, Issue:9 Topics: 4-Butyrolactone; Alkenes; Biological Products; Catalysis; Molecular Structure; Ruthenium; Stereoisomerism	2007
Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2007, Volume: 56, Issue:12 Topics: 4-Butyrolactone; Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Nucleus; Enzyme Induction; Heme Oxygenase-1; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; NF-E2-Related Factor 2; Plant Extracts; Protoporphyrins; Sesquiterpenes; Tumor Necrosis Factor-alpha	2007
Induction of G2-M phase arrest and apoptosis by alpha-methylene-gamma-butyrolactones in human leukemia cells. Cancer letters, 2008, Sep-28, Volume: 269, Issue:1 Topics: 4-Butyrolactone; Antineoplastic Agents; Apoptosis; Caspases; Cell Division; Cell Survival; Cytochromes c; G2 Phase; HL-60 Cells; Humans; Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; U937 Cells	2008
Striatal dopamine in the response of brain and liver unsaturated and saturated free fatty acids following administration of C75 in CD-1 mice. Neuroscience letters, 2010, Jan-29, Volume: 469, Issue:3 Topics: 4-Butyrolactone; Animals; Anti-Obesity Agents; Biogenic Monoamines; Brain; Cerulenin; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Eating; Fatty Acids, Monounsaturated; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Liver; Male; Mice; Mice, Inbred Strains; Neurotransmitter Agents; Serotonin; Time Factors	2010
Stereoselective synthesis of β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones. Organic letters, 2011, May-20, Volume: 13, Issue:10 Topics: 4-Butyrolactone; Catalysis; Chromium; Furans; Lactones; Lignans; Stereoisomerism; Zinc	2011
Free radical copolymerization kinetics of γ-methyl-α-methylene-γ-butyrolactone (MeMBL). Biomacromolecules, 2011, Jun-13, Volume: 12, Issue:6 Topics: 4-Butyrolactone; Acrylates; Chromatography, Gel; Free Radicals; Green Chemistry Technology; Kinetics; Lasers; Methylmethacrylate; Models, Chemical; Polymerization; Polymers; Styrene; Temperature; Thermodynamics; Viscosity	2011
Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents. European journal of medicinal chemistry, 2011, Volume: 46, Issue:8 Topics: 4-Butyrolactone; Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; DNA Fragmentation; Humans; Male; Mice; Neoplasm Transplantation; NF-kappa B; Nitriles; Oxides; Prostatic Neoplasms; Sesquiterpenes; Spiro Compounds; Structure-Activity Relationship	2011
A novel lactone-forming carboxylesterase: molecular identification of a tuliposide A-converting enzyme in tulip. Plant physiology, 2012, Volume: 159, Issue:2 Topics: 4-Butyrolactone; Amino Acid Sequence; Carboxylesterase; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Escherichia coli; Esterification; Flowers; Glycosides; Lactones; Molecular Sequence Data; Mutagenesis, Site-Directed; Plant Proteins; Plastids; Recombinant Proteins; Sodium Oxybate; Substrate Specificity; Tulipa	2012
Zinc or indium-mediated Barbier-type allylation of aldehydes with 3-bromomethyl-5H-furan-2-one in aqueous media: an efficient synthesis method for α-methylene-γ-butyrolactone. Organic & biomolecular chemistry, 2012, May-28, Volume: 10, Issue:20 Topics: 4-Butyrolactone; Aldehydes; Furans; Indium; Molecular Structure; Solvents; Zinc	2012
Enantioselective conversion of primary alcohols to α-exo-methylene γ-butyrolactones via iridium-catalyzed C-C bond-forming transfer hydrogenation: 2-(alkoxycarbonyl)allylation. Journal of the American Chemical Society, 2012, Jul-11, Volume: 134, Issue:27 Topics: 4-Butyrolactone; Alcohols; Allyl Compounds; Catalysis; Hydrogenation; Iridium; Stereoisomerism	2012
Thermoplastic elastomers derived from menthide and tulipalin A. Biomacromolecules, 2012, Nov-12, Volume: 13, Issue:11 Topics: 4-Butyrolactone; Biocompatible Materials; Elasticity; Elastomers; Ethylene Glycols; Lactones; Polymerization; Temperature; Tensile Strength	2012
Highly stereoselective synthesis of (Z)- and (E)-chloro-substituted-α-methylene-γ-butyrolactone by possibly controlling cis- and trans-chloropalladation. Molecular diversity, 2013, Volume: 17, Issue:1 Topics: 4-Butyrolactone; Alkynes; Catalysis; Lactones; Palladium; Propionates; Stereoisomerism	2013
Pd-catalyzed diastereoselective allylation of aldehydes with 3-bromomethyl-5H-furan-2-one: stereoselective synthesis of β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones with a syn configuration. Chemical communications (Cambridge, England), 2013, May-21, Volume: 49, Issue:41 Topics: 4-Butyrolactone; Aldehydes; Catalysis; Furans; Palladium; Stereoisomerism	2013
The first synthesis of a borylated α-methylene-γ-butyrolactone. Future medicinal chemistry, 2013, Volume: 5, Issue:6 Topics: 4-Butyrolactone; Antineoplastic Agents; Catalysis; Cell Line, Tumor; Cell Survival; Halogenation; Humans; Palladium	2013
New antifungal scaffold derived from a natural pharmacophore: synthesis of α-methylene-γ-butyrolactone derivatives and their antifungal activity against Colletotrichum lagenarium. Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15 Topics: 4-Butyrolactone; Antifungal Agents; Cell Line; Cell Survival; Colletotrichum; Crystallography, X-Ray; Drug Design; HeLa Cells; Humans; Microbial Sensitivity Tests; Molecular Conformation; Structure-Activity Relationship	2013
exo-Selective construction of spiro-[butyrolactone-pyrrolidine] via 1,3-dipolar cycloaddition of azomethine ylides with α-methylene-γ-butyrolactone catalyzed by Cu(I)/DTBM-BIPHEP. Chemical communications (Cambridge, England), 2013, Oct-25, Volume: 49, Issue:83 Topics: 4-Butyrolactone; Azo Compounds; Biphenyl Compounds; Catalysis; Copper; Cycloaddition Reaction; Pyrrolidines; Spiro Compounds; Stereoisomerism; Thiosemicarbazones	2013
Synthetic α-(aminomethyl)-γ-butyrolactones and their anti-pancreatic cancer activities. Bioorganic & medicinal chemistry letters, 2013, Dec-15, Volume: 23, Issue:24 Topics: 4-Butyrolactone; Amination; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Humans; Pancreatic Neoplasms; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship	2013
Ruthenium-catalyzed hydrohydroxyalkylation of acrylates with diols and α-hydroxycarbonyl compounds to form spiro- and α-methylene-γ-butyrolactones. Journal of the American Chemical Society, 2013, Nov-13, Volume: 135, Issue:45 Topics: 4-Butyrolactone; Acrylates; Alkylation; Catalysis; Crystallography, X-Ray; Models, Molecular; Ruthenium; Spiro Compounds	2013
Construction of spiro-fused 2-oxindole/α-methylene- γ-butyrolactone systems with extremely high enantioselectivity via indium-catalyzed amide allylation of N-methyl isatin. Organic letters, 2013, Dec-20, Volume: 15, Issue:24 Topics: 4-Butyrolactone; Amides; Catalysis; Indium; Indoles; Isatin; Molecular Structure; Organometallic Compounds; Oxindoles; Spiro Compounds; Stereoisomerism	2013
Tulipaline A: structure-activity aspects as a nematicide and V-ATPase inhibitor. Pesticide biochemistry and physiology, 2014, Volume: 112 Topics: 4-Butyrolactone; Aldehydes; Animals; Antinematodal Agents; Cell Survival; Dose-Response Relationship, Drug; HeLa Cells; Helminth Proteins; Humans; Hydrogen-Ion Concentration; Lactones; Lysosomes; Microscopy, Fluorescence; Molecular Structure; Organelles; Species Specificity; Structure-Activity Relationship; Tylenchoidea; Vacuolar Proton-Translocating ATPases	2014
Catalytic enantioselective amide allylation of isatins and its application in the synthesis of 2-oxindole derivatives spiro-fused to the α-methylene-γ-butyrolactone functionality. Chemistry (Weinheim an der Bergstrasse, Germany), 2014, Aug-25, Volume: 20, Issue:35 Topics: 4-Butyrolactone; Amides; Catalysis; Indoles; Isatin; Models, Molecular; Molecular Structure; Oxindoles; Spiro Compounds; Stereoisomerism	2014
Catalytic amide allylation of α-ketoesters: extremely high enantioselective synthesis of ester functionalised α-methylene-γ-butyrolactones. Organic & biomolecular chemistry, 2014, Oct-21, Volume: 12, Issue:39 Topics: 4-Butyrolactone; Amides; Catalysis; Chemistry Techniques, Synthetic; Esters; Stereoisomerism; Substrate Specificity	2014
Enantioselective Synthesis of α-exo-Methylene γ-Butyrolactones via Chromium Catalysis. Organic letters, 2015, Nov-06, Volume: 17, Issue:21 Topics: 4-Butyrolactone; Catalysis; Chromium; Lactones; Molecular Structure; Organometallic Compounds; Stereoisomerism	2015
Matrix Effect of Human Reconstructed Epidermis on the Chemoselectivity of a Skin Sensitizing α-Methylene-γ-Butyrolactone: Consequences for the Development of in Chemico Alternative Methods. Chemical research in toxicology, 2015, Nov-16, Volume: 28, Issue:11 Topics: 4-Butyrolactone; Allergens; Amino Acids; Animal Testing Alternatives; Epidermis; Haptens; Humans; Magnetic Resonance Spectroscopy; Serum Albumin	2015
A selective C-H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products. Organic & biomolecular chemistry, 2016, Feb-07, Volume: 14, Issue:5 Topics: 4-Butyrolactone; Biological Products; Molecular Structure; Stereoisomerism	2016
New α-Methylene-γ-Butyrolactone Derivatives as Potential Fungicidal Agents: Design, Synthesis and Antifungal Activities. Molecules (Basel, Switzerland), 2016, Jan-22, Volume: 21, Issue:2 Topics: 4-Butyrolactone; Antifungal Agents; Botrytis; Colletotrichum; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship	2016
A proteomic approach for the identification of immunotoxic properties of Tulipalin A. Proteomics, 2016, Volume: 16, Issue:23 Topics: 4-Butyrolactone; Apoptosis; Cell Cycle; Cell Survival; Dermatitis, Allergic Contact; DNA Repair; Electrophoresis, Gel, Two-Dimensional; Humans; Jurkat Cells; Metabolome; Protein Folding; Proteomics; Purines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Toxicity Tests	2016
Contact dermatitis caused by tulips: identification of contact sensitizers in tulip workers of Kashmir Valley in North India. Contact dermatitis, 2018, Volume: 78, Issue:1 Topics: 4-Butyrolactone; Agriculture; Cross-Sectional Studies; Dermatitis, Contact; Dermatitis, Occupational; Female; Hand Dermatoses; Humans; India; Male; Patch Tests; Plant Extracts; Plant Roots; Prevalence; Tulipa	2018
Silyl Ketene Acetals/B(C₆F₅)₃ Lewis Pair-Catalyzed Living Group Transfer Polymerization of Renewable Cyclic Acrylic Monomers. Molecules (Basel, Switzerland), 2018, Mar-15, Volume: 23, Issue:3 Topics: 4-Butyrolactone; Acetals; Catalysis; Ketones; Methylmethacrylate; Molecular Structure; Polymerization	2018
One-Step Enzymatic Synthesis of 1-Tuliposide A Using Tuliposide-Converting Enzyme. Applied biochemistry and biotechnology, 2019, Volume: 188, Issue:1 Topics: 4-Butyrolactone; Carbon-13 Magnetic Resonance Spectroscopy; Catalysis; Enzymes; Genes, Plant; Glycosides; Hydrogen-Ion Concentration; Plant Leaves; Proton Magnetic Resonance Spectroscopy; Sodium Oxybate; Spectrometry, Mass, Electrospray Ionization; Tulipa	2019
Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth. The Journal of biological chemistry, 2020, 03-13, Volume: 295, Issue:11 Topics: 4-Butyrolactone; Apoptosis; beta Catenin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Proteolysis; Sesquiterpenes; Ubiquitin-Specific Peptidase 7; Ubiquitination; Wnt Signaling Pathway	2020
Symbiotic prodrugs (SymProDs) dual targeting of NFkappaB and CDK. Chemical biology & drug design, 2020, Volume: 96, Issue:2 Topics: 4-Butyrolactone; Amines; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Drug Screening Assays, Antitumor; Female; Humans; Molecular Targeted Therapy; NF-kappa B; Ovarian Neoplasms; Piperazines; Piperidines; Prodrugs; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Sesquiterpenes; Signal Transduction; Structure-Activity Relationship	2020
β,γ-Diaryl α-methylene-γ-butyrolactones as potent antibacterials against methicillin-resistant Staphylococcus aureus. Bioorganic chemistry, 2020, Volume: 104 Topics: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Macrophages; Metalloendopeptidases; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship	2020
Dual-initiating and living frustrated Lewis pairs: expeditious synthesis of biobased thermoplastic elastomers. Nature communications, 2021, 08-12, Volume: 12, Issue:1 Topics: 4-Butyrolactone; Acrylic Resins; Crystallography, X-Ray; Elastomers; Kinetics; Lewis Acids; Models, Chemical; Molecular Structure; Phosphines; Polymerization; Polymers; Temperature	2021
Dimers of isatin derived α-methylene-γ-butyrolactone as potent anti-cancer agents. Bioorganic & medicinal chemistry letters, 2022, 06-01, Volume: 65 Topics: 4-Butyrolactone; Antineoplastic Agents; Cell Line, Tumor; I-kappa B Kinase; Isatin; NF-kappa B; Phosphorylation; Protein Serine-Threonine Kinases; Transcription Factor RelA	2022
Botanical Briefs: Tulipalin A. Cutis, 2022, Volume: 110, Issue:3 Topics: 4-Butyrolactone; Dermatitis, Contact; Eczema; Fingers; Humans	2022